Influenza A(H1N1)pdm09 vaccine effectiveness and other characteristics associated with hospitalization in chronic liver disease patients
Identifieur interne : 001925 ( Istex/Corpus ); précédent : 001924; suivant : 001926Influenza A(H1N1)pdm09 vaccine effectiveness and other characteristics associated with hospitalization in chronic liver disease patients
Auteurs : Satoko Ohfuji ; Wakaba Fukushima ; Yachiyo Sasaki ; Akihiro Tamori ; Osamu Kurai ; Kiyohide Kioka ; Kazuhiro Maeda ; Akiko Maeda ; Yoshio HirotaSource :
- Liver International [ 1478-3223 ] ; 2014-05.
Abstract
Background & Aims: To date, few studies have investigated the clinical effectiveness of influenza vaccine in chronic liver disease patients. The aim of this study was to examine the effectiveness of monovalent inactivated influenza A(H1N1)pdm09 vaccine and other characteristics associated with hospitalization in patients with chronic hepatitis C. Methods: We conducted a hospital‐based cohort study during influenza A(H1N1)pdm09 pandemic. A total of 408 patients (132 vaccinated, 276 unvaccinated) with detectable HCV‐RNA were followed up with respect to any hospitalization using a weekly postal questionnaire. Reported hospitalizations were verified by medical records. Results: During the epidemic period, 28 hospitalizations (6 vaccinated, 22 unvaccinated) were observed. After adjustment for potential confounders, vaccination decreased the odds ratio (OR) for hospitalization with marginal significance (OR = 0.43, 95%CI = 0.16–1.17). Besides, positive association with hospitalization was observed in patients with albumin levels <3.5 g/dl (OR = 8.40, 3.66–19.3) and steroid users (OR = 5.58, 0.98–31.7). Conclusions: Among patients with chronic hepatitis C, A(H1N1)pdm09 vaccine appeared to have a protective effect against hospitalization. Those patients with a higher risk for hospitalization should be carefully followed during the influenza season, even when vaccinated.
Url:
DOI: 10.1111/liv.12295
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last="Fukushima">Wakaba Fukushima</name><affiliation><mods:affiliation>Department of Public Health, Osaka City University Faculty of Medicine, Osaka, Japan</mods:affiliation></affiliation></author><author><name sortKey="Sasaki, Yachiyo" sort="Sasaki, Yachiyo" uniqKey="Sasaki Y" first="Yachiyo" last="Sasaki">Yachiyo Sasaki</name><affiliation><mods:affiliation>Department of Public Health, Osaka City University Faculty of Medicine, Osaka, Japan</mods:affiliation></affiliation></author><author><name sortKey="Tamori, Akihiro" sort="Tamori, Akihiro" uniqKey="Tamori A" first="Akihiro" last="Tamori">Akihiro Tamori</name><affiliation><mods:affiliation>Department of Hepatology, Osaka City University Faculty of Medicine, Osaka, Japan</mods:affiliation></affiliation></author><author><name sortKey="Kurai, Osamu" sort="Kurai, Osamu" uniqKey="Kurai O" first="Osamu" last="Kurai">Osamu Kurai</name><affiliation><mods:affiliation>Department of Gastroenterology and Hepatology, Osaka City Juso Hospital, Osaka, Japan</mods:affiliation></affiliation></author><author><name sortKey="Kioka, Kiyohide" sort="Kioka, Kiyohide" uniqKey="Kioka K" first="Kiyohide" last="Kioka">Kiyohide Kioka</name><affiliation><mods:affiliation>Department of Hepatology, Osaka City General Hospital, Osaka, Japan</mods:affiliation></affiliation></author><author><name sortKey="Maeda, Kazuhiro" sort="Maeda, Kazuhiro" uniqKey="Maeda K" first="Kazuhiro" last="Maeda">Kazuhiro Maeda</name><affiliation><mods:affiliation>The Research Foundation for Microbial Diseases of Osaka University, Osaka, Japan</mods:affiliation></affiliation></author><author><name sortKey="Maeda, Akiko" sort="Maeda, Akiko" uniqKey="Maeda A" first="Akiko" last="Maeda">Akiko Maeda</name><affiliation><mods:affiliation>Department of Public Health, Osaka City University Faculty of Medicine, Osaka, Japan</mods:affiliation></affiliation></author><author><name sortKey="Hirota, Yoshio" sort="Hirota, Yoshio" uniqKey="Hirota Y" first="Yoshio" 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Ohfuji</name><affiliation><mods:affiliation>Department of Public Health, Osaka City University Faculty of Medicine, Osaka, Japan</mods:affiliation></affiliation><affiliation><mods:affiliation>Satoko Ohfuji, MD, PhD, Department of Public Health, Osaka City University Faculty of Medicine, 1‐4‐3, Asahi‐machi, Abeno‐ku, Osaka 545‐8585, JapanTel: +81 6 6645 3756Fax: +81 6 6645 3757e‐mail:</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: satop@med.osaka-cu.ac.jp</mods:affiliation></affiliation></author><author><name sortKey="Fukushima, Wakaba" sort="Fukushima, Wakaba" uniqKey="Fukushima W" first="Wakaba" last="Fukushima">Wakaba Fukushima</name><affiliation><mods:affiliation>Department of Public Health, Osaka City University Faculty of Medicine, Osaka, Japan</mods:affiliation></affiliation></author><author><name sortKey="Sasaki, Yachiyo" sort="Sasaki, Yachiyo" uniqKey="Sasaki Y" first="Yachiyo" last="Sasaki">Yachiyo Sasaki</name><affiliation><mods:affiliation>Department of Public Health, Osaka City University Faculty of Medicine, Osaka, Japan</mods:affiliation></affiliation></author><author><name sortKey="Tamori, Akihiro" sort="Tamori, Akihiro" uniqKey="Tamori A" first="Akihiro" last="Tamori">Akihiro Tamori</name><affiliation><mods:affiliation>Department of Hepatology, Osaka City University Faculty of Medicine, Osaka, Japan</mods:affiliation></affiliation></author><author><name sortKey="Kurai, Osamu" sort="Kurai, Osamu" uniqKey="Kurai O" first="Osamu" last="Kurai">Osamu Kurai</name><affiliation><mods:affiliation>Department of Gastroenterology and Hepatology, Osaka City Juso Hospital, Osaka, Japan</mods:affiliation></affiliation></author><author><name sortKey="Kioka, Kiyohide" sort="Kioka, Kiyohide" uniqKey="Kioka K" first="Kiyohide" last="Kioka">Kiyohide Kioka</name><affiliation><mods:affiliation>Department of Hepatology, Osaka City General Hospital, Osaka, Japan</mods:affiliation></affiliation></author><author><name sortKey="Maeda, Kazuhiro" sort="Maeda, Kazuhiro" uniqKey="Maeda K" first="Kazuhiro" last="Maeda">Kazuhiro Maeda</name><affiliation><mods:affiliation>The Research Foundation for Microbial Diseases of Osaka University, Osaka, Japan</mods:affiliation></affiliation></author><author><name sortKey="Maeda, Akiko" sort="Maeda, Akiko" uniqKey="Maeda A" first="Akiko" last="Maeda">Akiko Maeda</name><affiliation><mods:affiliation>Department of Public Health, Osaka City University Faculty of Medicine, Osaka, Japan</mods:affiliation></affiliation></author><author><name sortKey="Hirota, Yoshio" sort="Hirota, Yoshio" uniqKey="Hirota Y" first="Yoshio" last="Hirota">Yoshio Hirota</name><affiliation><mods:affiliation>Department of Public Health, Osaka City University Faculty of Medicine, Osaka, Japan</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Liver International</title><title level="j" type="alt">LIVER INTERNATIONAL</title><idno type="ISSN">1478-3223</idno><idno type="eISSN">1478-3231</idno><imprint><biblScope unit="vol">34</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="700">700</biblScope><biblScope unit="page" to="706">706</biblScope><biblScope unit="page-count">7</biblScope><date type="published" when="2014-05">2014-05</date></imprint><idno type="ISSN">1478-3223</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1478-3223</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Background & Aims: To date, few studies have investigated the clinical effectiveness of influenza vaccine in chronic liver disease patients. The aim of this study was to examine the effectiveness of monovalent inactivated influenza A(H1N1)pdm09 vaccine and other characteristics associated with hospitalization in patients with chronic hepatitis C. Methods: We conducted a hospital‐based cohort study during influenza A(H1N1)pdm09 pandemic. A total of 408 patients (132 vaccinated, 276 unvaccinated) with detectable HCV‐RNA were followed up with respect to any hospitalization using a weekly postal questionnaire. Reported hospitalizations were verified by medical records. Results: During the epidemic period, 28 hospitalizations (6 vaccinated, 22 unvaccinated) were observed. After adjustment for potential confounders, vaccination decreased the odds ratio (OR) for hospitalization with marginal significance (OR = 0.43, 95%CI = 0.16–1.17). Besides, positive association with hospitalization was observed in patients with albumin levels <3.5 g/dl (OR = 8.40, 3.66–19.3) and steroid users (OR = 5.58, 0.98–31.7). Conclusions: Among patients with chronic hepatitis C, A(H1N1)pdm09 vaccine appeared to have a protective effect against hospitalization. Those patients with a higher risk for hospitalization should be carefully followed during the influenza season, even when vaccinated.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Satoko Ohfuji</name><affiliations><json:string>Department of Public Health, Osaka City University Faculty of Medicine, Osaka, Japan</json:string><json:string>Satoko Ohfuji, MD, PhD, Department of Public Health, Osaka City University Faculty of Medicine, 1‐4‐3, Asahi‐machi, Abeno‐ku, Osaka 545‐8585, JapanTel: +81 6 6645 3756Fax: +81 6 6645 3757e‐mail:</json:string><json:string>E-mail: satop@med.osaka-cu.ac.jp</json:string></affiliations></json:item><json:item><name>Wakaba Fukushima</name><affiliations><json:string>Department of Public Health, Osaka City University Faculty of Medicine, Osaka, Japan</json:string></affiliations></json:item><json:item><name>Yachiyo Sasaki</name><affiliations><json:string>Department of Public Health, Osaka City University Faculty of Medicine, Osaka, Japan</json:string></affiliations></json:item><json:item><name>Akihiro Tamori</name><affiliations><json:string>Department of Hepatology, Osaka City University Faculty of Medicine, Osaka, Japan</json:string></affiliations></json:item><json:item><name>Osamu Kurai</name><affiliations><json:string>Department of Gastroenterology and Hepatology, Osaka City Juso Hospital, Osaka, Japan</json:string></affiliations></json:item><json:item><name>Kiyohide Kioka</name><affiliations><json:string>Department of Hepatology, Osaka City General Hospital, Osaka, Japan</json:string></affiliations></json:item><json:item><name>Kazuhiro Maeda</name><affiliations><json:string>The Research Foundation for Microbial Diseases of Osaka University, Osaka, Japan</json:string></affiliations></json:item><json:item><name>Akiko Maeda</name><affiliations><json:string>Department of Public Health, Osaka City University Faculty of Medicine, Osaka, Japan</json:string></affiliations></json:item><json:item><name>Yoshio Hirota</name><affiliations><json:string>Department of Public Health, Osaka City University Faculty of Medicine, Osaka, Japan</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>effectiveness</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>hospitalization</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>influenza A(H1N1)pdm09 vaccine</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>liver function</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>risk factors</value></json:item></subject><articleId><json:string>LIV12295</json:string></articleId><arkIstex>ark:/67375/WNG-07HZ2WLB-R</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Background & Aims: To date, few studies have investigated the clinical effectiveness of influenza vaccine in chronic liver disease patients. The aim of this study was to examine the effectiveness of monovalent inactivated influenza A(H1N1)pdm09 vaccine and other characteristics associated with hospitalization in patients with chronic hepatitis C. Methods: We conducted a hospital‐based cohort study during influenza A(H1N1)pdm09 pandemic. A total of 408 patients (132 vaccinated, 276 unvaccinated) with detectable HCV‐RNA were followed up with respect to any hospitalization using a weekly postal questionnaire. Reported hospitalizations were verified by medical records. Results: During the epidemic period, 28 hospitalizations (6 vaccinated, 22 unvaccinated) were observed. After adjustment for potential confounders, vaccination decreased the odds ratio (OR) for hospitalization with marginal significance (OR = 0.43, 95%CI = 0.16–1.17). Besides, positive association with hospitalization was observed in patients with albumin levels >3.5 g/dl (OR = 8.40, 3.66–19.3) and steroid users (OR = 5.58, 0.98–31.7). Conclusions: Among patients with chronic hepatitis C, A(H1N1)pdm09 vaccine appeared to have a protective effect against hospitalization. Those patients with a higher risk for hospitalization should be carefully followed during the influenza season, even when vaccinated.</abstract><qualityIndicators><score>8.109</score><pdfWordCount>3973</pdfWordCount><pdfCharCount>27831</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>7</pdfPageCount><pdfPageSize>595.276 x 782.362 pts</pdfPageSize><pdfWordsPerPage>568</pdfWordsPerPage><pdfText>true</pdfText><refBibsNative>true</refBibsNative><abstractWordCount>178</abstractWordCount><abstractCharCount>1384</abstractCharCount><keywordCount>5</keywordCount></qualityIndicators><title>Influenza A(H1N1)pdm09 vaccine effectiveness and other characteristics associated with hospitalization in chronic liver disease patients</title><genre><json:string>article</json:string></genre><host><title>Liver International</title><language><json:string>unknown</json:string></language><doi><json:string>10.1111/(ISSN)1478-3231</json:string></doi><issn><json:string>1478-3223</json:string></issn><eissn><json:string>1478-3231</json:string></eissn><publisherId><json:string>LIV</json:string></publisherId><volume>34</volume><issue>5</issue><pages><first>700</first><last>706</last><total>7</total></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>Cirrhosis and Liver Failure</value></json:item><json:item><value>Cirrhosis and Liver Failure</value></json:item></subject></host><ark><json:string>ark:/67375/WNG-07HZ2WLB-R</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - gastroenterology & hepatology</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - clinical medicine</json:string><json:string>3 - gastroenterology & hepatology</json:string></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Hepatology</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences medicales</json:string></inist></categories><publicationDate>2014</publicationDate><copyrightDate>2014</copyrightDate><doi><json:string>10.1111/liv.12295</json:string></doi><id>4962BE181D1E5A68AEBF35E17176BC86FAA4797F</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-07HZ2WLB-R/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-07HZ2WLB-R/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/WNG-07HZ2WLB-R/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">Influenza A(H1N1)pdm09 vaccine effectiveness and other characteristics associated with hospitalization in chronic liver disease patients</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher ref="https://scientific-publisher.data.istex.fr/ark:/67375/H02-QW5Q88H5-V">Wiley Publishing Ltd</publisher><availability><licence>© 2013 The Authors. 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<ref target="http://www.tei-c.org/">We use TEI</ref></desc></application></appInfo></encodingDesc><profileDesc><abstract style="main" xml:id="liv12295-abs-0001"><head>Abstract</head><head>Background & Aims</head><p>To date, few studies have investigated the clinical effectiveness of influenza vaccine in chronic liver disease patients. The aim of this study was to examine the effectiveness of monovalent inactivated influenza A(H1N1)pdm09 vaccine and other characteristics associated with hospitalization in patients with chronic hepatitis C.</p><head>Methods</head><p>We conducted a hospital‐based cohort study during influenza A(H1N1)pdm09 pandemic. A total of 408 patients (132 vaccinated, 276 unvaccinated) with detectable HCV‐RNA were followed up with respect to any hospitalization using a weekly postal questionnaire. Reported hospitalizations were verified by medical records.</p><head>Results</head><p>During the epidemic period, 28 hospitalizations (6 vaccinated, 22 unvaccinated) were observed. After adjustment for potential confounders, vaccination decreased the odds ratio (OR) for hospitalization with marginal significance (OR = 0.43, 95%CI = 0.16–1.17). Besides, positive association with hospitalization was observed in patients with albumin levels <3.5 g/dl (OR = 8.40, 3.66–19.3) and steroid users (OR = 5.58, 0.98–31.7).</p><head>Conclusions</head><p>Among patients with chronic hepatitis C, A(H1N1)pdm09 vaccine appeared to have a protective effect against hospitalization. Those patients with a higher risk for hospitalization should be carefully followed during the influenza season, even when vaccinated.</p></abstract><textClass><keywords><term xml:id="liv12295-kwd-0001">effectiveness</term><term xml:id="liv12295-kwd-0002">hospitalization</term><term xml:id="liv12295-kwd-0003">influenza A(H1N1)pdm09 vaccine</term><term xml:id="liv12295-kwd-0004">liver function</term><term xml:id="liv12295-kwd-0005">risk factors</term></keywords><keywords rend="articleCategory"><term>Cirrhosis and Liver Failure</term></keywords><keywords rend="tocHeading1"><term>Cirrhosis and Liver Failure</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc><revisionDesc><change when="2019-12-20" who="#istex" xml:id="pub2tei">formatting</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-07HZ2WLB-R/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component type="serialArticle" version="2.0" xml:id="liv12295" xml:lang="en"><header><publicationMeta level="product"><doi origin="wiley" registered="yes">10.1111/(ISSN)1478-3231</doi><issn type="print">1478-3223</issn><issn type="electronic">1478-3231</issn><idGroup><id type="product" value="LIV"></id></idGroup><titleGroup><title sort="LIVER INTERNATIONAL" type="main">Liver International</title><title type="short">Liver Int</title></titleGroup></publicationMeta><publicationMeta level="part" position="50"><doi origin="wiley">10.1111/liv.2014.34.issue-5</doi><copyright ownership="publisher">© 2014 John Wiley & Sons A/S</copyright><numberingGroup><numbering type="journalVolume" number="34">34</numbering><numbering type="journalIssue">5</numbering></numberingGroup><coverDate startDate="2014-05">May 2014</coverDate></publicationMeta><publicationMeta level="unit" position="90" status="forIssue" type="article" accessType="open"><doi>10.1111/liv.12295</doi><idGroup><id type="unit" value="LIV12295"></id></idGroup><countGroup><count number="7" type="pageTotal"></count></countGroup><titleGroup><title type="articleCategory">Cirrhosis and Liver Failure</title><title type="tocHeading1">Cirrhosis and Liver Failure</title></titleGroup><copyright ownership="publisher">© 2013 The Authors. Liver International published by John Wiley & Sons Ltd.</copyright><legalStatement type="creativeCommonsBy-nc-nd"><p>This is an open access article under the terms of the <url href="http://creativecommons.org/licenses/by-nc-nd/3.0/">Creative Commons Attribution‐NonCommercial‐NoDerivs</url> License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.</p></legalStatement><eventGroup><event date="2013-04-24" type="manuscriptReceived"></event><event date="2013-07-24" type="manuscriptAccepted"></event><event agent="SPS" date="2013-08-08" type="xmlCreated"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.3.0 mode:FullText" date="2014-04-08"></event><event type="publishedOnlineAccepted" date="2013-08-02"></event><event type="publishedOnlineEarlyUnpaginated" date="2013-08-28"></event><event type="firstOnline" date="2013-08-28"></event><event type="publishedOnlineFinalForm" date="2014-04-08"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.6.4 mode:FullText" date="2015-10-07"></event></eventGroup><numberingGroup><numbering type="pageFirst">700</numbering><numbering type="pageLast">706</numbering></numberingGroup><correspondenceTo><lineatedText><line><b>Correspondence</b></line><line>Satoko Ohfuji, MD, PhD, Department of Public Health, Osaka City University Faculty of Medicine, 1‐4‐3, Asahi‐machi, Abeno‐ku, Osaka 545‐8585, Japan</line><line>Tel: +81 6 6645 3756</line><line>Fax: +81 6 6645 3757</line><line>e‐mail: <email>satop@med.osaka-cu.ac.jp</email></line></lineatedText></correspondenceTo><selfCitationGroup><citation type="self" xml:id="liv12295-cit-1001"><journalTitle>Liver Int</journalTitle>. <pubYear year="2014">2014</pubYear>: <vol>34</vol>: <pageFirst>700</pageFirst>–<pageLast>706</pageLast></citation></selfCitationGroup><linkGroup><link type="toTypesetVersion" href="file:LIV.LIV12295.pdf"></link></linkGroup></publicationMeta><contentMeta><titleGroup><title type="main">Influenza A(H1N1)pdm09 vaccine effectiveness and other characteristics associated with hospitalization in chronic liver disease patients</title><title type="shortAuthors">Ohfuji <i>et al</i>.</title></titleGroup><creators><creator affiliationRef="#liv12295-aff-0001" corresponding="yes" creatorRole="author" xml:id="liv12295-cr-0001"><personName><givenNames>Satoko</givenNames> <familyName>Ohfuji</familyName></personName></creator><creator affiliationRef="#liv12295-aff-0001" creatorRole="author" xml:id="liv12295-cr-0002"><personName><givenNames>Wakaba</givenNames> <familyName>Fukushima</familyName></personName></creator><creator affiliationRef="#liv12295-aff-0001" creatorRole="author" xml:id="liv12295-cr-0003"><personName><givenNames>Yachiyo</givenNames> <familyName>Sasaki</familyName></personName></creator><creator affiliationRef="#liv12295-aff-0002" creatorRole="author" xml:id="liv12295-cr-0004"><personName><givenNames>Akihiro</givenNames> <familyName>Tamori</familyName></personName></creator><creator affiliationRef="#liv12295-aff-0003" creatorRole="author" xml:id="liv12295-cr-0005"><personName><givenNames>Osamu</givenNames> <familyName>Kurai</familyName></personName></creator><creator affiliationRef="#liv12295-aff-0004" creatorRole="author" xml:id="liv12295-cr-0006"><personName><givenNames>Kiyohide</givenNames> <familyName>Kioka</familyName></personName></creator><creator affiliationRef="#liv12295-aff-0005" creatorRole="author" xml:id="liv12295-cr-0007"><personName><givenNames>Kazuhiro</givenNames> <familyName>Maeda</familyName></personName></creator><creator affiliationRef="#liv12295-aff-0001" creatorRole="author" xml:id="liv12295-cr-0008"><personName><givenNames>Akiko</givenNames> <familyName>Maeda</familyName></personName></creator><creator affiliationRef="#liv12295-aff-0001" creatorRole="author" xml:id="liv12295-cr-0009"><personName><givenNames>Yoshio</givenNames> <familyName>Hirota</familyName></personName></creator></creators><affiliationGroup><affiliation countryCode="JP" type="organization" xml:id="liv12295-aff-0001"><orgDiv>Department of Public Health</orgDiv> <orgName>Osaka City University Faculty of Medicine</orgName> <address><city>Osaka</city> <country>Japan</country></address></affiliation><affiliation countryCode="JP" type="organization" xml:id="liv12295-aff-0002"><orgDiv>Department of Hepatology</orgDiv> <orgName>Osaka City University Faculty of Medicine</orgName> <address><city>Osaka</city> <country>Japan</country></address></affiliation><affiliation countryCode="JP" type="organization" xml:id="liv12295-aff-0003"><orgDiv>Department of Gastroenterology and Hepatology</orgDiv> <orgName>Osaka City Juso Hospital</orgName> <address><city>Osaka</city> <country>Japan</country></address></affiliation><affiliation countryCode="JP" type="organization" xml:id="liv12295-aff-0004"><orgDiv>Department of Hepatology</orgDiv> <orgName>Osaka City General Hospital</orgName> <address><city>Osaka</city> <country>Japan</country></address></affiliation><affiliation countryCode="JP" type="organization" xml:id="liv12295-aff-0005"><orgName>The Research Foundation for Microbial Diseases of Osaka University</orgName> <address><city>Osaka</city> <country>Japan</country></address></affiliation></affiliationGroup><keywordGroup type="author"><keyword xml:id="liv12295-kwd-0001">effectiveness</keyword><keyword xml:id="liv12295-kwd-0002">hospitalization</keyword><keyword xml:id="liv12295-kwd-0003">influenza A(H1N1)pdm09 vaccine</keyword><keyword xml:id="liv12295-kwd-0004">liver function</keyword><keyword xml:id="liv12295-kwd-0005">risk factors</keyword></keywordGroup><fundingInfo><fundingAgency>Ministry of Health, Labor and Welfare, Japan</fundingAgency><fundingNumber>H20‐SHINKO‐IPPAN‐002</fundingNumber></fundingInfo><abstractGroup><abstract type="main" xml:id="liv12295-abs-0001"><title type="main">Abstract</title><section xml:id="liv12295-sec-0001"><title type="main">Background & Aims</title><p>To date, few studies have investigated the clinical effectiveness of influenza vaccine in chronic liver disease patients. The aim of this study was to examine the effectiveness of monovalent inactivated influenza A(H1N1)pdm09 vaccine and other characteristics associated with hospitalization in patients with chronic hepatitis C.</p></section><section xml:id="liv12295-sec-0002"><title type="main">Methods</title><p>We conducted a hospital‐based cohort study during influenza A(H1N1)pdm09 pandemic. A total of 408 patients (132 vaccinated, 276 unvaccinated) with detectable HCV‐RNA were followed up with respect to any hospitalization using a weekly postal questionnaire. Reported hospitalizations were verified by medical records.</p></section><section xml:id="liv12295-sec-0003"><title type="main">Results</title><p>During the epidemic period, 28 hospitalizations (6 vaccinated, 22 unvaccinated) were observed. After adjustment for potential confounders, vaccination decreased the odds ratio (OR) for hospitalization with marginal significance (OR = 0.43, 95%CI = 0.16–1.17). Besides, positive association with hospitalization was observed in patients with albumin levels <3.5 g/dl (OR = 8.40, 3.66–19.3) and steroid users (OR = 5.58, 0.98–31.7).</p></section><section xml:id="liv12295-sec-0004"><title type="main">Conclusions</title><p>Among patients with chronic hepatitis C, A(H1N1)pdm09 vaccine appeared to have a protective effect against hospitalization. Those patients with a higher risk for hospitalization should be carefully followed during the influenza season, even when vaccinated.</p></section></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Influenza A(H1N1)pdm09 vaccine effectiveness and other characteristics associated with hospitalization in chronic liver disease patients</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Influenza A(H1N1)pdm09 vaccine effectiveness and other characteristics associated with hospitalization in chronic liver disease patients</title></titleInfo><name type="personal"><namePart type="given">Satoko</namePart><namePart type="family">Ohfuji</namePart><affiliation>Department of Public Health, Osaka City University Faculty of Medicine, Osaka, Japan</affiliation><affiliation>Satoko Ohfuji, MD, PhD, Department of Public Health, Osaka City University Faculty of Medicine, 1‐4‐3, Asahi‐machi, Abeno‐ku, Osaka 545‐8585, JapanTel: +81 6 6645 3756Fax: +81 6 6645 3757e‐mail:</affiliation><affiliation>E-mail: satop@med.osaka-cu.ac.jp</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Wakaba</namePart><namePart type="family">Fukushima</namePart><affiliation>Department of Public Health, Osaka City University Faculty of Medicine, Osaka, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yachiyo</namePart><namePart type="family">Sasaki</namePart><affiliation>Department of Public Health, Osaka City University Faculty of Medicine, Osaka, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Akihiro</namePart><namePart type="family">Tamori</namePart><affiliation>Department of Hepatology, Osaka City University Faculty of Medicine, Osaka, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Osamu</namePart><namePart type="family">Kurai</namePart><affiliation>Department of Gastroenterology and Hepatology, Osaka City Juso Hospital, Osaka, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kiyohide</namePart><namePart type="family">Kioka</namePart><affiliation>Department of Hepatology, Osaka City General Hospital, Osaka, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kazuhiro</namePart><namePart type="family">Maeda</namePart><affiliation>The Research Foundation for Microbial Diseases of Osaka University, Osaka, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Akiko</namePart><namePart type="family">Maeda</namePart><affiliation>Department of Public Health, Osaka City University Faculty of Medicine, Osaka, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yoshio</namePart><namePart type="family">Hirota</namePart><affiliation>Department of Public Health, Osaka City University Faculty of Medicine, Osaka, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><dateIssued encoding="w3cdtf">2014-05</dateIssued><dateCreated encoding="w3cdtf">2013-08-08</dateCreated><dateCaptured encoding="w3cdtf">2013-04-24</dateCaptured><dateValid encoding="w3cdtf">2013-07-24</dateValid><edition>Liver Int. 2014: 34: 700–706</edition><copyrightDate encoding="w3cdtf">2014</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract>Background & Aims: To date, few studies have investigated the clinical effectiveness of influenza vaccine in chronic liver disease patients. The aim of this study was to examine the effectiveness of monovalent inactivated influenza A(H1N1)pdm09 vaccine and other characteristics associated with hospitalization in patients with chronic hepatitis C. Methods: We conducted a hospital‐based cohort study during influenza A(H1N1)pdm09 pandemic. A total of 408 patients (132 vaccinated, 276 unvaccinated) with detectable HCV‐RNA were followed up with respect to any hospitalization using a weekly postal questionnaire. Reported hospitalizations were verified by medical records. Results: During the epidemic period, 28 hospitalizations (6 vaccinated, 22 unvaccinated) were observed. After adjustment for potential confounders, vaccination decreased the odds ratio (OR) for hospitalization with marginal significance (OR = 0.43, 95%CI = 0.16–1.17). Besides, positive association with hospitalization was observed in patients with albumin levels <3.5 g/dl (OR = 8.40, 3.66–19.3) and steroid users (OR = 5.58, 0.98–31.7). Conclusions: Among patients with chronic hepatitis C, A(H1N1)pdm09 vaccine appeared to have a protective effect against hospitalization. Those patients with a higher risk for hospitalization should be carefully followed during the influenza season, even when vaccinated.</abstract><note type="funding">Ministry of Health, Labor and Welfare, Japan - No. H20‐SHINKO‐IPPAN‐002; </note><subject><genre>keywords</genre><topic>effectiveness</topic><topic>hospitalization</topic><topic>influenza A(H1N1)pdm09 vaccine</topic><topic>liver function</topic><topic>risk factors</topic></subject><relatedItem type="host"><titleInfo><title>Liver International</title></titleInfo><titleInfo type="abbreviated"><title>Liver Int</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>article-category</genre><topic>Cirrhosis and Liver Failure</topic><topic>Cirrhosis and Liver Failure</topic></subject><identifier type="ISSN">1478-3223</identifier><identifier type="eISSN">1478-3231</identifier><identifier type="DOI">10.1111/(ISSN)1478-3231</identifier><identifier type="PublisherID">LIV</identifier><part><date>2014</date><detail type="volume"><caption>vol.</caption><number>34</number></detail><detail type="issue"><caption>no.</caption><number>5</number></detail><extent unit="pages"><start>700</start><end>706</end><total>7</total></extent></part></relatedItem><relatedItem type="references" displayLabel="liv12295-cit-0001"><titleInfo><title>Underlying medical conditions and hospitalization for pandemic (H1N1) 2009, Japan</title></titleInfo><name type="personal"><namePart type="given">T</namePart><namePart type="family">Tomizuka</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Takayama</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Shobayashi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Fukushima</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Suzuki</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Tomizuka T, Takayama Y, Shobayashi T, Fukushima Y, Suzuki Y. 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