Severe pandemic (H1N1)v influenza A infection: Report on the first deaths in Spain
Identifieur interne : 001924 ( Istex/Curation ); précédent : 001923; suivant : 001925Severe pandemic (H1N1)v influenza A infection: Report on the first deaths in Spain
Auteurs : Ignacio Martin-Loeches ; Alejandro Rodriguez ; Juan Bonastre ; Rafael Zaragoza ; Rafael Sierra ; Asunci N Marques ; Jose Juliá-Narvaez ; Emili Diaz ; Jordi Rello [Espagne]Source :
- Respirology [ 1323-7799 ] ; 2011-01.
English descriptors
- Teeft :
- Acute physiology, Antiviral, Antiviral drugs, Antiviral therapy, Antiviral treatment, Asian society, Authors respirology, Barcelona, Bilateral patchy alveolar opacities, Care units, Carlos, Chronic health evaluation, Ciber enfermedades respiratorias, Complejo hospitalario, Crit, Critical care department, Critical illness, Disease control, Dysfunction syndrome, Early detection, Equal periods, European society, Fatal cases, Fteen patients, Fulminant, Fulminant myocarditis, Gran canaria, High rate, High risk, Hospital admission, Hospital barcelona, Hospital infanta elena, Hospital nuestra, Hospital puerta, Hospital sant joan, Hospital santa, Hospital universitario, Hospital virgen, Infection, Intensive care medicine, Intensive care unit, Intensive care units, Interquartile range, Intravenous corticosteroids, Invasive ventilation, Joan xxiii university hospital, Leucocyte count, Madrid, Median, Median time, Mortality rate, Multicentre study, Ndings, Pandemic, Patients percentage, Platelet count, Pneumonia, Present cohort, Present study, Primary cause, Prone position, Rafael, Renal replacement therapy, Respirology, Risk factor, Risk factors, Sequential organ failure assessment, Sofa score, Universitario, University hospital, Valencia, Vasopressor drugs, Vast majority, Viral, Viral load, Viral pneumonia, Virgen, Virus infection, World health organization.
Abstract
Background and objective: The impact of pandemic influenza A (H1N1)v infection is still unknown but it is associated with a high case‐fatality rate. Methods: This was a prospective, observational, multicentre study conducted in 144 Spanish intensive care units. Demographic and clinical data were reviewed for all cases of pandemic influenza A (H1N1)v infection reported from 23 June 2009 through 11 February 2010 and confirmed by reverse transcriptase PCR assay. Results: Out of 872 cases reported by statewide surveillance, data for the first 131 deceased patients were analysed. Thirty‐seven patients (28.2%) died within the first 14 days. The median age of these patients was 46 years (interquartile range 35–58) and 60.3% were male. Twenty‐eight patients (21.4%) did not present with any comorbidities on admission. Forty‐six per cent of patients were reported to be obese and 22 (16.8%) had COPD. The vast majority of the patients (72.5%) had viral pneumonia; 95.4% of these had bilateral patchy alveolar opacities (predominantly basal), affecting three or four quadrants. One hundred and fifteen patients (87.8%) developed multi‐organ dysfunction syndrome. Ninety‐seven patients (74%) required vasopressor drugs, 37 (27.2%) received renal replacement therapy, and 47 (35.1%) received intravenous corticosteroids on admission to the intensive care unit. Only 68 patients (51.9%) received empirical antiviral treatment. Conclusions: One‐third of patients with pandemic influenza A (H1N1)v infection died within the first two weeks and these were young patients, with rapidly progressive viral pneumonia as the primary cause of admission. Obese patients were at high risk but one in four patients did not present with any risk factors on admission. Only half the patients received empirical antiviral therapy and this was administered late.
The impact of pandemic (H1N1)v influenza A infection is still unknown but it is associated with a high case‐fatality rate. This prospective, observational, multicentre study conducted in 144 Spanish intensive care units, summarizes the clinical characteristics of the first 131 patients who died during the initial wave of infection.
Url:
DOI: 10.1111/j.1440-1843.2010.01874.x
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001924
Links to Exploration step
ISTEX:08F85C3B6D14253B8F7E73C285160B0D11FC59DECuration
No country items
Ignacio Martin-Loeches<affiliation><mods:affiliation>E-mail: drmartinloeches@gmail.com</mods:affiliation>
<wicri:noCountry code="no comma">E-mail: drmartinloeches@gmail.com</wicri:noCountry>
</affiliation>
<affiliation><mods:affiliation>Critical Care Department, Joan XXIII University Hospital, University Rovira i Virgili, IISPV, CIBER Enfermedades Respiratorias (CIBERes), Tarragona</mods:affiliation>
<wicri:noCountry code="subField">Tarragona</wicri:noCountry>
</affiliation>
<affiliation><mods:affiliation>Critical Care Department, La Fe University Hospital</mods:affiliation>
<wicri:noCountry code="subField">Hospital</wicri:noCountry>
</affiliation>
<affiliation><mods:affiliation>Critical Care Department, Dr Peset University Hospital</mods:affiliation>
<wicri:noCountry code="subField">Hospital</wicri:noCountry>
</affiliation>
<affiliation><mods:affiliation>Critical Care Department, Puerta del Mar University Hospital, Cádiz</mods:affiliation>
<wicri:noCountry code="subField">Cádiz</wicri:noCountry>
</affiliation>
<affiliation><mods:affiliation>Critical Care Department, La Ribera University Hospital, Valencia</mods:affiliation>
<wicri:noCountry code="subField">Valencia</wicri:noCountry>
</affiliation>
<affiliation><mods:affiliation>Critical Care Department, Infanta Cristina University Hospital, Badajoz</mods:affiliation>
<wicri:noCountry code="subField">Badajoz</wicri:noCountry>
</affiliation>
<affiliation><mods:affiliation>Critical Care Department, Joan XXIII University Hospital, University Rovira i Virgili, IISPV, CIBER Enfermedades Respiratorias (CIBERes), Tarragona</mods:affiliation>
<wicri:noCountry code="subField">Tarragona</wicri:noCountry>
</affiliation>
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Severe pandemic (H1N1)v influenza A infection: Report on the first deaths in Spain</title>
<author><name sortKey="Martin Oeches, Ignacio" sort="Martin Oeches, Ignacio" uniqKey="Martin Oeches I" first="Ignacio" last="Martin-Loeches">Ignacio Martin-Loeches</name>
<affiliation><mods:affiliation>Critical Care Department, Joan XXIII University Hospital, University Rovira i Virgili, IISPV, CIBER Enfermedades Respiratorias (CIBERes), Tarragona</mods:affiliation>
<wicri:noCountry code="subField">Tarragona</wicri:noCountry>
</affiliation>
<affiliation><mods:affiliation>E-mail: drmartinloeches@gmail.com</mods:affiliation>
<wicri:noCountry code="no comma">E-mail: drmartinloeches@gmail.com</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Rodriguez, Alejandro" sort="Rodriguez, Alejandro" uniqKey="Rodriguez A" first="Alejandro" last="Rodriguez">Alejandro Rodriguez</name>
<affiliation><mods:affiliation>Critical Care Department, Joan XXIII University Hospital, University Rovira i Virgili, IISPV, CIBER Enfermedades Respiratorias (CIBERes), Tarragona</mods:affiliation>
<wicri:noCountry code="subField">Tarragona</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Bonastre, Juan" sort="Bonastre, Juan" uniqKey="Bonastre J" first="Juan" last="Bonastre">Juan Bonastre</name>
<affiliation><mods:affiliation>Critical Care Department, La Fe University Hospital</mods:affiliation>
<wicri:noCountry code="subField">Hospital</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Zaragoza, Rafael" sort="Zaragoza, Rafael" uniqKey="Zaragoza R" first="Rafael" last="Zaragoza">Rafael Zaragoza</name>
<affiliation><mods:affiliation>Critical Care Department, Dr Peset University Hospital</mods:affiliation>
<wicri:noCountry code="subField">Hospital</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Sierra, Rafael" sort="Sierra, Rafael" uniqKey="Sierra R" first="Rafael" last="Sierra">Rafael Sierra</name>
<affiliation><mods:affiliation>Critical Care Department, Puerta del Mar University Hospital, Cádiz</mods:affiliation>
<wicri:noCountry code="subField">Cádiz</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Marques, Asunci N" sort="Marques, Asunci N" uniqKey="Marques A" first="Asunci N" last="Marques">Asunci N Marques</name>
<affiliation><mods:affiliation>Critical Care Department, La Ribera University Hospital, Valencia</mods:affiliation>
<wicri:noCountry code="subField">Valencia</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Julia Arvaez, Jose" sort="Julia Arvaez, Jose" uniqKey="Julia Arvaez J" first="Jose" last="Juliá-Narvaez">Jose Juliá-Narvaez</name>
<affiliation><mods:affiliation>Critical Care Department, Infanta Cristina University Hospital, Badajoz</mods:affiliation>
<wicri:noCountry code="subField">Badajoz</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Diaz, Emili" sort="Diaz, Emili" uniqKey="Diaz E" first="Emili" last="Diaz">Emili Diaz</name>
<affiliation><mods:affiliation>Critical Care Department, Joan XXIII University Hospital, University Rovira i Virgili, IISPV, CIBER Enfermedades Respiratorias (CIBERes), Tarragona</mods:affiliation>
<wicri:noCountry code="subField">Tarragona</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Rello, Jordi" sort="Rello, Jordi" uniqKey="Rello J" first="Jordi" last="Rello">Jordi Rello</name>
<affiliation wicri:level="1"><mods:affiliation>Critical Care Department, Vall d'Hebron University Hospital, Institut de Recerca Vall d'Hebron, CIBER Enfermedades Respiratorias (CIBERes), Universitat Autónoma de Barcelona, Barcelona, Spain</mods:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Critical Care Department, Vall d'Hebron University Hospital, Institut de Recerca Vall d'Hebron, CIBER Enfermedades Respiratorias (CIBERes), Universitat Autónoma de Barcelona, Barcelona</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:08F85C3B6D14253B8F7E73C285160B0D11FC59DE</idno>
<date when="2011" year="2011">2011</date>
<idno type="doi">10.1111/j.1440-1843.2010.01874.x</idno>
<idno type="url">https://api.istex.fr/ark:/67375/WNG-4T715RPN-3/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">001924</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001924</idno>
<idno type="wicri:Area/Istex/Curation">001924</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main">Severe pandemic (H1N1)v influenza A infection: Report on the first deaths in Spain</title>
<author><name sortKey="Martin Oeches, Ignacio" sort="Martin Oeches, Ignacio" uniqKey="Martin Oeches I" first="Ignacio" last="Martin-Loeches">Ignacio Martin-Loeches</name>
<affiliation><mods:affiliation>Critical Care Department, Joan XXIII University Hospital, University Rovira i Virgili, IISPV, CIBER Enfermedades Respiratorias (CIBERes), Tarragona</mods:affiliation>
</affiliation>
<affiliation><mods:affiliation>E-mail: drmartinloeches@gmail.com</mods:affiliation>
<wicri:noCountry code="no comma">E-mail: drmartinloeches@gmail.com</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Rodriguez, Alejandro" sort="Rodriguez, Alejandro" uniqKey="Rodriguez A" first="Alejandro" last="Rodriguez">Alejandro Rodriguez</name>
<affiliation><mods:affiliation>Critical Care Department, Joan XXIII University Hospital, University Rovira i Virgili, IISPV, CIBER Enfermedades Respiratorias (CIBERes), Tarragona</mods:affiliation>
<wicri:noCountry code="subField">Tarragona</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Bonastre, Juan" sort="Bonastre, Juan" uniqKey="Bonastre J" first="Juan" last="Bonastre">Juan Bonastre</name>
<affiliation><mods:affiliation>Critical Care Department, La Fe University Hospital</mods:affiliation>
<wicri:noCountry code="subField">Hospital</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Zaragoza, Rafael" sort="Zaragoza, Rafael" uniqKey="Zaragoza R" first="Rafael" last="Zaragoza">Rafael Zaragoza</name>
<affiliation><mods:affiliation>Critical Care Department, Dr Peset University Hospital</mods:affiliation>
<wicri:noCountry code="subField">Hospital</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Sierra, Rafael" sort="Sierra, Rafael" uniqKey="Sierra R" first="Rafael" last="Sierra">Rafael Sierra</name>
<affiliation><mods:affiliation>Critical Care Department, Puerta del Mar University Hospital, Cádiz</mods:affiliation>
<wicri:noCountry code="subField">Cádiz</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Marques, Asunci N" sort="Marques, Asunci N" uniqKey="Marques A" first="Asunci N" last="Marques">Asunci N Marques</name>
<affiliation><mods:affiliation>Critical Care Department, La Ribera University Hospital, Valencia</mods:affiliation>
<wicri:noCountry code="subField">Valencia</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Julia Arvaez, Jose" sort="Julia Arvaez, Jose" uniqKey="Julia Arvaez J" first="Jose" last="Juliá-Narvaez">Jose Juliá-Narvaez</name>
<affiliation><mods:affiliation>Critical Care Department, Infanta Cristina University Hospital, Badajoz</mods:affiliation>
<wicri:noCountry code="subField">Badajoz</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Diaz, Emili" sort="Diaz, Emili" uniqKey="Diaz E" first="Emili" last="Diaz">Emili Diaz</name>
<affiliation><mods:affiliation>Critical Care Department, Joan XXIII University Hospital, University Rovira i Virgili, IISPV, CIBER Enfermedades Respiratorias (CIBERes), Tarragona</mods:affiliation>
<wicri:noCountry code="subField">Tarragona</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Rello, Jordi" sort="Rello, Jordi" uniqKey="Rello J" first="Jordi" last="Rello">Jordi Rello</name>
<affiliation wicri:level="1"><mods:affiliation>Critical Care Department, Vall d'Hebron University Hospital, Institut de Recerca Vall d'Hebron, CIBER Enfermedades Respiratorias (CIBERes), Universitat Autónoma de Barcelona, Barcelona, Spain</mods:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Critical Care Department, Vall d'Hebron University Hospital, Institut de Recerca Vall d'Hebron, CIBER Enfermedades Respiratorias (CIBERes), Universitat Autónoma de Barcelona, Barcelona</wicri:regionArea>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j" type="main">Respirology</title>
<title level="j" type="alt">RESPIROLOGY</title>
<idno type="ISSN">1323-7799</idno>
<idno type="eISSN">1440-1843</idno>
<imprint><biblScope unit="vol">16</biblScope>
<biblScope unit="issue">1</biblScope>
<biblScope unit="page" from="78">78</biblScope>
<biblScope unit="page" to="85">85</biblScope>
<biblScope unit="page-count">8</biblScope>
<publisher>Blackwell Publishing Asia</publisher>
<pubPlace>Melbourne, Australia</pubPlace>
<date type="published" when="2011-01">2011-01</date>
</imprint>
<idno type="ISSN">1323-7799</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">1323-7799</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acute physiology</term>
<term>Antiviral</term>
<term>Antiviral drugs</term>
<term>Antiviral therapy</term>
<term>Antiviral treatment</term>
<term>Asian society</term>
<term>Authors respirology</term>
<term>Barcelona</term>
<term>Bilateral patchy alveolar opacities</term>
<term>Care units</term>
<term>Carlos</term>
<term>Chronic health evaluation</term>
<term>Ciber enfermedades respiratorias</term>
<term>Complejo hospitalario</term>
<term>Crit</term>
<term>Critical care department</term>
<term>Critical illness</term>
<term>Disease control</term>
<term>Dysfunction syndrome</term>
<term>Early detection</term>
<term>Equal periods</term>
<term>European society</term>
<term>Fatal cases</term>
<term>Fteen patients</term>
<term>Fulminant</term>
<term>Fulminant myocarditis</term>
<term>Gran canaria</term>
<term>High rate</term>
<term>High risk</term>
<term>Hospital admission</term>
<term>Hospital barcelona</term>
<term>Hospital infanta elena</term>
<term>Hospital nuestra</term>
<term>Hospital puerta</term>
<term>Hospital sant joan</term>
<term>Hospital santa</term>
<term>Hospital universitario</term>
<term>Hospital virgen</term>
<term>Infection</term>
<term>Intensive care medicine</term>
<term>Intensive care unit</term>
<term>Intensive care units</term>
<term>Interquartile range</term>
<term>Intravenous corticosteroids</term>
<term>Invasive ventilation</term>
<term>Joan xxiii university hospital</term>
<term>Leucocyte count</term>
<term>Madrid</term>
<term>Median</term>
<term>Median time</term>
<term>Mortality rate</term>
<term>Multicentre study</term>
<term>Ndings</term>
<term>Pandemic</term>
<term>Patients percentage</term>
<term>Platelet count</term>
<term>Pneumonia</term>
<term>Present cohort</term>
<term>Present study</term>
<term>Primary cause</term>
<term>Prone position</term>
<term>Rafael</term>
<term>Renal replacement therapy</term>
<term>Respirology</term>
<term>Risk factor</term>
<term>Risk factors</term>
<term>Sequential organ failure assessment</term>
<term>Sofa score</term>
<term>Universitario</term>
<term>University hospital</term>
<term>Valencia</term>
<term>Vasopressor drugs</term>
<term>Vast majority</term>
<term>Viral</term>
<term>Viral load</term>
<term>Viral pneumonia</term>
<term>Virgen</term>
<term>Virus infection</term>
<term>World health organization</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Background and objective: The impact of pandemic influenza A (H1N1)v infection is still unknown but it is associated with a high case‐fatality rate. Methods: This was a prospective, observational, multicentre study conducted in 144 Spanish intensive care units. Demographic and clinical data were reviewed for all cases of pandemic influenza A (H1N1)v infection reported from 23 June 2009 through 11 February 2010 and confirmed by reverse transcriptase PCR assay. Results: Out of 872 cases reported by statewide surveillance, data for the first 131 deceased patients were analysed. Thirty‐seven patients (28.2%) died within the first 14 days. The median age of these patients was 46 years (interquartile range 35–58) and 60.3% were male. Twenty‐eight patients (21.4%) did not present with any comorbidities on admission. Forty‐six per cent of patients were reported to be obese and 22 (16.8%) had COPD. The vast majority of the patients (72.5%) had viral pneumonia; 95.4% of these had bilateral patchy alveolar opacities (predominantly basal), affecting three or four quadrants. One hundred and fifteen patients (87.8%) developed multi‐organ dysfunction syndrome. Ninety‐seven patients (74%) required vasopressor drugs, 37 (27.2%) received renal replacement therapy, and 47 (35.1%) received intravenous corticosteroids on admission to the intensive care unit. Only 68 patients (51.9%) received empirical antiviral treatment. Conclusions: One‐third of patients with pandemic influenza A (H1N1)v infection died within the first two weeks and these were young patients, with rapidly progressive viral pneumonia as the primary cause of admission. Obese patients were at high risk but one in four patients did not present with any risk factors on admission. Only half the patients received empirical antiviral therapy and this was administered late.</div>
<div type="abstract">The impact of pandemic (H1N1)v influenza A infection is still unknown but it is associated with a high case‐fatality rate. This prospective, observational, multicentre study conducted in 144 Spanish intensive care units, summarizes the clinical characteristics of the first 131 patients who died during the initial wave of infection.</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/PandemieGrippaleV1/Data/Istex/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001924 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Curation/biblio.hfd -nk 001924 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= PandemieGrippaleV1 |flux= Istex |étape= Curation |type= RBID |clé= ISTEX:08F85C3B6D14253B8F7E73C285160B0D11FC59DE |texte= Severe pandemic (H1N1)v influenza A infection: Report on the first deaths in Spain }}
![]() | This area was generated with Dilib version V0.6.34. | ![]() |