Recent progress in designing inhibitors that target the drug‐resistant M2 proton channels from the influenza A viruses
Identifieur interne : 001A03 ( Istex/Corpus ); précédent : 001A02; suivant : 001A04Recent progress in designing inhibitors that target the drug‐resistant M2 proton channels from the influenza A viruses
Auteurs : Jun Wang ; Fang Li ; Chunlong MaSource :
- Peptide Science [ 0006-3525 ] ; 2015-07.
Abstract
Influenza viruses are the causative agents for seasonal influenza, which results in thousands of deaths and millions of hospitalizations each year. Moreover, sporadic transmission of avian or swan influenza viruses to humans often leads to an influenza pandemic, as there is no preimmunity in the human body to fight against such novel strains. The metastable genome of the influenza viruses, coupled with the reassortment of different strains from a wide range of host origins, leads to the continuous evolution of the influenza virus diversity. Such characteristics of influenza viruses present a grand challenge in devising therapeutic strategies to combat influenza virus infection. This review summarizes recent progress in designing small molecule inhibitors that target the drug‐resistant influenza A virus M2 proton channels and highlights the contribution of mechanistic studies of proton conductance to drug discovery. The lessons learned throughout the course of M2 drug discovery might provide insights for designing inhibitors that target other therapeutically important ion channels. © 2015 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 104: 291–309, 2015.
Url:
DOI: 10.1002/bip.22623
Links to Exploration step
ISTEX:C31C6FE1008D98D0FE36A1F885D8BE6FCE892834Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Recent progress in designing inhibitors that target the drug‐resistant M2 proton channels from the influenza A viruses</title><author><name sortKey="Wang, Jun" sort="Wang, Jun" uniqKey="Wang J" first="Jun" last="Wang">Jun Wang</name><affiliation><mods:affiliation>Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, 85721, Tucson, AZ</mods:affiliation></affiliation><affiliation><mods:affiliation>BIO5 Institute, University of Arizona, AZ, 85721, Tucson</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: junwang@pharmacy.arizona.edu</mods:affiliation></affiliation></author><author><name sortKey="Li, Fang" sort="Li, Fang" uniqKey="Li F" first="Fang" last="Li">Fang Li</name><affiliation><mods:affiliation>Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, AZ, 85721, Tucson</mods:affiliation></affiliation></author><author><name sortKey="Ma, Chunlong" sort="Ma, Chunlong" uniqKey="Ma C" first="Chunlong" last="Ma">Chunlong Ma</name><affiliation><mods:affiliation>Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, AZ, 85721, Tucson</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:C31C6FE1008D98D0FE36A1F885D8BE6FCE892834</idno><date when="2015" year="2015">2015</date><idno type="doi">10.1002/bip.22623</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-NRQG52NJ-H/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001A03</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001A03</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Recent progress in designing inhibitors that target the drug‐resistant M2 proton channels from the influenza A viruses</title><author><name sortKey="Wang, Jun" sort="Wang, Jun" uniqKey="Wang J" first="Jun" last="Wang">Jun Wang</name><affiliation><mods:affiliation>Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, 85721, Tucson, AZ</mods:affiliation></affiliation><affiliation><mods:affiliation>BIO5 Institute, University of Arizona, AZ, 85721, Tucson</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: junwang@pharmacy.arizona.edu</mods:affiliation></affiliation></author><author><name sortKey="Li, Fang" sort="Li, Fang" uniqKey="Li F" first="Fang" last="Li">Fang Li</name><affiliation><mods:affiliation>Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, AZ, 85721, Tucson</mods:affiliation></affiliation></author><author><name sortKey="Ma, Chunlong" sort="Ma, Chunlong" uniqKey="Ma C" first="Chunlong" last="Ma">Chunlong Ma</name><affiliation><mods:affiliation>Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, AZ, 85721, Tucson</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Peptide Science</title><title level="j" type="sub">Dedicated to Bill DeGrado on the occasion of his 60th Birthday</title><title level="j" type="alt">PEPTIDE SCIENCE</title><idno type="ISSN">0006-3525</idno><idno type="eISSN">1097-0282</idno><imprint><biblScope unit="vol">104</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="291">291</biblScope><biblScope unit="page" to="309">309</biblScope><biblScope unit="page-count">19</biblScope><date type="published" when="2015-07">2015-07</date></imprint><idno type="ISSN">0006-3525</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0006-3525</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Influenza viruses are the causative agents for seasonal influenza, which results in thousands of deaths and millions of hospitalizations each year. Moreover, sporadic transmission of avian or swan influenza viruses to humans often leads to an influenza pandemic, as there is no preimmunity in the human body to fight against such novel strains. The metastable genome of the influenza viruses, coupled with the reassortment of different strains from a wide range of host origins, leads to the continuous evolution of the influenza virus diversity. Such characteristics of influenza viruses present a grand challenge in devising therapeutic strategies to combat influenza virus infection. This review summarizes recent progress in designing small molecule inhibitors that target the drug‐resistant influenza A virus M2 proton channels and highlights the contribution of mechanistic studies of proton conductance to drug discovery. The lessons learned throughout the course of M2 drug discovery might provide insights for designing inhibitors that target other therapeutically important ion channels. © 2015 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 104: 291–309, 2015.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Jun Wang</name><affiliations><json:string>Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, 85721, Tucson, AZ</json:string><json:string>BIO5 Institute, University of Arizona, AZ, 85721, Tucson</json:string><json:string>E-mail: junwang@pharmacy.arizona.edu</json:string></affiliations></json:item><json:item><name>Fang Li</name><affiliations><json:string>Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, AZ, 85721, Tucson</json:string></affiliations></json:item><json:item><name>Chunlong Ma</name><affiliations><json:string>Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, AZ, 85721, Tucson</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>M2</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>proton channel</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>antiviral resistance</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>S31N</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>adamantane</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>influenza</value></json:item></subject><articleId><json:string>BIP22623</json:string></articleId><arkIstex>ark:/67375/WNG-NRQG52NJ-H</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>reviewArticle</json:string></originalGenre><abstract>Influenza viruses are the causative agents for seasonal influenza, which results in thousands of deaths and millions of hospitalizations each year. Moreover, sporadic transmission of avian or swan influenza viruses to humans often leads to an influenza pandemic, as there is no preimmunity in the human body to fight against such novel strains. The metastable genome of the influenza viruses, coupled with the reassortment of different strains from a wide range of host origins, leads to the continuous evolution of the influenza virus diversity. Such characteristics of influenza viruses present a grand challenge in devising therapeutic strategies to combat influenza virus infection. This review summarizes recent progress in designing small molecule inhibitors that target the drug‐resistant influenza A virus M2 proton channels and highlights the contribution of mechanistic studies of proton conductance to drug discovery. The lessons learned throughout the course of M2 drug discovery might provide insights for designing inhibitors that target other therapeutically important ion channels. © 2015 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 104: 291–309, 2015.</abstract><qualityIndicators><score>9.028</score><pdfWordCount>10715</pdfWordCount><pdfCharCount>64828</pdfCharCount><pdfVersion>1.5</pdfVersion><pdfPageCount>19</pdfPageCount><pdfPageSize>629.972 x 809.972 pts</pdfPageSize><pdfWordsPerPage>564</pdfWordsPerPage><pdfText>true</pdfText><refBibsNative>true</refBibsNative><abstractWordCount>169</abstractWordCount><abstractCharCount>1171</abstractCharCount><keywordCount>6</keywordCount></qualityIndicators><title>Recent progress in designing inhibitors that target the drug‐resistant M2 proton channels from the influenza A viruses</title><genre><json:string>review-article</json:string></genre><host><title>Peptide Science</title><language><json:string>unknown</json:string></language><doi><json:string>10.1002/(ISSN)1097-0282a</json:string></doi><issn><json:string>0006-3525</json:string></issn><eissn><json:string>1097-0282</json:string></eissn><publisherId><json:string>BIP</json:string></publisherId><volume>104</volume><issue>4</issue><pages><first>291</first><last>309</last><total>19</total></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>Review</value></json:item><json:item><value>Reviews</value></json:item></subject></host><ark><json:string>ark:/67375/WNG-NRQG52NJ-H</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - biophysics</json:string><json:string>2 - biochemistry & molecular biology</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - biomedical research</json:string><json:string>3 - biophysics</json:string></scienceMetrix><scopus><json:string>1 - Physical Sciences</json:string><json:string>2 - Chemistry</json:string><json:string>3 - Organic Chemistry</json:string><json:string>1 - Physical Sciences</json:string><json:string>2 - Materials Science</json:string><json:string>3 - Biomaterials</json:string><json:string>1 - Life Sciences</json:string><json:string>2 - Biochemistry, Genetics and Molecular Biology</json:string><json:string>3 - Biochemistry</json:string><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - General Medicine</json:string><json:string>1 - Life Sciences</json:string><json:string>2 - Biochemistry, Genetics and Molecular Biology</json:string><json:string>3 - Biophysics</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences medicales</json:string></inist></categories><publicationDate>2015</publicationDate><copyrightDate>2015</copyrightDate><doi><json:string>10.1002/bip.22623</json:string></doi><id>C31C6FE1008D98D0FE36A1F885D8BE6FCE892834</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-NRQG52NJ-H/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-NRQG52NJ-H/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/WNG-NRQG52NJ-H/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">Recent progress in designing inhibitors that target the drug‐resistant M2 proton channels from the influenza A viruses</title><title level="a" type="short">Insights for Designing Inhibitors</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher ref="https://scientific-publisher.data.istex.fr/ark:/67375/H02-QW5Q88H5-V">Wiley Publishing Ltd</publisher><availability><licence>© 2015 Wiley Periodicals, Inc.</licence></availability><date type="published" when="2015-07"></date></publicationStmt><notesStmt><note type="content-type" subtype="review-article" source="reviewArticle" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-L5L7X3NF-P">review-article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="review-article"><analytic><title level="a" type="main">Recent progress in designing inhibitors that target the drug‐resistant M2 proton channels from the influenza A viruses</title><title level="a" type="short">Insights for Designing Inhibitors</title><author xml:id="author-0000" role="corresp"><persName><forename type="first">Jun</forename><surname>Wang</surname></persName><affiliation><orgName type="division">Department of Pharmacology and Toxicology</orgName><orgName type="institution">College of Pharmacy, University of Arizona</orgName><address><settlement>Tucson</settlement><region>AZ</region><postCode>85721</postCode></address></affiliation><affiliation><orgName type="division">BIO5 Institute</orgName><orgName type="institution">University of Arizona</orgName><address><settlement>Tucson</settlement><region>AZ</region><postCode>85721</postCode></address></affiliation></author><author xml:id="author-0001"><persName><forename type="first">Fang</forename><surname>Li</surname></persName><affiliation><orgName type="division">Department of Pharmacology and Toxicology</orgName><orgName type="institution">College of Pharmacy, University of Arizona</orgName><address><settlement>Tucson</settlement><region>AZ</region><postCode>85721</postCode></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">Chunlong</forename><surname>Ma</surname></persName><affiliation><orgName type="division">Department of Pharmacology and Toxicology</orgName><orgName type="institution">College of Pharmacy, University of Arizona</orgName><address><settlement>Tucson</settlement><region>AZ</region><postCode>85721</postCode></address></affiliation></author><idno type="istex">C31C6FE1008D98D0FE36A1F885D8BE6FCE892834</idno><idno type="ark">ark:/67375/WNG-NRQG52NJ-H</idno><idno type="DOI">10.1002/bip.22623</idno><idno type="unit">BIP22623</idno><idno type="toTypesetVersion">file:BIP.BIP22623.pdf</idno></analytic><monogr><title level="j" type="main">Peptide Science</title><title level="j" type="sub">Dedicated to Bill DeGrado on the occasion of his 60th Birthday</title><title level="j" type="alt">PEPTIDE SCIENCE</title><idno type="pISSN">0006-3525</idno><idno type="eISSN">1097-0282</idno><idno type="book-DOI">10.1002/(ISSN)1097-0282a</idno><idno type="book-part-DOI">10.1002/bip.v104.4</idno><idno type="product">BIP</idno><imprint><biblScope unit="vol">104</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="291">291</biblScope><biblScope unit="page" to="309">309</biblScope><biblScope unit="page-count">19</biblScope><date type="published" when="2015-07"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><encodingDesc><schemaRef type="ODD" url="https://xml-schema.delivery.istex.fr/tei-istex.odd"></schemaRef><appInfo><application ident="pub2tei" version="1.0.10" when="2019-12-20"><label>pub2TEI-ISTEX</label><desc>A set of style sheets for converting XML documents encoded in various scientific publisher formats into a common TEI format.
<ref target="http://www.tei-c.org/">We use TEI</ref></desc></application></appInfo></encodingDesc><profileDesc><abstract style="main"><head>ABSTRACT</head><p>Influenza viruses are the causative agents for seasonal influenza, which results in thousands of deaths and millions of hospitalizations each year. Moreover, sporadic transmission of avian or swan influenza viruses to humans often leads to an influenza pandemic, as there is no preimmunity in the human body to fight against such novel strains. The metastable genome of the influenza viruses, coupled with the reassortment of different strains from a wide range of host origins, leads to the continuous evolution of the influenza virus diversity. Such characteristics of influenza viruses present a grand challenge in devising therapeutic strategies to combat influenza virus infection. This review summarizes recent progress in designing small molecule inhibitors that target the drug‐resistant influenza A virus M2 proton channels and highlights the contribution of mechanistic studies of proton conductance to drug discovery. The lessons learned throughout the course of M2 drug discovery might provide insights for designing inhibitors that target other therapeutically important ion channels. © 2015 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 104: 291–309, 2015.</p></abstract><textClass><keywords><term xml:id="bip22623-kwd-0001">M2</term><term xml:id="bip22623-kwd-0002">proton channel</term><term xml:id="bip22623-kwd-0003">antiviral resistance</term><term xml:id="bip22623-kwd-0004">S31N</term><term xml:id="bip22623-kwd-0005">adamantane</term><term xml:id="bip22623-kwd-0006">influenza</term></keywords><keywords rend="articleCategory"><term>Review</term></keywords><keywords rend="tocHeading1"><term>Reviews</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc><revisionDesc><change when="2019-12-20" who="#istex" xml:id="pub2tei">formatting</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-NRQG52NJ-H/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en" xml:id="bip22623"><header><publicationMeta level="product"><doi origin="wiley" registered="yes">10.1002/(ISSN)1097-0282a</doi><issn type="print">0006-3525</issn><issn type="electronic">1097-0282</issn><idGroup><id type="product" value="BIP"></id></idGroup><titleGroup><title type="main" sort="PEPTIDE SCIENCE">Peptide Science</title><title type="short">Biopolymers</title></titleGroup></publicationMeta><publicationMeta level="part" position="40"><doi>10.1002/bip.v104.4</doi><titleGroup><title type="specialIssueTitle">Dedicated to Bill DeGrado on the occasion of his 60th Birthday</title></titleGroup><copyright ownership="publisher">© 2015 Wiley Periodicals, Inc.</copyright><numberingGroup><numbering type="journalVolume" number="104">104</numbering><numbering type="journalIssue">4</numbering></numberingGroup><coverDate startDate="2015-07">July 2015</coverDate></publicationMeta><publicationMeta level="unit" position="80" type="reviewArticle" status="forIssue"><doi>10.1002/bip.22623</doi><idGroup><id type="unit" value="BIP22623"></id></idGroup><countGroup><count type="pageTotal" number="19"></count></countGroup><titleGroup><title type="articleCategory">Review</title><title type="tocHeading1">Reviews</title></titleGroup><copyright ownership="publisher">© 2015 Wiley Periodicals, Inc.</copyright><eventGroup><event type="manuscriptReceived" date="2014-12-11"></event><event type="manuscriptAccepted" date="2015-01-24"></event><event type="xmlCreated" agent="Cenveo Publisher Services" date="2015-02-12"></event><event type="publishedOnlineAccepted" date="2015-02-06"></event><event type="firstOnline" date="2015-07-27"></event><event type="publishedOnlineFinalForm" date="2015-07-27"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.7.5 mode:FullText" date="2016-01-22"></event></eventGroup><numberingGroup><numbering type="pageFirst">291</numbering><numbering type="pageLast">309</numbering></numberingGroup><correspondenceTo><i>Correspondence to</i>: Jun Wang, Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ 85721; e‐mail: <email>junwang@pharmacy.arizona.edu</email></correspondenceTo><objectNameGroup><objectName elementName="figure">Scheme</objectName><objectName elementName="figure">Figure</objectName></objectNameGroup><linkGroup><link type="toTypesetVersion" href="file:BIP.BIP22623.pdf"></link></linkGroup></publicationMeta><contentMeta><titleGroup><title type="main">Recent progress in designing inhibitors that target the drug‐resistant M2 proton channels from the influenza A viruses</title><title type="short">Insights for Designing Inhibitors</title><title type="shortAuthors">Wang et al.</title></titleGroup><creators><creator affiliationRef="#bip22623-aff-0001 #bip22623-aff-0002" corresponding="yes" creatorRole="author" xml:id="bip22623-cr-0001"><personName><givenNames>Jun</givenNames><familyName>Wang</familyName></personName></creator><creator affiliationRef="#bip22623-aff-0001" creatorRole="author" xml:id="bip22623-cr-0002"><personName><givenNames>Fang</givenNames><familyName>Li</familyName></personName></creator><creator affiliationRef="#bip22623-aff-0001" creatorRole="author" xml:id="bip22623-cr-0003"><personName><givenNames>Chunlong</givenNames><familyName>Ma</familyName></personName></creator></creators><affiliationGroup><affiliation type="organization" xml:id="bip22623-aff-0001"><orgDiv>Department of Pharmacology and Toxicology</orgDiv><orgName>College of Pharmacy, University of Arizona</orgName><address><city>Tucson</city><countryPart>AZ</countryPart><postCode>85721</postCode></address></affiliation><affiliation type="organization" xml:id="bip22623-aff-0002"><orgDiv>BIO5 Institute</orgDiv><orgName>University of Arizona</orgName><address><city>Tucson</city><countryPart>AZ</countryPart><postCode>85721</postCode></address></affiliation></affiliationGroup><keywordGroup type="author"><keyword xml:id="bip22623-kwd-0001">M2</keyword><keyword xml:id="bip22623-kwd-0002">proton channel</keyword><keyword xml:id="bip22623-kwd-0003">antiviral resistance</keyword><keyword xml:id="bip22623-kwd-0004">S31N</keyword><keyword xml:id="bip22623-kwd-0005">adamantane</keyword><keyword xml:id="bip22623-kwd-0006">influenza</keyword></keywordGroup><fundingInfo><fundingAgency>University of Arizona
</fundingAgency></fundingInfo><abstractGroup><abstract type="main"><title type="main">ABSTRACT</title><p>Influenza viruses are the causative agents for seasonal influenza, which results in thousands of deaths and millions of hospitalizations each year. Moreover, sporadic transmission of avian or swan influenza viruses to humans often leads to an influenza pandemic, as there is no preimmunity in the human body to fight against such novel strains. The metastable genome of the influenza viruses, coupled with the reassortment of different strains from a wide range of host origins, leads to the continuous evolution of the influenza virus diversity. Such characteristics of influenza viruses present a grand challenge in devising therapeutic strategies to combat influenza virus infection. This review summarizes recent progress in designing small molecule inhibitors that target the drug‐resistant influenza A virus M2 proton channels and highlights the contribution of mechanistic studies of proton conductance to drug discovery. The lessons learned throughout the course of M2 drug discovery might provide insights for designing inhibitors that target other therapeutically important ion channels. © 2015 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 104: 291–309, 2015.</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="bip22623-note-0007"><p>This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of any preprints from the past two calendar years by emailing the Biopolymers editorial office at <email>biopolymers@wiley.com</email>.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Recent progress in designing inhibitors that target the drug‐resistant M2 proton channels from the influenza A viruses</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Insights for Designing Inhibitors</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Recent progress in designing inhibitors that target the drug‐resistant M2 proton channels from the influenza A viruses</title></titleInfo><name type="personal"><namePart type="given">Jun</namePart><namePart type="family">Wang</namePart><affiliation>Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, 85721, Tucson, AZ</affiliation><affiliation>BIO5 Institute, University of Arizona, AZ, 85721, Tucson</affiliation><affiliation>E-mail: junwang@pharmacy.arizona.edu</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Fang</namePart><namePart type="family">Li</namePart><affiliation>Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, AZ, 85721, Tucson</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Chunlong</namePart><namePart type="family">Ma</namePart><affiliation>Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, AZ, 85721, Tucson</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="review-article" displayLabel="reviewArticle" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-L5L7X3NF-P">review-article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><dateIssued encoding="w3cdtf">2015-07</dateIssued><dateCreated encoding="w3cdtf">2015-02-12</dateCreated><dateCaptured encoding="w3cdtf">2014-12-11</dateCaptured><dateValid encoding="w3cdtf">2015-01-24</dateValid><copyrightDate encoding="w3cdtf">2015</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract>Influenza viruses are the causative agents for seasonal influenza, which results in thousands of deaths and millions of hospitalizations each year. Moreover, sporadic transmission of avian or swan influenza viruses to humans often leads to an influenza pandemic, as there is no preimmunity in the human body to fight against such novel strains. The metastable genome of the influenza viruses, coupled with the reassortment of different strains from a wide range of host origins, leads to the continuous evolution of the influenza virus diversity. Such characteristics of influenza viruses present a grand challenge in devising therapeutic strategies to combat influenza virus infection. This review summarizes recent progress in designing small molecule inhibitors that target the drug‐resistant influenza A virus M2 proton channels and highlights the contribution of mechanistic studies of proton conductance to drug discovery. The lessons learned throughout the course of M2 drug discovery might provide insights for designing inhibitors that target other therapeutically important ion channels. © 2015 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 104: 291–309, 2015.</abstract><note type="funding">University of Arizona</note><subject><genre>keywords</genre><topic>M2</topic><topic>proton channel</topic><topic>antiviral resistance</topic><topic>S31N</topic><topic>adamantane</topic><topic>influenza</topic></subject><relatedItem type="host"><titleInfo><title>Peptide Science</title></titleInfo><titleInfo type="abbreviated"><title>Biopolymers</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>article-category</genre><topic>Review</topic><topic>Reviews</topic></subject><identifier type="ISSN">0006-3525</identifier><identifier type="eISSN">1097-0282</identifier><identifier type="DOI">10.1002/(ISSN)1097-0282a</identifier><identifier type="PublisherID">BIP</identifier><part><date>2015</date><detail type="title"><title>Dedicated to Bill DeGrado on the occasion of his 60th Birthday</title></detail><detail type="volume"><caption>vol.</caption><number>104</number></detail><detail type="issue"><caption>no.</caption><number>4</number></detail><extent unit="pages"><start>291</start><end>309</end><total>19</total></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0001"><titleInfo><title>http://www.cdc.gov/flu/about/disease/us_flu-related_deaths.htm.</title></titleInfo><genre>other</genre></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0002"><titleInfo><title>http://www.cdc.gov/nchs/data/nvsr/nvsr61/nvsr61_04.pdf.</title></titleInfo><genre>other</genre></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0003"><titleInfo><title>Webster, R. G.; Monto, A. S.; Braciale, T. J.; Lamb, R. A., Eds. Textbook of Influenza, 2nd Edition. Wiley: Oxford, UK.</title></titleInfo><note type="citation/reference">Webster, R. G.; Monto, A. S.; Braciale, T. J.; Lamb, R. A., Eds. Textbook of Influenza, 2nd Edition. Wiley: Oxford, UK.</note><name type="personal"><namePart type="given">R. G.</namePart><namePart type="family">Webster</namePart><role><roleTerm type="text">editor</roleTerm></role></name><name type="personal"><namePart type="given">A. S.</namePart><namePart type="family">Monto</namePart><role><roleTerm type="text">editor</roleTerm></role></name><name type="personal"><namePart type="given">T. J.</namePart><namePart type="family">Braciale</namePart><role><roleTerm type="text">editor</roleTerm></role></name><name type="personal"><namePart type="given">R. A.</namePart><namePart type="family">Lamb</namePart><role><roleTerm type="text">editor</roleTerm></role></name><genre>book</genre><originInfo><publisher>WileyOxford, UK</publisher></originInfo></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0004"><titleInfo><title>J Am Med Assoc</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Taubenberger, J. K.; Morens, D. M.; Fauci, A. S. J Am Med Assoc 2007, 297, 2025–2027.</note><name type="personal"><namePart type="given">J. K.</namePart><namePart type="family">Taubenberger</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D. M.</namePart><namePart type="family">Morens</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. S.</namePart><namePart type="family">Fauci</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>297</number></detail><extent unit="pages"><start>2025</start><end>2027</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0005"><titleInfo><title>Bull Hist Med</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Johnson, N. P.; Mueller, J. Bull Hist Med 2002, 76, 105–115.</note><name type="personal"><namePart type="given">N. P.</namePart><namePart type="family">Johnson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Mueller</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>76</number></detail><extent unit="pages"><start>105</start><end>115</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0006"><titleInfo><title>PLoS Pathog</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Watanabe, T.; Kawaoka, Y. PLoS Pathog 2011, 7, e1001218.</note><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Watanabe</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Kawaoka</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>7</number></detail><extent unit="pages"><start>e1001218</start></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0007"><titleInfo><title>mBio</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Taubenberger, J. K.; Baltimore, D.; Doherty, P. C.; Markel, H.; Morens, D. M.; Webster, R. G.; Wilson, I. A. mBio 2012, 3, e00201–e00212.</note><name type="personal"><namePart type="given">J. K.</namePart><namePart type="family">Taubenberger</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Baltimore</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P. C.</namePart><namePart type="family">Doherty</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Markel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D. M.</namePart><namePart type="family">Morens</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. G.</namePart><namePart type="family">Webster</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I. A.</namePart><namePart type="family">Wilson</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2012</date><detail type="volume"><caption>vol.</caption><number>3</number></detail><extent unit="pages"><start>e00201</start><end>e00212</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0008"><titleInfo><title>Science</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Tumpey, T. M.; Basler, C. F.; Aguilar, P. V.; Zeng, H.; Solórzano, A.; Swayne, D. E.; Cox, N. J.; Katz, J. M.; Taubenberger, J. K.; Palese, P.; García‐Sastre, A. Science 2005, 310, 77–80.</note><name type="personal"><namePart type="given">T. M.</namePart><namePart type="family">Tumpey</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C. F.</namePart><namePart type="family">Basler</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P. V.</namePart><namePart type="family">Aguilar</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Zeng</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Solórzano</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D. E.</namePart><namePart type="family">Swayne</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N. J.</namePart><namePart type="family">Cox</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. M.</namePart><namePart type="family">Katz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. K.</namePart><namePart type="family">Taubenberger</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Palese</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">García‐Sastre</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>310</number></detail><extent unit="pages"><start>77</start><end>80</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0009"><titleInfo><title>http://www.flu.gov/about_the_flu/h5n1/.</title></titleInfo><genre>other</genre></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0010"><titleInfo><title>http://www.who.int/csr/disease/ebola/situation‐reports/en/.</title></titleInfo><genre>other</genre></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0011"><titleInfo><title>http://www.who.int/influenza/human_animal_interface/influenza_h7n9/10u_ReportWebH7N9Number.pdf?ua=1.</title></titleInfo><genre>other</genre></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0012"><titleInfo><title>Cell</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Tharakaraman, K.; Raman, R.; Viswanathan, K.; Stebbins, N.; Jayaraman, A.; Krishnan, A.; Sasisekharan, V.; Sasisekharan, R. Cell 2013, 153, 1475–1485.</note><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Tharakaraman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Raman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Viswanathan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N.</namePart><namePart type="family">Stebbins</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Jayaraman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Krishnan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V.</namePart><namePart type="family">Sasisekharan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Sasisekharan</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>153</number></detail><extent unit="pages"><start>1475</start><end>1485</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0013"><titleInfo><title>Cell</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Linster, M.; van Boheemen, S.; de Graaf, M.; Schrauwen, Eefje J. A.; Lexmond, P.; Mänz, B.; Bestebroer, Theo M.; Baumann, J.; van Riel, D.; Rimmelzwaan, Guus F.; Osterhaus, Albert D. M. E.; Matrosovich, M.; Fouchier, Ron A. M.; Herfst, S. Cell, 157, 329–339.</note><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Linster</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">van Boheemen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">de Graaf</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Eefje J. A.</namePart><namePart type="family">Schrauwen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Lexmond</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Mänz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Theo M.</namePart><namePart type="family">Bestebroer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Baumann</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">van Riel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Guus F.</namePart><namePart type="family">Rimmelzwaan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Albert D. M. E.</namePart><namePart type="family">Osterhaus</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Matrosovich</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ron A. M.</namePart><namePart type="family">Fouchier</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Herfst</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><detail type="volume"><caption>vol.</caption><number>157</number></detail><extent unit="pages"><start>329</start><end>339</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0014"><titleInfo><title>Ann N Y Acad Sci</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Webster, R. G.; Govorkova, E. A. Ann N Y Acad Sci 2014, 1323, 115–139.</note><name type="personal"><namePart type="given">R. G.</namePart><namePart type="family">Webster</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E. A.</namePart><namePart type="family">Govorkova</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2014</date><detail type="volume"><caption>vol.</caption><number>1323</number></detail><extent unit="pages"><start>115</start><end>139</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0015"><titleInfo><title>MMWR Recomm Rep</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Grohskopf, L.; Shay, D.; Shimabukuro, T.; Sokolow, L.; Keitel, W.; Bresee, J.; Cox, N. MMWR Recomm Rep 2013, 62, 1–43.</note><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Grohskopf</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Shay</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Shimabukuro</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Sokolow</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W.</namePart><namePart type="family">Keitel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Bresee</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N.</namePart><namePart type="family">Cox</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>62</number></detail><extent unit="pages"><start>1</start><end>43</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0016"><titleInfo><title>Nat Rev Drug Discov</title></titleInfo><genre>journal-article</genre><note type="citation/reference">De Clercq, E. Nat Rev Drug Discov 2006, 5, 1015–1025.</note><name type="personal"><namePart type="given">E.</namePart><namePart type="family">De Clercq</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>5</number></detail><extent unit="pages"><start>1015</start><end>1025</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0017"><titleInfo><title>Lancet Infect Dis</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Osterholm, M.; Kelley, N.; Sommer, A.; Belongia, E. Lancet Infect Dis 2012, 12, 36–44.</note><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Osterholm</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N.</namePart><namePart type="family">Kelley</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Sommer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Belongia</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2012</date><detail type="volume"><caption>vol.</caption><number>12</number></detail><extent unit="pages"><start>36</start><end>44</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0018"><titleInfo><title>Vaccine</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Gerdil, C. Vaccine 2003, 21, 1776–1779.</note><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Gerdil</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>21</number></detail><extent unit="pages"><start>1776</start><end>1779</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0019"><titleInfo><title>Curr Opin Virol</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Hurt, A. C. Curr Opin Virol 2014, 8, 22–29.</note><name type="personal"><namePart type="given">A. C.</namePart><namePart type="family">Hurt</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2014</date><detail type="volume"><caption>vol.</caption><number>8</number></detail><extent unit="pages"><start>22</start><end>29</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0020"><titleInfo><title>Ann Intern Med</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Hsu, J.; Santesso, N.; Mustafa, R.; Brozek, J.; Yao Long, C.; Hopkins, J. P.; Cheung, A.; Hovhannisyan, G.; Ivanova, L.; Flottorp, S. A.; Sæterdal, I.; Wong, A. D.; Tian, J.; Uyeki, T. M.; Akl, E. A.; Alonso‐Coello, P.; Smaill, F.; Schünemann, H. J. Ann Intern Med 2012, 156, 512–524.</note><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Hsu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N.</namePart><namePart type="family">Santesso</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Mustafa</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Brozek</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Yao Long</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. P.</namePart><namePart type="family">Hopkins</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Cheung</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Hovhannisyan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Ivanova</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S. A.</namePart><namePart type="family">Flottorp</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I.</namePart><namePart type="family">Sæterdal</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. D.</namePart><namePart type="family">Wong</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Tian</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T. M.</namePart><namePart type="family">Uyeki</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E. A.</namePart><namePart type="family">Akl</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Alonso‐Coello</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Smaill</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H. J.</namePart><namePart type="family">Schünemann</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2012</date><detail type="volume"><caption>vol.</caption><number>156</number></detail><extent unit="pages"><start>512</start><end>524</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0021"><titleInfo><title>Emerg Microbes Infect</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Liu, X.; Li, T.; Zheng, Y.; Wong, K.‐W.; Lu, S.; Lu, H. Emerg Microbes Infect 2013, 2, e27.</note><name type="personal"><namePart type="given">X.</namePart><namePart type="family">Liu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Li</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Zheng</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.‐W.</namePart><namePart type="family">Wong</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Lu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Lu</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>2</number></detail><extent unit="pages"><start>e27</start></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0022"><titleInfo><title>N Engl J Med</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Moscona, A. N Engl J Med 2005, 353, 1363–1373.</note><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Moscona</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>353</number></detail><extent unit="pages"><start>1363</start><end>1373</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0023"><titleInfo><title>Drugs</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Boltz, D.; Aldridge, J.; Webster, R.; Govorkova, E. Drugs 2010, 70, 1349–1362.</note><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Boltz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Aldridge</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Webster</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Govorkova</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>70</number></detail><extent unit="pages"><start>1349</start><end>1362</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0024"><titleInfo><title>Cell Mol Life Sci</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Loregian, A.; Mercorelli, B.; Nannetti, G.; Compagnin, C.; Palù, G. Cell Mol Life Sci 2014, 1–25.</note><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Loregian</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Mercorelli</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Nannetti</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Compagnin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Palù</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2014</date><extent unit="pages"><start>1</start><end>25</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0025"><titleInfo><title>Influenza Other Respir Viruses</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Hayden, F. Influenza Other Respir Viruses 2013, 7, 63–75.</note><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Hayden</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>7</number></detail><extent unit="pages"><start>63</start><end>75</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0026"><titleInfo><title>Clin Infect Dis</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Hayden, F. Clin Infect Dis 2009, 48, S3–S13.</note><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Hayden</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>48</number></detail><extent unit="pages"><start>S3</start><end>S13</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0027"><titleInfo><title>Med Res Rev</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Lagoja, I. M.; De Clercq, E. Med Res Rev 2008, 28, 1–38.</note><name type="personal"><namePart type="given">I. M.</namePart><namePart type="family">Lagoja</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">De Clercq</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>28</number></detail><extent unit="pages"><start>1</start><end>38</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0028"><titleInfo><title>Curr Opin Struct Biol</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Wang, J.; Qiu, J. X.; Soto, C.; DeGrado, W. F. Curr Opin Struct Biol 2011, 21, 68–80.</note><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. X.</namePart><namePart type="family">Qiu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Soto</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W. F.</namePart><namePart type="family">DeGrado</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>21</number></detail><extent unit="pages"><start>68</start><end>80</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0029"><titleInfo><title>Protein Sci</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Hong, M.; DeGrado, W. F. Protein Sci 2012, 21, 1620–1633.</note><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Hong</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W. F.</namePart><namePart type="family">DeGrado</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2012</date><detail type="volume"><caption>vol.</caption><number>21</number></detail><extent unit="pages"><start>1620</start><end>1633</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0030"><titleInfo><title>J Med Chem</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Wang, J.; Ma, C.; Wang, J.; Jo, H.; Canturk, B.; Fiorin, G.; Pinto, L. H.; Lamb, R. A.; Klein, M. L.; DeGrado, W. F. J Med Chem 2013, 56, 2804–2812.</note><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Ma</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Jo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Canturk</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Fiorin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L. H.</namePart><namePart type="family">Pinto</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. A.</namePart><namePart type="family">Lamb</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. L.</namePart><namePart type="family">Klein</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W. F.</namePart><namePart type="family">DeGrado</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>56</number></detail><extent unit="pages"><start>2804</start><end>2812</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0031"><titleInfo><title>Proc Natl Acad Sci U S A</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Wang, J.; Wu, Y.; Ma, C.; Fiorin, G.; Wang, J.; Pinto, L. H.; Lamb, R. A.; Klein, M. L.; DeGrado, W. F. Proc Natl Acad Sci U S A 2013, 110, 1315–1320.</note><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Wu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Ma</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Fiorin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L. H.</namePart><namePart type="family">Pinto</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. A.</namePart><namePart type="family">Lamb</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. L.</namePart><namePart type="family">Klein</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W. F.</namePart><namePart type="family">DeGrado</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>110</number></detail><extent unit="pages"><start>1315</start><end>1320</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0032"><titleInfo><title>J Am Chem Soc</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Wang, J.; Ma, C.; Fiorin, G.; Carnevale, V.; Wang, T.; Hu, F.; Lamb, R. A.; Pinto, L. H.; Hong, M.; Kein, M. L.; DeGrado, W. F. J Am Chem Soc 2011, 133, 12834–12841.</note><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Ma</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Fiorin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V.</namePart><namePart type="family">Carnevale</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Hu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. A.</namePart><namePart type="family">Lamb</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L. H.</namePart><namePart type="family">Pinto</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Hong</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. L.</namePart><namePart type="family">Kein</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W. F.</namePart><namePart type="family">DeGrado</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>133</number></detail><extent unit="pages"><start>12834</start><end>12841</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0033"><titleInfo><title>Ann Rev Anim Biosci</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Ozawa, M.; Kawaoka, Y. Ann Rev Anim Biosci 2013, 1, 21–42.</note><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Ozawa</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Kawaoka</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>1</number></detail><extent unit="pages"><start>21</start><end>42</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0034"><titleInfo><title>J Biol Chem</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Pinto, L.; Lamb, R. J Biol Chem 2006, 281, 8997–9000.</note><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Pinto</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Lamb</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>281</number></detail><extent unit="pages"><start>8997</start><end>9000</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0035"><titleInfo><title>Virology</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Ciampor, F.; Bayley, P. M.; Nermut, M. V.; Hirst, E. M. A.; Sugrue, R. J.; Hay, A. J. Virology 1992, 188, 14–24.</note><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Ciampor</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P. M.</namePart><namePart type="family">Bayley</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. V.</namePart><namePart type="family">Nermut</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E. M. A.</namePart><namePart type="family">Hirst</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. J.</namePart><namePart type="family">Sugrue</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. J.</namePart><namePart type="family">Hay</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1992</date><detail type="volume"><caption>vol.</caption><number>188</number></detail><extent unit="pages"><start>14</start><end>24</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0036"><titleInfo><title>Virology</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Grambas, S.; Hay, A. J. Virology 1992, 190, 11–18.</note><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Grambas</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. J.</namePart><namePart type="family">Hay</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1992</date><detail type="volume"><caption>vol.</caption><number>190</number></detail><extent unit="pages"><start>11</start><end>18</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0037"><titleInfo><title>J Am Chem Soc</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Schmidt, N. W.; Mishra, A.; Wang, J.; DeGrado, W. F.; Wong, G. C. L. J Am Chem Soc 2013, 135, 13710–13719.</note><name type="personal"><namePart type="given">N. W.</namePart><namePart type="family">Schmidt</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Mishra</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W. F.</namePart><namePart type="family">DeGrado</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G. C. L.</namePart><namePart type="family">Wong</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>135</number></detail><extent unit="pages"><start>13710</start><end>13719</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0038"><titleInfo><title>Cell</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Rossman, J. S.; Jing, X.; Leser, G. P.; Lamb, R. A. Cell 2010, 142, 902–913.</note><name type="personal"><namePart type="given">J. S.</namePart><namePart type="family">Rossman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">X.</namePart><namePart type="family">Jing</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G. P.</namePart><namePart type="family">Leser</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. A.</namePart><namePart type="family">Lamb</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>142</number></detail><extent unit="pages"><start>902</start><end>913</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0039"><titleInfo><title>Proc Natl Acad Sci U S A</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Ma, C.; Polishchuk, A. L.; Ohigashi, Y.; Stouffer, A. L.; Schön, A.; Magavern, E.; Jing, X.; Lear, J. D.; Freire, E.; Lamb, R. A.; DeGrado, W. F.; Pinto, L. H. Proc Natl Acad Sci U S A 2009, 106, 12283–12288.</note><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Ma</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. L.</namePart><namePart type="family">Polishchuk</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Ohigashi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. L.</namePart><namePart type="family">Stouffer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Schön</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Magavern</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">X.</namePart><namePart type="family">Jing</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. D.</namePart><namePart type="family">Lear</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Freire</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. A.</namePart><namePart type="family">Lamb</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W. F.</namePart><namePart type="family">DeGrado</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L. H.</namePart><namePart type="family">Pinto</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>106</number></detail><extent unit="pages"><start>12283</start><end>12288</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0040"><titleInfo><title>J Physiol</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Chizhmakov, I. V.; Geraghty, F. M.; Ogden, D. C.; Hayhurst, A.; Antoniou, M.; Hay, A. J. J Physiol 1996, 494, 329–336.</note><name type="personal"><namePart type="given">I. V.</namePart><namePart type="family">Chizhmakov</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F. M.</namePart><namePart type="family">Geraghty</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D. C.</namePart><namePart type="family">Ogden</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Hayhurst</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Antoniou</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. J.</namePart><namePart type="family">Hay</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>494</number></detail><extent unit="pages"><start>329</start><end>336</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0041"><titleInfo><title>J Physiol</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Chizhmakov, I. V.; Ogden, D. C.; Geraghty, F. M.; Hayhurst, A.; Skinner, A.; Betakova, T.; Hay, A. J. J Physiol 2003, 546, 427–438.</note><name type="personal"><namePart type="given">I. V.</namePart><namePart type="family">Chizhmakov</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D. C.</namePart><namePart type="family">Ogden</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F. M.</namePart><namePart type="family">Geraghty</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Hayhurst</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Skinner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Betakova</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. J.</namePart><namePart type="family">Hay</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>546</number></detail><extent unit="pages"><start>427</start><end>438</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0042"><titleInfo><title>Antiviral Res</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Scholtissek, C.; Quack, G.; Klenk, H. D.; Webster, R. G. Antiviral Res 1998, 37, 83–95.</note><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Scholtissek</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Quack</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H. D.</namePart><namePart type="family">Klenk</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. G.</namePart><namePart type="family">Webster</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>37</number></detail><extent unit="pages"><start>83</start><end>95</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0043"><titleInfo><title>EMBO J</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Hay, A.; Wolstenholme, A.; Skehel, J.; Smith, M. EMBO J 1985, 4, 3021–3024.</note><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Hay</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Wolstenholme</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Skehel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Smith</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1985</date><detail type="volume"><caption>vol.</caption><number>4</number></detail><extent unit="pages"><start>3021</start><end>3024</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0044"><titleInfo><title>Antimicrob Agents Chemother</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Brown, A. N.; McSharry, J. J.; Weng, Q.; Driebe, E. M.; Engelthaler, D. M.; Sheff, K.; Keim, P. S.; Nguyen, J.; Drusano, G. L. Antimicrob Agents Chemother 2010, 54, 3442–3450.</note><name type="personal"><namePart type="given">A. N.</namePart><namePart type="family">Brown</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. J.</namePart><namePart type="family">McSharry</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Q.</namePart><namePart type="family">Weng</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E. M.</namePart><namePart type="family">Driebe</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D. M.</namePart><namePart type="family">Engelthaler</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Sheff</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P. S.</namePart><namePart type="family">Keim</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Nguyen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G. L.</namePart><namePart type="family">Drusano</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>54</number></detail><extent unit="pages"><start>3442</start><end>3450</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0045"><titleInfo><title>Antimicrob Agents Chemother</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Abed, Y.; Goyette, N.; Boivin, G. Antimicrob Agents Chemother 2005, 49, 556–559.</note><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Abed</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N.</namePart><namePart type="family">Goyette</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Boivin</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>49</number></detail><extent unit="pages"><start>556</start><end>559</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0046"><titleInfo><title>J Infect Dis</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Shiraishi, K.; Mitamura, K.; Sakai‐Tagawa, Y.; Goto, H.; Sugaya, N.; Kawaoka, Y. J Infect Dis 2003, 188, 57–61.</note><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Shiraishi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Mitamura</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Sakai‐Tagawa</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Goto</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N.</namePart><namePart type="family">Sugaya</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Kawaoka</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>188</number></detail><extent unit="pages"><start>57</start><end>61</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0047"><titleInfo><title>Biochemistry</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Balannik, V.; Carnevale, V.; Fiorin, G.; Levine, B.; Lamb, R.; Klein, M.; DeGrado, W.; Pinto, L. Biochemistry 2010, 49, 696–708.</note><name type="personal"><namePart type="given">V.</namePart><namePart type="family">Balannik</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V.</namePart><namePart type="family">Carnevale</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Fiorin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Levine</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Lamb</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Klein</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W.</namePart><namePart type="family">DeGrado</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Pinto</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>49</number></detail><extent unit="pages"><start>696</start><end>708</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0048"><titleInfo><title>Structure</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Stouffer, A. L.; Ma, C.; Cristian, L.; Ohigashi, Y.; Lamb, R. A.; Lear, J. D.; Pinto, L. H.; DeGrado, W. F. Structure 2008, 16, 1067–1076.</note><name type="personal"><namePart type="given">A. L.</namePart><namePart type="family">Stouffer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Ma</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Cristian</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Ohigashi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. A.</namePart><namePart type="family">Lamb</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. D.</namePart><namePart type="family">Lear</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L. H.</namePart><namePart type="family">Pinto</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W. F.</namePart><namePart type="family">DeGrado</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>16</number></detail><extent unit="pages"><start>1067</start><end>1076</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0049"><titleInfo><title>J Infect Chemother</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Suzuki, H.; Saito, R.; Masuda, H.; Oshitani, H.; Sato, M.; Sato, I. J Infect Chemother 2003, 9, 195–200.</note><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Suzuki</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Saito</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Masuda</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Oshitani</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Sato</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I.</namePart><namePart type="family">Sato</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>9</number></detail><extent unit="pages"><start>195</start><end>200</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0050"><titleInfo><title>Virol J</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Furuse, Y.; Suzuki, A.; Kamigaki, T.; Oshitani, H. Virol J 2009, 6, 67.</note><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Furuse</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Suzuki</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Kamigaki</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Oshitani</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>6</number></detail><extent unit="pages"><start>67</start></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0051"><titleInfo><title>Antimicrob Agents Chemother</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Furuse, Y.; Suzuki, A.; Oshitani, H. Antimicrob Agents Chemother 2009, 53, 4457–4463.</note><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Furuse</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Suzuki</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Oshitani</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>53</number></detail><extent unit="pages"><start>4457</start><end>4463</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0052"><titleInfo><title>J Thorac Dis</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Shen, X.; Zhang, X.; Liu, S. J Thorac Dis 2013, S3, S149–S159.</note><name type="personal"><namePart type="given">X.</namePart><namePart type="family">Shen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">X.</namePart><namePart type="family">Zhang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Liu</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>S3</number></detail><extent unit="pages"><start>S149</start><end>S159</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0053"><titleInfo><title>J Med Chem</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Kolocouris, A.; Tzitzoglaki, C.; Johnson, F. B.; Zell, R.; Wright, A. K.; Cross, T. A.; Tietjen, I.; Fedida, D.; Busath, D. D. J Med Chem 2014, 57, 4629–4639.</note><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Kolocouris</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Tzitzoglaki</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F. B.</namePart><namePart type="family">Johnson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Zell</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. K.</namePart><namePart type="family">Wright</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T. A.</namePart><namePart type="family">Cross</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I.</namePart><namePart type="family">Tietjen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Fedida</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D. D.</namePart><namePart type="family">Busath</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2014</date><detail type="volume"><caption>vol.</caption><number>57</number></detail><extent unit="pages"><start>4629</start><end>4639</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0054"><titleInfo><title>Antiviral Res</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Ilyushina, N.; Bovin, N.; Webster, R.; Govorkova, E. Antiviral Res 2006, 70, 121–131.</note><name type="personal"><namePart type="given">N.</namePart><namePart type="family">Ilyushina</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N.</namePart><namePart type="family">Bovin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Webster</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Govorkova</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>70</number></detail><extent unit="pages"><start>121</start><end>131</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0055"><titleInfo><title>Chem Rev</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Wanka, L.; Iqbal, K.; Schreiner, P. Chem Rev 2013, 113, 3516–3604.</note><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Wanka</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Iqbal</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Schreiner</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>113</number></detail><extent unit="pages"><start>3516</start><end>3604</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0056"><titleInfo><title>Duque, M. D.; Valverde, E.; Barniol, M.; Guardiola, S.; Rey, M.; Vazquez, S. Transworld Research Network; Recent Advances in Pharmaceutical Sciences: Kerala, India, 2011; pp 35–64.</title></titleInfo><note type="citation/reference">Duque, M. D.; Valverde, E.; Barniol, M.; Guardiola, S.; Rey, M.; Vazquez, S. Transworld Research Network; Recent Advances in Pharmaceutical Sciences: Kerala, India, 2011; pp 35–64.</note><name type="personal"><namePart type="given">M. D.</namePart><namePart type="family">Duque</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Valverde</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Barniol</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Guardiola</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Rey</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Vazquez</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>book</genre><originInfo><publisher>Recent Advances in Pharmaceutical Sciences</publisher><place><placeTerm type="text">Kerala, India</placeTerm></place></originInfo><part><date>2011</date><extent unit="pages"><start>35</start><end>64</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0057"><titleInfo><title>Med Res Rev</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Vanderlinden, E.; Naesens, L. Med Res Rev 2014, 34, 301–339.</note><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Vanderlinden</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Naesens</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2014</date><detail type="volume"><caption>vol.</caption><number>34</number></detail><extent unit="pages"><start>301</start><end>339</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0058"><titleInfo><title>Chin J Chem</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Zhang, W.; Xu, J.; Liu, F.; Li, C.; Jie, Y.; Chen, S.; Li, Z.; Liu, J.; Chen, L.; Zhou, G. Chin J Chem 2010, 28, 1417–1423.</note><name type="personal"><namePart type="given">W.</namePart><namePart type="family">Zhang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Xu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Liu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Li</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Jie</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Chen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Z.</namePart><namePart type="family">Li</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Liu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Chen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Zhou</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>28</number></detail><extent unit="pages"><start>1417</start><end>1423</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0059"><titleInfo><title>Bull Exp Biol Med</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Shibnev, V. A.; Garaev, T. M.; Finogenova, M. P.; Shevchenko, E. S.; Burtseva, E. I. Bull Exp Biol Med 2012, 153, 233–235.</note><name type="personal"><namePart type="given">V. A.</namePart><namePart type="family">Shibnev</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T. M.</namePart><namePart type="family">Garaev</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. P.</namePart><namePart type="family">Finogenova</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E. S.</namePart><namePart type="family">Shevchenko</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E. I.</namePart><namePart type="family">Burtseva</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2012</date><detail type="volume"><caption>vol.</caption><number>153</number></detail><extent unit="pages"><start>233</start><end>235</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0060"><titleInfo><title>J Biomol Screen</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Severson, W. E.; McDowell, M.; Ananthan, S.; Chung, D.‐H.; Rasmussen, L.; Sosa, M. I.; White, E. L.; Noah, J.; Jonsson, C. B. J Biomol Screen 2008, 13, 879–887.</note><name type="personal"><namePart type="given">W. E.</namePart><namePart type="family">Severson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">McDowell</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Ananthan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.‐H.</namePart><namePart type="family">Chung</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Rasmussen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. I.</namePart><namePart type="family">Sosa</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E. L.</namePart><namePart type="family">White</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Noah</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C. B.</namePart><namePart type="family">Jonsson</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>13</number></detail><extent unit="pages"><start>879</start><end>887</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0061"><titleInfo><title>Antiviral Res</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Torres, E.; Duque, M. D.; Vanderlinden, E.; Ma, C.; Pinto, L. H.; Camps, P.; Froeyen, M.; Vázquez, S.; Naesens, L. Antiviral Res 2013, 99, 281–291.</note><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Torres</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. D.</namePart><namePart type="family">Duque</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Vanderlinden</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Ma</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L. H.</namePart><namePart type="family">Pinto</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Camps</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Froeyen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Vázquez</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Naesens</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>99</number></detail><extent unit="pages"><start>281</start><end>291</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0062"><titleInfo><title>J Am Chem Soc</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Cady, S. D.; Wang, J.; Wu, Y.; DeGrado, W. F.; Hong, M. J Am Chem Soc 2011, 133, 4274–4284.</note><name type="personal"><namePart type="given">S. D.</namePart><namePart type="family">Cady</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Wu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W. F.</namePart><namePart type="family">DeGrado</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Hong</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>133</number></detail><extent unit="pages"><start>4274</start><end>4284</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0063"><titleInfo><title>J Med Chem</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Rey‐Carrizo, M.; Torres, E.; Ma, C.; Barniol‐Xicota, M.; Wang, J.; Wu, Y.; Naesens, L.; DeGrado, W.; Lamb, R.; Pinto, L.; Vazquez, S. J Med Chem 2013, 56, 9265–9274.</note><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Rey‐Carrizo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Torres</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Ma</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Barniol‐Xicota</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Wu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Naesens</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W.</namePart><namePart type="family">DeGrado</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Lamb</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Pinto</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Vazquez</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>56</number></detail><extent unit="pages"><start>9265</start><end>9274</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0064"><titleInfo><title>Protein Sci</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Thomaston, J. L.; Nguyen, P. A.; Brown, E. C.; Upshur, M. A.; Wang, J.; DeGrado, W. F.; Howard, K. P. Protein Sci 2013, 22, 65–73.</note><name type="personal"><namePart type="given">J. L.</namePart><namePart type="family">Thomaston</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P. A.</namePart><namePart type="family">Nguyen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E. C.</namePart><namePart type="family">Brown</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. A.</namePart><namePart type="family">Upshur</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W. F.</namePart><namePart type="family">DeGrado</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K. P.</namePart><namePart type="family">Howard</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>22</number></detail><extent unit="pages"><start>65</start><end>73</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0065"><titleInfo><title>J Chem Phys</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Ghosh, A.; Wang, J.; Moroz, Y. S.; Korendovych, I. V.; Zanni, M.; DeGrado, W. F.; Gai, F.; Hochstrasser, R. M. J Chem Phys 2014, 140, 235105.</note><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Ghosh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y. S.</namePart><namePart type="family">Moroz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I. V.</namePart><namePart type="family">Korendovych</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Zanni</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W. F.</namePart><namePart type="family">DeGrado</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Gai</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. M.</namePart><namePart type="family">Hochstrasser</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2014</date><detail type="volume"><caption>vol.</caption><number>140</number></detail><extent unit="pages"><start>235105</start></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0066"><titleInfo><title>Proc Natl Acad Sci U S A</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Rosenberg, M. R.; Casarotto, M. G. Proc Natl Acad Sci U S A 2010, 107, 13866–13871.</note><name type="personal"><namePart type="given">M. R.</namePart><namePart type="family">Rosenberg</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. G.</namePart><namePart type="family">Casarotto</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>107</number></detail><extent unit="pages"><start>13866</start><end>13871</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0067"><titleInfo><title>Virus Res</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Czabotar, P. E.; Martin, S. R.; Hay, A. J. Virus Res 2004, 99, 57–61.</note><name type="personal"><namePart type="given">P. E.</namePart><namePart type="family">Czabotar</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S. R.</namePart><namePart type="family">Martin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. J.</namePart><namePart type="family">Hay</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>99</number></detail><extent unit="pages"><start>57</start><end>61</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0068"><titleInfo><title>Bioorg Med Chem Lett</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Kolocouris, A.; Spearpoint, P.; Martin, S. R.; Hay, A. J.; López‐Querol, M.; Sureda, F. X.; Padalko, E.; Neyts, J.; De Clercq, E. Bioorg Med Chem Lett 2008, 18, 6156–6160.</note><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Kolocouris</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Spearpoint</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S. R.</namePart><namePart type="family">Martin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. J.</namePart><namePart type="family">Hay</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">López‐Querol</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F. X.</namePart><namePart type="family">Sureda</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Padalko</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Neyts</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">De Clercq</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>18</number></detail><extent unit="pages"><start>6156</start><end>6160</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0069"><titleInfo><title>Nature</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Schnell, J. R.; Chou, J. J. Nature 2008, 451, 591–595.</note><name type="personal"><namePart type="given">J. R.</namePart><namePart type="family">Schnell</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. J.</namePart><namePart type="family">Chou</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>451</number></detail><extent unit="pages"><start>591</start><end>595</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0070"><titleInfo><title>Protein Sci</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Zhou, H.‐X.; Cross, T. A. Protein Sci 2013, 22, 381–394.</note><name type="personal"><namePart type="given">H.‐X.</namePart><namePart type="family">Zhou</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T. A.</namePart><namePart type="family">Cross</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>22</number></detail><extent unit="pages"><start>381</start><end>394</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0071"><titleInfo><title>J Am Chem Soc</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Williams, J. K.; Tietze, D.; Wang, J.; Wu, Y.; DeGrado, W. F.; Hong, M. J Am Chem Soc 2013, 135, 9885–9897.</note><name type="personal"><namePart type="given">J. K.</namePart><namePart type="family">Williams</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Tietze</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Wu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W. F.</namePart><namePart type="family">DeGrado</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Hong</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>135</number></detail><extent unit="pages"><start>9885</start><end>9897</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0072"><titleInfo><title>Proc Natl Acad Sci U S A</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Jing, X.; Ma, C.; Ohigashi, Y.; Oliveira, F. A.; Jardetzky, T. S.; Pinto, L. H.; Lamb, R. A. Proc Natl Acad Sci U S A 2008, 105, 10967–10972.</note><name type="personal"><namePart type="given">X.</namePart><namePart type="family">Jing</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Ma</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Ohigashi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F. A.</namePart><namePart type="family">Oliveira</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T. S.</namePart><namePart type="family">Jardetzky</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L. H.</namePart><namePart type="family">Pinto</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. A.</namePart><namePart type="family">Lamb</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>105</number></detail><extent unit="pages"><start>10967</start><end>10972</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0073"><titleInfo><title>Protein Cell</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Pielak, R.; Chou, J. Protein Cell 2010, 1, 246–258.</note><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Pielak</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Chou</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>1</number></detail><extent unit="pages"><start>246</start><end>258</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0074"><titleInfo><title>Nature</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Stouffer, A. L.; Acharya, R.; Salom, D.; Levine, A. S.; Di Costanzo, L.; Soto, C. S.; Tereshko, V.; Nanda, V.; Stayrook, S.; DeGrado, W. F. Nature 2008, 452, 380–380.</note><name type="personal"><namePart type="given">A. L.</namePart><namePart type="family">Stouffer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Acharya</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Salom</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. S.</namePart><namePart type="family">Levine</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Di Costanzo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C. S.</namePart><namePart type="family">Soto</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V.</namePart><namePart type="family">Tereshko</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V.</namePart><namePart type="family">Nanda</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Stayrook</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W. F.</namePart><namePart type="family">DeGrado</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>452</number></detail><extent unit="pages"><start>380</start><end>380</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0075"><titleInfo><title>Nature</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Cady, S. D.; Schmidt‐Rohr, K.; Wang, J.; Soto, C. S.; DeGrado, W. F.; Hong, M. Nature 2010, 463, 689–692.</note><name type="personal"><namePart type="given">S. D.</namePart><namePart type="family">Cady</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Schmidt‐Rohr</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C. S.</namePart><namePart type="family">Soto</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W. F.</namePart><namePart type="family">DeGrado</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Hong</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>463</number></detail><extent unit="pages"><start>689</start><end>692</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0076"><titleInfo><title>Biochim Biophys Acta Biomembranes</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Sharma, M.; Li, C.; Busath, D. D.; Zhou, H.‐X.; Cross, T. A. Biochim Biophys Acta Biomembranes 2011, 1808, 538–546.</note><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Sharma</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Li</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D. D.</namePart><namePart type="family">Busath</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.‐X.</namePart><namePart type="family">Zhou</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T. A.</namePart><namePart type="family">Cross</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>1808</number></detail><extent unit="pages"><start>538</start><end>546</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0077"><titleInfo><title>Proc Natl Acad Sci U S A</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Ohigashi, Y.; Ma, C.; Jing, X.; Balannick, V.; Pinto, L. H.; Lamb, R. A. Proc Natl Acad Sci U S A 2009, 106, 18775–18779.</note><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Ohigashi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Ma</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">X.</namePart><namePart type="family">Jing</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V.</namePart><namePart type="family">Balannick</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L. H.</namePart><namePart type="family">Pinto</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. A.</namePart><namePart type="family">Lamb</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>106</number></detail><extent unit="pages"><start>18775</start><end>18779</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0078"><titleInfo><title>Trends in Pharmacol Sci</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Gu, R.‐X.; Liu, L. A.; Wei, D.‐Q. Trends in Pharmacol Sci 2013, 34, 571–580.</note><name type="personal"><namePart type="given">R.‐X.</namePart><namePart type="family">Gu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L. A.</namePart><namePart type="family">Liu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.‐Q.</namePart><namePart type="family">Wei</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>34</number></detail><extent unit="pages"><start>571</start><end>580</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0079"><titleInfo><title>Biophys J</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Chuang, G.‐Y.; Kozakov, D.; Brenke, R.; Beglov, D.; Guarnieri, F.; Vajda, S. Biophys J 2009, 97, 2846–2853.</note><name type="personal"><namePart type="given">G.‐Y.</namePart><namePart type="family">Chuang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Kozakov</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Brenke</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Beglov</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Guarnieri</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Vajda</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>97</number></detail><extent unit="pages"><start>2846</start><end>2853</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0080"><titleInfo><title>Trends Biochem Sci</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Kozakov, D.; Chuang, G.‐Y.; Beglov, D.; Vajda, S. Trends Biochem Sci 2010, 35, 471–475.</note><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Kozakov</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.‐Y.</namePart><namePart type="family">Chuang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Beglov</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Vajda</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>35</number></detail><extent unit="pages"><start>471</start><end>475</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0081"><titleInfo><title>Annu Rev Phys Chem</title></titleInfo><genre>journal-article</genre><note type="citation/reference">De Paëpe, G. Annu Rev Phys Chem 2012, 63, 661–684.</note><name type="personal"><namePart type="given">G.</namePart><namePart type="family">De Paëpe</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2012</date><detail type="volume"><caption>vol.</caption><number>63</number></detail><extent unit="pages"><start>661</start><end>684</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0082"><titleInfo><title>J Am Chem Soc</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Wang, J.; Ma, C.; Wu, Y.; Lamb, R. A.; Pinto, L. H.; DeGrado, W. F. J Am Chem Soc 2011, 133, 13844–13847.</note><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Ma</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Wu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. A.</namePart><namePart type="family">Lamb</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L. H.</namePart><namePart type="family">Pinto</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W. F.</namePart><namePart type="family">DeGrado</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>133</number></detail><extent unit="pages"><start>13844</start><end>13847</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0083"><titleInfo><title>Structure</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Pielak, R. M.; Oxenoid, K.; Chou, J. J. Structure 2011, 19, 1655–1663.</note><name type="personal"><namePart type="given">R. M.</namePart><namePart type="family">Pielak</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Oxenoid</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. J.</namePart><namePart type="family">Chou</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>19</number></detail><extent unit="pages"><start>1655</start><end>1663</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0084"><titleInfo><title>J Phys Chem C</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Carnevale, V.; Fiorin, G.; Levine, B. G.; DeGrado, W. F.; Klein, M. L. J Phys Chem C 2010, 114, 20856–20863.</note><name type="personal"><namePart type="given">V.</namePart><namePart type="family">Carnevale</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Fiorin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B. G.</namePart><namePart type="family">Levine</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W. F.</namePart><namePart type="family">DeGrado</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. L.</namePart><namePart type="family">Klein</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>114</number></detail><extent unit="pages"><start>20856</start><end>20863</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0085"><titleInfo><title>J Phys Chem B</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Gianti, E.; Carnevale, V.; DeGrado, W. F.; Klein, M. L.; Fiorin, G. J Phys Chem B 2015, 119, 1173–1183.</note><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Gianti</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V.</namePart><namePart type="family">Carnevale</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W. F.</namePart><namePart type="family">DeGrado</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. L.</namePart><namePart type="family">Klein</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Fiorin</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2015</date><detail type="volume"><caption>vol.</caption><number>119</number></detail><extent unit="pages"><start>1173</start><end>1183</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0086"><titleInfo><title>J Am Chem Soc</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Luo, W.; Hong, M. J Am Chem Soc 2010, 132, 2378–2384.</note><name type="personal"><namePart type="given">W.</namePart><namePart type="family">Luo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Hong</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>132</number></detail><extent unit="pages"><start>2378</start><end>2384</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0087"><titleInfo><title>J Med Chem</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Hu, W.; Zeng, S.; Li, C.; Jie, Y.; Li, Z.; Chen, L. J Med Chem 2010, 53, 3831–3834.</note><name type="personal"><namePart type="given">W.</namePart><namePart type="family">Hu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Zeng</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Li</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Jie</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Z.</namePart><namePart type="family">Li</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Chen</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>53</number></detail><extent unit="pages"><start>3831</start><end>3834</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0088"><titleInfo><title>J Med Chem</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Duque, M. D.; Ma, C.; Torres, E.; Wang, J.; Naesens, L.; Juarez‐Jimenez, J.; Camps, P.; Javier Luque, F.; DeGrado, W. F.; Lamb, R. A.; Pinto, L. H.; Vazquez, S. J Med Chem 2011, 54, 2646–2657.</note><name type="personal"><namePart type="given">M. D.</namePart><namePart type="family">Duque</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Ma</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Torres</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Naesens</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Juarez‐Jimenez</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Camps</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Javier Luque</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W. F.</namePart><namePart type="family">DeGrado</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. A.</namePart><namePart type="family">Lamb</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L. H.</namePart><namePart type="family">Pinto</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Vazquez</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>54</number></detail><extent unit="pages"><start>2646</start><end>2657</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0089"><titleInfo><title>ACS Med Chem Lett</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Wang, J.; Ma, C.; Balannik, V.; Pinto, L. H.; Lamb, R. A.; DeGrado, W. F. ACS Med Chem Lett 2011, 2, 307–312.</note><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Ma</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V.</namePart><namePart type="family">Balannik</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L. H.</namePart><namePart type="family">Pinto</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. A.</namePart><namePart type="family">Lamb</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W. F.</namePart><namePart type="family">DeGrado</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>2</number></detail><extent unit="pages"><start>307</start><end>312</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0090"><titleInfo><title>J Am Chem Soc</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Wang, J.; Cady, S. D.; Balannik, V.; Pinto, L. H.; DeGrado, W. F.; Hong, M. J Am Chem Soc 2009, 131, 8066–8076.</note><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S. D.</namePart><namePart type="family">Cady</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V.</namePart><namePart type="family">Balannik</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L. H.</namePart><namePart type="family">Pinto</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W. F.</namePart><namePart type="family">DeGrado</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Hong</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>131</number></detail><extent unit="pages"><start>8066</start><end>8076</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0091"><titleInfo><title>Proc Natl Acad Sci U S A</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Hu, J.; Fu, R.; Nishimura, K.; Zhang, L.; Zhou, H.‐X.; Busath, D. D.; Vijayvergiya, V.; Cross, T. A. Proc Natl Acad Sci U S A 2006, 103, 6865–6870.</note><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Hu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Fu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Nishimura</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Zhang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.‐X.</namePart><namePart type="family">Zhou</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D. D.</namePart><namePart type="family">Busath</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V.</namePart><namePart type="family">Vijayvergiya</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T. A.</namePart><namePart type="family">Cross</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>103</number></detail><extent unit="pages"><start>6865</start><end>6870</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0092"><titleInfo><title>Antimicrob Agents and Chemother</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Kurtz, S.; Luo, G.; Hahnenberger, K. M.; Brooks, C.; Gecha, O.; Ingalls, K.; Numata, K.; Krystal, M. Antimicrob Agents and Chemother 1995, 39, 2204–2209.</note><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Kurtz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Luo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K. M.</namePart><namePart type="family">Hahnenberger</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Brooks</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">O.</namePart><namePart type="family">Gecha</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Ingalls</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Numata</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Krystal</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1995</date><detail type="volume"><caption>vol.</caption><number>39</number></detail><extent unit="pages"><start>2204</start><end>2209</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0093"><titleInfo><title>J Virol</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Tu, Q.; Pinto, L. H.; Luo, G.; Shaughnessy, M. A.; Mullaney, D.; Kurtz, S.; Krystal, M.; Lamb, R. A. J Virol 1996, 70, 4246–4252.</note><name type="personal"><namePart type="given">Q.</namePart><namePart type="family">Tu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L. H.</namePart><namePart type="family">Pinto</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Luo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. A.</namePart><namePart type="family">Shaughnessy</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Mullaney</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Kurtz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Krystal</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. A.</namePart><namePart type="family">Lamb</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>70</number></detail><extent unit="pages"><start>4246</start><end>4252</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0094"><titleInfo><title>Biochemistry</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Balannik, V.; Wang, J.; Ohigashi, Y.; Jing, X.; Magavern, E.; Lamb, R. A.; DeGrado, W. F.; Pinto, L. H. Biochemistry 2009, 48, 11872–11882.</note><name type="personal"><namePart type="given">V.</namePart><namePart type="family">Balannik</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Ohigashi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">X.</namePart><namePart type="family">Jing</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Magavern</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. A.</namePart><namePart type="family">Lamb</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W. F.</namePart><namePart type="family">DeGrado</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L. H.</namePart><namePart type="family">Pinto</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>48</number></detail><extent unit="pages"><start>11872</start><end>11882</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0095"><titleInfo><title>Proc Natl Acad Sci U S A</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Acharya, R.; Carnevale, V.; Fiorin, G.; Levine, B. G.; Polishchuk, A. L.; Balannik, V.; Samish, I.; Lamb, R. A.; Pinto, L. H.; DeGrado, W. F.; Klein, M. L. Proc Natl Acad Sci U S A 2010, 107, 15075–15080.</note><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Acharya</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V.</namePart><namePart type="family">Carnevale</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Fiorin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B. G.</namePart><namePart type="family">Levine</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. L.</namePart><namePart type="family">Polishchuk</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V.</namePart><namePart type="family">Balannik</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I.</namePart><namePart type="family">Samish</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. A.</namePart><namePart type="family">Lamb</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L. H.</namePart><namePart type="family">Pinto</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W. F.</namePart><namePart type="family">DeGrado</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. L.</namePart><namePart type="family">Klein</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>107</number></detail><extent unit="pages"><start>15075</start><end>15080</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0096"><titleInfo><title>Biochem Biophy Res Commun</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Pielak, R. M.; Chou, J. J. Biochem Biophy Res Commun 2010, 401, 58–63.</note><name type="personal"><namePart type="given">R. M.</namePart><namePart type="family">Pielak</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. J.</namePart><namePart type="family">Chou</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>401</number></detail><extent unit="pages"><start>58</start><end>63</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0097"><titleInfo><title>J Med Chem</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Rey‐Carrizo, M.; Torres, E.; Ma, C.; Barniol‐Xicota, M.; Wang, J.; Wu, Y.; Naesens, L.; DeGrado, W. F.; Lamb, R. A.; Pinto, L. H.; Vazquez, S. J Med Chem 2013, 56, 9265–9274.</note><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Rey‐Carrizo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Torres</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Ma</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Barniol‐Xicota</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Wu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Naesens</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W. F.</namePart><namePart type="family">DeGrado</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. A.</namePart><namePart type="family">Lamb</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L. H.</namePart><namePart type="family">Pinto</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Vazquez</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>56</number></detail><extent unit="pages"><start>9265</start><end>9274</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0098"><titleInfo><title>J Med Chem</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Rey‐Carrizo, M.; Barniol‐Xicota, M.; Ma, C.; Frigolé‐Vivas, M.; Torres, E.; Naesens, L.; Llabrés, S.; Juárez‐Jiménez, J.; Luque, F. J.; DeGrado, W. F.; Lamb, R. A.; Pinto, L. H.; Vázquez, S. J Med Chem 2014, 57, 5738–5747.</note><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Rey‐Carrizo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Barniol‐Xicota</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Ma</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Frigolé‐Vivas</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Torres</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Naesens</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Llabrés</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Juárez‐Jiménez</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F. J.</namePart><namePart type="family">Luque</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W. F.</namePart><namePart type="family">DeGrado</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. A.</namePart><namePart type="family">Lamb</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L. H.</namePart><namePart type="family">Pinto</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Vázquez</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2014</date><detail type="volume"><caption>vol.</caption><number>57</number></detail><extent unit="pages"><start>5738</start><end>5747</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0099"><titleInfo><title>J Phys Chem B</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Gu, R.‐X.; Liu, L. A.; Wang, Y.‐H.; Xu, Q.; Wei, D.‐Q. J Phys Chem B 2013, 117, 6042–6051.</note><name type="personal"><namePart type="given">R.‐X.</namePart><namePart type="family">Gu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L. A.</namePart><namePart type="family">Liu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.‐H.</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Q.</namePart><namePart type="family">Xu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.‐Q.</namePart><namePart type="family">Wei</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>117</number></detail><extent unit="pages"><start>6042</start><end>6051</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0100"><titleInfo><title>J Phys Chem B</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Gleed, M. L.; Busath, D. D. J Phys Chem B 2015, 119, 1225–1231.</note><name type="personal"><namePart type="given">M. L.</namePart><namePart type="family">Gleed</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D. D.</namePart><namePart type="family">Busath</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2015</date><detail type="volume"><caption>vol.</caption><number>119</number></detail><extent unit="pages"><start>1225</start><end>1231</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0101"><titleInfo><title>Proc Natl Acad Sci U S A</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Khurana, E.; Dal Peraro, M.; DeVane, R.; Vemparala, S.; DeGrado, W.; Klein, M. Proc Natl Acad Sci U S A 2009, 106, 1069.</note><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Khurana</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Dal Peraro</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">DeVane</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Vemparala</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W.</namePart><namePart type="family">DeGrado</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Klein</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>106</number></detail><extent unit="pages"><start>1069</start></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0102"><titleInfo><title>Annu Rev Biochem</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Grigoryan, G.; Moore, D. T.; DeGrado, W. F. Annu Rev Biochem 2011, 80, 211–237.</note><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Grigoryan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D. T.</namePart><namePart type="family">Moore</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W. F.</namePart><namePart type="family">DeGrado</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>80</number></detail><extent unit="pages"><start>211</start><end>237</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0103"><titleInfo><title>Protein Sci</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Hong, M.; DeGrado, W. F. Protein Sci 2012, 21, 1620–1633.</note><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Hong</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W. F.</namePart><namePart type="family">DeGrado</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2012</date><detail type="volume"><caption>vol.</caption><number>21</number></detail><extent unit="pages"><start>1620</start><end>1633</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0104"><titleInfo><title>Antiviral Res</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Zhao, X.; Jie, Y.; Rosenberg, M. R.; Wan, J.; Zeng, S.; Cui, W.; Xiao, Y.; Li, Z.; Tu, Z.; Casarotto, M. G.; Hu, W. Antiviral Res 2012, 96, 91–99.</note><name type="personal"><namePart type="given">X.</namePart><namePart type="family">Zhao</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Jie</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. R.</namePart><namePart type="family">Rosenberg</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Wan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Zeng</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W.</namePart><namePart type="family">Cui</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Xiao</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Z.</namePart><namePart type="family">Li</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Z.</namePart><namePart type="family">Tu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. G.</namePart><namePart type="family">Casarotto</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W.</namePart><namePart type="family">Hu</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2012</date><detail type="volume"><caption>vol.</caption><number>96</number></detail><extent unit="pages"><start>91</start><end>99</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0105"><titleInfo><title>Proc Natl Acad Sci U S A</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Pielak, R.; Schnell, J.; Chou, J. Proc Natl Acad Sci U S A 2009, 106, 7379–7384.</note><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Pielak</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Schnell</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Chou</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>106</number></detail><extent unit="pages"><start>7379</start><end>7384</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0106"><titleInfo><title>Trends Biochem Sci</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Cross, T. A.; Sharma, M.; Yi, M.; Zhou, H.‐X. Trends Biochem Sci 2011, 36, 117–125.</note><name type="personal"><namePart type="given">T. A.</namePart><namePart type="family">Cross</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Sharma</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Yi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.‐X.</namePart><namePart type="family">Zhou</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>36</number></detail><extent unit="pages"><start>117</start><end>125</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0107"><titleInfo><title>Curr Opin Virol</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Cross, T. A.; Dong, H.; Sharma, M.; Busath, D. D.; Zhou, H.‐X. Curr Opin Virol 2012, 2, 128–133.</note><name type="personal"><namePart type="given">T. A.</namePart><namePart type="family">Cross</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Dong</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Sharma</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D. D.</namePart><namePart type="family">Busath</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.‐X.</namePart><namePart type="family">Zhou</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2012</date><detail type="volume"><caption>vol.</caption><number>2</number></detail><extent unit="pages"><start>128</start><end>133</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0108"><titleInfo><title>Science</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Sharma, M.; Yi, M.; Dong, H.; Qin, H.; Peterson, E.; Busath, D. D.; Zhou, H.‐X.; Cross, T. A. Science 2010, 330, 509–512.</note><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Sharma</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Yi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Dong</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Qin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Peterson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D. D.</namePart><namePart type="family">Busath</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.‐X.</namePart><namePart type="family">Zhou</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T. A.</namePart><namePart type="family">Cross</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>330</number></detail><extent unit="pages"><start>509</start><end>512</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0109"><titleInfo><title>J Am Chem Soc</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Wu, Y.; Canturk, B.; Jo, H.; Ma, C.; Gianti, E.; Klein, M. L.; Pinto, L. H.; Lamb, R. A.; Fiorin, G.; Wang, J.; DeGrado, W. F. J Am Chem Soc 2014, 136, 17987–17995.</note><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Wu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Canturk</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Jo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Ma</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Gianti</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. L.</namePart><namePart type="family">Klein</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L. H.</namePart><namePart type="family">Pinto</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. A.</namePart><namePart type="family">Lamb</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Fiorin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W. F.</namePart><namePart type="family">DeGrado</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2014</date><detail type="volume"><caption>vol.</caption><number>136</number></detail><extent unit="pages"><start>17987</start><end>17995</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0110"><titleInfo><title>Curr Opin Pharmacol</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Kolmar, H. Curr Opin Pharmacol 2009, 9, 608–614.</note><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Kolmar</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>9</number></detail><extent unit="pages"><start>608</start><end>614</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0111"><titleInfo><title>Curr Pharm Des</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Kolmar, H. Curr Pharm Des 2011, 17, 4329–4336.</note><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Kolmar</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>17</number></detail><extent unit="pages"><start>4329</start><end>4336</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0112"><titleInfo><title>Br J Pharmacol</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Vink, S.; Alewood, P. F. Br J Pharmacol 2012, 167, 970–989.</note><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Vink</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P. F.</namePart><namePart type="family">Alewood</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2012</date><detail type="volume"><caption>vol.</caption><number>167</number></detail><extent unit="pages"><start>970</start><end>989</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0113"><titleInfo><title>J Med Chem</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Bagal, S. K.; Brown, A. D.; Cox, P. J.; Omoto, K.; Owen, R. M.; Pryde, D. C.; Sidders, B.; Skerratt, S. E.; Stevens, E. B.; Storer, R. I.; Swain, N. A. J Med Chem 2012, 56, 593–624.</note><name type="personal"><namePart type="given">S. K.</namePart><namePart type="family">Bagal</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. D.</namePart><namePart type="family">Brown</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P. J.</namePart><namePart type="family">Cox</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Omoto</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. M.</namePart><namePart type="family">Owen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D. C.</namePart><namePart type="family">Pryde</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Sidders</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S. E.</namePart><namePart type="family">Skerratt</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E. B.</namePart><namePart type="family">Stevens</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. I.</namePart><namePart type="family">Storer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N. A.</namePart><namePart type="family">Swain</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2012</date><detail type="volume"><caption>vol.</caption><number>56</number></detail><extent unit="pages"><start>593</start><end>624</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0114"><titleInfo><title>Biochemistry</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Yu, L.; Sun, C.; Song, D.; Shen, J.; Xu, N.; Gunasekera, A.; Hajduk, P. J.; Olejniczak, E. T. Biochemistry 2005, 44, 15834–15841.</note><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Yu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Sun</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Song</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Shen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N.</namePart><namePart type="family">Xu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Gunasekera</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P. J.</namePart><namePart type="family">Hajduk</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E. T.</namePart><namePart type="family">Olejniczak</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>44</number></detail><extent unit="pages"><start>15834</start><end>15841</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0115"><titleInfo><title>J Mol Biol</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Yohannan, S.; Hu, Y.; Zhou, Y. J Mol Biol 2007, 366, 806–814.</note><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Yohannan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Hu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Zhou</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>366</number></detail><extent unit="pages"><start>806</start><end>814</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0116"><titleInfo><title>Antimicrob Agents Chemother</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Millet, V. M.; Dreisbach, M.; Bryson, Y. J. Antimicrob Agents Chemother 1982, 21, 1–4.</note><name type="personal"><namePart type="given">V. M.</namePart><namePart type="family">Millet</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Dreisbach</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y. J.</namePart><namePart type="family">Bryson</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1982</date><detail type="volume"><caption>vol.</caption><number>21</number></detail><extent unit="pages"><start>1</start><end>4</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0117"><titleInfo><title>Pharmacotherapy</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Neumiller, J. J.; Wood, L.; Campbell, R. K. Pharmacotherapy 2010, 30, 463–484.</note><name type="personal"><namePart type="given">J. J.</namePart><namePart type="family">Neumiller</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Wood</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. K.</namePart><namePart type="family">Campbell</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>30</number></detail><extent unit="pages"><start>463</start><end>484</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0118"><titleInfo><title>Pharmacol Rev</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Verspohl, E. J. Pharmacol Rev 2012, 64, 188–237.</note><name type="personal"><namePart type="given">E. J.</namePart><namePart type="family">Verspohl</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2012</date><detail type="volume"><caption>vol.</caption><number>64</number></detail><extent unit="pages"><start>188</start><end>237</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0119"><titleInfo><title>Influenza Other Respir Viruses</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Ison, M. G. Influenza Other Respir Viruses 2013, 7, 60–66.</note><name type="personal"><namePart type="given">M. G.</namePart><namePart type="family">Ison</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>7</number></detail><extent unit="pages"><start>60</start><end>66</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0120"><titleInfo><title>J Am Med Assoc</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Gulick, R.; Mellors, J.; Havlir, D.; Eron, J.; Gonzalez, C.; McMahon, D.; Jonas, L.; Meibohm, A.; Holder, D.; Schleif, W.; Condra, J.; Emini, E.; Isaacs, R.; Chodakewitz, J.; Richman, D. J Am Med Assoc 1998, 280, 35–41.</note><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Gulick</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Mellors</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Havlir</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Eron</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Gonzalez</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">McMahon</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Jonas</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Meibohm</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Holder</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W.</namePart><namePart type="family">Schleif</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Condra</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Emini</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Isaacs</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Chodakewitz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Richman</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>280</number></detail><extent unit="pages"><start>35</start><end>41</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0121"><titleInfo><title>N Engl J Med</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Gulick, R.; Mellors, J.; Havlir, D.; Eron, J.; Gonzalez, C.; McMahon, D.; Richman, D.; Valentine, F.; Jonas, L.; Meibohm, A.; Emini, E.; Chodakewitz, J. N Engl J Med 1997, 337, 734–739.</note><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Gulick</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Mellors</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Havlir</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Eron</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Gonzalez</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">McMahon</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Richman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Valentine</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Jonas</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Meibohm</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Emini</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Chodakewitz</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1997</date><detail type="volume"><caption>vol.</caption><number>337</number></detail><extent unit="pages"><start>734</start><end>739</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0122"><titleInfo><title>PLoS Comput Biol</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Chang, S.‐S.; Huang, H.‐J.; Chen, C. Y.‐C. PLoS Comput Biol 2011, 7, e1002315.</note><name type="personal"><namePart type="given">S.‐S.</namePart><namePart type="family">Chang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.‐J.</namePart><namePart type="family">Huang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C. Y.‐C.</namePart><namePart type="family">Chen</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>7</number></detail><extent unit="pages"><start>e1002315</start></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0123"><titleInfo><title>Future Med Chem</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Cheng, C.‐K.; Tsai, C.‐H.; Shie, J.‐J.; Fang, J.‐M. Future Med Chem 2014, 6, 757–774.</note><name type="personal"><namePart type="given">C.‐K.</namePart><namePart type="family">Cheng</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.‐H.</namePart><namePart type="family">Tsai</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.‐J.</namePart><namePart type="family">Shie</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.‐M.</namePart><namePart type="family">Fang</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2014</date><detail type="volume"><caption>vol.</caption><number>6</number></detail><extent unit="pages"><start>757</start><end>774</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0124"><titleInfo><title>J Med Chem</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Liu, K.‐C.; Fang, J.‐M.; Jan, J.‐T.; Cheng, T.‐J. R.; Wang, S.‐Y.; Yang, S.‐T.; Cheng, Y.‐S. E.; Wong, C.‐H. J Med Chem 2012, 55, 8493–8501.</note><name type="personal"><namePart type="given">K.‐C.</namePart><namePart type="family">Liu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.‐M.</namePart><namePart type="family">Fang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.‐T.</namePart><namePart type="family">Jan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.‐J. R.</namePart><namePart type="family">Cheng</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.‐Y.</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.‐T.</namePart><namePart type="family">Yang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.‐S. E.</namePart><namePart type="family">Cheng</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.‐H.</namePart><namePart type="family">Wong</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2012</date><detail type="volume"><caption>vol.</caption><number>55</number></detail><extent unit="pages"><start>8493</start><end>8501</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0125"><titleInfo><title>J Med Chem</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Wen, W.‐H.; Lin, M.; Su, C.‐Y.; Wang, S.‐Y.; Cheng, Y.‐S. E.; Fang, J.‐M.; Wong, C.‐H. J Med Chem 2009, 52, 4903–4910.</note><name type="personal"><namePart type="given">W.‐H.</namePart><namePart type="family">Wen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Lin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.‐Y.</namePart><namePart type="family">Su</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.‐Y.</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.‐S. E.</namePart><namePart type="family">Cheng</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.‐M.</namePart><namePart type="family">Fang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.‐H.</namePart><namePart type="family">Wong</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>52</number></detail><extent unit="pages"><start>4903</start><end>4910</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0126"><titleInfo><title>Antiviral Res</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Lee, S. M.; Yen, H. L. Antiviral Res 2012, 96, 391–404.</note><name type="personal"><namePart type="given">S. M.</namePart><namePart type="family">Lee</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H. L.</namePart><namePart type="family">Yen</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2012</date><detail type="volume"><caption>vol.</caption><number>96</number></detail><extent unit="pages"><start>391</start><end>404</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0127"><titleInfo><title>Influenza Other Respir Viruses</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Wathen, M. W.; Barro, M.; Bright, R. A. Influenza Other Respir Viruses 2013, 7, 76–80.</note><name type="personal"><namePart type="given">M. W.</namePart><namePart type="family">Wathen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Barro</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. A.</namePart><namePart type="family">Bright</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>7</number></detail><extent unit="pages"><start>76</start><end>80</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0128"><titleInfo><title>Antiviral Res</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Ochiai, H.; Sakai, S.; Hirabayashi, T.; Shimizu, Y.; Terasawa, K. Antiviral Res 1995, 27, 425–430.</note><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Ochiai</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Sakai</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Hirabayashi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Shimizu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Terasawa</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>1995</date><detail type="volume"><caption>vol.</caption><number>27</number></detail><extent unit="pages"><start>425</start><end>430</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0129"><titleInfo><title>Br J Pharmacol</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Muller, K. H.; Kainov, D. E.; El Bakkouri, K.; Saelens, X.; De Brabander, J. K.; Kittel, C.; Samm, E.; Muller, C. P. Br J Pharmacol 2011, 164, 344–357.</note><name type="personal"><namePart type="given">K. H.</namePart><namePart type="family">Muller</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D. E.</namePart><namePart type="family">Kainov</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">El Bakkouri</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">X.</namePart><namePart type="family">Saelens</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. K.</namePart><namePart type="family">De Brabander</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Kittel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Samm</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C. P.</namePart><namePart type="family">Muller</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>164</number></detail><extent unit="pages"><start>344</start><end>357</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0130"><titleInfo><title>Influenza Other Respir Viruses</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Hurt, A. C.; Hui, D. S.; Hay, A.; Hayden, F. G. Influenza Other Respir Viruses 2015, 9, 20–31.</note><name type="personal"><namePart type="given">A. C.</namePart><namePart type="family">Hurt</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D. S.</namePart><namePart type="family">Hui</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Hay</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F. G.</namePart><namePart type="family">Hayden</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2015</date><detail type="volume"><caption>vol.</caption><number>9</number></detail><extent unit="pages"><start>20</start><end>31</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0131"><titleInfo><title>J Antimicrob Chemother</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Triana‐Baltzer, G. B.; Sanders, R. L.; Hedlund, M.; Jensen, K. A.; Aschenbrenner, L. M.; Larson, J. L.; Fang, F. J Antimicrob Chemother 2011, 66, 15–28.</note><name type="personal"><namePart type="given">G. B.</namePart><namePart type="family">Triana‐Baltzer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. L.</namePart><namePart type="family">Sanders</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Hedlund</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K. A.</namePart><namePart type="family">Jensen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L. M.</namePart><namePart type="family">Aschenbrenner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. L.</namePart><namePart type="family">Larson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Fang</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>66</number></detail><extent unit="pages"><start>15</start><end>28</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0132"><titleInfo><title>Plos One</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Balgi, A. D.; Wang, J.; Cheng, D. Y. H.; Ma, C.; Pfeifer, T. A.; Shimizu, Y.; Anderson, H. J.; Pinto, L. H.; Lamb, R. A.; DeGrado, W. F.; Roberge, M. Plos One 2013, 8, e55271.</note><name type="personal"><namePart type="given">A. D.</namePart><namePart type="family">Balgi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D. Y. H.</namePart><namePart type="family">Cheng</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Ma</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T. A.</namePart><namePart type="family">Pfeifer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Shimizu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H. J.</namePart><namePart type="family">Anderson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L. H.</namePart><namePart type="family">Pinto</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. A.</namePart><namePart type="family">Lamb</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W. F.</namePart><namePart type="family">DeGrado</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Roberge</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>8</number></detail><extent unit="pages"><start>e55271</start></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0133"><titleInfo><title>Biochim Biophys Acta</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Astrahan, P.; Flitman‐Tene, R.; Bennett, E. R.; Krugliak, M.; Gilon, C.; Arkin, I. T. Biochim Biophys Acta 2011, 1808, 394–398.</note><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Astrahan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Flitman‐Tene</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E. R.</namePart><namePart type="family">Bennett</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Krugliak</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Gilon</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I. T.</namePart><namePart type="family">Arkin</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>1808</number></detail><extent unit="pages"><start>394</start><end>398</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0134"><titleInfo><title>Biochim Biophys Acta</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Alhadeff, R.; Assa, D.; Astrahan, P.; Krugliak, M.; Arkin, I. T. Biochim Biophys Acta 2014, 1838, 1068–1073.</note><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Alhadeff</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Assa</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Astrahan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Krugliak</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I. T.</namePart><namePart type="family">Arkin</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2014</date><detail type="volume"><caption>vol.</caption><number>1838</number></detail><extent unit="pages"><start>1068</start><end>1073</end></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0135"><titleInfo><title>Plos One</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Mao, L.; Wang, J.; DeGrado, W. F.; Inouye, M. Plos One 2013, 8, e54070.</note><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Mao</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W. F.</namePart><namePart type="family">DeGrado</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Inouye</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>8</number></detail><extent unit="pages"><start>e54070</start></extent></part></relatedItem><relatedItem type="references" displayLabel="bip22623-cit-0136"><titleInfo><title>J Virol</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Sulli, C.; Banik, S. S. R.; Schilling, J.; Moser, A.; Xiang, X.; Payne, R.; Wanless, A.; Willis, S. H.; Paes, C.; Rucker, J. B.; Doranz, B. J. J Virol 2013, 87, 10679–10686.</note><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Sulli</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S. S. R.</namePart><namePart type="family">Banik</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Schilling</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Moser</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">X.</namePart><namePart type="family">Xiang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Payne</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Wanless</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S. H.</namePart><namePart type="family">Willis</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Paes</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. B.</namePart><namePart type="family">Rucker</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B. J.</namePart><namePart type="family">Doranz</namePart><role><roleTerm type="text">author</roleTerm></role></name><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>87</number></detail><extent unit="pages"><start>10679</start><end>10686</end></extent></part></relatedItem><identifier type="istex">C31C6FE1008D98D0FE36A1F885D8BE6FCE892834</identifier><identifier type="ark">ark:/67375/WNG-NRQG52NJ-H</identifier><identifier type="DOI">10.1002/bip.22623</identifier><identifier type="ArticleID">BIP22623</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2015 Wiley Periodicals, Inc.© 2015 Wiley Periodicals, Inc.</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource><recordOrigin>Converted from (version ) to MODS version 3.6.</recordOrigin><recordCreationDate encoding="w3cdtf">2019-11-13</recordCreationDate></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-NRQG52NJ-H/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/PandemieGrippaleV1/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001A03 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 001A03 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= PandemieGrippaleV1
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:C31C6FE1008D98D0FE36A1F885D8BE6FCE892834
|texte= Recent progress in designing inhibitors that target the drug‐resistant M2 proton channels from the influenza A viruses
}}
| This area was generated with Dilib version V0.6.34. |  |