A[H1N1] flu and refractory hypoxaemia: Is extracorporeal lung support the holy grail?
Identifieur interne : 001A66 ( Istex/Corpus ); précédent : 001A65; suivant : 001A67A[H1N1] flu and refractory hypoxaemia: Is extracorporeal lung support the holy grail?
Auteurs : T V Veenith ; M. Rana ; A. Ercole ; K. Gunning ; R. MahroofSource :
- Thorax [ 0040-6376 ] ; 2011-09.
English descriptors
- Teeft :
- Ards, Care unit, Conventional ventilation, Conventional ventilatory support, Convincing evidence, Distress syndrome, Ecls, Ecmo, Extracorporeal, Extracorporeal lung support, Extracorporeal membrane oxygenation, Fio2, Foundation trust, Health technol, Hypoxaemia, Lung compliance, Oxygenation, Plateau pressure, Positive pressure, Refractory, Refractory hypoxaemia, Replacement therapy, Respiratory failure, Routine implementation, Severe adult, Severe hypoxaemic, Tidal volume, Ventilatory, Ventilatory management.
Abstract
There is a call for methodologically robust randomised clinical trials in adult extracorporeal membrane oxygenation for its routine implementation for patients with “failing” conventional ventilation. Adherence to lung protective ventilation strategies, along with fluid balance [if required early renal replacement therapy] and inotropes to support the circulation to minimise ventilator-induced lung injury, may mitigate deterioration requiring extracorporeal lung support. Currently there is no convincing evidence to routinely advocate extracorporeal lung support in failed conventional ventilation, and a prospective trial is needed to define standard best practice and to tailor extracorporeal lung support referral criteria in young patient cohort with severe refractory respiratory failure.
Url:
DOI: 10.1136/thoraxjnl-2011-200092
Links to Exploration step
ISTEX:ACA28EB5631BC73C950E8C14EB2EF079F35CF64DLe document en format XML
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Adherence to lung protective ventilation strategies, along with fluid balance [if required early renal replacement therapy] and inotropes to support the circulation to minimise ventilator-induced lung injury, may mitigate deterioration requiring extracorporeal lung support. Currently there is no convincing evidence to routinely advocate extracorporeal lung support in failed conventional ventilation, and a prospective trial is needed to define standard best practice and to tailor extracorporeal lung support referral criteria in young patient cohort with severe refractory respiratory failure.</p></abstract></profileDesc><revisionDesc><change when="2011-04-22">Created</change><change when="2011-09">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/NVC-TZV6XTX2-P/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus bmj" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="no"</istex:xmlDeclaration><istex:docType PUBLIC="-//NLM//DTD Journal Archiving and Interchange DTD v2.3 20070202//EN" URI="archivearticle.dtd" name="istex:docType"></istex:docType><istex:document><article article-type="case-report"><front><journal-meta><journal-id journal-id-type="hwp">thoraxjnl</journal-id><journal-id journal-id-type="nlm-ta">Thorax</journal-id><journal-id journal-id-type="publisher-id">thorax</journal-id><journal-title>Thorax</journal-title><abbrev-journal-title abbrev-type="publisher">Thorax</abbrev-journal-title><abbrev-journal-title>Thorax</abbrev-journal-title><issn pub-type="ppub">0040-6376</issn><issn pub-type="epub">1468-3296</issn><publisher><publisher-name>BMJ Publishing Group Ltd and British Thoracic Society</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">thoraxjnl-2011-200092</article-id><article-id pub-id-type="doi">10.1136/thoraxjnl-2011-200092</article-id><article-id pub-id-type="other">thoraxjnl;66/9/836</article-id><article-id pub-id-type="other">thoraxjnl;thoraxjnl-2011-200092</article-id><article-id pub-id-type="pmid">21515552</article-id><article-id pub-id-type="other">836</article-id><article-id pub-id-type="other">thoraxjnl-2011-200092</article-id><article-categories><subj-group subj-group-type="heading"><subject>Chest clinic</subject></subj-group><series-title>Case based discussion</series-title></article-categories><title-group><article-title>A[H1N1] flu and refractory hypoxaemia: Is extracorporeal lung support the holy grail?</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Veenith</surname><given-names>T V</given-names></name></contrib><contrib contrib-type="author"><name><surname>Rana</surname><given-names>M</given-names></name></contrib><contrib contrib-type="author"><name><surname>Ercole</surname><given-names>A</given-names></name></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Gunning</surname><given-names>K</given-names></name></contrib><contrib contrib-type="author"><name><surname>Mahroof</surname><given-names>R</given-names></name></contrib></contrib-group><aff>John Farman Intensive Care Unit, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK</aff><author-notes><corresp><label>Correspondence to</label> Dr K Gunning, John Farman Intensive Care Unit, Addenbrooke's Hospital, Cambridge University Hospital NHS Foundation Trust, Hills Road, Cambridge CB2 0QQ, UK; <email>kevin.gunning@addenbrookes.nhs.uk</email></corresp></author-notes><pub-date pub-type="epub-original"><day>22</day><month>4</month><year>2011</year></pub-date><pub-date pub-type="ppub"><month>9</month><year>2011</year></pub-date><pub-date pub-type="epub"><day>22</day><month>4</month><year>2011</year></pub-date><volume>66</volume><volume-id pub-id-type="other">66</volume-id><volume-id pub-id-type="other">66</volume-id><issue>9</issue><issue-id pub-id-type="other">thoraxjnl;66/9</issue-id><issue-id pub-id-type="other">9</issue-id><issue-id pub-id-type="other">66/9</issue-id><fpage>836</fpage><history><date date-type="received"><day>25</day><month>02</month><year>2011</year></date><date date-type="accepted"><day>18</day><month>03</month><year>2011</year></date></history><permissions><copyright-statement>© 2011, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</copyright-statement><copyright-year>2011</copyright-year></permissions><self-uri content-type="pdf" xlink:role="full-text" xlink:href="thoraxjnl-66-836.pdf"></self-uri><abstract><p>There is a call for methodologically robust randomised clinical trials in adult extracorporeal membrane oxygenation for its routine implementation for patients with “failing” conventional ventilation. Adherence to lung protective ventilation strategies, along with fluid balance [if required early renal replacement therapy] and inotropes to support the circulation to minimise ventilator-induced lung injury, may mitigate deterioration requiring extracorporeal lung support. Currently there is no convincing evidence to routinely advocate extracorporeal lung support in failed conventional ventilation, and a prospective trial is needed to define standard best practice and to tailor extracorporeal lung support referral criteria in young patient cohort with severe refractory respiratory failure.</p></abstract></article-meta></front></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>A[H1N1] flu and refractory hypoxaemia: Is extracorporeal lung support the holy grail?</title><partName>Case based discussion</partName></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>A[H1N1] flu and refractory hypoxaemia: Is extracorporeal lung support the holy grail?</title><partName>Case based discussion</partName></titleInfo><name type="personal"><namePart type="given">T V</namePart><namePart type="family">Veenith</namePart><affiliation>John Farman Intensive Care Unit, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Rana</namePart><affiliation>John Farman Intensive Care Unit, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Ercole</namePart><affiliation>John Farman Intensive Care Unit, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal" displayLabel="corresp"><namePart type="given">K</namePart><namePart type="family">Gunning</namePart><affiliation>John Farman Intensive Care Unit, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK</affiliation><affiliation>E-mail: kevin.gunning@addenbrookes.nhs.uk</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Mahroof</namePart><affiliation>John Farman Intensive Care Unit, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="case-report" displayLabel="case-report" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-29919SZJ-6">case-report</genre><originInfo><publisher>BMJ Publishing Group Ltd and British Thoracic Society</publisher><dateIssued encoding="w3cdtf">2011-09</dateIssued><dateCreated encoding="w3cdtf">2011-04-22</dateCreated><copyrightDate encoding="w3cdtf">2011</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract>There is a call for methodologically robust randomised clinical trials in adult extracorporeal membrane oxygenation for its routine implementation for patients with “failing” conventional ventilation. Adherence to lung protective ventilation strategies, along with fluid balance [if required early renal replacement therapy] and inotropes to support the circulation to minimise ventilator-induced lung injury, may mitigate deterioration requiring extracorporeal lung support. Currently there is no convincing evidence to routinely advocate extracorporeal lung support in failed conventional ventilation, and a prospective trial is needed to define standard best practice and to tailor extracorporeal lung support referral criteria in young patient cohort with severe refractory respiratory failure.</abstract><relatedItem type="host"><titleInfo><title>Thorax</title></titleInfo><titleInfo type="abbreviated"><title>Thorax</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><identifier type="ISSN">0040-6376</identifier><identifier type="eISSN">1468-3296</identifier><identifier type="PublisherID">thorax</identifier><identifier type="PublisherID-hwp">thoraxjnl</identifier><identifier type="PublisherID-nlm-ta">Thorax</identifier><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>66</number></detail><detail type="issue"><caption>no.</caption><number>9</number></detail><extent unit="pages"><start>836</start></extent></part></relatedItem><identifier type="istex">ACA28EB5631BC73C950E8C14EB2EF079F35CF64D</identifier><identifier type="ark">ark:/67375/NVC-TZV6XTX2-P</identifier><identifier type="DOI">10.1136/thoraxjnl-2011-200092</identifier><identifier type="href">thoraxjnl-66-836.pdf</identifier><identifier type="ArticleID">thoraxjnl-2011-200092</identifier><identifier type="PMID">21515552</identifier><identifier type="local">thoraxjnl;66/9/836</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2011, Published by the BMJ Publishing Group Limited. 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