Longitudinal and Integrative Biomodeling of Effector and Memory Immune Compartments after Inactivated Influenza Vaccination
Identifieur interne : 000371 ( Hal/Curation ); précédent : 000370; suivant : 000372Longitudinal and Integrative Biomodeling of Effector and Memory Immune Compartments after Inactivated Influenza Vaccination
Auteurs : O. Bonduelle [France] ; N. Yahia [France] ; S. Siberil [France] ; N. Benhabiles [France] ; F. Carrat [France] ; A. Krivine [France] ; F. Rozenberg [France] ; J. Dimitrov ; S. Kaveri ; A. Curjol [France] ; M. Tindel [France] ; M. Louet [France] ; F. Desert [France] ; O. Launay [France] ; P. Loulergue [France] ; G. Badre [France] ; C. Katlama [France] ; F. Bricaire [France] ; A. Samri [France] ; D. Rousset [France] ; S. Van Der Werf [France] ; S. Jauréguiberry [France] ; B. Combadiere [France]Source :
- Journal of Immunology [ 0022-1767 ] ; 2013-07-03.
Abstract
Most vaccines, including those against influenza, were developed by focusing solely on humoral response for protection. However, vaccination activates different adaptive compartments that might play a role in protection. We took advantage of the pandemic 2009 A(H1N1) influenza vaccination to conduct a longitudinal integrative multiparametric analysis of seven immune parameters in vaccinated subjects. A global analysis underlined the predominance of induction of humoral and CD4 T cell responses, whereas pandemic 2009 A(H1N1)-specific CD8 responses did not improve after vaccination. A principal component analysis and hierarchical clustering of individuals showed a differential upregulation of influenza vaccine-specific immunity including hemagglutination inhibition titers, IgA$^+$ and IgG$^+$ Ab-secreting cells, effector CD4 or CD8 T cell frequencies at day 21 among individuals, suggesting a fine-tuning of the immune parameters after vaccination. This is related to individual factors including the magnitude and quality of influenza-specific immune responses before vaccination. We propose a graphical delineation of immune determinants that would be essential for a better understanding of vaccine-induced immunity in vaccination strategies
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DOI: 10.4049/jimmunol.1203483
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Van Der Werf</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-417138" status="OLD"> <idno type="IdRef">235658278</idno> <idno type="RNSR">200818198A</idno> <orgName>Génétique Moléculaire des Virus à ARN - Molecular Genetics of RNA Viruses</orgName> <orgName type="acronym">GMV-ARN (UMR_3569 / U-Pasteur_2)</orgName> <date type="end">2019-12-31</date> <desc> <address> <addrLine>Département de Virologie, 25-28 rue du docteur Roux, 75724 Paris cedex 15</addrLine> <country key="FR"></country> </address> <ref type="url">https://research.pasteur.fr/en/team/molecular-genetics-of-rna-viruses/</ref> </desc> <listRelation> <relation name="UMR_3569" active="#struct-441569" type="direct"></relation> <relation name="U-Pasteur_2" active="#struct-300301" type="direct"></relation> <relation active="#struct-300027" type="direct"></relation> </listRelation> <tutelles><tutelle name="UMR_3569" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle><tutelle name="U-Pasteur_2" active="#struct-300301" type="direct"><org type="institution" xml:id="struct-300301" status="OLD"> <idno type="ISNI">0000000121514068</idno> <idno type="IdRef">027542084</idno> <orgName>Université Paris Diderot - Paris 7</orgName> <orgName type="acronym">UPD7</orgName> <date type="end">2019-12-31</date> <desc> <address> <addrLine>5 rue Thomas-Mann - 75205 Paris cedex 13</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-paris-diderot.fr</ref> </desc> </org></tutelle><tutelle active="#struct-300027" type="direct"><org type="institution" xml:id="struct-300027" status="VALID"> <idno type="IdRef">027936643</idno> <idno type="ISNI">0000 0001 2353 6535</idno> <orgName>Institut Pasteur [Paris]</orgName> <date type="start">1887-06-04</date> <desc> <address> <addrLine>25-28, rue du docteur Roux, 75724 Paris cedex 15</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.pasteur.fr</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Jaureguiberry, S" sort="Jaureguiberry, S" uniqKey="Jaureguiberry S" first="S." last="Jauréguiberry">S. Jauréguiberry</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-507629" status="INCOMING"> <orgName>Hôpital La Pitie Salpetriere</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Combadiere, B" sort="Combadiere, B" uniqKey="Combadiere B" first="B." last="Combadiere">B. Combadiere</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-246601" status="OLD"> <idno type="RNSR">201420916D</idno> <orgName>Centre d'Immunologie et de Maladies Infectieuses</orgName> <orgName type="acronym">CIMI</orgName> <desc> <address> <addrLine>91 Boulevard de l'hôpital 75013 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.cimi-paris.upmc.fr</ref> </desc> <listRelation> <relation active="#struct-93591" type="direct"></relation> <relation name="U1135" active="#struct-303623" type="direct"></relation> <relation name="ERL8255" active="#struct-441569" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-93591" type="direct"><org type="institution" xml:id="struct-93591" status="OLD"> <orgName>Université Pierre et Marie Curie - Paris 6</orgName> <orgName type="acronym">UPMC</orgName> <date type="end">2017-12-31</date> <desc> <address> <addrLine>4 place Jussieu - 75005 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.upmc.fr/</ref> </desc> </org></tutelle><tutelle name="U1135" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle name="ERL8255" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author></analytic><idno type="DOI">10.4049/jimmunol.1203483</idno><series><title level="j">Journal of Immunology</title><idno type="ISSN">0022-1767</idno><imprint><date type="datePub">2013-07-03</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"> <p>Most vaccines, including those against influenza, were developed by focusing solely on humoral response for protection. However, vaccination activates different adaptive compartments that might play a role in protection. We took advantage of the pandemic 2009 A(H1N1) influenza vaccination to conduct a longitudinal integrative multiparametric analysis of seven immune parameters in vaccinated subjects. A global analysis underlined the predominance of induction of humoral and CD4 T cell responses, whereas pandemic 2009 A(H1N1)-specific CD8 responses did not improve after vaccination. A principal component analysis and hierarchical clustering of individuals showed a differential upregulation of influenza vaccine-specific immunity including hemagglutination inhibition titers, IgA$^+$ and IgG$^+$ Ab-secreting cells, effector CD4 or CD8 T cell frequencies at day 21 among individuals, suggesting a fine-tuning of the immune parameters after vaccination. This is related to individual factors including the magnitude and quality of influenza-specific immune responses before vaccination. We propose a graphical delineation of immune determinants that would be essential for a better understanding of vaccine-induced immunity in vaccination strategies</p> </div></front></TEI><hal api="V3"> <titleStmt> <title xml:lang="en">Longitudinal and Integrative Biomodeling of Effector and Memory Immune Compartments after Inactivated Influenza Vaccination</title> <author role="aut"> <persName> <forename type="first">O.</forename> <surname>Bonduelle</surname> </persName> <idno type="halauthorid">11200869</idno> <affiliation ref="#struct-303623"></affiliation> </author> <author role="aut"> <persName> <forename type="first">N.</forename> <surname>Yahia</surname> </persName> <idno type="halauthorid">11200870</idno> <affiliation ref="#struct-303623"></affiliation> </author> <author role="aut"> <persName> <forename type="first">S.</forename> <surname>Siberil</surname> </persName> <idno type="halauthorid">341599</idno> <affiliation ref="#struct-303623"></affiliation> </author> <author role="aut"> <persName> <forename type="first">N.</forename> <surname>Benhabiles</surname> </persName> <idno type="halauthorid">11200871</idno> <affiliation ref="#struct-528161"></affiliation> </author> <author role="aut"> <persName> <forename type="first">F.</forename> <surname>Carrat</surname> </persName> <email type="md5">d3fac14bbecb5ab5a5029e3cc79cb4ca</email> <email type="domain">iplesp.upmc.fr</email> <idno type="idhal" notation="string">fabrice-carrat</idno> <idno type="idhal" notation="numeric">181388</idno> <idno type="halauthorid">237640</idno> <idno type="ORCID">https://orcid.org/0000-0002-8672-7918</idno> <idno type="ResearcherId">http://www.researcherid.com/rid/P-6177-2017</idno> <affiliation ref="#struct-245392"></affiliation> </author> <author role="aut"> <persName> <forename type="first">A.</forename> <surname>Krivine</surname> </persName> <idno type="halauthorid">1538592</idno> <affiliation ref="#struct-444301"></affiliation> </author> <author role="aut"> <persName> <forename type="first">F.</forename> <surname>Rozenberg</surname> </persName> <idno type="halauthorid">178560</idno> <affiliation ref="#struct-444301"></affiliation> </author> <author role="aut"> <persName> <forename type="first">J.</forename> <surname>Dimitrov</surname> </persName> <idno type="halauthorid">11200872</idno> <affiliation ref="#struct-434472"></affiliation> </author> <author role="aut"> <persName> <forename type="first">S.</forename> <surname>Kaveri</surname> </persName> <idno type="halauthorid">496736</idno> <affiliation ref="#struct-434472"></affiliation> </author> <author role="aut"> <persName> <forename type="first">A.</forename> <surname>Curjol</surname> </persName> <idno type="halauthorid">11200873</idno> <affiliation ref="#struct-17930"></affiliation> </author> <author role="aut"> <persName> <forename type="first">M.</forename> <surname>Tindel</surname> </persName> <idno type="halauthorid">11200874</idno> <affiliation ref="#struct-17930"></affiliation> </author> <author role="aut"> <persName> <forename type="first">M.</forename> <surname>Louet</surname> </persName> <idno type="halauthorid">11200875</idno> <affiliation ref="#struct-353778"></affiliation> </author> <author role="aut"> <persName> <forename type="first">F.</forename> <surname>Desert</surname> </persName> <idno type="halauthorid">591844</idno> <affiliation ref="#struct-353778"></affiliation> </author> <author role="aut"> <persName> <forename type="first">O.</forename> <surname>Launay</surname> </persName> <idno type="halauthorid">1154856</idno> <affiliation ref="#struct-2593"></affiliation> </author> <author role="aut"> <persName> <forename type="first">P.</forename> <surname>Loulergue</surname> </persName> <idno type="halauthorid">1154852</idno> <affiliation ref="#struct-303623"></affiliation> </author> <author role="aut"> <persName> <forename type="first">G.</forename> <surname>Badre</surname> </persName> <idno type="halauthorid">11200876</idno> <affiliation ref="#struct-444301"></affiliation> </author> <author role="aut"> <persName> <forename type="first">C.</forename> <surname>Katlama</surname> </persName> <idno type="halauthorid">818925</idno> <affiliation ref="#struct-17930"></affiliation> </author> <author role="aut"> <persName> <forename type="first">F.</forename> <surname>Bricaire</surname> </persName> <idno type="halauthorid">442714</idno> <affiliation ref="#struct-17930"></affiliation> </author> <author role="aut"> <persName> <forename type="first">A.</forename> <surname>Samri</surname> </persName> <idno type="halauthorid">429336</idno> <affiliation ref="#struct-303623"></affiliation> </author> <author role="aut"> <persName> <forename type="first">D.</forename> <surname>Rousset</surname> </persName> <idno type="halauthorid">88555</idno> <affiliation ref="#struct-417138"></affiliation> </author> <author role="aut"> <persName> <forename type="first">S.</forename> <surname>Van Der Werf</surname> </persName> <idno type="halauthorid">158298</idno> <affiliation ref="#struct-417138"></affiliation> </author> <author role="aut"> <persName> <forename type="first">S.</forename> <surname>Jauréguiberry</surname> </persName> <idno type="halauthorid">11199561</idno> <affiliation ref="#struct-507629"></affiliation> </author> <author role="aut"> <persName> <forename type="first">B.</forename> <surname>Combadiere</surname> </persName> <idno type="halauthorid">374575</idno> <affiliation ref="#struct-246601"></affiliation> <affiliation ref="#struct-541997"></affiliation> </author> <editor role="depositor"> <persName> <forename>Bruno</forename> <surname>Savelli</surname> </persName> <email type="md5">582f92ffece0afd20bf72539885be813</email> <email type="domain">cea.fr</email> </editor> <funder>This work was supported by a grant from the Programme de Recherche, A(H1N1) coordinated by the Institut de Microbiologie et Maladies Infectieuses (France). B.C. has been awarded an INSERM-Assistance Publique/Hôpitaux de Paris Interface Program contract and is supported by the Fondation pour la Recherche Medicale.</funder> </titleStmt> <editionStmt> <edition n="v1" type="current"> <date type="whenSubmitted">2019-02-11 14:06:01</date> <date type="whenModified">2020-04-11 02:17:39</date> <date type="whenReleased">2019-02-11 14:35:50</date> <date type="whenProduced">2013-07-03</date> <date type="whenEndEmbargoed">2019-02-11</date> <ref type="file" target="https://hal-cea.archives-ouvertes.fr/cea-01791413/document"> <date notBefore="2019-02-11"></date> </ref> <ref type="file" subtype="greenPublisher" n="1" target="https://hal-cea.archives-ouvertes.fr/cea-01791413/file/article%20Olivia%20Bonduelle.pdf"> <date notBefore="2019-02-11"></date> </ref> <ref type="externalLink" target="https://www.jimmunol.org/content/jimmunol/191/2/623.full.pdf"></ref> </edition> <respStmt> <resp>contributor</resp> <name key="178875"> <persName> <forename>Bruno</forename> <surname>Savelli</surname> </persName> <email type="md5">582f92ffece0afd20bf72539885be813</email> <email type="domain">cea.fr</email> </name> </respStmt> </editionStmt> <publicationStmt> <distributor>CCSD</distributor> <idno type="halId">cea-01791413</idno> <idno type="halUri">https://hal-cea.archives-ouvertes.fr/cea-01791413</idno> <idno type="halBibtex">bonduelle:cea-01791413</idno> <idno type="halRefHtml">Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2013, 191 (2), pp.623 - 631. ⟨10.4049/jimmunol.1203483⟩</idno> <idno type="halRef">Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2013, 191 (2), pp.623 - 631. ⟨10.4049/jimmunol.1203483⟩</idno> </publicationStmt> <seriesStmt> <idno type="stamp" n="CEA">CEA - Commissariat à l'énergie atomique</idno> <idno type="stamp" n="CIMI" corresp="SORBONNE-UNIVERSITE">Centre d'Immunologie et des Maladies Infectieuses</idno> <idno type="stamp" n="LIST" corresp="CEA">Laboratoire d'Intégration des Systèmes et des Technologies</idno> <idno type="stamp" n="DRT" corresp="CEA">Direction de la recherche technologique</idno> <idno type="stamp" n="CHU-UNIV-PARIS5">Les centres hospitaliers de Paris Descartes</idno> <idno type="stamp" n="CORDELIERS" corresp="SORBONNE-UNIVERSITE">Centre de recherche des Cordeliers</idno> <idno type="stamp" n="SORBONNE-UNIVERSITE">Sorbonne Université</idno> <idno type="stamp" n="APHP" corresp="INSERM">AP-HP</idno> <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno> <idno type="stamp" n="UPMC" corresp="SORBONNE-UNIVERSITE">Université Pierre et Marie Curie</idno> <idno type="stamp" n="UPMC_POLE_4" corresp="UPMC">UPMC Pôle 4</idno> <idno type="stamp" n="SU-INF-2018" corresp="SORBONNE-UNIVERSITE">SORBONNE université <2018</idno> <idno type="stamp" n="SU-MEDECINE" corresp="SORBONNE-UNIVERSITE">Faculté de Médecine de Sorbonne Université</idno> <idno type="stamp" n="UNIV-PARIS7" corresp="UNIV-PARIS">Université Denis Diderot - Paris VII</idno> <idno type="stamp" n="USPC">Université Sorbonne Paris Cité</idno> <idno type="stamp" n="DM2I" corresp="LIST">Département Métrologie Instrumentation & Information</idno> <idno type="stamp" n="SU-SCIENCES" corresp="SORBONNE-UNIVERSITE">Faculté des Sciences de Sorbonne Université</idno> <idno type="stamp" n="PASTEUR">Institut Pasteur</idno> <idno type="stamp" n="RIIP_PARIS">Institut Pasteur de Paris</idno> <idno type="stamp" n="UNIV-PARIS">Université de Paris</idno> <idno type="stamp" n="UP-SCIENCES">Université de Paris - Faculté des Sciences</idno> </seriesStmt> <notesStmt> <note type="audience" n="2">International</note> <note type="popular" n="0">No</note> <note type="peer" n="1">Yes</note> </notesStmt> <sourceDesc> <biblStruct> <analytic> <title xml:lang="en">Longitudinal and Integrative Biomodeling of Effector and Memory Immune Compartments after Inactivated Influenza Vaccination</title> <author role="aut"> <persName> <forename type="first">O.</forename> <surname>Bonduelle</surname> </persName> <idno type="halauthorid">11200869</idno> <affiliation ref="#struct-303623"></affiliation> </author> <author role="aut"> <persName> <forename type="first">N.</forename> <surname>Yahia</surname> </persName> <idno type="halauthorid">11200870</idno> <affiliation ref="#struct-303623"></affiliation> </author> <author role="aut"> <persName> <forename type="first">S.</forename> <surname>Siberil</surname> </persName> <idno type="halauthorid">341599</idno> <affiliation ref="#struct-303623"></affiliation> </author> <author role="aut"> <persName> <forename type="first">N.</forename> <surname>Benhabiles</surname> </persName> <idno type="halauthorid">11200871</idno> <affiliation ref="#struct-528161"></affiliation> </author> <author role="aut"> <persName> <forename type="first">F.</forename> <surname>Carrat</surname> </persName> <email type="md5">d3fac14bbecb5ab5a5029e3cc79cb4ca</email> <email type="domain">iplesp.upmc.fr</email> <idno type="idhal" notation="string">fabrice-carrat</idno> <idno type="idhal" notation="numeric">181388</idno> <idno type="halauthorid">237640</idno> <idno type="ORCID">https://orcid.org/0000-0002-8672-7918</idno> <idno type="ResearcherId">http://www.researcherid.com/rid/P-6177-2017</idno> <affiliation ref="#struct-245392"></affiliation> </author> <author role="aut"> <persName> <forename type="first">A.</forename> <surname>Krivine</surname> </persName> <idno type="halauthorid">1538592</idno> <affiliation ref="#struct-444301"></affiliation> </author> <author role="aut"> <persName> <forename type="first">F.</forename> <surname>Rozenberg</surname> </persName> <idno type="halauthorid">178560</idno> <affiliation ref="#struct-444301"></affiliation> </author> <author role="aut"> <persName> <forename type="first">J.</forename> <surname>Dimitrov</surname> </persName> <idno type="halauthorid">11200872</idno> <affiliation ref="#struct-434472"></affiliation> </author> <author role="aut"> <persName> <forename type="first">S.</forename> <surname>Kaveri</surname> </persName> <idno type="halauthorid">496736</idno> <affiliation ref="#struct-434472"></affiliation> </author> <author role="aut"> <persName> <forename type="first">A.</forename> <surname>Curjol</surname> </persName> <idno type="halauthorid">11200873</idno> <affiliation ref="#struct-17930"></affiliation> </author> <author role="aut"> <persName> <forename type="first">M.</forename> <surname>Tindel</surname> </persName> <idno type="halauthorid">11200874</idno> <affiliation ref="#struct-17930"></affiliation> </author> <author role="aut"> <persName> <forename type="first">M.</forename> <surname>Louet</surname> </persName> <idno type="halauthorid">11200875</idno> <affiliation ref="#struct-353778"></affiliation> </author> <author role="aut"> <persName> <forename type="first">F.</forename> <surname>Desert</surname> </persName> <idno type="halauthorid">591844</idno> <affiliation ref="#struct-353778"></affiliation> </author> <author role="aut"> <persName> <forename type="first">O.</forename> <surname>Launay</surname> </persName> <idno type="halauthorid">1154856</idno> <affiliation ref="#struct-2593"></affiliation> </author> <author role="aut"> <persName> <forename type="first">P.</forename> <surname>Loulergue</surname> </persName> <idno type="halauthorid">1154852</idno> <affiliation ref="#struct-303623"></affiliation> </author> <author role="aut"> <persName> <forename type="first">G.</forename> <surname>Badre</surname> </persName> <idno type="halauthorid">11200876</idno> <affiliation ref="#struct-444301"></affiliation> </author> <author role="aut"> <persName> <forename type="first">C.</forename> <surname>Katlama</surname> </persName> <idno type="halauthorid">818925</idno> <affiliation ref="#struct-17930"></affiliation> </author> <author role="aut"> <persName> <forename type="first">F.</forename> <surname>Bricaire</surname> </persName> <idno type="halauthorid">442714</idno> <affiliation ref="#struct-17930"></affiliation> </author> <author role="aut"> <persName> <forename type="first">A.</forename> <surname>Samri</surname> </persName> <idno type="halauthorid">429336</idno> <affiliation ref="#struct-303623"></affiliation> </author> <author role="aut"> <persName> <forename type="first">D.</forename> <surname>Rousset</surname> </persName> <idno type="halauthorid">88555</idno> <affiliation ref="#struct-417138"></affiliation> </author> <author role="aut"> <persName> <forename type="first">S.</forename> <surname>Van Der Werf</surname> </persName> <idno type="halauthorid">158298</idno> <affiliation ref="#struct-417138"></affiliation> </author> <author role="aut"> <persName> <forename type="first">S.</forename> <surname>Jauréguiberry</surname> </persName> <idno type="halauthorid">11199561</idno> <affiliation ref="#struct-507629"></affiliation> </author> <author role="aut"> <persName> <forename type="first">B.</forename> <surname>Combadiere</surname> </persName> <idno type="halauthorid">374575</idno> <affiliation ref="#struct-246601"></affiliation> <affiliation ref="#struct-541997"></affiliation> </author> </analytic> <monogr> <idno type="halJournalId" status="VALID">6184</idno> <idno type="issn">0022-1767</idno> <idno type="eissn">1550-6606</idno> <title level="j">Journal of Immunology</title> <imprint> <publisher>Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists</publisher> <biblScope unit="volume">191</biblScope> <biblScope unit="issue">2</biblScope> <biblScope unit="pp">623 - 631</biblScope> <date type="datePub">2013-07-03</date> </imprint> </monogr> <idno type="doi">10.4049/jimmunol.1203483</idno> <idno type="pubmed">23776176</idno> </biblStruct> </sourceDesc> <profileDesc> <langUsage> <language ident="en">English</language> </langUsage> <textClass> <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode> <classCode scheme="halDomain" n="sdv.imm">Life Sciences [q-bio]/Immunology</classCode> <classCode scheme="halTypology" n="ART">Journal articles</classCode> </textClass> <abstract xml:lang="en"> <p>Most vaccines, including those against influenza, were developed by focusing solely on humoral response for protection. However, vaccination activates different adaptive compartments that might play a role in protection. We took advantage of the pandemic 2009 A(H1N1) influenza vaccination to conduct a longitudinal integrative multiparametric analysis of seven immune parameters in vaccinated subjects. A global analysis underlined the predominance of induction of humoral and CD4 T cell responses, whereas pandemic 2009 A(H1N1)-specific CD8 responses did not improve after vaccination. A principal component analysis and hierarchical clustering of individuals showed a differential upregulation of influenza vaccine-specific immunity including hemagglutination inhibition titers, IgA$^+$ and IgG$^+$ Ab-secreting cells, effector CD4 or CD8 T cell frequencies at day 21 among individuals, suggesting a fine-tuning of the immune parameters after vaccination. This is related to individual factors including the magnitude and quality of influenza-specific immune responses before vaccination. We propose a graphical delineation of immune determinants that would be essential for a better understanding of vaccine-induced immunity in vaccination strategies</p> </abstract> </profileDesc> </hal></record>Pour manipuler ce document sous Unix (Dilib)
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