Genes, viruses and neurodevelopmental schizophrenia
Identifieur interne : 001F37 ( Istex/Corpus ); précédent : 001F36; suivant : 001F38Genes, viruses and neurodevelopmental schizophrenia
Auteurs : Robin M. Murray ; Peter Jones ; Eadbhard O'Callaghan ; Noriyoshi Takei ; Pak ShamSource :
- Journal of Psychiatric Research [ 0022-3956 ] ; 1992.
English descriptors
- Teeft :
- Adult life, Adult schrzophremcs, Archrves, Bogerts, Brain development, Brrtrsh, Causal role, Cerebral cortex, City birth, Cortical dysgenesls, Crow, Developmental origin, Early adult life, Early onset, Environmental hazards, Excess risk, Family history, Fmdmgs, General psychiatry, General psychratry, Genetic control, Higher risk, Human brain, Influenza, Influenza epidemics, Jones murray, Late onset cases, Late winter, Male schlzophrema, Male schlzophremcs, Maternal influenza, Medmck, Mfectlous diseases, Monozygotlc twins, Murray, Nervous system, Neurodevelopmental, Neuronal, Neurones, Obstetric complications, Psychiatry, Psychratry, Risk factors, Schizophrenia, Schlzophrema, Schlzophrema archrves, Schlzophrema brrtrsh journal, Schlzophremc, Schlzophremc births, Schlzophremc twins, Schlzophremcs, Schlzophremcs journal, Schrzophrema, Schtzophrema, Sham, Torrey, Unpublished data, Ventricular size, Ventricular zone.
Abstract
Abstract: Recent neuroimaging and neuropathological studies suggest a developmental origin for schizophrenia. Some cases may, therefore, be caused by a genetic defect in the specification of brain development. Early environmental hazards such as obstetric complications, and maternal exposure during pregnancy to influenza epidemics, have also been found to increase the risk of later schizophrenia. The relationship between the prevalence of influenza and birth date has been found more consistently for female than male schizophrenics. Female schizophrenia is also associated with a higher risk of schizophrenia in first degree relatives. This raises the question of whether part of the genetic predisposition to schizophrenia may comprise an abnormal reaction to maternal influenza.
Url:
DOI: 10.1016/0022-3956(92)90029-N
Links to Exploration step
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<front><div type="abstract" xml:lang="en">Abstract: Recent neuroimaging and neuropathological studies suggest a developmental origin for schizophrenia. Some cases may, therefore, be caused by a genetic defect in the specification of brain development. Early environmental hazards such as obstetric complications, and maternal exposure during pregnancy to influenza epidemics, have also been found to increase the risk of later schizophrenia. The relationship between the prevalence of influenza and birth date has been found more consistently for female than male schizophrenics. Female schizophrenia is also associated with a higher risk of schizophrenia in first degree relatives. This raises the question of whether part of the genetic predisposition to schizophrenia may comprise an abnormal reaction to maternal influenza.</div>
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<abstract xml:lang="en"><p>Abstract: Recent neuroimaging and neuropathological studies suggest a developmental origin for schizophrenia. Some cases may, therefore, be caused by a genetic defect in the specification of brain development. Early environmental hazards such as obstetric complications, and maternal exposure during pregnancy to influenza epidemics, have also been found to increase the risk of later schizophrenia. The relationship between the prevalence of influenza and birth date has been found more consistently for female than male schizophrenics. Female schizophrenia is also associated with a higher risk of schizophrenia in first degree relatives. This raises the question of whether part of the genetic predisposition to schizophrenia may comprise an abnormal reaction to maternal influenza.</p>
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<ce:abstract-sec><ce:simple-para>Recent neuroimaging and neuropathological studies suggest a developmental origin for schizophrenia. Some cases may, therefore, be caused by a genetic defect in the specification of brain development. Early environmental hazards such as obstetric complications, and maternal exposure during pregnancy to influenza epidemics, have also been found to increase the risk of later schizophrenia. The relationship between the prevalence of influenza and birth date has been found more consistently for female than male schizophrenics. Female schizophrenia is also associated with a higher risk of schizophrenia in first degree relatives. This raises the question of whether part of the genetic predisposition to schizophrenia may comprise an abnormal reaction to maternal influenza.</ce:simple-para>
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<abstract lang="en">Abstract: Recent neuroimaging and neuropathological studies suggest a developmental origin for schizophrenia. Some cases may, therefore, be caused by a genetic defect in the specification of brain development. Early environmental hazards such as obstetric complications, and maternal exposure during pregnancy to influenza epidemics, have also been found to increase the risk of later schizophrenia. The relationship between the prevalence of influenza and birth date has been found more consistently for female than male schizophrenics. Female schizophrenia is also associated with a higher risk of schizophrenia in first degree relatives. This raises the question of whether part of the genetic predisposition to schizophrenia may comprise an abnormal reaction to maternal influenza.</abstract>
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