Shedding of the Pandemic Swine-Origin Influenza A Virus (H1N1) after Oseltamivir Administration
Identifieur interne : 000535 ( Hal/Curation ); précédent : 000534; suivant : 000536Shedding of the Pandemic Swine-Origin Influenza A Virus (H1N1) after Oseltamivir Administration
Auteurs : Leiyun Weng [République populaire de Chine] ; Qiang Wang [République populaire de Chine] ; Wei Wang [République populaire de Chine] ; Peijun Ren [République populaire de Chine] ; Vincent Deubel [République populaire de Chine] ; Tetsuya Toyoda [République populaire de Chine]Source :
- Influenza Research and Treatment [ 2090-1380 ] ; 2010-11-15.
Abstract
We analyzed the virus shedding of an oseltamivir-treated patient who had been infected with the pandemic swine-origin influenza A (H1N1) virus which had an oseltamivir-sensitive neuraminidase. The virus was isolated from the pharyngeal swabs of the patient using MDCK cells, and the virus genome RNA was detected in the same samples both by real-time RT-PCR and RTPCR. The virus was isolated until 44 h after oseltamivir administration although the virus genome was detected until one day after oseltamivir treatment was stopped. Due to their high sensitivity, RT-PCR and real-time RT-PCR may cause misdiagnosis by detection of viral genome which does not infect, and classical virus isolation and clinical symptoms are recommended for the evaluation of oseltamivir treatment.
Url:
DOI: 10.1155/2010/976084
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<front><div type="abstract" xml:lang="en"> <p>We analyzed the virus shedding of an oseltamivir-treated patient who had been infected with the pandemic swine-origin influenza A (H1N1) virus which had an oseltamivir-sensitive neuraminidase. The virus was isolated from the pharyngeal swabs of the patient using MDCK cells, and the virus genome RNA was detected in the same samples both by real-time RT-PCR and RTPCR. The virus was isolated until 44 h after oseltamivir administration although the virus genome was detected until one day after oseltamivir treatment was stopped. Due to their high sensitivity, RT-PCR and real-time RT-PCR may cause misdiagnosis by detection of viral genome which does not infect, and classical virus isolation and clinical symptoms are recommended for the evaluation of oseltamivir treatment.</p>
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<funder>This work was supported by Grants-in-Aid from the Chinese Academy of Sciences (no. 0514P51131), National Science Foundation of China (no. 30670090), Li Ka Shing Foundation (no. 0682P11131), the French Agency for Development (SISEA Project; no. 0682P21111), and FLUINNATE (no. SP5B-CT-2006-044161). The GenBank account numbers of the influenza virus A/Shanghai/P1/2009 (H1N1) sequences are AB539736-AB539743. The real-time RT-PCR and RT-PCR protocols are available on request.</funder>
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<sourceDesc> <biblStruct> <analytic> <title xml:lang="en">Shedding of the Pandemic Swine-Origin Influenza A Virus (H1N1) after Oseltamivir Administration</title>
<author role="aut"> <persName> <forename type="first">Leiyun</forename>
<surname>Weng</surname>
</persName>
<idno type="halauthorid">640003</idno>
<affiliation ref="#struct-54027"></affiliation>
</author>
<author role="aut"> <persName> <forename type="first">Qiang</forename>
<surname>Wang</surname>
</persName>
<idno type="halauthorid">643734</idno>
<affiliation ref="#struct-54027"></affiliation>
</author>
<author role="aut"> <persName> <forename type="first">Wei</forename>
<surname>Wang</surname>
</persName>
<idno type="halauthorid">82966</idno>
<affiliation ref="#struct-54027"></affiliation>
</author>
<author role="aut"> <persName> <forename type="first">Peijun</forename>
<surname>Ren</surname>
</persName>
<idno type="halauthorid">568262</idno>
<affiliation ref="#struct-54027"></affiliation>
</author>
<author role="aut"> <persName> <forename type="first">Vincent</forename>
<surname>Deubel</surname>
</persName>
<idno type="halauthorid">470084</idno>
<affiliation ref="#struct-54027"></affiliation>
<affiliation ref="#struct-54022"></affiliation>
</author>
<author role="crp"> <persName> <forename type="first">Tetsuya</forename>
<surname>Toyoda</surname>
</persName>
<email type="md5">56edbbf79889a7294bfa84e03fbf6509</email>
<email type="domain">yahoo.co.jp</email>
<idno type="halauthorid">640007</idno>
<affiliation ref="#struct-54027"></affiliation>
<affiliation ref="#struct-167560"></affiliation>
<affiliation ref="#struct-193142"></affiliation>
</author>
</analytic>
<monogr> <idno type="halJournalId" status="VALID">73761</idno>
<idno type="issn">2090-1380</idno>
<idno type="eissn">2090-1399</idno>
<title level="j">Influenza Research and Treatment</title>
<imprint> <publisher>Hindawi Publishing Corporation</publisher>
<biblScope unit="volume">2010</biblScope>
<biblScope unit="issue">ID 976084</biblScope>
<biblScope unit="pp">3 pages</biblScope>
<date type="datePub">2010-11-15</date>
</imprint>
</monogr>
<idno type="doi">10.1155/2010/976084</idno>
</biblStruct>
</sourceDesc>
<profileDesc> <langUsage> <language ident="en">English</language>
</langUsage>
<textClass> <classCode scheme="halDomain" n="sdv.mp.vir">Life Sciences [q-bio]/Microbiology and Parasitology/Virology</classCode>
<classCode scheme="halTypology" n="ART">Journal articles</classCode>
</textClass>
<abstract xml:lang="en"> <p>We analyzed the virus shedding of an oseltamivir-treated patient who had been infected with the pandemic swine-origin influenza A (H1N1) virus which had an oseltamivir-sensitive neuraminidase. The virus was isolated from the pharyngeal swabs of the patient using MDCK cells, and the virus genome RNA was detected in the same samples both by real-time RT-PCR and RTPCR. The virus was isolated until 44 h after oseltamivir administration although the virus genome was detected until one day after oseltamivir treatment was stopped. Due to their high sensitivity, RT-PCR and real-time RT-PCR may cause misdiagnosis by detection of viral genome which does not infect, and classical virus isolation and clinical symptoms are recommended for the evaluation of oseltamivir treatment.</p>
</abstract>
</profileDesc>
</hal>
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