Recent progress in designing inhibitors that target the drug‐resistant M2 proton channels from the influenza A viruses
Identifieur interne : 001A03 ( Istex/Corpus ); précédent : 001A02; suivant : 001A04Recent progress in designing inhibitors that target the drug‐resistant M2 proton channels from the influenza A viruses
Auteurs : Jun Wang ; Fang Li ; Chunlong MaSource :
- Peptide Science [ 0006-3525 ] ; 2015-07.
Abstract
Influenza viruses are the causative agents for seasonal influenza, which results in thousands of deaths and millions of hospitalizations each year. Moreover, sporadic transmission of avian or swan influenza viruses to humans often leads to an influenza pandemic, as there is no preimmunity in the human body to fight against such novel strains. The metastable genome of the influenza viruses, coupled with the reassortment of different strains from a wide range of host origins, leads to the continuous evolution of the influenza virus diversity. Such characteristics of influenza viruses present a grand challenge in devising therapeutic strategies to combat influenza virus infection. This review summarizes recent progress in designing small molecule inhibitors that target the drug‐resistant influenza A virus M2 proton channels and highlights the contribution of mechanistic studies of proton conductance to drug discovery. The lessons learned throughout the course of M2 drug discovery might provide insights for designing inhibitors that target other therapeutically important ion channels. © 2015 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 104: 291–309, 2015.
Url:
DOI: 10.1002/bip.22623
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<front><div type="abstract">Influenza viruses are the causative agents for seasonal influenza, which results in thousands of deaths and millions of hospitalizations each year. Moreover, sporadic transmission of avian or swan influenza viruses to humans often leads to an influenza pandemic, as there is no preimmunity in the human body to fight against such novel strains. The metastable genome of the influenza viruses, coupled with the reassortment of different strains from a wide range of host origins, leads to the continuous evolution of the influenza virus diversity. Such characteristics of influenza viruses present a grand challenge in devising therapeutic strategies to combat influenza virus infection. This review summarizes recent progress in designing small molecule inhibitors that target the drug‐resistant influenza A virus M2 proton channels and highlights the contribution of mechanistic studies of proton conductance to drug discovery. The lessons learned throughout the course of M2 drug discovery might provide insights for designing inhibitors that target other therapeutically important ion channels. © 2015 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 104: 291–309, 2015.</div>
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<p>Influenza viruses are the causative agents for seasonal influenza, which results in thousands of deaths and millions of hospitalizations each year. Moreover, sporadic transmission of avian or swan influenza viruses to humans often leads to an influenza pandemic, as there is no preimmunity in the human body to fight against such novel strains. The metastable genome of the influenza viruses, coupled with the reassortment of different strains from a wide range of host origins, leads to the continuous evolution of the influenza virus diversity. Such characteristics of influenza viruses present a grand challenge in devising therapeutic strategies to combat influenza virus infection. This review summarizes recent progress in designing small molecule inhibitors that target the drug‐resistant influenza A virus M2 proton channels and highlights the contribution of mechanistic studies of proton conductance to drug discovery. The lessons learned throughout the course of M2 drug discovery might provide insights for designing inhibitors that target other therapeutically important ion channels. © 2015 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 104: 291–309, 2015.</p>
</abstract>
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<noteGroup><note xml:id="bip22623-note-0007"><p>This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of any preprints from the past two calendar years by emailing the Biopolymers editorial office at <email>biopolymers@wiley.com</email>
.</p>
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<mods version="3.6"><titleInfo lang="en"><title>Recent progress in designing inhibitors that target the drug‐resistant M2 proton channels from the influenza A viruses</title>
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<titleInfo type="abbreviated" lang="en"><title>Insights for Designing Inhibitors</title>
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<titleInfo type="alternative" contentType="CDATA" lang="en"><title>Recent progress in designing inhibitors that target the drug‐resistant M2 proton channels from the influenza A viruses</title>
</titleInfo>
<name type="personal"><namePart type="given">Jun</namePart>
<namePart type="family">Wang</namePart>
<affiliation>Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, 85721, Tucson, AZ</affiliation>
<affiliation>BIO5 Institute, University of Arizona, AZ, 85721, Tucson</affiliation>
<affiliation>E-mail: junwang@pharmacy.arizona.edu</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Fang</namePart>
<namePart type="family">Li</namePart>
<affiliation>Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, AZ, 85721, Tucson</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Chunlong</namePart>
<namePart type="family">Ma</namePart>
<affiliation>Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, AZ, 85721, Tucson</affiliation>
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<dateIssued encoding="w3cdtf">2015-07</dateIssued>
<dateCreated encoding="w3cdtf">2015-02-12</dateCreated>
<dateCaptured encoding="w3cdtf">2014-12-11</dateCaptured>
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<abstract>Influenza viruses are the causative agents for seasonal influenza, which results in thousands of deaths and millions of hospitalizations each year. Moreover, sporadic transmission of avian or swan influenza viruses to humans often leads to an influenza pandemic, as there is no preimmunity in the human body to fight against such novel strains. The metastable genome of the influenza viruses, coupled with the reassortment of different strains from a wide range of host origins, leads to the continuous evolution of the influenza virus diversity. Such characteristics of influenza viruses present a grand challenge in devising therapeutic strategies to combat influenza virus infection. This review summarizes recent progress in designing small molecule inhibitors that target the drug‐resistant influenza A virus M2 proton channels and highlights the contribution of mechanistic studies of proton conductance to drug discovery. The lessons learned throughout the course of M2 drug discovery might provide insights for designing inhibitors that target other therapeutically important ion channels. © 2015 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 104: 291–309, 2015.</abstract>
<note type="funding">University of Arizona</note>
<subject><genre>keywords</genre>
<topic>M2</topic>
<topic>proton channel</topic>
<topic>antiviral resistance</topic>
<topic>S31N</topic>
<topic>adamantane</topic>
<topic>influenza</topic>
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<titleInfo type="abbreviated"><title>Biopolymers</title>
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<subject><genre>article-category</genre>
<topic>Review</topic>
<topic>Reviews</topic>
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<identifier type="ISSN">0006-3525</identifier>
<identifier type="eISSN">1097-0282</identifier>
<identifier type="DOI">10.1002/(ISSN)1097-0282a</identifier>
<identifier type="PublisherID">BIP</identifier>
<part><date>2015</date>
<detail type="title"><title>Dedicated to Bill DeGrado on the occasion of his 60th Birthday</title>
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