The nuclear import machinery is a determinant of influenza virus host adaptation
Identifieur interne : 001162 ( Istex/Corpus ); précédent : 001161; suivant : 001163The nuclear import machinery is a determinant of influenza virus host adaptation
Auteurs : Patricia Resa-Infante ; Gülsah GabrielSource :
- BioEssays [ 0265-9247 ] ; 2013-01.
English descriptors
- Teeft :
- Adaptive, Amino acids, Avian, Avian cells, Avian virus, Avian viruses, Biol, Biol chem, Cell biol, Cell host microbe, Cellular, Cellular conditions, Cellular isoforms, Cellular proteins, Crucial role, Different mechanisms, Direct binding, Distinct mechanisms, Entire protein sequence, Gene expression, Host adaptation, Host adaptive mutations, Host cell, Host factors, Human cells, Import pathway, Importin, Isoforms, Mammalian cells, Mammalian host, Mammalian strains, Multiple functions, Mutation, Nuclear entry, Nuclear envelope, Nuclear import, Nuclear import machinery, Nuclear localization signal, Nuclear transport, Plos pathog, Polymerase, Polymerase activity, Polymerase subunit, Proc natl acad, Replication, Subunit, Unknown mechanism, Viral, Viral polymerase, Viral polymerase activity, Viral transcription, Virus polymerase, Virus replication, Vrnp, Vrnp activity, Vrnp components, Wiley periodicals.
Abstract
After viral entry into the cell, the nuclear envelope poses a major cellular barrier that needs to be overcome upon adaptation of highly pathogenic avian influenza viruses (HPAIV) to the new host. To ensure efficient viral transcription and replication in the nucleus of the host cell, the viral polymerase complex of avian influenza viruses needs to switch from recognition of avian to mammalian components of the nuclear import machinery. Recent evidence suggests that influenza viruses have evolved different mechanisms to utilize importin‐α isoforms as components of this machinery, bridging pre‐ and post‐nuclear import on both sides of the nuclear envelope.
Importin‐α isoforms possess multiple functions carried out on both sites of the nuclear envelope. Influenza viruses utilize importin‐α functions directly related to the nuclear import of cargo proteins or other functions beyond transport to regulate polymerase activity in the nucleus of the host cell.
Url:
DOI: 10.1002/bies.201200138
Links to Exploration step
ISTEX:3E548C7605B488F5FF933909B975E3CB536E551BLe document en format XML
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Germany</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">host adaptation</keyword><keyword xml:id="kwd2">importin</keyword><keyword xml:id="kwd3">influenza</keyword><keyword xml:id="kwd4">nuclear transport</keyword><keyword xml:id="kwd5">polymerase</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>After viral entry into the cell, the nuclear envelope poses a major cellular barrier that needs to be overcome upon adaptation of highly pathogenic avian influenza viruses (HPAIV) to the new host. To ensure efficient viral transcription and replication in the nucleus of the host cell, the viral polymerase complex of avian influenza viruses needs to switch from recognition of avian to mammalian components of the nuclear import machinery. Recent evidence suggests that influenza viruses have evolved different mechanisms to utilize importin‐α isoforms as components of this machinery, bridging pre‐ and post‐nuclear import on both sides of the nuclear envelope.</p></abstract><abstract type="graphical" xml:lang="en"><p>Importin‐α isoforms possess multiple functions carried out on both sites of the nuclear envelope. Influenza viruses utilize importin‐α functions directly related to the nuclear import of cargo proteins or other functions beyond transport to regulate polymerase activity in the nucleus of the host cell. <blockFixed type="graphic"><mediaResourceGroup><mediaResource alt="image" eRights="yes" copyright="WILEY Periodicals, Inc." href="urn:x-wiley:02659247:media:BIES201200138:content"></mediaResource></mediaResourceGroup></blockFixed></p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>The nuclear import machinery is a determinant of influenza virus host adaptation</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Prospects & Overviews</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>The nuclear import machinery is a determinant of influenza virus host adaptation</title></titleInfo><name type="personal"><namePart type="given">Patricia</namePart><namePart type="family">Resa‐Infante</namePart><affiliation>Heinrich‐Pette‐Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Gülsah</namePart><namePart type="family">Gabriel</namePart><affiliation>Heinrich‐Pette‐Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany</affiliation><affiliation>E-mail: guelsah.gabriel@hpi.uni‐hamburg.de</affiliation><affiliation>Correspondence address: Heinrich‐Pette‐Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>WILEY‐VCH Verlag</publisher><place><placeTerm type="text">Weinheim</placeTerm></place><dateIssued encoding="w3cdtf">2013-01</dateIssued><copyrightDate encoding="w3cdtf">2013</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">1</extent><extent unit="tables">1</extent><extent unit="references">30</extent><extent unit="words">3486</extent></physicalDescription><abstract lang="en">After viral entry into the cell, the nuclear envelope poses a major cellular barrier that needs to be overcome upon adaptation of highly pathogenic avian influenza viruses (HPAIV) to the new host. To ensure efficient viral transcription and replication in the nucleus of the host cell, the viral polymerase complex of avian influenza viruses needs to switch from recognition of avian to mammalian components of the nuclear import machinery. Recent evidence suggests that influenza viruses have evolved different mechanisms to utilize importin‐α isoforms as components of this machinery, bridging pre‐ and post‐nuclear import on both sides of the nuclear envelope.</abstract><abstract type="graphical" lang="en">Importin‐α isoforms possess multiple functions carried out on both sites of the nuclear envelope. Influenza viruses utilize importin‐α functions directly related to the nuclear import of cargo proteins or other functions beyond transport to regulate polymerase activity in the nucleus of the host cell.</abstract><subject lang="en"><genre>keywords</genre><topic>host adaptation</topic><topic>importin</topic><topic>influenza</topic><topic>nuclear transport</topic><topic>polymerase</topic></subject><relatedItem type="host"><titleInfo><title>BioEssays</title></titleInfo><titleInfo type="abbreviated"><title>Bioessays</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>article-category</genre><topic>Prospects & Overviews</topic><topic>Prospects & Overviews</topic><topic>Recently in press</topic></subject><identifier type="ISSN">0265-9247</identifier><identifier type="eISSN">1521-1878</identifier><identifier type="DOI">10.1002/(ISSN)1521-1878</identifier><identifier type="PublisherID">BIES</identifier><part><date>2013</date><detail type="volume"><caption>vol.</caption><number>35</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>23</start><end>27</end><total>5</total></extent></part></relatedItem><relatedItem type="references" displayLabel="cit1"><titleInfo><title>Molecular mechanisms of interspecies transmission and pathogenicity of influenza viruses: lessons from the 2009 pandemic</title></titleInfo><name type="personal"><namePart type="given">HD</namePart><namePart type="family">Klenk</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W</namePart><namePart type="family">Garten</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Matrosovich</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Klenk HD, Garten W, Matrosovich M. 2011. 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