Involvement of superantigenic toxins in the process of staphylococcus aureus toxic and septic shock
Identifieur interne : 000349 ( Hal/Curation ); précédent : 000348; suivant : 000350Involvement of superantigenic toxins in the process of staphylococcus aureus toxic and septic shock
Auteurs : Tristan Ferry [France]Source :
Descripteurs français
- mix :
English descriptors
Abstract
S. aureus can produce a wide range of virulence factors. Superantigenic toxins are responsible for a pro-inflammatory response during staphylococcal toxic shock syndrome (STSS) and are suspected to be involved in the process of S. aureus septic shock. These molecules bypass the normal antigen presentation by cross-linking the major histocompatibility complex class II molecules of antigen-presentating cells to the Vbeta domain of the T-cell receptor. By this way, each superantigenic toxin selectively stimulates and expands one or several Vbeta subsets producing a Vbeta signature.
We firstly showed in patients with menstrual and non-menstrual STSS due to the production of TSST-1 or SEB, that the Vbeta signature of the toxin could be detected in the Vbeta repertoire of patients at the early stage of the disease. Secondly, during S. aureus bacteremia, the prevalence of the gene encoding SEA was higher when septic shock occurred and the major meticillin-resistant S. aureus (MRSA) clone in France, named “clone Lyon” harbored this gene. in vitro, SEA induced a strong pro-inflammatory response that may enhanced the pro-inflammatory cascade during septic shock. However, the Vbeta signature of SEA has not been detected in patients with S. aureus (including MRSA) septic shock infected with a stain that produced SEA in vitro. Finally, in an animal model of sepsis, Lyon clone MRSA isolates induced a higher rate of mortality than meticillin-susceptible isolates, but this was not directly attributable to SEA.
The detection of a production of superantigenic toxins in vivo may lead to an early diagnosis of STSS and may facilitate the introduction of anti-toxinic agents that may improve the prognosis. The involvement of superantigenic toxins and especially SEA, in the pathophysiology of S. aureus septic shock remained uncertain.
Url:
Links toward previous steps (curation, corpus...)
- to stream Hal, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000349
Links to Exploration step
Hal:tel-00184923Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Involvement of superantigenic toxins in the process of staphylococcus aureus toxic and septic shock</title>
<title xml:lang="fr">Rôle des exotoxines superantigéniques dans le choc toxique et le choc septique à Staphylococcus aureus</title>
<author><name sortKey="Ferry, Tristan" sort="Ferry, Tristan" uniqKey="Ferry T" first="Tristan" last="Ferry">Tristan Ferry</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-27478" status="OLD"> <orgName>Immunité infection vaccination</orgName>
<orgName type="acronym">I2V</orgName>
<desc> <address> <addrLine>CERVI 21, avenue tony garnier 69365 LYON CEDEX 07</addrLine>
<country key="FR"></country>
</address>
</desc>
<listRelation> <relation active="#struct-194495" type="direct"></relation>
<relation active="#struct-301088" type="indirect"></relation>
<relation active="#struct-300626" type="direct"></relation>
<relation name="U851" active="#struct-303623" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-194495" type="direct"><org type="institution" xml:id="struct-194495" status="VALID"> <idno type="IdRef">026402823</idno>
<idno type="ISNI">0000000121686185</idno>
<orgName>Université Claude Bernard Lyon 1</orgName>
<orgName type="acronym">UCBL</orgName>
<desc> <address> <addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-lyon1.fr/</ref>
</desc>
<listRelation> <relation active="#struct-301088" type="direct"></relation>
</listRelation>
</org>
</tutelle>
<tutelle active="#struct-301088" type="indirect"><org type="regroupinstitution" xml:id="struct-301088" status="VALID"> <orgName>Université de Lyon</orgName>
<desc> <address> <addrLine>92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07</addrLine>
<country key="FR"></country>
</address>
<ref type="url">https://www.universite-lyon.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-300626" type="direct"><org type="institution" xml:id="struct-300626" status="VALID"> <orgName>IFR128</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle name="U851" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno>
<orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
<orgName type="acronym">INSERM</orgName>
<desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.inserm.fr</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Lyon</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
<orgName type="university">Université Claude Bernard Lyon 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université de Lyon</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">HAL</idno>
<idno type="RBID">Hal:tel-00184923</idno>
<idno type="halId">tel-00184923</idno>
<idno type="halUri">https://tel.archives-ouvertes.fr/tel-00184923</idno>
<idno type="url">https://tel.archives-ouvertes.fr/tel-00184923</idno>
<date when="2007-10-16">2007-10-16</date>
<idno type="wicri:Area/Hal/Corpus">000349</idno>
<idno type="wicri:Area/Hal/Curation">000349</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Involvement of superantigenic toxins in the process of staphylococcus aureus toxic and septic shock</title>
<title xml:lang="fr">Rôle des exotoxines superantigéniques dans le choc toxique et le choc septique à Staphylococcus aureus</title>
<author><name sortKey="Ferry, Tristan" sort="Ferry, Tristan" uniqKey="Ferry T" first="Tristan" last="Ferry">Tristan Ferry</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-27478" status="OLD"> <orgName>Immunité infection vaccination</orgName>
<orgName type="acronym">I2V</orgName>
<desc> <address> <addrLine>CERVI 21, avenue tony garnier 69365 LYON CEDEX 07</addrLine>
<country key="FR"></country>
</address>
</desc>
<listRelation> <relation active="#struct-194495" type="direct"></relation>
<relation active="#struct-301088" type="indirect"></relation>
<relation active="#struct-300626" type="direct"></relation>
<relation name="U851" active="#struct-303623" type="direct"></relation>
</listRelation>
<tutelles><tutelle active="#struct-194495" type="direct"><org type="institution" xml:id="struct-194495" status="VALID"> <idno type="IdRef">026402823</idno>
<idno type="ISNI">0000000121686185</idno>
<orgName>Université Claude Bernard Lyon 1</orgName>
<orgName type="acronym">UCBL</orgName>
<desc> <address> <addrLine>43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-lyon1.fr/</ref>
</desc>
<listRelation> <relation active="#struct-301088" type="direct"></relation>
</listRelation>
</org>
</tutelle>
<tutelle active="#struct-301088" type="indirect"><org type="regroupinstitution" xml:id="struct-301088" status="VALID"> <orgName>Université de Lyon</orgName>
<desc> <address> <addrLine>92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07</addrLine>
<country key="FR"></country>
</address>
<ref type="url">https://www.universite-lyon.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle active="#struct-300626" type="direct"><org type="institution" xml:id="struct-300626" status="VALID"> <orgName>IFR128</orgName>
<desc> <address> <country key="FR"></country>
</address>
</desc>
</org>
</tutelle>
<tutelle name="U851" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno>
<orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
<orgName type="acronym">INSERM</orgName>
<desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.inserm.fr</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Lyon</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
<orgName type="university">Université Claude Bernard Lyon 1</orgName>
<orgName type="institution" wicri:auto="newGroup">Université de Lyon</orgName>
</affiliation>
</author>
</analytic>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>pandemic MRSA clone</term>
<term>septic shock</term>
<term>superantigenic toxin</term>
<term>toxic choc syndrome</term>
</keywords>
<keywords scheme="mix" xml:lang="fr"><term>S. aureus</term>
<term>choc septique</term>
<term>choc toxique staphylococcique</term>
<term>clone SARM pandémique</term>
<term>exotoxine superantigénique</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"> <p>S. aureus can produce a wide range of virulence factors. Superantigenic toxins are responsible for a pro-inflammatory response during staphylococcal toxic shock syndrome (STSS) and are suspected to be involved in the process of S. aureus septic shock. These molecules bypass the normal antigen presentation by cross-linking the major histocompatibility complex class II molecules of antigen-presentating cells to the Vbeta domain of the T-cell receptor. By this way, each superantigenic toxin selectively stimulates and expands one or several Vbeta subsets producing a Vbeta signature.
We firstly showed in patients with menstrual and non-menstrual STSS due to the production of TSST-1 or SEB, that the Vbeta signature of the toxin could be detected in the Vbeta repertoire of patients at the early stage of the disease. Secondly, during S. aureus bacteremia, the prevalence of the gene encoding SEA was higher when septic shock occurred and the major meticillin-resistant S. aureus (MRSA) clone in France, named “clone Lyon” harbored this gene. in vitro, SEA induced a strong pro-inflammatory response that may enhanced the pro-inflammatory cascade during septic shock. However, the Vbeta signature of SEA has not been detected in patients with S. aureus (including MRSA) septic shock infected with a stain that produced SEA in vitro. Finally, in an animal model of sepsis, Lyon clone MRSA isolates induced a higher rate of mortality than meticillin-susceptible isolates, but this was not directly attributable to SEA.
The detection of a production of superantigenic toxins in vivo may lead to an early diagnosis of STSS and may facilitate the introduction of anti-toxinic agents that may improve the prognosis. The involvement of superantigenic toxins and especially SEA, in the pathophysiology of S. aureus septic shock remained uncertain.</p>
</div>
</front>
</TEI>
<hal api="V3"> <titleStmt> <title xml:lang="en">Involvement of superantigenic toxins in the process of staphylococcus aureus toxic and septic shock</title>
<title xml:lang="fr">Rôle des exotoxines superantigéniques dans le choc toxique et le choc septique à Staphylococcus aureus</title>
<author role="aut"> <persName> <forename type="first">Tristan</forename>
<surname>Ferry</surname>
</persName>
<email type="md5">cd9b59c352edc99e1f63d457aa3a8cf4</email>
<email type="domain">univ-lyon1.fr</email>
<idno type="halauthorid">222056</idno>
<affiliation ref="#struct-27478"></affiliation>
<affiliation ref="#struct-5"></affiliation>
</author>
<editor role="depositor"> <persName> <forename>Tristan</forename>
<surname>Ferry</surname>
</persName>
<email type="md5">cd9b59c352edc99e1f63d457aa3a8cf4</email>
<email type="domain">univ-lyon1.fr</email>
</editor>
</titleStmt>
<editionStmt> <edition n="v1"> <date type="whenSubmitted">2007-11-03 10:00:58</date>
</edition>
<edition n="v2" type="current"> <date type="whenSubmitted">2007-11-11 18:52:05</date>
<date type="whenModified">2020-04-10 17:23:57</date>
<date type="whenReleased">2007-11-12 08:52:15</date>
<date type="whenProduced">2007-10-16</date>
<date type="whenEndEmbargoed">2007-11-11</date>
<ref type="file" target="https://tel.archives-ouvertes.fr/tel-00184923v2/document"> <date notBefore="2007-11-11"></date>
</ref>
<ref type="file" n="1" target="https://tel.archives-ouvertes.fr/tel-00184923/file/TheseFerry2007.pdf"> <date notBefore="2007-11-11"></date>
</ref>
<ref type="annex" subtype="other" n="0" target="https://tel.archives-ouvertes.fr/tel-00184923/file/Soutenance.pdf"> <date notBefore="2007-11-11"></date>
</ref>
</edition>
<respStmt> <resp>contributor</resp>
<name key="121987"> <persName> <forename>Tristan</forename>
<surname>Ferry</surname>
</persName>
<email type="md5">cd9b59c352edc99e1f63d457aa3a8cf4</email>
<email type="domain">univ-lyon1.fr</email>
</name>
</respStmt>
</editionStmt>
<publicationStmt> <distributor>CCSD</distributor>
<idno type="halId">tel-00184923</idno>
<idno type="halUri">https://tel.archives-ouvertes.fr/tel-00184923</idno>
<idno type="halBibtex">ferry:tel-00184923</idno>
<idno type="halRefHtml">Autre [q-bio.OT]. Université Claude Bernard - Lyon I, 2007. Français</idno>
<idno type="halRef">Autre [q-bio.OT]. Université Claude Bernard - Lyon I, 2007. Français</idno>
</publicationStmt>
<seriesStmt> <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno>
<idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
<idno type="stamp" n="LPTENS" corresp="ENS-PARIS">Laboratoire de Physique Théorique de l'Ecole Normale Supérieure</idno>
<idno type="stamp" n="ENS-PARIS">Ecole Normale Supérieure de Paris</idno>
<idno type="stamp" n="UPMC" corresp="SORBONNE-UNIVERSITE">Université Pierre et Marie Curie</idno>
<idno type="stamp" n="GIP-BE">GIP Bretagne Environnement</idno>
<idno type="stamp" n="PSL">Paris Sciences et Lettres (PSL) Research University</idno>
<idno type="stamp" n="UPMC_POLE_2" corresp="UPMC">UPMC Pôle 2</idno>
<idno type="stamp" n="UNIV-LYON1">Université Claude Bernard - Lyon I</idno>
<idno type="stamp" n="SORBONNE-UNIVERSITE">Sorbonne Université</idno>
<idno type="stamp" n="SU-SCIENCES" corresp="SORBONNE-UNIVERSITE">Faculté des Sciences de Sorbonne Université</idno>
<idno type="stamp" n="UDL">UDL</idno>
<idno type="stamp" n="UNIV-LYON">Université de Lyon</idno>
<idno type="stamp" n="UP-SCIENCES">Université de Paris - Faculté des Sciences</idno>
</seriesStmt>
<notesStmt></notesStmt>
<sourceDesc> <biblStruct> <analytic> <title xml:lang="en">Involvement of superantigenic toxins in the process of staphylococcus aureus toxic and septic shock</title>
<title xml:lang="fr">Rôle des exotoxines superantigéniques dans le choc toxique et le choc septique à Staphylococcus aureus</title>
<author role="aut"> <persName> <forename type="first">Tristan</forename>
<surname>Ferry</surname>
</persName>
<email type="md5">cd9b59c352edc99e1f63d457aa3a8cf4</email>
<email type="domain">univ-lyon1.fr</email>
<idno type="halauthorid">222056</idno>
<affiliation ref="#struct-27478"></affiliation>
<affiliation ref="#struct-5"></affiliation>
</author>
</analytic>
<monogr> <imprint> <date type="dateDefended">2007-10-16</date>
</imprint>
<authority type="institution">Université Claude Bernard - Lyon I</authority>
<authority type="school">EVOLUTION, ECOSYSTEMES, MICROBIOLOGIE, MODELISATION (E2M2)</authority>
<authority type="supervisor">Jérôme Etienne(jetiennne@univ-lyon1.fr)</authority>
<authority type="jury">Dominique Peyramond (Président)</authority>
<authority type="jury">Anne-Claude Cremieux (Rapporteur)</authority>
<authority type="jury">Jean-François Timsit (Rapporteur)</authority>
<authority type="jury">Frederic Lucht</authority>
<authority type="jury">Guillaume Monneret</authority>
</monogr>
</biblStruct>
</sourceDesc>
<profileDesc> <langUsage> <language ident="fr">French</language>
</langUsage>
<textClass> <keywords scheme="author"> <term xml:lang="en">superantigenic toxin</term>
<term xml:lang="en">toxic choc syndrome</term>
<term xml:lang="en">septic shock</term>
<term xml:lang="en">pandemic MRSA clone</term>
<term xml:lang="fr">S. aureus</term>
<term xml:lang="fr">exotoxine superantigénique</term>
<term xml:lang="fr">choc toxique staphylococcique</term>
<term xml:lang="fr">choc septique</term>
<term xml:lang="fr">clone SARM pandémique</term>
</keywords>
<classCode scheme="halDomain" n="sdv.ot">Life Sciences [q-bio]/Other [q-bio.OT]</classCode>
<classCode scheme="halDomain" n="sdv.ee">Life Sciences [q-bio]/Ecology, environment</classCode>
<classCode scheme="halDomain" n="sdv.imm">Life Sciences [q-bio]/Immunology</classCode>
<classCode scheme="halTypology" n="THESE">Theses</classCode>
</textClass>
<abstract xml:lang="en"> <p>S. aureus can produce a wide range of virulence factors. Superantigenic toxins are responsible for a pro-inflammatory response during staphylococcal toxic shock syndrome (STSS) and are suspected to be involved in the process of S. aureus septic shock. These molecules bypass the normal antigen presentation by cross-linking the major histocompatibility complex class II molecules of antigen-presentating cells to the Vbeta domain of the T-cell receptor. By this way, each superantigenic toxin selectively stimulates and expands one or several Vbeta subsets producing a Vbeta signature.
We firstly showed in patients with menstrual and non-menstrual STSS due to the production of TSST-1 or SEB, that the Vbeta signature of the toxin could be detected in the Vbeta repertoire of patients at the early stage of the disease. Secondly, during S. aureus bacteremia, the prevalence of the gene encoding SEA was higher when septic shock occurred and the major meticillin-resistant S. aureus (MRSA) clone in France, named “clone Lyon” harbored this gene. in vitro, SEA induced a strong pro-inflammatory response that may enhanced the pro-inflammatory cascade during septic shock. However, the Vbeta signature of SEA has not been detected in patients with S. aureus (including MRSA) septic shock infected with a stain that produced SEA in vitro. Finally, in an animal model of sepsis, Lyon clone MRSA isolates induced a higher rate of mortality than meticillin-susceptible isolates, but this was not directly attributable to SEA.
The detection of a production of superantigenic toxins in vivo may lead to an early diagnosis of STSS and may facilitate the introduction of anti-toxinic agents that may improve the prognosis. The involvement of superantigenic toxins and especially SEA, in the pathophysiology of S. aureus septic shock remained uncertain.</p>
</abstract>
<abstract xml:lang="fr"> <p>S. aureus peut produire de très nombreux facteurs de virulence. Les exotoxines superantigéniques sont responsables de la réponse pro-inflammatoire observée au cours du choc toxique staphylococcique et sont suspectées d'être impliquées dans le choc septique à S. aureus. En se fixant sur la partie variable Vbeta du récepteur T des lymphocytes T, ces toxines induisent une prolifération lymphocytaire T Vbeta dépendante et chacune de ces toxines a théoriquement une « signature Vbeta » spécifique.
Chez des patients présentant un choc toxique menstruel ou non-menstruel, nous avons respectivement retrouvé la signature des toxines TSST-1 ou SEB à la phase aiguë de la maladie, après avoir identifié in vitro la signature Vbeta des principales exotoxines superantigéniques. Au cours de bactériémies à S. aureus, les isolats responsables de choc septique possédaient plus fréquemment le gène codant la toxine SEA et le clone de S. aureus résistant à la méticilline prédominant en France (dénommé clone Lyon) possédait également ce gène. De plus, SEA a des propriétés pro-inflammatoires particulières que nous avons documentées in vitro. Cela renforcait l'hypothèse que SEA est impliqué dans le choc septique à S. aureus. Cependant, la signature Vbeta de SEA n'a pas été retrouvée chez des patients présentant un choc septique à S. aureus (sensible ou résistant à la méticilline) et dans un modèle animal de choc septique, le clone Lyon induisait certes une plus grande mortalité par rapport à des isolats sensibles à la méticilline, mais celle-ci n'était pas directement attribuable à SEA.
La mise en évidence in vivo de la signature Vbeta des exotoxines superantigéniques au cours du choc toxique staphylococcique permet de préciser quelle toxine est en cause, permet de faire le diagnostic plus précocement et facilite l'optimisation du traitement de cette pathologie. L'implication des exotoxines superantigéniques et notamment de SEA, dans le choc septique qui résulte de l'expression de multiples facteurs de virulence, reste incertaine.</p>
</abstract>
</profileDesc>
</hal>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/PandemieGrippaleV1/Data/Hal/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000349 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Hal/Curation/biblio.hfd -nk 000349 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= PandemieGrippaleV1 |flux= Hal |étape= Curation |type= RBID |clé= Hal:tel-00184923 |texte= Involvement of superantigenic toxins in the process of staphylococcus aureus toxic and septic shock }}
![]() | This area was generated with Dilib version V0.6.34. | ![]() |