Seasonality of congenital anomalies in Europe
Identifieur interne : 001890 ( Istex/Corpus ); précédent : 001889; suivant : 001891Seasonality of congenital anomalies in Europe
Auteurs : Johannes Michiel Luteijn ; Helen Dolk ; Marie-Claude Addor ; Larraitz Arriola ; Ingeborg Barisic ; Fabrizio Bianchi ; Elisa Calzolari ; Elizabeth Draper ; Ester Garne ; Miriam Gatt ; Martin Haeusler ; Babak Khoshnood ; Bob Mcdonnell ; Vera Nelen ; Mary O'Mahony ; Carmel Mullaney ; Annette Queisser-Luft ; Judith Rankin ; David Tucker ; Christine Verellen-Dumoulin ; Hermien De Walle ; Lyubov YevtushokSource :
- Birth Defects Research Part A: Clinical and Molecular Teratology [ 1542-0752 ] ; 2014-04.
Abstract
Background: This study describes seasonality of congenital anomalies in Europe to provide a baseline against which to assess the impact of specific time varying exposures such as the H1N1 pandemic influenza, and to provide a comprehensive and recent picture of seasonality and its possible relation to etiologic factors. Methods: Data on births conceived in 2000 to 2008 were extracted from 20 European Surveillance for Congenital Anomalies population‐based congenital anomaly registries in 14 European countries. We performed Poisson regression analysis encompassing sine and cosine terms to investigate seasonality of 65,764 nonchromosomal and 12,682 chromosomal congenital anomalies covering 3.3 million births. Analysis was performed by estimated month of conception. Analyses were performed for 86 congenital anomaly subgroups, including a combined subgroup of congenital anomalies previously associated with influenza. Results: We detected statistically significant seasonality in prevalence of anomalies previously associated with influenza, but the conception peak was in June (2.4% excess). We also detected seasonality in congenital cataract (April conceptions, 27%), hip dislocation and/or dysplasia (April, 12%), congenital hydronephrosis (July, 12%), urinary defects (July, 5%), and situs inversus (December, 36%), but not for nonchromosomal anomalies combined, chromosomal anomalies combined, or other anomalies analyzed. Conclusion: We have confirmed previously described seasonality for congenital cataract and hip dislocation and/or dysplasia, and found seasonality for congenital hydronephrosis and situs inversus which have not previously been studied. We did not find evidence of seasonality for several anomalies which had previously been found to be seasonal. Influenza does not appear to be an important factor in the seasonality of congenital anomalies. Birth Defects Research (Part A) 100:260–269, 2014. © 2014 Wiley Periodicals, Inc.
Url:
DOI: 10.1002/bdra.23231
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Belgium</mods:affiliation></affiliation></author><author><name sortKey="De Walle, Hermien" sort="De Walle, Hermien" uniqKey="De Walle H" first="Hermien" last="De Walle">Hermien De Walle</name><affiliation><mods:affiliation>University Medical Center Groningen, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Yevtushok, Lyubov" sort="Yevtushok, Lyubov" uniqKey="Yevtushok L" first="Lyubov" last="Yevtushok">Lyubov Yevtushok</name><affiliation><mods:affiliation>OMNI‐Net for Children and Rivne Medical Diagnostic Center, Rivne, Ukraine</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:EA3DE4896B25C05D97909845927648D28A674CFA</idno><date when="2014" year="2014">2014</date><idno type="doi">10.1002/bdra.23231</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-PVZ5SZ6B-D/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001890</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001890</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Seasonality of congenital anomalies in Europe</title><author><name sortKey="Luteijn, Johannes Michiel" sort="Luteijn, Johannes Michiel" uniqKey="Luteijn J" first="Johannes Michiel" last="Luteijn">Johannes Michiel Luteijn</name><affiliation><mods:affiliation>Institute of Nursing Research/School of Nursing, University of Ulster, Jordanstown Campus, Newtownabbey, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Dolk, Helen" sort="Dolk, Helen" uniqKey="Dolk H" first="Helen" last="Dolk">Helen Dolk</name><affiliation><mods:affiliation>Institute of Nursing Research/School of Nursing, University of Ulster, Jordanstown Campus, Newtownabbey, United Kingdom</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: h.dolk@ulster.ac.uk</mods:affiliation></affiliation></author><author><name sortKey="Addor, Marie Laude" sort="Addor, Marie Laude" uniqKey="Addor M" first="Marie-Claude" last="Addor">Marie-Claude Addor</name><affiliation><mods:affiliation>Division of Medical Genetics, Lausanne, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Arriola, Larraitz" sort="Arriola, Larraitz" uniqKey="Arriola L" first="Larraitz" last="Arriola">Larraitz Arriola</name><affiliation><mods:affiliation>Public Health Division of Gipuzkoa, Instituto BIO‐Donostia, Basque Government, CIBER Epidemiología y Salud Pública ‐ CIBERESP, Spain</mods:affiliation></affiliation></author><author><name sortKey="Barisic, Ingeborg" sort="Barisic, Ingeborg" uniqKey="Barisic I" first="Ingeborg" last="Barisic">Ingeborg Barisic</name><affiliation><mods:affiliation>Children's Hospital Zagreb, Medical School University of Zagreb, Croatia</mods:affiliation></affiliation></author><author><name sortKey="Bianchi, Fabrizio" sort="Bianchi, Fabrizio" uniqKey="Bianchi F" first="Fabrizio" last="Bianchi">Fabrizio Bianchi</name><affiliation><mods:affiliation>Unit of Epidemiology, Institute of Clinical Physiology, Pisa, Italy</mods:affiliation></affiliation></author><author><name sortKey="Calzolari, Elisa" sort="Calzolari, Elisa" uniqKey="Calzolari E" first="Elisa" last="Calzolari">Elisa Calzolari</name><affiliation><mods:affiliation>IMER Registry ‐ Azienda Ospedaliero‐Universitaria di Ferrara, Ferrara, Italy</mods:affiliation></affiliation></author><author><name sortKey="Draper, Elizabeth" sort="Draper, Elizabeth" uniqKey="Draper E" first="Elizabeth" last="Draper">Elizabeth Draper</name><affiliation><mods:affiliation>Department of Health Sciences, University of Leicester, Leicester, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Garne, Ester" sort="Garne, Ester" uniqKey="Garne E" first="Ester" last="Garne">Ester Garne</name><affiliation><mods:affiliation>Department of Paediatrics, Hospital Lillebaelt, Kolding, Denmark</mods:affiliation></affiliation></author><author><name sortKey="Gatt, Miriam" sort="Gatt, Miriam" uniqKey="Gatt M" first="Miriam" last="Gatt">Miriam Gatt</name><affiliation><mods:affiliation>Department of Health Information, Malta Congenital Anomalies Registry, Guardamangia, Malta</mods:affiliation></affiliation></author><author><name sortKey="Haeusler, Martin" sort="Haeusler, Martin" uniqKey="Haeusler M" first="Martin" last="Haeusler">Martin Haeusler</name><affiliation><mods:affiliation>Medical University of Graz, Austria</mods:affiliation></affiliation></author><author><name sortKey="Khoshnood, Babak" sort="Khoshnood, Babak" uniqKey="Khoshnood B" first="Babak" last="Khoshnood">Babak Khoshnood</name><affiliation><mods:affiliation>INSERM U953, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Mcdonnell, Bob" sort="Mcdonnell, Bob" uniqKey="Mcdonnell B" first="Bob" last="Mcdonnell">Bob Mcdonnell</name><affiliation><mods:affiliation>Health Service Executive, Dublin, Ireland</mods:affiliation></affiliation></author><author><name sortKey="Nelen, Vera" sort="Nelen, Vera" uniqKey="Nelen V" first="Vera" last="Nelen">Vera Nelen</name><affiliation><mods:affiliation>Provinciaal Instituut voor Hygiene, Antwerp, Belgium</mods:affiliation></affiliation></author><author><name sortKey="O Mahony, Mary" sort="O Mahony, Mary" uniqKey="O Mahony M" first="Mary" last="O'Mahony">Mary O'Mahony</name><affiliation><mods:affiliation>Health Service Executive, Cork, Ireland</mods:affiliation></affiliation></author><author><name sortKey="Mullaney, Carmel" sort="Mullaney, Carmel" uniqKey="Mullaney C" first="Carmel" last="Mullaney">Carmel Mullaney</name><affiliation><mods:affiliation>Health Service Executive, Kilkenny, Ireland</mods:affiliation></affiliation></author><author><name sortKey="Queisser Uft, Annette" sort="Queisser Uft, Annette" uniqKey="Queisser Uft A" first="Annette" last="Queisser-Luft">Annette Queisser-Luft</name><affiliation><mods:affiliation>University Medical Center of the Johannes Gutenberg University, Mainz, Germany</mods:affiliation></affiliation></author><author><name sortKey="Rankin, Judith" sort="Rankin, Judith" uniqKey="Rankin J" first="Judith" last="Rankin">Judith Rankin</name><affiliation><mods:affiliation>Institute of Health & Society, Newcastle‐upon‐Tyne, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Tucker, David" sort="Tucker, David" uniqKey="Tucker D" first="David" last="Tucker">David Tucker</name><affiliation><mods:affiliation>Public Health Wales, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Verellen Umoulin, Christine" sort="Verellen Umoulin, Christine" uniqKey="Verellen Umoulin C" first="Christine" last="Verellen-Dumoulin">Christine Verellen-Dumoulin</name><affiliation><mods:affiliation>Institut de Pathologie et de Génétique, Charleroi, Belgium</mods:affiliation></affiliation></author><author><name sortKey="De Walle, Hermien" sort="De Walle, Hermien" uniqKey="De Walle H" first="Hermien" last="De Walle">Hermien De Walle</name><affiliation><mods:affiliation>University Medical Center Groningen, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Yevtushok, Lyubov" sort="Yevtushok, Lyubov" uniqKey="Yevtushok L" first="Lyubov" last="Yevtushok">Lyubov Yevtushok</name><affiliation><mods:affiliation>OMNI‐Net for Children and Rivne Medical Diagnostic Center, Rivne, Ukraine</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Birth Defects Research Part A: Clinical and Molecular Teratology</title><title level="j" type="alt">BIRTH DEFECTS RESEARCH PART A: CLINICAL AND MOLECULAR TERATOLOGY</title><idno type="ISSN">1542-0752</idno><idno type="eISSN">1542-0760</idno><imprint><biblScope unit="vol">100</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="260">260</biblScope><biblScope unit="page" to="269">269</biblScope><biblScope unit="page-count">10</biblScope><date type="published" when="2014-04">2014-04</date></imprint><idno type="ISSN">1542-0752</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1542-0752</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Background: This study describes seasonality of congenital anomalies in Europe to provide a baseline against which to assess the impact of specific time varying exposures such as the H1N1 pandemic influenza, and to provide a comprehensive and recent picture of seasonality and its possible relation to etiologic factors. Methods: Data on births conceived in 2000 to 2008 were extracted from 20 European Surveillance for Congenital Anomalies population‐based congenital anomaly registries in 14 European countries. We performed Poisson regression analysis encompassing sine and cosine terms to investigate seasonality of 65,764 nonchromosomal and 12,682 chromosomal congenital anomalies covering 3.3 million births. Analysis was performed by estimated month of conception. Analyses were performed for 86 congenital anomaly subgroups, including a combined subgroup of congenital anomalies previously associated with influenza. Results: We detected statistically significant seasonality in prevalence of anomalies previously associated with influenza, but the conception peak was in June (2.4% excess). We also detected seasonality in congenital cataract (April conceptions, 27%), hip dislocation and/or dysplasia (April, 12%), congenital hydronephrosis (July, 12%), urinary defects (July, 5%), and situs inversus (December, 36%), but not for nonchromosomal anomalies combined, chromosomal anomalies combined, or other anomalies analyzed. Conclusion: We have confirmed previously described seasonality for congenital cataract and hip dislocation and/or dysplasia, and found seasonality for congenital hydronephrosis and situs inversus which have not previously been studied. We did not find evidence of seasonality for several anomalies which had previously been found to be seasonal. Influenza does not appear to be an important factor in the seasonality of congenital anomalies. Birth Defects Research (Part A) 100:260–269, 2014. © 2014 Wiley Periodicals, Inc.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Johannes Michiel Luteijn</name><affiliations><json:string>Institute of Nursing Research/School of Nursing, University of Ulster, Jordanstown Campus, Newtownabbey, United Kingdom</json:string></affiliations></json:item><json:item><name>Helen Dolk</name><affiliations><json:string>Institute of Nursing Research/School of Nursing, University of Ulster, Jordanstown Campus, Newtownabbey, United Kingdom</json:string><json:string>E-mail: h.dolk@ulster.ac.uk</json:string></affiliations></json:item><json:item><name>Marie‐Claude Addor</name><affiliations><json:string>Division of Medical Genetics, Lausanne, Switzerland</json:string></affiliations></json:item><json:item><name>Larraitz Arriola</name><affiliations><json:string>Public Health Division of Gipuzkoa, Instituto BIO‐Donostia, Basque Government, CIBER Epidemiología y Salud Pública ‐ CIBERESP, Spain</json:string></affiliations></json:item><json:item><name>Ingeborg Barisic</name><affiliations><json:string>Children's Hospital Zagreb, Medical School University of Zagreb, Croatia</json:string></affiliations></json:item><json:item><name>Fabrizio Bianchi</name><affiliations><json:string>Unit of Epidemiology, Institute of Clinical Physiology, Pisa, Italy</json:string></affiliations></json:item><json:item><name>Elisa Calzolari</name><affiliations><json:string>IMER Registry ‐ Azienda Ospedaliero‐Universitaria di Ferrara, Ferrara, Italy</json:string></affiliations></json:item><json:item><name>Elizabeth Draper</name><affiliations><json:string>Department of Health Sciences, University of Leicester, Leicester, United Kingdom</json:string></affiliations></json:item><json:item><name>Ester Garne</name><affiliations><json:string>Department of Paediatrics, Hospital Lillebaelt, Kolding, Denmark</json:string></affiliations></json:item><json:item><name>Miriam Gatt</name><affiliations><json:string>Department of Health Information, Malta Congenital Anomalies Registry, Guardamangia, Malta</json:string></affiliations></json:item><json:item><name>Martin Haeusler</name><affiliations><json:string>Medical University of Graz, Austria</json:string></affiliations></json:item><json:item><name>Babak Khoshnood</name><affiliations><json:string>INSERM U953, Paris, France</json:string></affiliations></json:item><json:item><name>Bob McDonnell</name><affiliations><json:string>Health Service Executive, Dublin, Ireland</json:string></affiliations></json:item><json:item><name>Vera Nelen</name><affiliations><json:string>Provinciaal Instituut voor Hygiene, Antwerp, Belgium</json:string></affiliations></json:item><json:item><name>Mary O'Mahony</name><affiliations><json:string>Health Service Executive, Cork, Ireland</json:string></affiliations></json:item><json:item><name>Carmel Mullaney</name><affiliations><json:string>Health Service Executive, Kilkenny, Ireland</json:string></affiliations></json:item><json:item><name>Annette Queisser‐Luft</name><affiliations><json:string>University Medical Center of the Johannes Gutenberg University, Mainz, Germany</json:string></affiliations></json:item><json:item><name>Judith Rankin</name><affiliations><json:string>Institute of Health & Society, Newcastle‐upon‐Tyne, United Kingdom</json:string></affiliations></json:item><json:item><name>David Tucker</name><affiliations><json:string>Public Health Wales, United Kingdom</json:string></affiliations></json:item><json:item><name>Christine Verellen‐Dumoulin</name><affiliations><json:string>Institut de Pathologie et de Génétique, Charleroi, Belgium</json:string></affiliations></json:item><json:item><name>Hermien de Walle</name><affiliations><json:string>University Medical Center Groningen, The Netherlands</json:string></affiliations></json:item><json:item><name>Lyubov Yevtushok</name><affiliations><json:string>OMNI‐Net for Children and Rivne Medical Diagnostic Center, Rivne, Ukraine</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>abnormalities, congenital</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Seasonal Variation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>epidemiology</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>public health</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Influenza, Human</value></json:item></subject><articleId><json:string>BDRA23231</json:string></articleId><arkIstex>ark:/67375/WNG-PVZ5SZ6B-D</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Background: This study describes seasonality of congenital anomalies in Europe to provide a baseline against which to assess the impact of specific time varying exposures such as the H1N1 pandemic influenza, and to provide a comprehensive and recent picture of seasonality and its possible relation to etiologic factors. Methods: Data on births conceived in 2000 to 2008 were extracted from 20 European Surveillance for Congenital Anomalies population‐based congenital anomaly registries in 14 European countries. We performed Poisson regression analysis encompassing sine and cosine terms to investigate seasonality of 65,764 nonchromosomal and 12,682 chromosomal congenital anomalies covering 3.3 million births. Analysis was performed by estimated month of conception. Analyses were performed for 86 congenital anomaly subgroups, including a combined subgroup of congenital anomalies previously associated with influenza. Results: We detected statistically significant seasonality in prevalence of anomalies previously associated with influenza, but the conception peak was in June (2.4% excess). We also detected seasonality in congenital cataract (April conceptions, 27%), hip dislocation and/or dysplasia (April, 12%), congenital hydronephrosis (July, 12%), urinary defects (July, 5%), and situs inversus (December, 36%), but not for nonchromosomal anomalies combined, chromosomal anomalies combined, or other anomalies analyzed. Conclusion: We have confirmed previously described seasonality for congenital cataract and hip dislocation and/or dysplasia, and found seasonality for congenital hydronephrosis and situs inversus which have not previously been studied. We did not find evidence of seasonality for several anomalies which had previously been found to be seasonal. Influenza does not appear to be an important factor in the seasonality of congenital anomalies. 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Teratology</title><language><json:string>unknown</json:string></language><doi><json:string>10.1002/(ISSN)1542-0760</json:string></doi><issn><json:string>1542-0752</json:string></issn><eissn><json:string>1542-0760</json:string></eissn><publisherId><json:string>BDRA</json:string></publisherId><volume>100</volume><issue>4</issue><pages><first>260</first><last>269</last><total>10</total></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>Original Article</value></json:item><json:item><value>Original Research Articles</value></json:item></subject></host><ark><json:string>ark:/67375/WNG-PVZ5SZ6B-D</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - toxicology</json:string><json:string>2 - developmental biology</json:string></wos><scienceMetrix></scienceMetrix><scopus><json:string>1 - Life Sciences</json:string><json:string>2 - Biochemistry, Genetics and Molecular Biology</json:string><json:string>3 - Developmental 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circulatoire</json:string></inist></categories><publicationDate>2014</publicationDate><copyrightDate>2014</copyrightDate><doi><json:string>10.1002/bdra.23231</json:string></doi><id>EA3DE4896B25C05D97909845927648D28A674CFA</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-PVZ5SZ6B-D/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-PVZ5SZ6B-D/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/WNG-PVZ5SZ6B-D/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">Seasonality of congenital anomalies in Europe</title><title level="a" type="short">Seasonality of Congenital Anomalies in Europe</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher ref="https://scientific-publisher.data.istex.fr/ark:/67375/H02-QW5Q88H5-V">Wiley Publishing Ltd</publisher><availability><licence>Copyright © 2014 Wiley Periodicals, Inc.</licence></availability><date type="published" when="2014-04"></date></publicationStmt><notesStmt><note type="content-type" subtype="article" source="article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main">Seasonality of congenital anomalies in Europe</title><title level="a" type="short">Seasonality of Congenital Anomalies in Europe</title><author xml:id="author-0000"><persName><forename type="first">Johannes Michiel</forename><surname>Luteijn</surname></persName><affiliation><orgName type="division">Institute of Nursing Research/School of Nursing</orgName><orgName type="institution">University of Ulster</orgName><address><street>Jordanstown Campus</street><region>Newtownabbey</region><country key="GB" xml:lang="en">UNITED KINGDOM</country></address></affiliation></author><author xml:id="author-0001" role="corresp"><persName><forename type="first">Helen</forename><surname>Dolk</surname></persName><affiliation><orgName type="division">Institute of Nursing Research/School of Nursing</orgName><orgName type="institution">University of Ulster</orgName><address><street>Jordanstown Campus</street><region>Newtownabbey</region><country key="GB" xml:lang="en">UNITED KINGDOM</country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">Marie‐Claude</forename><surname>Addor</surname></persName><affiliation><orgName type="institution">Division of Medical Genetics</orgName><address><region>Lausanne</region><country key="CH" xml:lang="en">SWITZERLAND</country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">Larraitz</forename><surname>Arriola</surname></persName><affiliation><orgName type="division">Public Health Division of Gipuzkoa</orgName><orgName type="institution">Instituto BIO‐Donostia, Basque Government, CIBER Epidemiología y Salud Pública ‐ CIBERESP</orgName><address><country key="ES" xml:lang="en">SPAIN</country></address></affiliation></author><author xml:id="author-0004"><persName><forename type="first">Ingeborg</forename><surname>Barisic</surname></persName><affiliation><orgName type="division">Children's Hospital Zagreb</orgName><orgName type="institution">Medical School University of Zagreb</orgName><address><country key="HR" xml:lang="en">CROATIA</country></address></affiliation></author><author xml:id="author-0005"><persName><forename type="first">Fabrizio</forename><surname>Bianchi</surname></persName><affiliation><orgName type="division">Unit of Epidemiology</orgName><orgName type="institution">Institute of Clinical Physiology</orgName><address><region>Pisa</region><country key="IT" xml:lang="en">ITALY</country></address></affiliation></author><author xml:id="author-0006"><persName><forename type="first">Elisa</forename><surname>Calzolari</surname></persName><affiliation><orgName type="institution">IMER Registry ‐ Azienda Ospedaliero‐Universitaria di Ferrara</orgName><address><region>Ferrara</region><country key="IT" xml:lang="en">ITALY</country></address></affiliation></author><author xml:id="author-0007"><persName><forename type="first">Elizabeth</forename><surname>Draper</surname></persName><affiliation><orgName type="division">Department of Health Sciences</orgName><orgName type="institution">University of Leicester</orgName><address><region>Leicester</region><country key="GB" xml:lang="en">UNITED KINGDOM</country></address></affiliation></author><author xml:id="author-0008"><persName><forename type="first">Ester</forename><surname>Garne</surname></persName><affiliation><orgName type="division">Department of Paediatrics</orgName><orgName type="institution">Hospital Lillebaelt</orgName><address><region>Kolding</region><country key="DK" xml:lang="en">DENMARK</country></address></affiliation></author><author xml:id="author-0009"><persName><forename type="first">Miriam</forename><surname>Gatt</surname></persName><affiliation><orgName type="institution">Malta Congenital Anomalies Registry</orgName><orgName type="division">Department of Health Information</orgName><address><region>Guardamangia</region><country key="MT" xml:lang="en">MALTA</country></address></affiliation></author><author xml:id="author-0010"><persName><forename type="first">Martin</forename><surname>Haeusler</surname></persName><affiliation><orgName type="institution">Medical University of Graz</orgName><address><country key="AT" xml:lang="en">AUSTRIA</country></address></affiliation></author><author xml:id="author-0011"><persName><forename type="first">Babak</forename><surname>Khoshnood</surname></persName><affiliation><orgName type="institution">INSERM U953</orgName><address><settlement>Paris</settlement><country key="FR" xml:lang="en">FRANCE</country></address></affiliation></author><author xml:id="author-0012"><persName><forename type="first">Bob</forename><surname>McDonnell</surname></persName><affiliation><orgName type="institution">Health Service Executive</orgName><address><settlement>Dublin</settlement><country key="IE" xml:lang="en">IRELAND</country></address></affiliation></author><author xml:id="author-0013"><persName><forename type="first">Vera</forename><surname>Nelen</surname></persName><affiliation><orgName type="institution">Provinciaal Instituut voor Hygiene</orgName><address><settlement>Antwerp</settlement><country key="BE" xml:lang="en">BELGIUM</country></address></affiliation></author><author xml:id="author-0014"><persName><forename type="first">Mary</forename><surname>O'Mahony</surname></persName><affiliation><orgName type="institution">Health Service Executive</orgName><address><settlement>Cork</settlement><country key="IE" xml:lang="en">IRELAND</country></address></affiliation></author><author xml:id="author-0015"><persName><forename type="first">Carmel</forename><surname>Mullaney</surname></persName><affiliation><orgName type="institution">Health Service Executive</orgName><address><settlement>Kilkenny</settlement><country key="IE" xml:lang="en">IRELAND</country></address></affiliation></author><author xml:id="author-0016"><persName><forename type="first">Annette</forename><surname>Queisser‐Luft</surname></persName><affiliation><orgName type="institution">University Medical Center of the Johannes Gutenberg University</orgName><address><settlement>Mainz</settlement><country key="DE" xml:lang="en">GERMANY</country></address></affiliation></author><author xml:id="author-0017"><persName><forename type="first">Judith</forename><surname>Rankin</surname></persName><affiliation><orgName type="division">Institute of Health & Society</orgName><orgName type="institution">Newcastle‐upon‐Tyne</orgName><address><country key="GB" xml:lang="en">UNITED KINGDOM</country></address></affiliation></author><author xml:id="author-0018"><persName><forename type="first">David</forename><surname>Tucker</surname></persName><affiliation><orgName type="institution">Public Health Wales</orgName><address><country key="GB" xml:lang="en">UNITED KINGDOM</country></address></affiliation></author><author xml:id="author-0019"><persName><forename type="first">Christine</forename><surname>Verellen‐Dumoulin</surname></persName><affiliation><orgName type="institution">Institut de Pathologie et de Génétique</orgName><address><settlement>Charleroi</settlement><country key="BE" xml:lang="en">BELGIUM</country></address></affiliation></author><author xml:id="author-0020"><persName><forename type="first">Hermien</forename><surname>Walle</surname></persName><affiliation><orgName type="institution">University Medical Center Groningen</orgName><address><country key="NL" xml:lang="en">THE NETHERLANDS</country></address></affiliation></author><author xml:id="author-0021"><persName><forename type="first">Lyubov</forename><surname>Yevtushok</surname></persName><affiliation><orgName type="institution">OMNI‐Net for Children and Rivne Medical Diagnostic Center</orgName><address><settlement>Rivne</settlement><country key="UA" xml:lang="en">UKRAINE</country></address></affiliation></author><idno type="istex">EA3DE4896B25C05D97909845927648D28A674CFA</idno><idno type="ark">ark:/67375/WNG-PVZ5SZ6B-D</idno><idno type="DOI">10.1002/bdra.23231</idno><idno type="unit">BDRA23231</idno><idno type="toTypesetVersion">file:BDRA.BDRA23231.pdf</idno></analytic><monogr><title level="j" type="main">Birth Defects Research Part A: Clinical and Molecular Teratology</title><title level="j" type="alt">BIRTH DEFECTS RESEARCH PART A: CLINICAL AND MOLECULAR TERATOLOGY</title><idno type="pISSN">1542-0752</idno><idno type="eISSN">1542-0760</idno><idno type="book-DOI">10.1002/(ISSN)1542-0760</idno><idno type="book-part-DOI">10.1002/bdra.v100.4</idno><idno type="product">BDRA</idno><imprint><biblScope unit="vol">100</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="260">260</biblScope><biblScope unit="page" to="269">269</biblScope><biblScope unit="page-count">10</biblScope><date type="published" when="2014-04"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><encodingDesc><schemaRef type="ODD" url="https://xml-schema.delivery.istex.fr/tei-istex.odd"></schemaRef><appInfo><application ident="pub2tei" version="1.0.10" when="2019-12-20"><label>pub2TEI-ISTEX</label><desc>A set of style sheets for converting XML documents encoded in various scientific publisher formats into a common TEI format.
<ref target="http://www.tei-c.org/">We use TEI</ref></desc></application></appInfo></encodingDesc><profileDesc><abstract style="main"><head>Background</head><p>This study describes seasonality of congenital anomalies in Europe to provide a baseline against which to assess the impact of specific time varying exposures such as the H1N1 pandemic influenza, and to provide a comprehensive and recent picture of seasonality and its possible relation to etiologic factors. <hi rend="bold">Methods:</hi> Data on births conceived in 2000 to 2008 were extracted from 20 European Surveillance for Congenital Anomalies population‐based congenital anomaly registries in 14 European countries. We performed Poisson regression analysis encompassing sine and cosine terms to investigate seasonality of 65,764 nonchromosomal and 12,682 chromosomal congenital anomalies covering 3.3 million births. Analysis was performed by estimated month of conception. Analyses were performed for 86 congenital anomaly subgroups, including a combined subgroup of congenital anomalies previously associated with influenza. <hi rend="bold">Results:</hi> We detected statistically significant seasonality in prevalence of anomalies previously associated with influenza, but the conception peak was in June (2.4% excess). We also detected seasonality in congenital cataract (April conceptions, 27%), hip dislocation and/or dysplasia (April, 12%), congenital hydronephrosis (July, 12%), urinary defects (July, 5%), and situs inversus (December, 36%), but not for nonchromosomal anomalies combined, chromosomal anomalies combined, or other anomalies analyzed. <hi rend="bold">Conclusion:</hi> We have confirmed previously described seasonality for congenital cataract and hip dislocation and/or dysplasia, and found seasonality for congenital hydronephrosis and situs inversus which have not previously been studied. We did not find evidence of seasonality for several anomalies which had previously been found to be seasonal. Influenza does not appear to be an important factor in the seasonality of congenital anomalies. Birth Defects Research (Part A) 100:260–269, 2014. © 2014 Wiley Periodicals, Inc.</p></abstract><textClass><keywords><term xml:id="bdra23231-kwd-0001">abnormalities, congenital</term><term xml:id="bdra23231-kwd-0002">Seasonal Variation</term><term xml:id="bdra23231-kwd-0003">epidemiology</term><term xml:id="bdra23231-kwd-0004">public health</term><term xml:id="bdra23231-kwd-0005">Influenza, Human</term></keywords><keywords rend="articleCategory"><term>Original Article</term></keywords><keywords rend="tocHeading1"><term>Original Research Articles</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc><revisionDesc><change when="2019-12-20" who="#istex" xml:id="pub2tei">formatting</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-PVZ5SZ6B-D/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en" xml:id="bdra23231"><header><publicationMeta level="product"><doi origin="wiley" registered="yes">10.1002/(ISSN)1542-0760</doi><issn type="print">1542-0752</issn><issn type="electronic">1542-0760</issn><idGroup><id type="product" value="BDRA"></id></idGroup><titleGroup><title type="main" sort="BIRTH DEFECTS RESEARCH PART A: CLINICAL AND MOLECULAR TERATOLOGY">Birth Defects Research Part A: Clinical and Molecular Teratology</title><title type="short">Birth Defects Research Part A: Clinical and Molecular Teratology</title></titleGroup></publicationMeta><publicationMeta level="part" position="40"><doi>10.1002/bdra.v100.4</doi><copyright ownership="publisher">Copyright © 2014 Wiley Periodicals, Inc.</copyright><numberingGroup><numbering type="journalVolume" number="100">100</numbering><numbering type="journalIssue">4</numbering></numberingGroup><coverDate startDate="2014-04">April 2014</coverDate></publicationMeta><publicationMeta level="unit" position="40" type="article" status="forIssue"><doi>10.1002/bdra.23231</doi><idGroup><id type="unit" value="BDRA23231"></id></idGroup><countGroup><count type="pageTotal" number="10"></count></countGroup><titleGroup><title type="articleCategory">Original Article</title><title type="tocHeading1">Original Research Articles</title></titleGroup><copyright ownership="publisher">Copyright © 2014 Wiley Periodicals, Inc.</copyright><eventGroup><event type="manuscriptReceived" date="2013-12-09"></event><event type="manuscriptRevised" date="2014-01-23"></event><event type="manuscriptAccepted" date="2014-01-28"></event><event type="xmlCreated" agent="Cenveo Publisher Services" date="2014-02-10"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.3.0 mode:FullText" date="2014-04-22"></event><event type="publishedOnlineEarlyUnpaginated" date="2014-03-17"></event><event type="firstOnline" date="2014-03-17"></event><event type="publishedOnlineFinalForm" date="2014-04-22"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.6.4 mode:FullText" date="2015-10-08"></event></eventGroup><numberingGroup><numbering type="pageFirst">260</numbering><numbering type="pageLast">269</numbering></numberingGroup><correspondenceTo>Correspondence to: Helen Dolk, University of Ulster, Jordanstown Campus, Shore Road, Newtownabbey, Co. Antrim, BT37 0QB. E‐mail: <email>h.dolk@ulster.ac.uk</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:BDRA.BDRA23231.pdf"></link></linkGroup></publicationMeta><contentMeta><titleGroup><title type="main">Seasonality of congenital anomalies in Europe</title><title type="short">Seasonality of Congenital Anomalies in Europe</title><title type="shortAuthors">Luteijn et al.</title></titleGroup><creators><creator affiliationRef="#bdra23231-aff-0001" creatorRole="author" xml:id="bdra23231-cr-0001"><personName><givenNames>Johannes Michiel</givenNames><familyName>Luteijn</familyName></personName></creator><creator affiliationRef="#bdra23231-aff-0001" corresponding="yes" creatorRole="author" xml:id="bdra23231-cr-0002"><personName><givenNames>Helen</givenNames><familyName>Dolk</familyName></personName></creator><creator affiliationRef="#bdra23231-aff-0002" creatorRole="author" 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xml:id="bdra23231-cr-0008"><personName><givenNames>Elizabeth</givenNames><familyName>Draper</familyName></personName></creator><creator affiliationRef="#bdra23231-aff-0008" creatorRole="author" xml:id="bdra23231-cr-0009"><personName><givenNames>Ester</givenNames><familyName>Garne</familyName></personName></creator><creator affiliationRef="#bdra23231-aff-0009" creatorRole="author" xml:id="bdra23231-cr-0010"><personName><givenNames>Miriam</givenNames><familyName>Gatt</familyName></personName></creator><creator affiliationRef="#bdra23231-aff-0010" creatorRole="author" xml:id="bdra23231-cr-0011"><personName><givenNames>Martin</givenNames><familyName>Haeusler</familyName></personName></creator><creator affiliationRef="#bdra23231-aff-0011" creatorRole="author" xml:id="bdra23231-cr-0012"><personName><givenNames>Babak</givenNames><familyName>Khoshnood</familyName></personName></creator><creator affiliationRef="#bdra23231-aff-0012" creatorRole="author" 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countryCode="GB" type="organization" xml:id="bdra23231-aff-0001"><orgDiv>Institute of Nursing Research/School of Nursing</orgDiv><orgName>University of Ulster</orgName><address><street>Jordanstown Campus</street><countryPart>Newtownabbey</countryPart><country>United Kingdom</country></address></affiliation><affiliation countryCode="CH" type="organization" xml:id="bdra23231-aff-0002"><orgName>Division of Medical Genetics</orgName><address><countryPart>Lausanne</countryPart><country>Switzerland</country></address></affiliation><affiliation countryCode="ES" type="organization" xml:id="bdra23231-aff-0003"><orgDiv>Public Health Division of Gipuzkoa</orgDiv><orgName>Instituto BIO‐Donostia, Basque Government, CIBER Epidemiología y Salud Pública ‐ CIBERESP</orgName><address><country>Spain</country></address></affiliation><affiliation countryCode="HR" type="organization" xml:id="bdra23231-aff-0004"><orgDiv>Children's Hospital Zagreb</orgDiv><orgName>Medical School University of Zagreb</orgName><address><country>Croatia</country></address></affiliation><affiliation countryCode="IT" type="organization" xml:id="bdra23231-aff-0005"><orgDiv>Unit of Epidemiology</orgDiv><orgName>Institute of Clinical Physiology</orgName><address><countryPart>Pisa</countryPart><country>Italy</country></address></affiliation><affiliation countryCode="IT" type="organization" xml:id="bdra23231-aff-0006"><orgName>IMER Registry ‐ Azienda Ospedaliero‐Universitaria di Ferrara</orgName><address><countryPart>Ferrara</countryPart><country>Italy</country></address></affiliation><affiliation countryCode="GB" type="organization" xml:id="bdra23231-aff-0007"><orgDiv>Department of Health Sciences</orgDiv><orgName>University of Leicester</orgName><address><countryPart>Leicester</countryPart><country>United Kingdom</country></address></affiliation><affiliation countryCode="DK" type="organization" xml:id="bdra23231-aff-0008"><orgDiv>Department of Paediatrics</orgDiv><orgName>Hospital Lillebaelt</orgName><address><countryPart>Kolding</countryPart><country>Denmark</country></address></affiliation><affiliation countryCode="MT" type="organization" xml:id="bdra23231-aff-0009"><orgName>Malta Congenital Anomalies Registry</orgName><orgDiv>Department of Health Information</orgDiv><address><countryPart>Guardamangia</countryPart><country>Malta</country></address></affiliation><affiliation countryCode="AT" type="organization" xml:id="bdra23231-aff-0010"><orgName>Medical University of Graz</orgName><address><country>Austria</country></address></affiliation><affiliation countryCode="FR" type="organization" xml:id="bdra23231-aff-0011"><orgName>INSERM U953</orgName><address><city>Paris</city><country>France</country></address></affiliation><affiliation countryCode="IE" type="organization" xml:id="bdra23231-aff-0012"><orgName>Health Service Executive</orgName><address><city>Dublin</city><country>Ireland</country></address></affiliation><affiliation countryCode="BE" type="organization" xml:id="bdra23231-aff-0013"><orgName>Provinciaal Instituut voor Hygiene</orgName><address><city>Antwerp</city><country>Belgium</country></address></affiliation><affiliation countryCode="IE" type="organization" xml:id="bdra23231-aff-0014"><orgName>Health Service Executive</orgName><address><city>Cork</city><country>Ireland</country></address></affiliation><affiliation countryCode="IE" type="organization" xml:id="bdra23231-aff-0015"><orgName>Health Service Executive</orgName><address><city>Kilkenny</city><country>Ireland</country></address></affiliation><affiliation countryCode="DE" type="organization" xml:id="bdra23231-aff-0016"><orgName>University Medical Center of the Johannes Gutenberg University</orgName><address><city>Mainz</city><country>Germany</country></address></affiliation><affiliation countryCode="GB" type="organization" xml:id="bdra23231-aff-0017"><orgDiv>Institute of Health & Society</orgDiv><orgName>Newcastle‐upon‐Tyne</orgName><address><country>United Kingdom</country></address></affiliation><affiliation countryCode="GB" type="organization" xml:id="bdra23231-aff-0018"><orgName>Public Health Wales</orgName><address><country>United Kingdom</country></address></affiliation><affiliation countryCode="BE" type="organization" xml:id="bdra23231-aff-0019"><orgName>Institut de Pathologie et de Génétique</orgName><address><city>Charleroi</city><country>Belgium</country></address></affiliation><affiliation countryCode="NL" type="organization" xml:id="bdra23231-aff-0020"><orgName>University Medical Center Groningen</orgName><address><country>The Netherlands</country></address></affiliation><affiliation countryCode="UA" type="organization" xml:id="bdra23231-aff-0021"><orgName>OMNI‐Net for Children and Rivne Medical Diagnostic Center</orgName><address><city>Rivne</city><country>Ukraine</country></address></affiliation></affiliationGroup><keywordGroup type="author"><keyword xml:id="bdra23231-kwd-0001">abnormalities, congenital</keyword><keyword xml:id="bdra23231-kwd-0002">Seasonal Variation</keyword><keyword xml:id="bdra23231-kwd-0003">epidemiology</keyword><keyword xml:id="bdra23231-kwd-0004">public health</keyword><keyword xml:id="bdra23231-kwd-0005">Influenza, Human</keyword></keywordGroup><abstractGroup><abstract type="main"><section xml:id="bdra23231-sec-0001"><title type="main">Background</title><p>This study describes seasonality of congenital anomalies in Europe to provide a baseline against which to assess the impact of specific time varying exposures such as the H1N1 pandemic influenza, and to provide a comprehensive and recent picture of seasonality and its possible relation to etiologic factors. <b>Methods:</b> Data on births conceived in 2000 to 2008 were extracted from 20 European Surveillance for Congenital Anomalies population‐based congenital anomaly registries in 14 European countries. We performed Poisson regression analysis encompassing sine and cosine terms to investigate seasonality of 65,764 nonchromosomal and 12,682 chromosomal congenital anomalies covering 3.3 million births. Analysis was performed by estimated month of conception. Analyses were performed for 86 congenital anomaly subgroups, including a combined subgroup of congenital anomalies previously associated with influenza. <b>Results:</b> We detected statistically significant seasonality in prevalence of anomalies previously associated with influenza, but the conception peak was in June (2.4% excess). We also detected seasonality in congenital cataract (April conceptions, 27%), hip dislocation and/or dysplasia (April, 12%), congenital hydronephrosis (July, 12%), urinary defects (July, 5%), and situs inversus (December, 36%), but not for nonchromosomal anomalies combined, chromosomal anomalies combined, or other anomalies analyzed. <b>Conclusion:</b> We have confirmed previously described seasonality for congenital cataract and hip dislocation and/or dysplasia, and found seasonality for congenital hydronephrosis and situs inversus which have not previously been studied. We did not find evidence of seasonality for several anomalies which had previously been found to be seasonal. Influenza does not appear to be an important factor in the seasonality of congenital anomalies. Birth Defects Research (Part A) 100:260–269, 2014. © 2014 Wiley Periodicals, Inc.</p></section></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="bdra23231-note-0001"><p>The study was co‐funded by the EC, under the framework of the EU Health Programme, Grant Agreement 2006103 (Executive Agency for Health & Consumers).</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Seasonality of congenital anomalies in Europe</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Seasonality of Congenital Anomalies in Europe</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Seasonality of congenital anomalies in Europe</title></titleInfo><name type="personal"><namePart type="given">Johannes Michiel</namePart><namePart type="family">Luteijn</namePart><affiliation>Institute of Nursing Research/School of Nursing, University of Ulster, Jordanstown Campus, Newtownabbey, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Helen</namePart><namePart type="family">Dolk</namePart><affiliation>Institute of Nursing Research/School of Nursing, University of Ulster, Jordanstown Campus, Newtownabbey, United Kingdom</affiliation><affiliation>E-mail: h.dolk@ulster.ac.uk</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Marie‐Claude</namePart><namePart type="family">Addor</namePart><affiliation>Division of Medical Genetics, Lausanne, Switzerland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Larraitz</namePart><namePart type="family">Arriola</namePart><affiliation>Public Health Division of Gipuzkoa, Instituto BIO‐Donostia, Basque Government, CIBER Epidemiología y Salud Pública ‐ CIBERESP, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ingeborg</namePart><namePart type="family">Barisic</namePart><affiliation>Children's Hospital Zagreb, Medical School University of Zagreb, Croatia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Fabrizio</namePart><namePart type="family">Bianchi</namePart><affiliation>Unit of Epidemiology, Institute of Clinical Physiology, Pisa, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Elisa</namePart><namePart type="family">Calzolari</namePart><affiliation>IMER Registry ‐ Azienda Ospedaliero‐Universitaria di Ferrara, Ferrara, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Elizabeth</namePart><namePart type="family">Draper</namePart><affiliation>Department of Health Sciences, University of Leicester, Leicester, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ester</namePart><namePart type="family">Garne</namePart><affiliation>Department of Paediatrics, Hospital Lillebaelt, Kolding, Denmark</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Miriam</namePart><namePart type="family">Gatt</namePart><affiliation>Department of Health Information, Malta Congenital Anomalies Registry, Guardamangia, Malta</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Martin</namePart><namePart type="family">Haeusler</namePart><affiliation>Medical University of Graz, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Babak</namePart><namePart type="family">Khoshnood</namePart><affiliation>INSERM U953, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Bob</namePart><namePart type="family">McDonnell</namePart><affiliation>Health Service Executive, Dublin, Ireland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Vera</namePart><namePart type="family">Nelen</namePart><affiliation>Provinciaal Instituut voor Hygiene, Antwerp, Belgium</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mary</namePart><namePart type="family">O'Mahony</namePart><affiliation>Health Service Executive, Cork, Ireland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Carmel</namePart><namePart type="family">Mullaney</namePart><affiliation>Health Service Executive, Kilkenny, Ireland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Annette</namePart><namePart type="family">Queisser‐Luft</namePart><affiliation>University Medical Center of the Johannes Gutenberg University, Mainz, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Judith</namePart><namePart type="family">Rankin</namePart><affiliation>Institute of Health & Society, Newcastle‐upon‐Tyne, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">David</namePart><namePart type="family">Tucker</namePart><affiliation>Public Health Wales, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Christine</namePart><namePart type="family">Verellen‐Dumoulin</namePart><affiliation>Institut de Pathologie et de Génétique, Charleroi, Belgium</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hermien</namePart><namePart type="family">de Walle</namePart><affiliation>University Medical Center Groningen, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Lyubov</namePart><namePart type="family">Yevtushok</namePart><affiliation>OMNI‐Net for Children and Rivne Medical Diagnostic Center, Rivne, Ukraine</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><dateIssued encoding="w3cdtf">2014-04</dateIssued><dateCreated encoding="w3cdtf">2014-02-10</dateCreated><dateCaptured encoding="w3cdtf">2013-12-09</dateCaptured><dateValid encoding="w3cdtf">2014-01-28</dateValid><copyrightDate encoding="w3cdtf">2014</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract>Background: This study describes seasonality of congenital anomalies in Europe to provide a baseline against which to assess the impact of specific time varying exposures such as the H1N1 pandemic influenza, and to provide a comprehensive and recent picture of seasonality and its possible relation to etiologic factors. Methods: Data on births conceived in 2000 to 2008 were extracted from 20 European Surveillance for Congenital Anomalies population‐based congenital anomaly registries in 14 European countries. We performed Poisson regression analysis encompassing sine and cosine terms to investigate seasonality of 65,764 nonchromosomal and 12,682 chromosomal congenital anomalies covering 3.3 million births. Analysis was performed by estimated month of conception. Analyses were performed for 86 congenital anomaly subgroups, including a combined subgroup of congenital anomalies previously associated with influenza. Results: We detected statistically significant seasonality in prevalence of anomalies previously associated with influenza, but the conception peak was in June (2.4% excess). We also detected seasonality in congenital cataract (April conceptions, 27%), hip dislocation and/or dysplasia (April, 12%), congenital hydronephrosis (July, 12%), urinary defects (July, 5%), and situs inversus (December, 36%), but not for nonchromosomal anomalies combined, chromosomal anomalies combined, or other anomalies analyzed. Conclusion: We have confirmed previously described seasonality for congenital cataract and hip dislocation and/or dysplasia, and found seasonality for congenital hydronephrosis and situs inversus which have not previously been studied. We did not find evidence of seasonality for several anomalies which had previously been found to be seasonal. Influenza does not appear to be an important factor in the seasonality of congenital anomalies. Birth Defects Research (Part A) 100:260–269, 2014. © 2014 Wiley Periodicals, Inc.</abstract><subject><genre>keywords</genre><topic>abnormalities, congenital</topic><topic>Seasonal Variation</topic><topic>epidemiology</topic><topic>public health</topic><topic>Influenza, Human</topic></subject><relatedItem type="host"><titleInfo><title>Birth Defects Research Part A: Clinical and Molecular Teratology</title></titleInfo><titleInfo type="abbreviated"><title>Birth Defects Research Part A: Clinical and Molecular Teratology</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>article-category</genre><topic>Original Article</topic><topic>Original Research Articles</topic></subject><identifier type="ISSN">1542-0752</identifier><identifier type="eISSN">1542-0760</identifier><identifier type="DOI">10.1002/(ISSN)1542-0760</identifier><identifier type="PublisherID">BDRA</identifier><part><date>2014</date><detail type="volume"><caption>vol.</caption><number>100</number></detail><detail type="issue"><caption>no.</caption><number>4</number></detail><extent unit="pages"><start>260</start><end>269</end><total>10</total></extent></part></relatedItem><relatedItem type="references" displayLabel="bdra23231-cit-0001"><titleInfo><title>Incidence of neonatal hip instability: are there seasonal variations?</title></titleInfo><name type="personal"><namePart type="given">JK</namePart><namePart type="family">Anand</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I</namePart><namePart type="family">Moden</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JW</namePart><namePart type="family">Myles</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Anand JK, Moden I, Myles JW. 1992. 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