European Aedes albopictus and Culex pipiens Are Competent Vectors for Japanese Encephalitis Virus.
Identifieur interne : 000673 ( Hal/Curation ); précédent : 000672; suivant : 000674European Aedes albopictus and Culex pipiens Are Competent Vectors for Japanese Encephalitis Virus.
Auteurs : Mélissanne De Wispelaere [France] ; Philippe Desprès [Réunion] ; Valérie Choumet [France]Source :
- PLoS Neglected Tropical Diseases [ 1935-2727 ] ; 2017-01-13.
Abstract
Japanese encephalitis virus (JEV) is the causative agent of Japanese encephalitis, the leading cause of viral encephalitis in Asia. JEV transmission cycle involves mosquitoes and vertebrate hosts. The detection of JEV RNA in a pool of Culex pipiens caught in 2010 in Italy raised the concern of a putative emergence of the virus in Europe. We aimed to study the vector competence of European mosquito populations, such as Cx. pipiens and Aedes albopictus for JEV genotypes 3 and 5.After oral feeding on an infectious blood meal, mosquitoes were dissected at various times post-virus exposure. We found that the peak for JEV infection and transmission was between 11 and 13 days post-virus exposure. We observed a faster dissemination of both JEV genotypes in Ae. albopictus mosquitoes, when compared with Cx. pipiens mosquitoes. We also dissected salivary glands and collected saliva from infected mosquitoes and showed that Ae. albopictus mosquitoes transmitted JEV earlier than Cx. pipiens. The virus collected from Ae. albopictus and Cx. pipiens saliva was competent at causing pathogenesis in a mouse model for JEV infection. Using this model, we found that mosquito saliva or salivary glands did not enhance the severity of the disease.In this study, we demonstrated that European populations of Ae. albopictus and Cx. pipiens were efficient vectors for JEV transmission. Susceptible vertebrate species that develop high viremia are an obligatory part of the JEV transmission cycle. This study highlights the need to investigate the susceptibility of potential JEV reservoir hosts in Europe, notably amongst swine populations and local water birds.
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DOI: 10.1371/journal.pntd.0005294
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JEV transmission cycle involves mosquitoes and vertebrate hosts. The detection of JEV RNA in a pool of Culex pipiens caught in 2010 in Italy raised the concern of a putative emergence of the virus in Europe. We aimed to study the vector competence of European mosquito populations, such as Cx. pipiens and Aedes albopictus for JEV genotypes 3 and 5.After oral feeding on an infectious blood meal, mosquitoes were dissected at various times post-virus exposure. We found that the peak for JEV infection and transmission was between 11 and 13 days post-virus exposure. We observed a faster dissemination of both JEV genotypes in Ae. albopictus mosquitoes, when compared with Cx. pipiens mosquitoes. We also dissected salivary glands and collected saliva from infected mosquitoes and showed that Ae. albopictus mosquitoes transmitted JEV earlier than Cx. pipiens. The virus collected from Ae. albopictus and Cx. pipiens saliva was competent at causing pathogenesis in a mouse model for JEV infection. Using this model, we found that mosquito saliva or salivary glands did not enhance the severity of the disease.In this study, we demonstrated that European populations of Ae. albopictus and Cx. pipiens were efficient vectors for JEV transmission. Susceptible vertebrate species that develop high viremia are an obligatory part of the JEV transmission cycle. This study highlights the need to investigate the susceptibility of potential JEV reservoir hosts in Europe, notably amongst swine populations and local water birds.</p> </div></front></TEI><hal api="V3"> <titleStmt> <title xml:lang="eng">European Aedes albopictus and Culex pipiens Are Competent Vectors for Japanese Encephalitis Virus.</title> <author role="aut"> <persName> <forename type="first">Mélissanne</forename> <surname>de Wispelaere</surname> </persName> <idno type="halauthorid">1163442</idno> <affiliation ref="#struct-237998"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Philippe</forename> <surname>Desprès</surname> </persName> <email type="md5">79edabce1e2071901b280d143a940dc3</email> <email type="domain">univ-reunion.fr</email> <idno type="halauthorid">1654371</idno> <affiliation ref="#struct-418783"></affiliation> <affiliation ref="#struct-234808"></affiliation> </author> <author role="crp"> <persName> <forename type="first">Valérie</forename> <surname>Choumet</surname> </persName> <email type="md5">03cb634ae52dc6b7435828dbc92f12ac</email> <email type="domain">pasteur.fr</email> <idno type="halauthorid">535069</idno> <affiliation ref="#struct-237998"></affiliation> </author> <editor role="depositor"> <persName> <forename>Valérie</forename> <surname>Choumet</surname> </persName> <email type="md5">a3d009d1ebe902c18d400797fe8aaf1b</email> <email type="domain">pasteur.fr</email> </editor> <funder ref="#projeurop-89460"></funder> <funder>The research leading to these results and MdW received funding from the European Union’s Seventh Framework Program for research, technological development and demonstration under Grant Agreement no 278433-PREDEMICS. website: http://predemics.biomedtrain.eu, European Commission CORDIS: http://cordis.europa.eu/result/rcn/55956_en.html </funder> </titleStmt> <editionStmt> <edition n="v1" type="current"> <date type="whenSubmitted">2017-02-02 17:35:20</date> <date type="whenWritten">2016-09-01</date> <date type="whenModified">2020-01-15 15:36:02</date> <date type="whenReleased">2017-02-06 11:42:05</date> <date type="whenProduced">2017-01-13</date> <date type="whenEndEmbargoed">2017-02-06</date> <ref type="file" target="https://hal-pasteur.archives-ouvertes.fr/pasteur-01453400/document"> <date notBefore="2017-02-06"></date> </ref> <ref type="file" subtype="greenPublisher" n="1" target="https://hal-pasteur.archives-ouvertes.fr/pasteur-01453400/file/journal.pntd.0005294.pdf"> <date notBefore="2017-02-06"></date> </ref> <ref type="externalLink" target="https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0005294&type=printable"></ref> </edition> <respStmt> <resp>contributor</resp> <name key="112627"> <persName> <forename>Valérie</forename> <surname>Choumet</surname> </persName> <email type="md5">a3d009d1ebe902c18d400797fe8aaf1b</email> <email type="domain">pasteur.fr</email> </name> </respStmt> </editionStmt> <publicationStmt> <distributor>CCSD</distributor> <idno type="halId">pasteur-01453400</idno> <idno type="halUri">https://hal-pasteur.archives-ouvertes.fr/pasteur-01453400</idno> <idno type="halBibtex">dewispelaere:pasteur-01453400</idno> <idno type="halRefHtml">PLoS Neglected Tropical Diseases, Public Library of Science, 2017, 11 (1), pp.e0005294. ⟨10.1371/journal.pntd.0005294⟩</idno> <idno type="halRef">PLoS Neglected Tropical Diseases, Public Library of Science, 2017, 11 (1), pp.e0005294. ⟨10.1371/journal.pntd.0005294⟩</idno> <availability status="restricted"> <licence target="http://creativecommons.org/licenses/by/">Attribution</licence> </availability> </publicationStmt> <seriesStmt> <idno type="stamp" n="PASTEUR">Institut Pasteur</idno> <idno type="stamp" n="CNRS">CNRS - 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JEV transmission cycle involves mosquitoes and vertebrate hosts. The detection of JEV RNA in a pool of Culex pipiens caught in 2010 in Italy raised the concern of a putative emergence of the virus in Europe. We aimed to study the vector competence of European mosquito populations, such as Cx. pipiens and Aedes albopictus for JEV genotypes 3 and 5.After oral feeding on an infectious blood meal, mosquitoes were dissected at various times post-virus exposure. We found that the peak for JEV infection and transmission was between 11 and 13 days post-virus exposure. We observed a faster dissemination of both JEV genotypes in Ae. albopictus mosquitoes, when compared with Cx. pipiens mosquitoes. We also dissected salivary glands and collected saliva from infected mosquitoes and showed that Ae. albopictus mosquitoes transmitted JEV earlier than Cx. pipiens. The virus collected from Ae. albopictus and Cx. pipiens saliva was competent at causing pathogenesis in a mouse model for JEV infection. Using this model, we found that mosquito saliva or salivary glands did not enhance the severity of the disease.In this study, we demonstrated that European populations of Ae. albopictus and Cx. pipiens were efficient vectors for JEV transmission. Susceptible vertebrate species that develop high viremia are an obligatory part of the JEV transmission cycle. This study highlights the need to investigate the susceptibility of potential JEV reservoir hosts in Europe, notably amongst swine populations and local water birds.</p> </abstract> </profileDesc> </hal></record>Pour manipuler ce document sous Unix (Dilib)
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