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Genes, viruses and neurodevelopmental schizophrenia

Identifieur interne : 001F37 ( Istex/Corpus ); précédent : 001F36; suivant : 001F38

Genes, viruses and neurodevelopmental schizophrenia

Auteurs : Robin M. Murray ; Peter Jones ; Eadbhard O'Callaghan ; Noriyoshi Takei ; Pak Sham

Source :

RBID : ISTEX:988C6412C097AB3796C1E12D65195DF7E53BD6E2

English descriptors

Abstract

Abstract: Recent neuroimaging and neuropathological studies suggest a developmental origin for schizophrenia. Some cases may, therefore, be caused by a genetic defect in the specification of brain development. Early environmental hazards such as obstetric complications, and maternal exposure during pregnancy to influenza epidemics, have also been found to increase the risk of later schizophrenia. The relationship between the prevalence of influenza and birth date has been found more consistently for female than male schizophrenics. Female schizophrenia is also associated with a higher risk of schizophrenia in first degree relatives. This raises the question of whether part of the genetic predisposition to schizophrenia may comprise an abnormal reaction to maternal influenza.

Url:
DOI: 10.1016/0022-3956(92)90029-N

Links to Exploration step

ISTEX:988C6412C097AB3796C1E12D65195DF7E53BD6E2

Le document en format XML

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