Obesity and susceptibility to severe outcomes following respiratory viral infection
Identifieur interne : 000303 ( Istex/Checkpoint ); précédent : 000302; suivant : 000304Obesity and susceptibility to severe outcomes following respiratory viral infection
Auteurs : Mark H. Almond [Royaume-Uni] ; Michael R. Edwards [Royaume-Uni] ; Wendy S. Barclay [Royaume-Uni] ; Sebastian L. Johnston [Royaume-Uni]Source :
- Thorax [ 0040-6376 ] ; 2013-07.
English descriptors
- Teeft :
- Airway disease infection section, Almond, Antiviral, Asthma, Attenuated, Brief synthesis, Chest clinic, Clinical infections, Cytokine, Disease severity, Ifns, Immunomodulatory, Immunomodulatory effects, Imperial college london, Independent risk factor, Infection, Interferon, Leptin, Lung institute, Mechanisms underpinning, Molecular patterns, Mrna expression, Multiple markers, National heart, Numerous nosocomial, Obese, Obese individuals, Obesity, Pandemic, Pandemic infection, Particular focus, Poor outcomes, Potential mechanism, Recent advances, Receptor, Rhinovirus, Rhinovirus infection, Severe outcomes, Thorax.
Abstract
During the 2009 H1N1 influenza pandemic, obesity was convincingly identified as a novel, independent risk factor for multiple markers of disease severity. Associations between numerous nosocomial and community-acquired clinical infections have previously been established; yet, little is known about the mechanisms underpinning the increased susceptibility to severe outcomes following pandemic H1N1/09 infection in obesity. Here, we present a brief synthesis of the recent advances in our understanding of the immunomodulatory effects of obesity on outcomes following respiratory viral infection, with a particular focus on pandemic influenza.
Url:
DOI: 10.1136/thoraxjnl-2012-203009
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
ISTEX:8686666D687A5E9BAA77BDC542C4C764418F6AEFLe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Obesity and susceptibility to severe outcomes following respiratory viral infection</title>
<author><name sortKey="Almond, Mark H" sort="Almond, Mark H" uniqKey="Almond M" first="Mark H" last="Almond">Mark H. Almond</name>
</author>
<author><name sortKey="Edwards, Michael R" sort="Edwards, Michael R" uniqKey="Edwards M" first="Michael R" last="Edwards">Michael R. Edwards</name>
</author>
<author><name sortKey="Barclay, Wendy S" sort="Barclay, Wendy S" uniqKey="Barclay W" first="Wendy S" last="Barclay">Wendy S. Barclay</name>
</author>
<author><name sortKey="Johnston, Sebastian L" sort="Johnston, Sebastian L" uniqKey="Johnston S" first="Sebastian L" last="Johnston">Sebastian L. Johnston</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:8686666D687A5E9BAA77BDC542C4C764418F6AEF</idno>
<date when="2013" year="2013">2013</date>
<idno type="doi">10.1136/thoraxjnl-2012-203009</idno>
<idno type="url">https://api.istex.fr/ark:/67375/NVC-KC1TJCBP-4/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">001A65</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001A65</idno>
<idno type="wicri:Area/Istex/Curation">001A65</idno>
<idno type="wicri:Area/Istex/Checkpoint">000303</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000303</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a">Obesity and susceptibility to severe outcomes following respiratory viral infection</title>
<author><name sortKey="Almond, Mark H" sort="Almond, Mark H" uniqKey="Almond M" first="Mark H" last="Almond">Mark H. Almond</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Airway Disease Infection Section, National Heart and Lung Institute, Imperial College London</wicri:regionArea>
<wicri:noRegion>Imperial College London</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Influenza, Imperial College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Edwards, Michael R" sort="Edwards, Michael R" uniqKey="Edwards M" first="Michael R" last="Edwards">Michael R. Edwards</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Airway Disease Infection Section, National Heart and Lung Institute, Imperial College London</wicri:regionArea>
<wicri:noRegion>Imperial College London</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Barclay, Wendy S" sort="Barclay, Wendy S" uniqKey="Barclay W" first="Wendy S" last="Barclay">Wendy S. Barclay</name>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Influenza, Imperial College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Johnston, Sebastian L" sort="Johnston, Sebastian L" uniqKey="Johnston S" first="Sebastian L" last="Johnston">Sebastian L. Johnston</name>
<affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Airway Disease Infection Section, National Heart and Lung Institute, Imperial College London</wicri:regionArea>
<wicri:noRegion>Imperial College London</wicri:noRegion>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Thorax</title>
<title level="j" type="abbrev">Thorax</title>
<idno type="ISSN">0040-6376</idno>
<idno type="eISSN">1468-3296</idno>
<imprint><publisher>BMJ Publishing Group Ltd and British Thoracic Society</publisher>
<date type="published" when="2013-07">2013-07</date>
<biblScope unit="volume">68</biblScope>
<biblScope unit="issue">7</biblScope>
<biblScope unit="page" from="684">684</biblScope>
</imprint>
<idno type="ISSN">0040-6376</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0040-6376</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Airway disease infection section</term>
<term>Almond</term>
<term>Antiviral</term>
<term>Asthma</term>
<term>Attenuated</term>
<term>Brief synthesis</term>
<term>Chest clinic</term>
<term>Clinical infections</term>
<term>Cytokine</term>
<term>Disease severity</term>
<term>Ifns</term>
<term>Immunomodulatory</term>
<term>Immunomodulatory effects</term>
<term>Imperial college london</term>
<term>Independent risk factor</term>
<term>Infection</term>
<term>Interferon</term>
<term>Leptin</term>
<term>Lung institute</term>
<term>Mechanisms underpinning</term>
<term>Molecular patterns</term>
<term>Mrna expression</term>
<term>Multiple markers</term>
<term>National heart</term>
<term>Numerous nosocomial</term>
<term>Obese</term>
<term>Obese individuals</term>
<term>Obesity</term>
<term>Pandemic</term>
<term>Pandemic infection</term>
<term>Particular focus</term>
<term>Poor outcomes</term>
<term>Potential mechanism</term>
<term>Recent advances</term>
<term>Receptor</term>
<term>Rhinovirus</term>
<term>Rhinovirus infection</term>
<term>Severe outcomes</term>
<term>Thorax</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract">During the 2009 H1N1 influenza pandemic, obesity was convincingly identified as a novel, independent risk factor for multiple markers of disease severity. Associations between numerous nosocomial and community-acquired clinical infections have previously been established; yet, little is known about the mechanisms underpinning the increased susceptibility to severe outcomes following pandemic H1N1/09 infection in obesity. Here, we present a brief synthesis of the recent advances in our understanding of the immunomodulatory effects of obesity on outcomes following respiratory viral infection, with a particular focus on pandemic influenza.</div>
</front>
</TEI>
<affiliations><list><country><li>Royaume-Uni</li>
</country>
<region><li>Angleterre</li>
<li>Grand Londres</li>
</region>
<settlement><li>Londres</li>
</settlement>
</list>
<tree><country name="Royaume-Uni"><noRegion><name sortKey="Almond, Mark H" sort="Almond, Mark H" uniqKey="Almond M" first="Mark H" last="Almond">Mark H. Almond</name>
</noRegion>
<name sortKey="Almond, Mark H" sort="Almond, Mark H" uniqKey="Almond M" first="Mark H" last="Almond">Mark H. Almond</name>
<name sortKey="Barclay, Wendy S" sort="Barclay, Wendy S" uniqKey="Barclay W" first="Wendy S" last="Barclay">Wendy S. Barclay</name>
<name sortKey="Edwards, Michael R" sort="Edwards, Michael R" uniqKey="Edwards M" first="Michael R" last="Edwards">Michael R. Edwards</name>
<name sortKey="Johnston, Sebastian L" sort="Johnston, Sebastian L" uniqKey="Johnston S" first="Sebastian L" last="Johnston">Sebastian L. Johnston</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/PandemieGrippaleV1/Data/Istex/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000303 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Checkpoint/biblio.hfd -nk 000303 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= PandemieGrippaleV1 |flux= Istex |étape= Checkpoint |type= RBID |clé= ISTEX:8686666D687A5E9BAA77BDC542C4C764418F6AEF |texte= Obesity and susceptibility to severe outcomes following respiratory viral infection }}
This area was generated with Dilib version V0.6.34. |