H1N1 hemagglutinin-specific HLA-DQ6-restricted CD4+ T cells can be readily detected in narcolepsy type 1 patients and healthy controls.
Identifieur interne : 000341 ( Main/Curation ); précédent : 000340; suivant : 000342H1N1 hemagglutinin-specific HLA-DQ6-restricted CD4+ T cells can be readily detected in narcolepsy type 1 patients and healthy controls.
Auteurs : M S Schinkelshoek [Pays-Bas] ; R. Fronczek [Pays-Bas] ; E M C. Kooy-Winkelaar [Pays-Bas] ; J. Petersen [Australie] ; H H Reid [Australie] ; A. Van Der Heide [Pays-Bas] ; J W Drijfhout [Pays-Bas] ; J. Rossjohn [Royaume-Uni] ; G J Lammers [Pays-Bas] ; F. Koning [Pays-Bas]Source :
- Journal of neuroimmunology [ 1872-8421 ] ; 2019.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Antigènes HLA-DQ (), Antigènes HLA-DQ (immunologie), Chaines alpha des antigènes HLA-DQ (analyse), Chaines bêta des antigènes HLA-DQ (analyse), Conformation des protéines, Cristallographie aux rayons X, Enfant, Femelle, Fragments peptidiques (), Fragments peptidiques (immunologie), Glycoprotéine hémagglutinine du virus influenza (), Glycoprotéine hémagglutinine du virus influenza (immunologie), Humains, Jeune adulte, Lymphocytes T CD4+ (immunologie), Mimétisme moléculaire, Modèles moléculaires, Mâle, Narcolepsie (immunologie), Narcolepsie (étiologie), Orexines (), Orexines (immunologie), Pandémies, Protéines du liquide céphalorachidien (analyse), Sous-populations de lymphocytes T (immunologie), Sous-type H1N1 du virus de la grippe A.
- MESH :
- analyse : Chaines alpha des antigènes HLA-DQ, Chaines bêta des antigènes HLA-DQ, Protéines du liquide céphalorachidien.
- immunologie : Antigènes HLA-DQ, Fragments peptidiques, Glycoprotéine hémagglutinine du virus influenza, Lymphocytes T CD4+, Narcolepsie, Orexines, Sous-populations de lymphocytes T.
- étiologie : Narcolepsie.
- Adolescent, Adulte, Adulte d'âge moyen, Antigènes HLA-DQ, Conformation des protéines, Cristallographie aux rayons X, Enfant, Femelle, Fragments peptidiques, Glycoprotéine hémagglutinine du virus influenza, Humains, Jeune adulte, Mimétisme moléculaire, Modèles moléculaires, Mâle, Orexines, Pandémies, Sous-type H1N1 du virus de la grippe A.
English descriptors
- KwdEn :
- Adolescent, Adult, CD4-Positive T-Lymphocytes (immunology), Cerebrospinal Fluid Proteins (analysis), Child, Crystallography, X-Ray, Female, HLA-DQ Antigens (chemistry), HLA-DQ Antigens (immunology), HLA-DQ alpha-Chains (analysis), HLA-DQ beta-Chains (analysis), Hemagglutinin Glycoproteins, Influenza Virus (chemistry), Hemagglutinin Glycoproteins, Influenza Virus (immunology), Humans, Influenza A Virus, H1N1 Subtype, Male, Middle Aged, Models, Molecular, Molecular Mimicry, Narcolepsy (etiology), Narcolepsy (immunology), Orexins (cerebrospinal fluid), Orexins (chemistry), Orexins (immunology), Pandemics, Peptide Fragments (chemistry), Peptide Fragments (immunology), Protein Conformation, T-Lymphocyte Subsets (immunology), Young Adult.
- MESH :
- chemical , analysis : Cerebrospinal Fluid Proteins, HLA-DQ alpha-Chains, HLA-DQ beta-Chains.
- chemical , cerebrospinal fluid : Orexins.
- chemical , chemistry : HLA-DQ Antigens, Hemagglutinin Glycoproteins, Influenza Virus, Orexins, Peptide Fragments.
- etiology : Narcolepsy.
- immunology : CD4-Positive T-Lymphocytes, HLA-DQ Antigens, Hemagglutinin Glycoproteins, Influenza Virus, Narcolepsy, Orexins, Peptide Fragments, T-Lymphocyte Subsets.
- Adolescent, Adult, Child, Crystallography, X-Ray, Female, Humans, Influenza A Virus, H1N1 Subtype, Male, Middle Aged, Models, Molecular, Molecular Mimicry, Pandemics, Protein Conformation, Young Adult.
Abstract
Following the 2009 H1N1 influenza pandemic, an increased risk of narcolepsy type 1 was observed. Homology between an H1N1 hemagglutinin and two hypocretin sequences has been reported. T cell reactivity to these peptides was assessed in 81 narcolepsy type 1 patients and 19 HLA-DQ6-matched healthy controls. HLA-DQ6-restricted H1N1 hemagglutinin-specific T cell responses were detected in 28.4% of patients and 15.8% of controls. Despite structural homology between HLA-DQ6-hypocretin and -H1N1 peptide complexes, T cell cross-reactivity was not detected. These results indicate that it is unlikely that cross-reactivity between H1N1 hemagglutinin and hypocretin peptides presented by HLA-DQ6 is involved in the development of narcolepsy.
DOI: 10.1016/j.jneuroim.2019.04.009
PubMed: 31048269
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Electronic address: M.S.Schinkelshoek@lumc.nl.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Neurology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, the Netherlands; Sleep Wake Centre SEIN, Achterweg 5, 2103 SW Heemstede</wicri:regionArea><wicri:noRegion>2103 SW Heemstede</wicri:noRegion></affiliation></author><author><name sortKey="Fronczek, R" sort="Fronczek, R" uniqKey="Fronczek R" first="R" last="Fronczek">R. Fronczek</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, the Netherlands; Sleep Wake Centre SEIN, Achterweg 5, 2103 SW Heemstede, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Neurology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, the Netherlands; Sleep Wake Centre SEIN, Achterweg 5, 2103 SW Heemstede</wicri:regionArea><wicri:noRegion>2103 SW Heemstede</wicri:noRegion></affiliation></author><author><name sortKey="Kooy Winkelaar, E M C" sort="Kooy Winkelaar, E M C" uniqKey="Kooy Winkelaar E" first="E M C" last="Kooy-Winkelaar">E M C. Kooy-Winkelaar</name><affiliation wicri:level="1"><nlm:affiliation>Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden</wicri:regionArea><wicri:noRegion>2300 RC Leiden</wicri:noRegion></affiliation></author><author><name sortKey="Petersen, J" sort="Petersen, J" uniqKey="Petersen J" first="J" last="Petersen">J. Petersen</name><affiliation wicri:level="1"><nlm:affiliation>Infection and Immunity Program, The Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, VIC 3800, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Infection and Immunity Program, The Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, VIC 3800</wicri:regionArea><wicri:noRegion>VIC 3800</wicri:noRegion></affiliation></author><author><name sortKey="Reid, H H" sort="Reid, H H" uniqKey="Reid H" first="H H" last="Reid">H H Reid</name><affiliation wicri:level="1"><nlm:affiliation>Infection and Immunity Program, The Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, VIC 3800, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Infection and Immunity Program, The Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, VIC 3800</wicri:regionArea><wicri:noRegion>VIC 3800</wicri:noRegion></affiliation></author><author><name sortKey="Van Der Heide, A" sort="Van Der Heide, A" uniqKey="Van Der Heide A" first="A" last="Van Der Heide">A. Van Der Heide</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Neurology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden</wicri:regionArea><wicri:noRegion>2300 RC Leiden</wicri:noRegion></affiliation></author><author><name sortKey="Drijfhout, J W" sort="Drijfhout, J W" uniqKey="Drijfhout J" first="J W" last="Drijfhout">J W Drijfhout</name><affiliation wicri:level="1"><nlm:affiliation>Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden</wicri:regionArea><wicri:noRegion>2300 RC Leiden</wicri:noRegion></affiliation></author><author><name sortKey="Rossjohn, J" sort="Rossjohn, J" uniqKey="Rossjohn J" first="J" last="Rossjohn">J. Rossjohn</name><affiliation wicri:level="1"><nlm:affiliation>Infection and Immunity Program, The Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, VIC 3800, Australia; Institute of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Infection and Immunity Program, The Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, VIC 3800, Australia; Institute of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN</wicri:regionArea><wicri:noRegion>Cardiff CF14 4XN</wicri:noRegion></affiliation></author><author><name sortKey="Lammers, G J" sort="Lammers, G J" uniqKey="Lammers G" first="G J" last="Lammers">G J Lammers</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, the Netherlands; Sleep Wake Centre SEIN, Achterweg 5, 2103 SW Heemstede, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Neurology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, the Netherlands; Sleep Wake Centre SEIN, Achterweg 5, 2103 SW Heemstede</wicri:regionArea><wicri:noRegion>2103 SW Heemstede</wicri:noRegion></affiliation></author><author><name sortKey="Koning, F" sort="Koning, F" uniqKey="Koning F" first="F" last="Koning">F. Koning</name><affiliation wicri:level="1"><nlm:affiliation>Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden</wicri:regionArea><wicri:noRegion>2300 RC Leiden</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of neuroimmunology</title><idno type="eISSN">1872-8421</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>CD4-Positive T-Lymphocytes (immunology)</term><term>Cerebrospinal Fluid Proteins (analysis)</term><term>Child</term><term>Crystallography, X-Ray</term><term>Female</term><term>HLA-DQ Antigens (chemistry)</term><term>HLA-DQ Antigens (immunology)</term><term>HLA-DQ alpha-Chains (analysis)</term><term>HLA-DQ beta-Chains (analysis)</term><term>Hemagglutinin Glycoproteins, Influenza Virus (chemistry)</term><term>Hemagglutinin Glycoproteins, Influenza Virus (immunology)</term><term>Humans</term><term>Influenza A Virus, H1N1 Subtype</term><term>Male</term><term>Middle Aged</term><term>Models, Molecular</term><term>Molecular Mimicry</term><term>Narcolepsy (etiology)</term><term>Narcolepsy (immunology)</term><term>Orexins (cerebrospinal fluid)</term><term>Orexins (chemistry)</term><term>Orexins (immunology)</term><term>Pandemics</term><term>Peptide Fragments (chemistry)</term><term>Peptide Fragments (immunology)</term><term>Protein Conformation</term><term>T-Lymphocyte Subsets (immunology)</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge 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(immunologie)</term><term>Sous-type H1N1 du virus de la grippe A</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Cerebrospinal Fluid Proteins</term><term>HLA-DQ alpha-Chains</term><term>HLA-DQ beta-Chains</term></keywords><keywords scheme="MESH" type="chemical" qualifier="cerebrospinal fluid" xml:lang="en"><term>Orexins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>HLA-DQ Antigens</term><term>Hemagglutinin Glycoproteins, Influenza Virus</term><term>Orexins</term><term>Peptide Fragments</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Chaines alpha des antigènes HLA-DQ</term><term>Chaines bêta des antigènes HLA-DQ</term><term>Protéines du liquide céphalorachidien</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Narcolepsy</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes HLA-DQ</term><term>Fragments peptidiques</term><term>Glycoprotéine hémagglutinine du virus influenza</term><term>Lymphocytes T CD4+</term><term>Narcolepsie</term><term>Orexines</term><term>Sous-populations de lymphocytes T</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>CD4-Positive T-Lymphocytes</term><term>HLA-DQ Antigens</term><term>Hemagglutinin Glycoproteins, Influenza Virus</term><term>Narcolepsy</term><term>Orexins</term><term>Peptide Fragments</term><term>T-Lymphocyte Subsets</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Narcolepsie</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Child</term><term>Crystallography, X-Ray</term><term>Female</term><term>Humans</term><term>Influenza A Virus, H1N1 Subtype</term><term>Male</term><term>Middle Aged</term><term>Models, Molecular</term><term>Molecular Mimicry</term><term>Pandemics</term><term>Protein Conformation</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Antigènes HLA-DQ</term><term>Conformation des protéines</term><term>Cristallographie aux rayons X</term><term>Enfant</term><term>Femelle</term><term>Fragments peptidiques</term><term>Glycoprotéine hémagglutinine du virus influenza</term><term>Humains</term><term>Jeune adulte</term><term>Mimétisme moléculaire</term><term>Modèles moléculaires</term><term>Mâle</term><term>Orexines</term><term>Pandémies</term><term>Sous-type H1N1 du virus de la grippe A</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Following the 2009 H1N1 influenza pandemic, an increased risk of narcolepsy type 1 was observed. Homology between an H1N1 hemagglutinin and two hypocretin sequences has been reported. T cell reactivity to these peptides was assessed in 81 narcolepsy type 1 patients and 19 HLA-DQ6-matched healthy controls. HLA-DQ6-restricted H1N1 hemagglutinin-specific T cell responses were detected in 28.4% of patients and 15.8% of controls. Despite structural homology between HLA-DQ6-hypocretin and -H1N1 peptide complexes, T cell cross-reactivity was not detected. These results indicate that it is unlikely that cross-reactivity between H1N1 hemagglutinin and hypocretin peptides presented by HLA-DQ6 is involved in the development of narcolepsy.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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