Longitudinal and Integrative Biomodeling of Effector and Memory Immune Compartments after Inactivated Influenza Vaccination
Identifieur interne : 000371 ( Hal/Curation ); précédent : 000370; suivant : 000372Longitudinal and Integrative Biomodeling of Effector and Memory Immune Compartments after Inactivated Influenza Vaccination
Auteurs : O. Bonduelle [France] ; N. Yahia [France] ; S. Siberil [France] ; N. Benhabiles [France] ; F. Carrat [France] ; A. Krivine [France] ; F. Rozenberg [France] ; J. Dimitrov ; S. Kaveri ; A. Curjol [France] ; M. Tindel [France] ; M. Louet [France] ; F. Desert [France] ; O. Launay [France] ; P. Loulergue [France] ; G. Badre [France] ; C. Katlama [France] ; F. Bricaire [France] ; A. Samri [France] ; D. Rousset [France] ; S. Van Der Werf [France] ; S. Jauréguiberry [France] ; B. Combadiere [France]Source :
- Journal of Immunology [ 0022-1767 ] ; 2013-07-03.
Abstract
Most vaccines, including those against influenza, were developed by focusing solely on humoral response for protection. However, vaccination activates different adaptive compartments that might play a role in protection. We took advantage of the pandemic 2009 A(H1N1) influenza vaccination to conduct a longitudinal integrative multiparametric analysis of seven immune parameters in vaccinated subjects. A global analysis underlined the predominance of induction of humoral and CD4 T cell responses, whereas pandemic 2009 A(H1N1)-specific CD8 responses did not improve after vaccination. A principal component analysis and hierarchical clustering of individuals showed a differential upregulation of influenza vaccine-specific immunity including hemagglutination inhibition titers, IgA$^+$ and IgG$^+$ Ab-secreting cells, effector CD4 or CD8 T cell frequencies at day 21 among individuals, suggesting a fine-tuning of the immune parameters after vaccination. This is related to individual factors including the magnitude and quality of influenza-specific immune responses before vaccination. We propose a graphical delineation of immune determinants that would be essential for a better understanding of vaccine-induced immunity in vaccination strategies
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DOI: 10.4049/jimmunol.1203483
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<idno type="DOI">10.4049/jimmunol.1203483</idno>
<series><title level="j">Journal of Immunology</title>
<idno type="ISSN">0022-1767</idno>
<imprint><date type="datePub">2013-07-03</date>
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<front><div type="abstract" xml:lang="en"> <p>Most vaccines, including those against influenza, were developed by focusing solely on humoral response for protection. However, vaccination activates different adaptive compartments that might play a role in protection. We took advantage of the pandemic 2009 A(H1N1) influenza vaccination to conduct a longitudinal integrative multiparametric analysis of seven immune parameters in vaccinated subjects. A global analysis underlined the predominance of induction of humoral and CD4 T cell responses, whereas pandemic 2009 A(H1N1)-specific CD8 responses did not improve after vaccination. A principal component analysis and hierarchical clustering of individuals showed a differential upregulation of influenza vaccine-specific immunity including hemagglutination inhibition titers, IgA$^+$ and IgG$^+$ Ab-secreting cells, effector CD4 or CD8 T cell frequencies at day 21 among individuals, suggesting a fine-tuning of the immune parameters after vaccination. This is related to individual factors including the magnitude and quality of influenza-specific immune responses before vaccination. We propose a graphical delineation of immune determinants that would be essential for a better understanding of vaccine-induced immunity in vaccination strategies</p>
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<hal api="V3"> <titleStmt> <title xml:lang="en">Longitudinal and Integrative Biomodeling of Effector and Memory Immune Compartments after Inactivated Influenza Vaccination</title>
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<funder>This work was supported by a grant from the Programme de Recherche, A(H1N1) coordinated by the Institut de Microbiologie et Maladies Infectieuses (France). B.C. has been awarded an INSERM-Assistance Publique/Hôpitaux de Paris Interface Program contract and is supported by the Fondation pour la Recherche Medicale.</funder>
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<name key="178875"> <persName> <forename>Bruno</forename>
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<author role="aut"> <persName> <forename type="first">O.</forename>
<surname>Bonduelle</surname>
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<author role="aut"> <persName> <forename type="first">S.</forename>
<surname>Siberil</surname>
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<idno type="halauthorid">341599</idno>
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</author>
<author role="aut"> <persName> <forename type="first">N.</forename>
<surname>Benhabiles</surname>
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<idno type="halauthorid">11200871</idno>
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</author>
<author role="aut"> <persName> <forename type="first">F.</forename>
<surname>Carrat</surname>
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<email type="md5">d3fac14bbecb5ab5a5029e3cc79cb4ca</email>
<email type="domain">iplesp.upmc.fr</email>
<idno type="idhal" notation="string">fabrice-carrat</idno>
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<idno type="halauthorid">237640</idno>
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<idno type="ResearcherId">http://www.researcherid.com/rid/P-6177-2017</idno>
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<author role="aut"> <persName> <forename type="first">A.</forename>
<surname>Krivine</surname>
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<idno type="halauthorid">1538592</idno>
<affiliation ref="#struct-444301"></affiliation>
</author>
<author role="aut"> <persName> <forename type="first">F.</forename>
<surname>Rozenberg</surname>
</persName>
<idno type="halauthorid">178560</idno>
<affiliation ref="#struct-444301"></affiliation>
</author>
<author role="aut"> <persName> <forename type="first">J.</forename>
<surname>Dimitrov</surname>
</persName>
<idno type="halauthorid">11200872</idno>
<affiliation ref="#struct-434472"></affiliation>
</author>
<author role="aut"> <persName> <forename type="first">S.</forename>
<surname>Kaveri</surname>
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<author role="aut"> <persName> <forename type="first">A.</forename>
<surname>Curjol</surname>
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</author>
<author role="aut"> <persName> <forename type="first">M.</forename>
<surname>Tindel</surname>
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<idno type="halauthorid">11200874</idno>
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<author role="aut"> <persName> <forename type="first">M.</forename>
<surname>Louet</surname>
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<author role="aut"> <persName> <forename type="first">F.</forename>
<surname>Desert</surname>
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<author role="aut"> <persName> <forename type="first">O.</forename>
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<author role="aut"> <persName> <forename type="first">P.</forename>
<surname>Loulergue</surname>
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<author role="aut"> <persName> <forename type="first">G.</forename>
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<surname>Samri</surname>
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<author role="aut"> <persName> <forename type="first">D.</forename>
<surname>Rousset</surname>
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<author role="aut"> <persName> <forename type="first">S.</forename>
<surname>Van Der Werf</surname>
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<affiliation ref="#struct-417138"></affiliation>
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<author role="aut"> <persName> <forename type="first">S.</forename>
<surname>Jauréguiberry</surname>
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<author role="aut"> <persName> <forename type="first">B.</forename>
<surname>Combadiere</surname>
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</analytic>
<monogr> <idno type="halJournalId" status="VALID">6184</idno>
<idno type="issn">0022-1767</idno>
<idno type="eissn">1550-6606</idno>
<title level="j">Journal of Immunology</title>
<imprint> <publisher>Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists</publisher>
<biblScope unit="volume">191</biblScope>
<biblScope unit="issue">2</biblScope>
<biblScope unit="pp">623 - 631</biblScope>
<date type="datePub">2013-07-03</date>
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<idno type="doi">10.4049/jimmunol.1203483</idno>
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<abstract xml:lang="en"> <p>Most vaccines, including those against influenza, were developed by focusing solely on humoral response for protection. However, vaccination activates different adaptive compartments that might play a role in protection. We took advantage of the pandemic 2009 A(H1N1) influenza vaccination to conduct a longitudinal integrative multiparametric analysis of seven immune parameters in vaccinated subjects. A global analysis underlined the predominance of induction of humoral and CD4 T cell responses, whereas pandemic 2009 A(H1N1)-specific CD8 responses did not improve after vaccination. A principal component analysis and hierarchical clustering of individuals showed a differential upregulation of influenza vaccine-specific immunity including hemagglutination inhibition titers, IgA$^+$ and IgG$^+$ Ab-secreting cells, effector CD4 or CD8 T cell frequencies at day 21 among individuals, suggesting a fine-tuning of the immune parameters after vaccination. This is related to individual factors including the magnitude and quality of influenza-specific immune responses before vaccination. We propose a graphical delineation of immune determinants that would be essential for a better understanding of vaccine-induced immunity in vaccination strategies</p>
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