Bacterial Outer Membrane Vesicles Provide Broad-Spectrum Protection against Influenza Virus Infection via Recruitment and Activation of Macrophages
Identifieur interne : 000370 ( Main/Curation ); précédent : 000369; suivant : 000371Bacterial Outer Membrane Vesicles Provide Broad-Spectrum Protection against Influenza Virus Infection via Recruitment and Activation of Macrophages
Auteurs : Eun-Hye Bae [Corée du Sud] ; Sang Hwan Seo [Corée du Sud] ; Chang-Ung Kim [Corée du Sud] ; Min Seong Jang [Corée du Sud] ; Min-Suk Song [Corée du Sud] ; Tae-Young Lee [Corée du Sud] ; Yu-Jin Jeong [Corée du Sud] ; Moo-Seung Lee [Corée du Sud] ; Jong-Hwan Park [Corée du Sud] ; Pureum Lee [Corée du Sud] ; Young Sang Kim [Corée du Sud] ; Sang-Hyun Kim [Corée du Sud] ; Doo-Jin Kim [Corée du Sud]Source :
- Journal of Innate Immunity [ 1662-811X ] ; 2019.
Abstract
Influenza A virus (IAV) poses a constant worldwide threat to human health. Although conventional vaccines are available, their protective efficacy is type or strain specific, and their production is time-consuming. For the control of an influenza pandemic in particular, agents that are immediately effective against a wide range of virus variants should be developed. Although pretreatment of various Toll-like receptor (TLR) ligands have already been reported to be effective in the defense against subsequent IAV infection, the efficacy was limited to specific subtypes, and safety concerns were also raised. In this study, we investigated the protective effect of an attenuated bacterial outer membrane vesicle harboring modified lipid A moiety of lipopolysaccharide (fmOMV) against IAV infection and the underlying mechanisms. Administration of fmOMV conferred significant protection against a lethal dose of pandemic H1N1, PR8, H5N2, and highly pathogenic H5N1 viruses; this broad antiviral activity was dependent on macrophages but independent of neutrophils. fmOMV induced recruitment and activation of macrophages and elicited type I IFNs. Intriguingly, fmOMV showed a more significant protective effect than other TLR ligands tested in previous reports, without exhibiting any adverse effect. These results show the potential of fmOMV as a prophylactic agent for the defense against influenza virus infection.
Url:
DOI: 10.1159/000494098
PubMed: 30844806
PubMed Central: 6738265
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000725
- to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :000725
- to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000092
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000162
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :000162
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000170
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :001F32
- to stream Ncbi, to step Curation: Pour aller vers cette notice dans l'étape Curation :001F32
- to stream Ncbi, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :001F32
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :000369
Links to Exploration step
PMC:6738265Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Bacterial Outer Membrane Vesicles Provide Broad-Spectrum Protection against Influenza Virus Infection via Recruitment and Activation of Macrophages</title>
<author><name sortKey="Bae, Eun Hye" sort="Bae, Eun Hye" uniqKey="Bae E" first="Eun-Hye" last="Bae">Eun-Hye Bae</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon</wicri:regionArea>
<wicri:noRegion>Daejeon</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Seo, Sang Hwan" sort="Seo, Sang Hwan" uniqKey="Seo S" first="Sang Hwan" last="Seo">Sang Hwan Seo</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon</wicri:regionArea>
<wicri:noRegion>Daejeon</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kim, Chang Ung" sort="Kim, Chang Ung" uniqKey="Kim C" first="Chang-Ung" last="Kim">Chang-Ung Kim</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon</wicri:regionArea>
<wicri:noRegion>Daejeon</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2">Department of Biochemistry, Chungnam National University, Daejeon, Republic of Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Biochemistry, Chungnam National University, Daejeon</wicri:regionArea>
<wicri:noRegion>Daejeon</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jang, Min Seong" sort="Jang, Min Seong" uniqKey="Jang M" first="Min Seong" last="Jang">Min Seong Jang</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon</wicri:regionArea>
<wicri:noRegion>Daejeon</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Song, Min Suk" sort="Song, Min Suk" uniqKey="Song M" first="Min-Suk" last="Song">Min-Suk Song</name>
<affiliation wicri:level="1"><nlm:aff id="aff3">College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju</wicri:regionArea>
<wicri:noRegion>Cheongju</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lee, Tae Young" sort="Lee, Tae Young" uniqKey="Lee T" first="Tae-Young" last="Lee">Tae-Young Lee</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon</wicri:regionArea>
<wicri:noRegion>Daejeon</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jeong, Yu Jin" sort="Jeong, Yu Jin" uniqKey="Jeong Y" first="Yu-Jin" last="Jeong">Yu-Jin Jeong</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon</wicri:regionArea>
<wicri:noRegion>Daejeon</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lee, Moo Seung" sort="Lee, Moo Seung" uniqKey="Lee M" first="Moo-Seung" last="Lee">Moo-Seung Lee</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon</wicri:regionArea>
<wicri:noRegion>Daejeon</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff5">University of Science and Technology (UST), Daejeon, Republic of Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>University of Science and Technology (UST), Daejeon</wicri:regionArea>
<wicri:noRegion>Daejeon</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Park, Jong Hwan" sort="Park, Jong Hwan" uniqKey="Park J" first="Jong-Hwan" last="Park">Jong-Hwan Park</name>
<affiliation wicri:level="1"><nlm:aff id="aff4">College of Veterinary Medicine, Chonnam National University, Gwangju, Republic of Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>College of Veterinary Medicine, Chonnam National University, Gwangju</wicri:regionArea>
<wicri:noRegion>Gwangju</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lee, Pureum" sort="Lee, Pureum" uniqKey="Lee P" first="Pureum" last="Lee">Pureum Lee</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon</wicri:regionArea>
<wicri:noRegion>Daejeon</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff5">University of Science and Technology (UST), Daejeon, Republic of Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>University of Science and Technology (UST), Daejeon</wicri:regionArea>
<wicri:noRegion>Daejeon</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kim, Young Sang" sort="Kim, Young Sang" uniqKey="Kim Y" first="Young Sang" last="Kim">Young Sang Kim</name>
<affiliation wicri:level="1"><nlm:aff id="aff2">Department of Biochemistry, Chungnam National University, Daejeon, Republic of Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Biochemistry, Chungnam National University, Daejeon</wicri:regionArea>
<wicri:noRegion>Daejeon</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kim, Sang Hyun" sort="Kim, Sang Hyun" uniqKey="Kim S" first="Sang-Hyun" last="Kim">Sang-Hyun Kim</name>
<affiliation wicri:level="1"><nlm:aff id="aff6">College of Veterinary Medicine, Gyeongsang National University, Jinju, Republic of Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>College of Veterinary Medicine, Gyeongsang National University, Jinju</wicri:regionArea>
<wicri:noRegion>Jinju</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kim, Doo Jin" sort="Kim, Doo Jin" uniqKey="Kim D" first="Doo-Jin" last="Kim">Doo-Jin Kim</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon</wicri:regionArea>
<wicri:noRegion>Daejeon</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2">Department of Biochemistry, Chungnam National University, Daejeon, Republic of Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Biochemistry, Chungnam National University, Daejeon</wicri:regionArea>
<wicri:noRegion>Daejeon</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff5">University of Science and Technology (UST), Daejeon, Republic of Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>University of Science and Technology (UST), Daejeon</wicri:regionArea>
<wicri:noRegion>Daejeon</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">30844806</idno>
<idno type="pmc">6738265</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738265</idno>
<idno type="RBID">PMC:6738265</idno>
<idno type="doi">10.1159/000494098</idno>
<date when="2019">2019</date>
<idno type="wicri:Area/Pmc/Corpus">000725</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000725</idno>
<idno type="wicri:Area/Pmc/Curation">000725</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000725</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000092</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000092</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:30844806</idno>
<idno type="wicri:Area/PubMed/Corpus">000162</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000162</idno>
<idno type="wicri:Area/PubMed/Curation">000162</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000162</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000170</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000170</idno>
<idno type="wicri:Area/Ncbi/Merge">001F32</idno>
<idno type="wicri:Area/Ncbi/Curation">001F32</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001F32</idno>
<idno type="wicri:doubleKey">1662-811X:2019:Bae E:bacterial:outer:membrane</idno>
<idno type="wicri:Area/Main/Merge">000369</idno>
<idno type="wicri:Area/Main/Curation">000370</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Bacterial Outer Membrane Vesicles Provide Broad-Spectrum Protection against Influenza Virus Infection via Recruitment and Activation of Macrophages</title>
<author><name sortKey="Bae, Eun Hye" sort="Bae, Eun Hye" uniqKey="Bae E" first="Eun-Hye" last="Bae">Eun-Hye Bae</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon</wicri:regionArea>
<wicri:noRegion>Daejeon</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Seo, Sang Hwan" sort="Seo, Sang Hwan" uniqKey="Seo S" first="Sang Hwan" last="Seo">Sang Hwan Seo</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon</wicri:regionArea>
<wicri:noRegion>Daejeon</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kim, Chang Ung" sort="Kim, Chang Ung" uniqKey="Kim C" first="Chang-Ung" last="Kim">Chang-Ung Kim</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon</wicri:regionArea>
<wicri:noRegion>Daejeon</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2">Department of Biochemistry, Chungnam National University, Daejeon, Republic of Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Biochemistry, Chungnam National University, Daejeon</wicri:regionArea>
<wicri:noRegion>Daejeon</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jang, Min Seong" sort="Jang, Min Seong" uniqKey="Jang M" first="Min Seong" last="Jang">Min Seong Jang</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon</wicri:regionArea>
<wicri:noRegion>Daejeon</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Song, Min Suk" sort="Song, Min Suk" uniqKey="Song M" first="Min-Suk" last="Song">Min-Suk Song</name>
<affiliation wicri:level="1"><nlm:aff id="aff3">College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, Republic of Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju</wicri:regionArea>
<wicri:noRegion>Cheongju</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lee, Tae Young" sort="Lee, Tae Young" uniqKey="Lee T" first="Tae-Young" last="Lee">Tae-Young Lee</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon</wicri:regionArea>
<wicri:noRegion>Daejeon</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jeong, Yu Jin" sort="Jeong, Yu Jin" uniqKey="Jeong Y" first="Yu-Jin" last="Jeong">Yu-Jin Jeong</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon</wicri:regionArea>
<wicri:noRegion>Daejeon</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lee, Moo Seung" sort="Lee, Moo Seung" uniqKey="Lee M" first="Moo-Seung" last="Lee">Moo-Seung Lee</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon</wicri:regionArea>
<wicri:noRegion>Daejeon</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff5">University of Science and Technology (UST), Daejeon, Republic of Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>University of Science and Technology (UST), Daejeon</wicri:regionArea>
<wicri:noRegion>Daejeon</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Park, Jong Hwan" sort="Park, Jong Hwan" uniqKey="Park J" first="Jong-Hwan" last="Park">Jong-Hwan Park</name>
<affiliation wicri:level="1"><nlm:aff id="aff4">College of Veterinary Medicine, Chonnam National University, Gwangju, Republic of Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>College of Veterinary Medicine, Chonnam National University, Gwangju</wicri:regionArea>
<wicri:noRegion>Gwangju</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lee, Pureum" sort="Lee, Pureum" uniqKey="Lee P" first="Pureum" last="Lee">Pureum Lee</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon</wicri:regionArea>
<wicri:noRegion>Daejeon</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff5">University of Science and Technology (UST), Daejeon, Republic of Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>University of Science and Technology (UST), Daejeon</wicri:regionArea>
<wicri:noRegion>Daejeon</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kim, Young Sang" sort="Kim, Young Sang" uniqKey="Kim Y" first="Young Sang" last="Kim">Young Sang Kim</name>
<affiliation wicri:level="1"><nlm:aff id="aff2">Department of Biochemistry, Chungnam National University, Daejeon, Republic of Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Biochemistry, Chungnam National University, Daejeon</wicri:regionArea>
<wicri:noRegion>Daejeon</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kim, Sang Hyun" sort="Kim, Sang Hyun" uniqKey="Kim S" first="Sang-Hyun" last="Kim">Sang-Hyun Kim</name>
<affiliation wicri:level="1"><nlm:aff id="aff6">College of Veterinary Medicine, Gyeongsang National University, Jinju, Republic of Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>College of Veterinary Medicine, Gyeongsang National University, Jinju</wicri:regionArea>
<wicri:noRegion>Jinju</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kim, Doo Jin" sort="Kim, Doo Jin" uniqKey="Kim D" first="Doo-Jin" last="Kim">Doo-Jin Kim</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon</wicri:regionArea>
<wicri:noRegion>Daejeon</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2">Department of Biochemistry, Chungnam National University, Daejeon, Republic of Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Biochemistry, Chungnam National University, Daejeon</wicri:regionArea>
<wicri:noRegion>Daejeon</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff5">University of Science and Technology (UST), Daejeon, Republic of Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>University of Science and Technology (UST), Daejeon</wicri:regionArea>
<wicri:noRegion>Daejeon</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of Innate Immunity</title>
<idno type="ISSN">1662-811X</idno>
<idno type="eISSN">1662-8128</idno>
<imprint><date when="2019">2019</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Influenza A virus (IAV) poses a constant worldwide threat to human health. Although conventional vaccines are available, their protective efficacy is type or strain specific, and their production is time-consuming. For the control of an influenza pandemic in particular, agents that are immediately effective against a wide range of virus variants should be developed. Although pretreatment of various Toll-like receptor (TLR) ligands have already been reported to be effective in the defense against subsequent IAV infection, the efficacy was limited to specific subtypes, and safety concerns were also raised. In this study, we investigated the protective effect of an attenuated bacterial outer membrane vesicle harboring modified lipid A moiety of lipopolysaccharide (fmOMV) against IAV infection and the underlying mechanisms. Administration of fmOMV conferred significant protection against a lethal dose of pandemic H1N1, PR8, H5N2, and highly pathogenic H5N1 viruses; this broad antiviral activity was dependent on macrophages but independent of neutrophils. fmOMV induced recruitment and activation of macrophages and elicited type I IFNs. Intriguingly, fmOMV showed a more significant protective effect than other TLR ligands tested in previous reports, without exhibiting any adverse effect. These results show the potential of fmOMV as a prophylactic agent for the defense against influenza virus infection.</p>
</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/PandemieGrippaleV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000370 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 000370 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= PandemieGrippaleV1 |flux= Main |étape= Curation |type= RBID |clé= PMC:6738265 |texte= Bacterial Outer Membrane Vesicles Provide Broad-Spectrum Protection against Influenza Virus Infection via Recruitment and Activation of Macrophages }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Curation/RBID.i -Sk "pubmed:30844806" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Curation/biblio.hfd \ | NlmPubMed2Wicri -a PandemieGrippaleV1
![]() | This area was generated with Dilib version V0.6.34. | ![]() |