Effectiveness of neuraminidase inhibitors in reducing mortality in patients admitted to hospital with influenza A H1N1pdm09 virus infection: an individual participant data meta-analysis
Identifieur interne : 000181 ( Hal/Curation ); précédent : 000180; suivant : 000182Effectiveness of neuraminidase inhibitors in reducing mortality in patients admitted to hospital with influenza A H1N1pdm09 virus infection: an individual participant data meta-analysis
Auteurs : Stella G. Muthuri ; Sudhir Venkatesan ; Puja R. Myles ; Jo Leonardi-Bee ; Tarig S. A. Al Khuwaitir ; Adbullah Al Mamun ; Ashish P. Anovadiya ; Eduardo Azziz-Baumgartner ; Clarisa Báez ; Matteo Bassetti ; Bojana Beovic ; Barbara Bertisch ; Isabelle Bonmarin [France] ; Robert Booy ; Victor H. Borja-Aburto ; Heinz Burgmann ; Bin Cao [République populaire de Chine] ; Jordi Carratala ; Justin T. Denholm ; Samuel R. Dominguez ; Pericles A. D. Duarte ; Gal Dubnov-Raz ; Marcela Echavarria ; Sergio Fanella ; Zhancheng Gao [République populaire de Chine] ; Patrick Gérardin [Réunion] ; Maddalena Giannella ; Sophie Gubbels ; Jethro Herberg ; Anjarath L. H. Iglesias ; Peter H. Hoger ; Xiaoyun Hu ; Quazi T. Islam ; Mirela F. Jiménez ; Amr Kandeel ; Gerben Keijzers ; Hossein Khalili ; Marian Knight [Royaume-Uni] ; Koichiro Kudo ; Gabriela Kusznierz ; Ilija Kuzman ; Arthur M. C. Kwan ; Idriss L. Amine ; Eduard Langenegger ; Kamran B. Lankarani ; Yee-Sin Leo ; Rita Linko ; Pei Liu ; Faris Madanat ; Elga Mayo-Montero ; Allison Mcgeer ; Ziad Memish ; Gokhan Metan ; Auks Mickiene ; Dragan Miki ; Kristin G. I. Mohn ; Ahmadreza Moradi ; Pagbajabyn Nymadawa ; Maria E. Oliva ; Mehpare Ozkan ; Dhruv Parekh ; Mical Paul ; Fernando P. Polack ; Barbara A. Rath ; Alejandro H. Rodríguez ; Elena B. Sarrouf ; Anna C. Seale ; Bunyamin Sertogullarindan ; Marilda M. Siqueira ; Joanna Skr T-Magierło ; Frank Stephan ; Ewa Talarek ; Julian W. Tang ; Kelvin K. W. To ; Antoni Torres ; Selda H. Törün ; Dat Tran ; Timothy M. Uyeki ; Annelies Van Zwol ; Wendy Vaudry ; Tjasa Vidmar ; Renata T. C. Yokota ; Paul Zarogoulidis ; Jonathan S. Nguyen-Van-TamSource :
- Lancet Respiratory medicine [ 2213-2600 ] ; 2014.
Abstract
Background: Neuraminidase inhibitors were widely used during the 2009–10 influenza A H1N1 pandemic, but evidence for their effectiveness in reducing mortality is uncertain. We did a meta-analysis of individual participant data to investigate the association between use of neuraminidase inhibitors and mortality in patients admitted to hospital with pandemic influenza A H1N1pdm09 virus infection.Methods: We assembled data for patients (all ages) admitted to hospital worldwide with laboratory confirmed or clinically diagnosed pandemic influenza A H1N1pdm09 virus infection. We identified potential data contributors from an earlier systematic review of reported studies addressing the same research question. In our systematic review, eligible studies were done between March 1, 2009 (Mexico), or April 1, 2009 (rest of the world), until the WHO declaration of the end of the pandemic (Aug 10, 2010); however, we continued to receive data up to March 14, 2011, from ongoing studies. We did a meta-analysis of individual participant data to assess the association between neuraminidase inhibitor treatment and mortality (primary outcome), adjusting for both treatment propensity and potential confounders, using generalised linear mixed modelling. We assessed the association with time to treatment using time-dependent Cox regression shared frailty modelling.Findings: We included data for 29 234 patients from 78 studies of patients admitted to hospital between Jan 2, 2009, and March 14, 2011. Compared with no treatment, neuraminidase inhibitor treatment (irrespective of timing) was associated with a reduction in mortality risk (adjusted odds ratio [OR] 0·81; 95% CI 0·70–0·93; p=0·0024). Compared with later treatment, early treatment (within 2 days of symptom onset) was associated with a reduction in mortality risk (adjusted OR 0·48; 95% CI 0·41–0·56; p<0·0001). Early treatment versus no treatment was also associated with a reduction in mortality (adjusted OR 0·50; 95% CI 0·37–0·67; p<0·0001). These associations with reduced mortality risk were less pronounced and not significant in children. There was an increase in the mortality hazard rate with each day's delay in initiation of treatment up to day 5 as compared with treatment initiated within 2 days of symptom onset (adjusted hazard ratio [HR 1·23] [95% CI 1·18–1·28]; p<0·0001 for the increasing HR with each day's delay).Interpretation: We advocate early instigation of neuraminidase inhibitor treatment in adults admitted to hospital with suspected or proven influenza infection. Funding F Hoffmann-La Roche.
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DOI: 10.1016/S2213-2600(14)70041-4
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To</name></author><author><name sortKey="Torres, Antoni" sort="Torres, Antoni" uniqKey="Torres A" first="Antoni" last="Torres">Antoni Torres</name></author><author><name sortKey="Torun, Selda H" sort="Torun, Selda H" uniqKey="Torun S" first="Selda H." last="Törün">Selda H. Törün</name></author><author><name sortKey="Tran, Dat" sort="Tran, Dat" uniqKey="Tran D" first="Dat" last="Tran">Dat Tran</name></author><author><name sortKey="Uyeki, Timothy M" sort="Uyeki, Timothy M" uniqKey="Uyeki T" first="Timothy M." last="Uyeki">Timothy M. Uyeki</name></author><author><name sortKey="Van Zwol, Annelies" sort="Van Zwol, Annelies" uniqKey="Van Zwol A" first="Annelies" last="Van Zwol">Annelies Van Zwol</name></author><author><name sortKey="Vaudry, Wendy" sort="Vaudry, Wendy" uniqKey="Vaudry W" first="Wendy" last="Vaudry">Wendy Vaudry</name></author><author><name sortKey="Vidmar, Tjasa" sort="Vidmar, Tjasa" uniqKey="Vidmar T" first="Tjasa" last="Vidmar">Tjasa Vidmar</name></author><author><name sortKey="Yokota, Renata T C" sort="Yokota, Renata T C" uniqKey="Yokota R" first="Renata T. C." last="Yokota">Renata T. C. Yokota</name></author><author><name sortKey="Zarogoulidis, Paul" sort="Zarogoulidis, Paul" uniqKey="Zarogoulidis P" first="Paul" last="Zarogoulidis">Paul Zarogoulidis</name></author><author><name sortKey="Nguyen Van Tam, Jonathan S" sort="Nguyen Van Tam, Jonathan S" uniqKey="Nguyen Van Tam J" first="Jonathan S." last="Nguyen-Van-Tam">Jonathan S. Nguyen-Van-Tam</name></author></titleStmt><publicationStmt><idno type="wicri:source">HAL</idno><idno type="RBID">Hal:hal-01274568</idno><idno type="halId">hal-01274568</idno><idno type="halUri">https://hal.univ-reunion.fr/hal-01274568</idno><idno type="url">https://hal.univ-reunion.fr/hal-01274568</idno><idno type="doi">10.1016/S2213-2600(14)70041-4</idno><date when="2014">2014</date><idno type="wicri:Area/Hal/Corpus">000181</idno><idno type="wicri:Area/Hal/Curation">000181</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Effectiveness of neuraminidase inhibitors in reducing mortality in patients admitted to hospital with influenza A H1N1pdm09 virus infection: an individual participant data meta-analysis</title><author><name sortKey="Muthuri, Stella G" sort="Muthuri, Stella G" uniqKey="Muthuri S" first="Stella G." last="Muthuri">Stella G. Muthuri</name></author><author><name sortKey="Venkatesan, Sudhir" sort="Venkatesan, Sudhir" uniqKey="Venkatesan S" first="Sudhir" last="Venkatesan">Sudhir Venkatesan</name></author><author><name sortKey="Myles, Puja R" sort="Myles, Puja R" uniqKey="Myles P" first="Puja R." last="Myles">Puja R. Myles</name></author><author><name sortKey="Leonardi Bee, Jo" sort="Leonardi Bee, Jo" uniqKey="Leonardi Bee J" first="Jo" last="Leonardi-Bee">Jo Leonardi-Bee</name></author><author><name sortKey="Al Khuwaitir, Tarig S A" sort="Al Khuwaitir, Tarig S A" uniqKey="Al Khuwaitir T" first="Tarig S. A." last="Al Khuwaitir">Tarig S. A. Al Khuwaitir</name></author><author><name sortKey="Al Mamun, Adbullah" sort="Al Mamun, Adbullah" uniqKey="Al Mamun A" first="Adbullah" last="Al Mamun">Adbullah Al Mamun</name></author><author><name sortKey="Anovadiya, Ashish P" sort="Anovadiya, Ashish P" uniqKey="Anovadiya A" first="Ashish P." last="Anovadiya">Ashish P. Anovadiya</name></author><author><name sortKey="Azziz Baumgartner, Eduardo" sort="Azziz Baumgartner, Eduardo" uniqKey="Azziz Baumgartner E" first="Eduardo" last="Azziz-Baumgartner">Eduardo Azziz-Baumgartner</name></author><author><name sortKey="Baez, Clarisa" sort="Baez, Clarisa" uniqKey="Baez C" first="Clarisa" last="Báez">Clarisa Báez</name></author><author><name sortKey="Bassetti, Matteo" sort="Bassetti, Matteo" uniqKey="Bassetti M" first="Matteo" last="Bassetti">Matteo Bassetti</name></author><author><name sortKey="Beovic, Bojana" sort="Beovic, Bojana" uniqKey="Beovic B" first="Bojana" last="Beovic">Bojana Beovic</name></author><author><name sortKey="Bertisch, Barbara" sort="Bertisch, Barbara" uniqKey="Bertisch B" first="Barbara" last="Bertisch">Barbara Bertisch</name></author><author><name sortKey="Bonmarin, Isabelle" sort="Bonmarin, Isabelle" uniqKey="Bonmarin I" first="Isabelle" last="Bonmarin">Isabelle Bonmarin</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-9892" status="VALID"> <orgName>Département des maladies infectieuses</orgName> <desc> <address> <addrLine>12, rue du vals D'Osne 94415 St Maurice Cedex</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300053" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300053" type="direct"><org type="institution" xml:id="struct-300053" status="VALID"> <orgName>Institut de Veille Sanitaire </orgName> <orgName type="acronym">INVS</orgName> <desc> <address> <addrLine>12 rue du Val d'Osne, 94415 Saint Maurice Cedex, France</addrLine> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Booy, Robert" sort="Booy, Robert" uniqKey="Booy R" first="Robert" last="Booy">Robert Booy</name></author><author><name sortKey="Borja Aburto, Victor H" sort="Borja Aburto, Victor H" uniqKey="Borja Aburto V" first="Victor H." last="Borja-Aburto">Victor H. Borja-Aburto</name></author><author><name sortKey="Burgmann, Heinz" sort="Burgmann, Heinz" uniqKey="Burgmann H" first="Heinz" last="Burgmann">Heinz Burgmann</name></author><author><name sortKey="Cao, Bin" sort="Cao, Bin" uniqKey="Cao B" first="Bin" last="Cao">Bin Cao</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-222142" status="INCOMING"> <orgName>Beijing Chao-Yang Hospital</orgName> <desc> <address> <addrLine>Beijing</addrLine> <country key="CN"></country> </address> </desc> <listRelation> <relation active="#struct-354012" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-354012" type="direct"><org type="institution" xml:id="struct-354012" status="INCOMING"> <orgName>Beijing Institute of Respiratory Diseases</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Carratala, Jordi" sort="Carratala, Jordi" uniqKey="Carratala J" first="Jordi" last="Carratala">Jordi Carratala</name></author><author><name sortKey="Denholm, Justin T" sort="Denholm, Justin T" uniqKey="Denholm J" first="Justin T." last="Denholm">Justin T. Denholm</name></author><author><name sortKey="Dominguez, Samuel R" sort="Dominguez, Samuel R" uniqKey="Dominguez S" first="Samuel R." last="Dominguez">Samuel R. Dominguez</name></author><author><name sortKey="Duarte, Pericles A D" sort="Duarte, Pericles A D" uniqKey="Duarte P" first="Pericles A. D." last="Duarte">Pericles A. D. Duarte</name></author><author><name sortKey="Dubnov Raz, Gal" sort="Dubnov Raz, Gal" uniqKey="Dubnov Raz G" first="Gal" last="Dubnov-Raz">Gal Dubnov-Raz</name></author><author><name sortKey="Echavarria, Marcela" sort="Echavarria, Marcela" uniqKey="Echavarria M" first="Marcela" last="Echavarria">Marcela Echavarria</name></author><author><name sortKey="Fanella, Sergio" sort="Fanella, Sergio" uniqKey="Fanella S" first="Sergio" last="Fanella">Sergio Fanella</name></author><author><name sortKey="Gao, Zhancheng" sort="Gao, Zhancheng" uniqKey="Gao Z" first="Zhancheng" last="Gao">Zhancheng Gao</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-222150" status="INCOMING"> <orgName>Peking University People's Hospital</orgName> <desc> <address> <addrLine>Beijing</addrLine> <country key="CN"></country> </address> </desc> <listRelation> <relation active="#struct-354017" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-354017" type="direct"><org type="institution" xml:id="struct-354017" status="INCOMING"> <orgName>Peking University People's Hospital</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>République populaire de Chine</country></affiliation></author><author><name sortKey="Gerardin, Patrick" sort="Gerardin, Patrick" uniqKey="Gerardin P" first="Patrick" last="Gérardin">Patrick Gérardin</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-214256" status="INCOMING"> <orgName>Réanimation médicale néonatale et pédiatrique</orgName> <desc> <address> <addrLine>avenue Francois mitterand 97410 Saint-Pierre</addrLine> <country key="RE"></country> </address> </desc> <listRelation> <relation active="#struct-352243" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-352243" type="direct"><org type="institution" xml:id="struct-352243" status="INCOMING"> <orgName>CHR la Reunion site Sud</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>Réunion</country></affiliation></author><author><name sortKey="Giannella, Maddalena" sort="Giannella, Maddalena" uniqKey="Giannella M" first="Maddalena" last="Giannella">Maddalena Giannella</name></author><author><name sortKey="Gubbels, Sophie" sort="Gubbels, Sophie" uniqKey="Gubbels S" first="Sophie" last="Gubbels">Sophie Gubbels</name></author><author><name sortKey="Herberg, Jethro" sort="Herberg, Jethro" uniqKey="Herberg J" first="Jethro" last="Herberg">Jethro Herberg</name></author><author><name sortKey="Iglesias, Anjarath L H" sort="Iglesias, Anjarath L H" uniqKey="Iglesias A" first="Anjarath L. H." last="Iglesias">Anjarath L. H. Iglesias</name></author><author><name sortKey="Hoger, Peter H" sort="Hoger, Peter H" uniqKey="Hoger P" first="Peter H." last="Hoger">Peter H. Hoger</name></author><author><name sortKey="Hu, Xiaoyun" sort="Hu, Xiaoyun" uniqKey="Hu X" first="Xiaoyun" last="Hu">Xiaoyun Hu</name></author><author><name sortKey="Islam, Quazi T" sort="Islam, Quazi T" uniqKey="Islam Q" first="Quazi T." last="Islam">Quazi T. Islam</name></author><author><name sortKey="Jimenez, Mirela F" sort="Jimenez, Mirela F" uniqKey="Jimenez M" first="Mirela F." last="Jiménez">Mirela F. Jiménez</name></author><author><name sortKey="Kandeel, Amr" sort="Kandeel, Amr" uniqKey="Kandeel A" first="Amr" last="Kandeel">Amr Kandeel</name></author><author><name sortKey="Keijzers, Gerben" sort="Keijzers, Gerben" uniqKey="Keijzers G" first="Gerben" last="Keijzers">Gerben Keijzers</name></author><author><name sortKey="Khalili, Hossein" sort="Khalili, Hossein" uniqKey="Khalili H" first="Hossein" last="Khalili">Hossein Khalili</name></author><author><name sortKey="Knight, Marian" sort="Knight, Marian" uniqKey="Knight M" first="Marian" last="Knight">Marian Knight</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-157448" status="INCOMING"> <orgName>National Perinatal Epidemiology Unit</orgName> <desc> <address> <addrLine>Oxford</addrLine> <country key="GB"></country> </address> </desc> <listRelation> <relation active="#struct-302612" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-302612" type="direct"><org type="institution" xml:id="struct-302612" status="VALID"> <orgName>University of Oxford [Oxford]</orgName> <desc> <address> <addrLine>Wellington Square, Oxford OX1 2JD</addrLine> <country key="GB"></country> </address> <ref type="url">http://www.ox.ac.uk/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Royaume-Uni</country></affiliation></author><author><name sortKey="Kudo, Koichiro" sort="Kudo, Koichiro" uniqKey="Kudo K" first="Koichiro" last="Kudo">Koichiro Kudo</name></author><author><name sortKey="Kusznierz, Gabriela" sort="Kusznierz, Gabriela" uniqKey="Kusznierz G" first="Gabriela" last="Kusznierz">Gabriela Kusznierz</name></author><author><name sortKey="Kuzman, Ilija" sort="Kuzman, Ilija" uniqKey="Kuzman I" first="Ilija" last="Kuzman">Ilija Kuzman</name></author><author><name sortKey="Kwan, Arthur M C" sort="Kwan, Arthur M C" uniqKey="Kwan A" first="Arthur M. C." last="Kwan">Arthur M. C. Kwan</name></author><author><name sortKey="Amine, Idriss L" sort="Amine, Idriss L" uniqKey="Amine I" first="Idriss L." last="Amine">Idriss L. Amine</name></author><author><name sortKey="Langenegger, Eduard" sort="Langenegger, Eduard" uniqKey="Langenegger E" first="Eduard" last="Langenegger">Eduard Langenegger</name></author><author><name sortKey="Lankarani, Kamran B" sort="Lankarani, Kamran B" uniqKey="Lankarani K" first="Kamran B." last="Lankarani">Kamran B. Lankarani</name></author><author><name sortKey="Leo, Yee Sin" sort="Leo, Yee Sin" uniqKey="Leo Y" first="Yee-Sin" last="Leo">Yee-Sin Leo</name></author><author><name sortKey="Linko, Rita" sort="Linko, Rita" uniqKey="Linko R" first="Rita" last="Linko">Rita Linko</name></author><author><name sortKey="Liu, Pei" sort="Liu, Pei" uniqKey="Liu P" first="Pei" last="Liu">Pei Liu</name></author><author><name sortKey="Madanat, Faris" sort="Madanat, Faris" uniqKey="Madanat F" first="Faris" last="Madanat">Faris Madanat</name></author><author><name sortKey="Mayo Montero, Elga" sort="Mayo Montero, Elga" uniqKey="Mayo Montero E" first="Elga" last="Mayo-Montero">Elga Mayo-Montero</name></author><author><name sortKey="Mcgeer, Allison" sort="Mcgeer, Allison" uniqKey="Mcgeer A" first="Allison" last="Mcgeer">Allison Mcgeer</name></author><author><name sortKey="Memish, Ziad" sort="Memish, Ziad" uniqKey="Memish Z" first="Ziad" last="Memish">Ziad Memish</name></author><author><name sortKey="Metan, Gokhan" sort="Metan, Gokhan" uniqKey="Metan G" first="Gokhan" last="Metan">Gokhan Metan</name></author><author><name sortKey="Mickiene, Auks" sort="Mickiene, Auks" uniqKey="Mickiene A" first="Auks" last="Mickiene">Auks Mickiene</name></author><author><name sortKey="Miki, Dragan" sort="Miki, Dragan" uniqKey="Miki D" first="Dragan" last="Miki">Dragan Miki</name></author><author><name sortKey="Mohn, Kristin G I" sort="Mohn, Kristin G I" uniqKey="Mohn K" first="Kristin G. I." last="Mohn">Kristin G. I. Mohn</name></author><author><name sortKey="Moradi, Ahmadreza" sort="Moradi, Ahmadreza" uniqKey="Moradi A" first="Ahmadreza" last="Moradi">Ahmadreza Moradi</name></author><author><name sortKey="Nymadawa, Pagbajabyn" sort="Nymadawa, Pagbajabyn" uniqKey="Nymadawa P" first="Pagbajabyn" last="Nymadawa">Pagbajabyn Nymadawa</name></author><author><name sortKey="Oliva, Maria E" sort="Oliva, Maria E" uniqKey="Oliva M" first="Maria E." last="Oliva">Maria E. Oliva</name></author><author><name sortKey="Ozkan, Mehpare" sort="Ozkan, Mehpare" uniqKey="Ozkan M" first="Mehpare" last="Ozkan">Mehpare Ozkan</name></author><author><name sortKey="Parekh, Dhruv" sort="Parekh, Dhruv" uniqKey="Parekh D" first="Dhruv" last="Parekh">Dhruv Parekh</name></author><author><name sortKey="Paul, Mical" sort="Paul, Mical" uniqKey="Paul M" first="Mical" last="Paul">Mical Paul</name></author><author><name sortKey="Polack, Fernando P" sort="Polack, Fernando P" uniqKey="Polack F" first="Fernando P." last="Polack">Fernando P. Polack</name></author><author><name sortKey="Rath, Barbara A" sort="Rath, Barbara A" uniqKey="Rath B" first="Barbara A." last="Rath">Barbara A. Rath</name></author><author><name sortKey="Rodriguez, Alejandro H" sort="Rodriguez, Alejandro H" uniqKey="Rodriguez A" first="Alejandro H." last="Rodríguez">Alejandro H. Rodríguez</name></author><author><name sortKey="Sarrouf, Elena B" sort="Sarrouf, Elena B" uniqKey="Sarrouf E" first="Elena B." last="Sarrouf">Elena B. Sarrouf</name></author><author><name sortKey="Seale, Anna C" sort="Seale, Anna C" uniqKey="Seale A" first="Anna C." last="Seale">Anna C. Seale</name></author><author><name sortKey="Sertogullarindan, Bunyamin" sort="Sertogullarindan, Bunyamin" uniqKey="Sertogullarindan B" first="Bunyamin" last="Sertogullarindan">Bunyamin Sertogullarindan</name></author><author><name sortKey="Siqueira, Marilda M" sort="Siqueira, Marilda M" uniqKey="Siqueira M" first="Marilda M." last="Siqueira">Marilda M. Siqueira</name></author><author><name sortKey="Skr T Magierlo, Joanna" sort="Skr T Magierlo, Joanna" uniqKey="Skr T Magierlo J" first="Joanna" last="Skr T-Magierło">Joanna Skr T-Magierło</name></author><author><name sortKey="Stephan, Frank" sort="Stephan, Frank" uniqKey="Stephan F" first="Frank" last="Stephan">Frank Stephan</name></author><author><name sortKey="Talarek, Ewa" sort="Talarek, Ewa" uniqKey="Talarek E" first="Ewa" last="Talarek">Ewa Talarek</name></author><author><name sortKey="Tang, Julian W" sort="Tang, Julian W" uniqKey="Tang J" first="Julian W." last="Tang">Julian W. Tang</name></author><author><name sortKey="To, Kelvin K W" sort="To, Kelvin K W" uniqKey="To K" first="Kelvin K. W." last="To">Kelvin K. W. To</name></author><author><name sortKey="Torres, Antoni" sort="Torres, Antoni" uniqKey="Torres A" first="Antoni" last="Torres">Antoni Torres</name></author><author><name sortKey="Torun, Selda H" sort="Torun, Selda H" uniqKey="Torun S" first="Selda H." last="Törün">Selda H. Törün</name></author><author><name sortKey="Tran, Dat" sort="Tran, Dat" uniqKey="Tran D" first="Dat" last="Tran">Dat Tran</name></author><author><name sortKey="Uyeki, Timothy M" sort="Uyeki, Timothy M" uniqKey="Uyeki T" first="Timothy M." last="Uyeki">Timothy M. Uyeki</name></author><author><name sortKey="Van Zwol, Annelies" sort="Van Zwol, Annelies" uniqKey="Van Zwol A" first="Annelies" last="Van Zwol">Annelies Van Zwol</name></author><author><name sortKey="Vaudry, Wendy" sort="Vaudry, Wendy" uniqKey="Vaudry W" first="Wendy" last="Vaudry">Wendy Vaudry</name></author><author><name sortKey="Vidmar, Tjasa" sort="Vidmar, Tjasa" uniqKey="Vidmar T" first="Tjasa" last="Vidmar">Tjasa Vidmar</name></author><author><name sortKey="Yokota, Renata T C" sort="Yokota, Renata T C" uniqKey="Yokota R" first="Renata T. C." last="Yokota">Renata T. C. Yokota</name></author><author><name sortKey="Zarogoulidis, Paul" sort="Zarogoulidis, Paul" uniqKey="Zarogoulidis P" first="Paul" last="Zarogoulidis">Paul Zarogoulidis</name></author><author><name sortKey="Nguyen Van Tam, Jonathan S" sort="Nguyen Van Tam, Jonathan S" uniqKey="Nguyen Van Tam J" first="Jonathan S." last="Nguyen-Van-Tam">Jonathan S. Nguyen-Van-Tam</name></author></analytic><idno type="DOI">10.1016/S2213-2600(14)70041-4</idno><series><title level="j">Lancet Respiratory medicine</title><idno type="ISSN">2213-2600</idno><imprint><date type="datePub">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"> <p>Background: Neuraminidase inhibitors were widely used during the 2009–10 influenza A H1N1 pandemic, but evidence for their effectiveness in reducing mortality is uncertain. We did a meta-analysis of individual participant data to investigate the association between use of neuraminidase inhibitors and mortality in patients admitted to hospital with pandemic influenza A H1N1pdm09 virus infection.Methods: We assembled data for patients (all ages) admitted to hospital worldwide with laboratory confirmed or clinically diagnosed pandemic influenza A H1N1pdm09 virus infection. We identified potential data contributors from an earlier systematic review of reported studies addressing the same research question. In our systematic review, eligible studies were done between March 1, 2009 (Mexico), or April 1, 2009 (rest of the world), until the WHO declaration of the end of the pandemic (Aug 10, 2010); however, we continued to receive data up to March 14, 2011, from ongoing studies. We did a meta-analysis of individual participant data to assess the association between neuraminidase inhibitor treatment and mortality (primary outcome), adjusting for both treatment propensity and potential confounders, using generalised linear mixed modelling. We assessed the association with time to treatment using time-dependent Cox regression shared frailty modelling.Findings: We included data for 29 234 patients from 78 studies of patients admitted to hospital between Jan 2, 2009, and March 14, 2011. Compared with no treatment, neuraminidase inhibitor treatment (irrespective of timing) was associated with a reduction in mortality risk (adjusted odds ratio [OR] 0·81; 95% CI 0·70–0·93; p=0·0024). Compared with later treatment, early treatment (within 2 days of symptom onset) was associated with a reduction in mortality risk (adjusted OR 0·48; 95% CI 0·41–0·56; p<0·0001). Early treatment versus no treatment was also associated with a reduction in mortality (adjusted OR 0·50; 95% CI 0·37–0·67; p<0·0001). These associations with reduced mortality risk were less pronounced and not significant in children. There was an increase in the mortality hazard rate with each day's delay in initiation of treatment up to day 5 as compared with treatment initiated within 2 days of symptom onset (adjusted hazard ratio [HR 1·23] [95% CI 1·18–1·28]; p<0·0001 for the increasing HR with each day's delay).Interpretation: We advocate early instigation of neuraminidase inhibitor treatment in adults admitted to hospital with suspected or proven influenza infection. Funding F Hoffmann-La Roche.</p> </div></front></TEI><hal api="V3"> <titleStmt> <title xml:lang="en">Effectiveness of neuraminidase inhibitors in reducing mortality in patients admitted to hospital with influenza A H1N1pdm09 virus infection: an individual participant data meta-analysis</title> <author role="aut"> <persName> <forename type="first">Stella G.</forename> <surname>Muthuri</surname> </persName> <idno type="halauthorid">1294261</idno> </author> <author role="aut"> <persName> <forename type="first">Sudhir</forename> <surname>Venkatesan</surname> </persName> <idno type="halauthorid">1294262</idno> </author> <author role="aut"> <persName> <forename type="first">Puja R.</forename> <surname>Myles</surname> </persName> <idno type="halauthorid">1294263</idno> </author> <author role="aut"> <persName> <forename type="first">Jo</forename> <surname>Leonardi-Bee</surname> </persName> <idno type="halauthorid">1294264</idno> </author> <author role="aut"> <persName> <forename type="first">Tarig S. A.</forename> <surname>Al Khuwaitir</surname> </persName> <idno type="halauthorid">1294265</idno> </author> <author role="aut"> <persName> <forename type="first">Adbullah</forename> <surname>Al Mamun</surname> </persName> <idno type="halauthorid">1294266</idno> </author> <author role="aut"> <persName> <forename type="first">Ashish P.</forename> <surname>Anovadiya</surname> </persName> <idno type="halauthorid">1294267</idno> </author> <author role="aut"> <persName> <forename type="first">Eduardo</forename> <surname>Azziz-Baumgartner</surname> </persName> <idno type="halauthorid">1294268</idno> </author> <author role="aut"> <persName> <forename type="first">Clarisa</forename> <surname>Báez</surname> </persName> <idno type="halauthorid">1294269</idno> </author> <author role="aut"> <persName> <forename type="first">Matteo</forename> <surname>Bassetti</surname> </persName> <email type="md5">57000192b9c4ebe2e2f77f8427166221</email> <email type="domain">hsanmartino.it</email> <idno type="halauthorid">648706</idno> </author> <author role="aut"> <persName> <forename type="first">Bojana</forename> <surname>Beovic</surname> </persName> <idno type="halauthorid">1249337</idno> </author> <author role="aut"> <persName> <forename type="first">Barbara</forename> <surname>Bertisch</surname> </persName> <idno type="halauthorid">1294270</idno> </author> <author role="aut"> <persName> <forename type="first">Isabelle</forename> <surname>Bonmarin</surname> </persName> <email type="md5">1dd8ae6fc547beb58b0a173bb55f4e86</email> <email type="domain">invs.sante.fr</email> <idno type="halauthorid">665610</idno> <affiliation ref="#struct-9892"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Robert</forename> <surname>Booy</surname> </persName> <idno type="halauthorid">1294271</idno> </author> <author role="aut"> <persName> <forename type="first">Victor H.</forename> <surname>Borja-Aburto</surname> </persName> <idno type="halauthorid">1294272</idno> </author> <author role="aut"> <persName> <forename type="first">Heinz</forename> <surname>Burgmann</surname> </persName> <idno type="halauthorid">1294273</idno> </author> <author role="aut"> <persName> <forename type="first">Bin</forename> <surname>Cao</surname> </persName> <idno type="halauthorid">850021</idno> <affiliation ref="#struct-222142"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Jordi</forename> <surname>Carratala</surname> </persName> <idno type="halauthorid">1294274</idno> </author> <author role="aut"> <persName> <forename type="first">Justin T.</forename> <surname>Denholm</surname> </persName> <idno type="halauthorid">1294275</idno> </author> <author role="aut"> <persName> <forename type="first">Samuel R.</forename> <surname>Dominguez</surname> </persName> <idno type="halauthorid">1294276</idno> </author> <author role="aut"> <persName> <forename type="first">Pericles A. 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C.</forename> <surname>Yokota</surname> </persName> <idno type="halauthorid">1294331</idno> </author> <author role="aut"> <persName> <forename type="first">Paul</forename> <surname>Zarogoulidis</surname> </persName> <idno type="halauthorid">1294332</idno> </author> <author role="aut"> <persName> <forename type="first">Jonathan S.</forename> <surname>Nguyen-Van-Tam</surname> </persName> <idno type="halauthorid">1294333</idno> </author> <editor role="depositor"> <persName> <forename>Réunion</forename> <surname>Univ</surname> </persName> <email type="md5">fcc6f146feaf44b21f9d6255bbfcdc9f</email> <email type="domain">univ-reunion.fr</email> </editor> </titleStmt> <editionStmt> <edition n="v1" type="current"> <date type="whenSubmitted">2018-06-21 15:05:51</date> <date type="whenModified">2019-11-07 16:10:03</date> <date type="whenReleased">2018-06-21 15:40:11</date> <date type="whenProduced">2014</date> <date type="whenEndEmbargoed">2018-06-21</date> <ref type="file" target="https://hal.univ-reunion.fr/hal-01274568/document"> <date notBefore="2018-06-21"></date> </ref> <ref type="file" subtype="author" n="1" target="https://hal.univ-reunion.fr/hal-01274568/file/Effectiveness_neuraminidase_inhibitors_reducing_mortality.pdf"> <date notBefore="2018-06-21"></date> </ref> <ref type="externalLink" target="http://spiral.imperial.ac.uk/bitstream/10044/1/29041/2/ms_lancet_resp_online_version.pdf"></ref> </edition> <respStmt> <resp>contributor</resp> <name key="313340"> <persName> <forename>Réunion</forename> <surname>Univ</surname> </persName> <email type="md5">fcc6f146feaf44b21f9d6255bbfcdc9f</email> <email type="domain">univ-reunion.fr</email> </name> </respStmt> </editionStmt> <publicationStmt> <distributor>CCSD</distributor> <idno type="halId">hal-01274568</idno> <idno type="halUri">https://hal.univ-reunion.fr/hal-01274568</idno> <idno type="halBibtex">muthuri:hal-01274568</idno> <idno type="halRefHtml">Lancet Respiratory medicine, Elsevier, 2014, 2 (5), pp.395-404. ⟨10.1016/S2213-2600(14)70041-4⟩</idno> <idno type="halRef">Lancet Respiratory medicine, Elsevier, 2014, 2 (5), pp.395-404. ⟨10.1016/S2213-2600(14)70041-4⟩</idno> </publicationStmt> <seriesStmt> <idno type="stamp" n="UNIV-REUNION">Université de la Réunion</idno> <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno> <idno type="stamp" n="INVS">Institut de veille sanitaire</idno> <idno type="stamp" n="LORIA2">Publications du LORIA</idno> <idno type="stamp" n="PIMIT" corresp="UNIV-REUNION">UMR PIMIT - Processus Infectieux en Milieu Insulaire Tropical</idno> <idno type="stamp" n="IRD">IRD - Institut de recherche pour le développement</idno> <idno type="stamp" n="PAPANGUE">Papangue</idno> </seriesStmt> <notesStmt> <note type="audience" n="2">International</note> <note type="popular" n="0">No</note> <note type="peer" n="1">Yes</note> </notesStmt> <sourceDesc> <biblStruct> <analytic> <title xml:lang="en">Effectiveness of neuraminidase inhibitors in reducing mortality in patients admitted to hospital with influenza A H1N1pdm09 virus infection: an individual participant data meta-analysis</title> <author role="aut"> <persName> <forename type="first">Stella G.</forename> <surname>Muthuri</surname> </persName> <idno type="halauthorid">1294261</idno> </author> <author role="aut"> <persName> <forename type="first">Sudhir</forename> <surname>Venkatesan</surname> </persName> <idno type="halauthorid">1294262</idno> </author> <author role="aut"> <persName> <forename type="first">Puja R.</forename> <surname>Myles</surname> </persName> <idno type="halauthorid">1294263</idno> </author> <author role="aut"> <persName> <forename type="first">Jo</forename> <surname>Leonardi-Bee</surname> </persName> <idno type="halauthorid">1294264</idno> </author> <author role="aut"> <persName> <forename type="first">Tarig S. A.</forename> <surname>Al Khuwaitir</surname> </persName> <idno type="halauthorid">1294265</idno> </author> <author role="aut"> <persName> <forename type="first">Adbullah</forename> <surname>Al Mamun</surname> </persName> <idno type="halauthorid">1294266</idno> </author> <author role="aut"> <persName> <forename type="first">Ashish P.</forename> <surname>Anovadiya</surname> </persName> <idno type="halauthorid">1294267</idno> </author> <author role="aut"> <persName> <forename type="first">Eduardo</forename> <surname>Azziz-Baumgartner</surname> </persName> <idno type="halauthorid">1294268</idno> </author> <author role="aut"> <persName> <forename type="first">Clarisa</forename> <surname>Báez</surname> </persName> <idno type="halauthorid">1294269</idno> </author> <author role="aut"> <persName> <forename type="first">Matteo</forename> <surname>Bassetti</surname> </persName> <email type="md5">57000192b9c4ebe2e2f77f8427166221</email> <email type="domain">hsanmartino.it</email> <idno type="halauthorid">648706</idno> </author> <author role="aut"> <persName> <forename type="first">Bojana</forename> <surname>Beovic</surname> </persName> <idno type="halauthorid">1249337</idno> </author> <author role="aut"> <persName> <forename type="first">Barbara</forename> <surname>Bertisch</surname> </persName> <idno type="halauthorid">1294270</idno> </author> <author role="aut"> <persName> <forename type="first">Isabelle</forename> <surname>Bonmarin</surname> </persName> <email type="md5">1dd8ae6fc547beb58b0a173bb55f4e86</email> <email type="domain">invs.sante.fr</email> <idno type="halauthorid">665610</idno> <affiliation ref="#struct-9892"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Robert</forename> <surname>Booy</surname> </persName> <idno type="halauthorid">1294271</idno> </author> <author role="aut"> <persName> <forename type="first">Victor H.</forename> <surname>Borja-Aburto</surname> </persName> <idno type="halauthorid">1294272</idno> </author> <author role="aut"> <persName> <forename type="first">Heinz</forename> <surname>Burgmann</surname> </persName> <idno type="halauthorid">1294273</idno> </author> <author role="aut"> <persName> <forename type="first">Bin</forename> <surname>Cao</surname> </persName> <idno type="halauthorid">850021</idno> <affiliation ref="#struct-222142"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Jordi</forename> <surname>Carratala</surname> </persName> <idno type="halauthorid">1294274</idno> </author> <author role="aut"> <persName> <forename type="first">Justin T.</forename> <surname>Denholm</surname> </persName> <idno type="halauthorid">1294275</idno> </author> <author role="aut"> <persName> <forename type="first">Samuel R.</forename> <surname>Dominguez</surname> </persName> <idno type="halauthorid">1294276</idno> </author> <author role="aut"> <persName> <forename type="first">Pericles A. D.</forename> <surname>Duarte</surname> </persName> <idno type="halauthorid">1294277</idno> </author> <author role="aut"> <persName> <forename type="first">Gal</forename> <surname>Dubnov-Raz</surname> </persName> <idno type="halauthorid">1294278</idno> </author> <author role="aut"> <persName> <forename type="first">Marcela</forename> <surname>Echavarria</surname> </persName> <idno type="halauthorid">1294279</idno> </author> <author role="aut"> <persName> <forename type="first">Sergio</forename> <surname>Fanella</surname> </persName> <idno type="halauthorid">1294280</idno> </author> <author role="aut"> <persName> <forename type="first">Zhancheng</forename> <surname>Gao</surname> </persName> <idno type="halauthorid">850031</idno> <affiliation ref="#struct-222150"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Patrick</forename> <surname>Gérardin</surname> </persName> <email type="md5">83a3e62cd817ac9295f42f88e6799e19</email> <email type="domain">chu-reunion.fr</email> <idno type="halauthorid">815639</idno> <affiliation ref="#struct-214256"></affiliation> <affiliation ref="#struct-22636"></affiliation> <affiliation ref="#struct-418783"></affiliation> <affiliation ref="#struct-351465"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Maddalena</forename> <surname>Giannella</surname> </persName> <idno type="halauthorid">1294281</idno> </author> <author role="aut"> <persName> <forename type="first">Sophie</forename> <surname>Gubbels</surname> </persName> <idno type="halauthorid">1294282</idno> </author> <author role="aut"> <persName> <forename type="first">Jethro</forename> <surname>Herberg</surname> </persName> <idno type="halauthorid">1294283</idno> </author> <author role="aut"> <persName> <forename type="first">Anjarath L. H.</forename> <surname>Iglesias</surname> </persName> <idno type="halauthorid">1294284</idno> </author> <author role="aut"> <persName> <forename type="first">Peter H.</forename> <surname>Hoger</surname> </persName> <idno type="halauthorid">1294285</idno> </author> <author role="aut"> <persName> <forename type="first">Xiaoyun</forename> <surname>Hu</surname> </persName> <idno type="halauthorid">1294286</idno> </author> <author role="aut"> <persName> <forename type="first">Quazi T.</forename> <surname>Islam</surname> </persName> <idno type="halauthorid">1294287</idno> </author> <author role="aut"> <persName> <forename type="first">Mirela F.</forename> <surname>Jiménez</surname> </persName> <idno type="halauthorid">1294288</idno> </author> <author role="aut"> <persName> <forename type="first">Amr</forename> <surname>Kandeel</surname> </persName> <idno type="halauthorid">862200</idno> </author> <author role="aut"> <persName> <forename type="first">Gerben</forename> <surname>Keijzers</surname> </persName> <idno type="halauthorid">1294289</idno> </author> <author role="aut"> <persName> <forename type="first">Hossein</forename> <surname>Khalili</surname> </persName> <idno type="halauthorid">1294290</idno> </author> <author role="aut"> <persName> <forename type="first">Marian</forename> <surname>Knight</surname> </persName> <email type="md5">08aeb7d9fad6198047b74b0a1478ddcd</email> <email type="domain">npeu.ox.ac.uk</email> <idno type="halauthorid">683939</idno> <affiliation ref="#struct-157448"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Koichiro</forename> <surname>Kudo</surname> </persName> <idno type="halauthorid">1294291</idno> </author> <author role="aut"> <persName> <forename type="first">Gabriela</forename> <surname>Kusznierz</surname> </persName> <idno type="halauthorid">1294292</idno> </author> <author role="aut"> <persName> <forename type="first">Ilija</forename> <surname>Kuzman</surname> </persName> <idno type="halauthorid">1294293</idno> </author> <author role="aut"> <persName> <forename type="first">Arthur M. C.</forename> <surname>Kwan</surname> </persName> <idno type="halauthorid">1294294</idno> </author> <author role="aut"> <persName> <forename type="first">Idriss L.</forename> <surname>Amine</surname> </persName> <idno type="halauthorid">1294295</idno> </author> <author role="aut"> <persName> <forename type="first">Eduard</forename> <surname>Langenegger</surname> </persName> <idno type="halauthorid">1294296</idno> </author> <author role="aut"> <persName> <forename type="first">Kamran B.</forename> <surname>Lankarani</surname> </persName> <idno type="halauthorid">1294297</idno> </author> <author role="aut"> <persName> <forename type="first">Yee-Sin</forename> <surname>Leo</surname> </persName> <idno type="halauthorid">1294298</idno> </author> <author role="aut"> <persName> <forename type="first">Rita</forename> <surname>Linko</surname> </persName> <idno type="halauthorid">1294299</idno> </author> <author role="aut"> <persName> <forename type="first">Pei</forename> <surname>Liu</surname> </persName> <idno type="halauthorid">1019228</idno> </author> <author role="aut"> <persName> <forename type="first">Faris</forename> <surname>Madanat</surname> </persName> <idno type="halauthorid">1294300</idno> </author> <author role="aut"> <persName> <forename type="first">Elga</forename> <surname>Mayo-Montero</surname> </persName> <idno type="halauthorid">1294301</idno> </author> <author role="aut"> <persName> <forename type="first">Allison</forename> <surname>McGeer</surname> </persName> <idno type="halauthorid">1294302</idno> </author> <author role="aut"> <persName> <forename type="first">Ziad</forename> <surname>Memish</surname> </persName> <idno type="halauthorid">1294303</idno> </author> <author role="aut"> <persName> <forename type="first">Gokhan</forename> <surname>Metan</surname> </persName> <idno type="halauthorid">1206065</idno> </author> <author role="aut"> <persName> <forename type="first">Auksė</forename> <surname>Mickiene</surname> </persName> <idno type="halauthorid">1294304</idno> </author> <author role="aut"> <persName> <forename type="first">Dragan</forename> <surname>Mikić</surname> </persName> <idno type="halauthorid">1294305</idno> </author> <author role="aut"> <persName> <forename type="first">Kristin G. I.</forename> <surname>Mohn</surname> </persName> <idno type="halauthorid">1294306</idno> </author> <author role="aut"> <persName> <forename type="first">Ahmadreza</forename> <surname>Moradi</surname> </persName> <idno type="halauthorid">1294307</idno> </author> <author role="aut"> <persName> <forename type="first">Pagbajabyn</forename> <surname>Nymadawa</surname> </persName> <idno type="halauthorid">1294308</idno> </author> <author role="aut"> <persName> <forename type="first">Maria E.</forename> <surname>Oliva</surname> </persName> <idno type="halauthorid">1294309</idno> </author> <author role="aut"> <persName> <forename type="first">Mehpare</forename> <surname>Ozkan</surname> </persName> <idno type="halauthorid">1294310</idno> </author> <author role="aut"> <persName> <forename type="first">Dhruv</forename> <surname>Parekh</surname> </persName> <idno type="halauthorid">1294311</idno> </author> <author role="aut"> <persName> <forename type="first">Mical</forename> <surname>Paul</surname> </persName> <idno type="halauthorid">1294312</idno> </author> <author role="aut"> <persName> <forename type="first">Fernando P.</forename> <surname>Polack</surname> </persName> <idno type="halauthorid">1294313</idno> </author> <author role="aut"> <persName> <forename type="first">Barbara A.</forename> <surname>Rath</surname> </persName> <idno type="halauthorid">1294314</idno> </author> <author role="aut"> <persName> <forename type="first">Alejandro H.</forename> <surname>Rodríguez</surname> </persName> <idno type="halauthorid">1294315</idno> </author> <author role="aut"> <persName> <forename type="first">Elena B.</forename> <surname>Sarrouf</surname> </persName> <idno type="halauthorid">1294316</idno> </author> <author role="aut"> <persName> <forename type="first">Anna C.</forename> <surname>Seale</surname> </persName> <idno type="halauthorid">1294317</idno> </author> <author role="aut"> <persName> <forename type="first">Bunyamin</forename> <surname>Sertogullarindan</surname> </persName> <idno type="halauthorid">1294318</idno> </author> <author role="aut"> <persName> <forename type="first">Marilda M.</forename> <surname>Siqueira</surname> </persName> <idno type="halauthorid">1294319</idno> </author> <author role="aut"> <persName> <forename type="first">Joanna</forename> <surname>Skręt-Magierło</surname> </persName> <idno type="halauthorid">1294320</idno> </author> <author role="aut"> <persName> <forename type="first">Frank</forename> <surname>Stephan</surname> </persName> <email type="md5">b57e441adb78cb40ab6bd765cb9398f2</email> <email type="domain">comp.nus.edu.sg</email> <idno type="halauthorid">230241</idno> </author> <author role="aut"> <persName> <forename type="first">Ewa</forename> <surname>Talarek</surname> </persName> <idno type="halauthorid">1294321</idno> </author> <author role="aut"> <persName> <forename type="first">Julian W.</forename> <surname>Tang</surname> </persName> <idno type="halauthorid">1294322</idno> </author> <author role="aut"> <persName> <forename type="first">Kelvin K. W.</forename> <surname>To</surname> </persName> <idno type="halauthorid">1294323</idno> </author> <author role="aut"> <persName> <forename type="first">Antoni</forename> <surname>Torres</surname> </persName> <idno type="halauthorid">1294324</idno> </author> <author role="aut"> <persName> <forename type="first">Selda H.</forename> <surname>Törün</surname> </persName> <idno type="halauthorid">1294325</idno> </author> <author role="aut"> <persName> <forename type="first">Dat</forename> <surname>Tran</surname> </persName> <idno type="halauthorid">1294326</idno> </author> <author role="aut"> <persName> <forename type="first">Timothy M.</forename> <surname>Uyeki</surname> </persName> <idno type="halauthorid">1294327</idno> </author> <author role="aut"> <persName> <forename type="first">Annelies</forename> <surname>Van Zwol</surname> </persName> <idno type="halauthorid">1294328</idno> </author> <author role="aut"> <persName> <forename type="first">Wendy</forename> <surname>Vaudry</surname> </persName> <idno type="halauthorid">1294329</idno> </author> <author role="aut"> <persName> <forename type="first">Tjasa</forename> <surname>Vidmar</surname> </persName> <idno type="halauthorid">1294330</idno> </author> <author role="aut"> <persName> <forename type="first">Renata T. C.</forename> <surname>Yokota</surname> </persName> <idno type="halauthorid">1294331</idno> </author> <author role="aut"> <persName> <forename type="first">Paul</forename> <surname>Zarogoulidis</surname> </persName> <idno type="halauthorid">1294332</idno> </author> <author role="aut"> <persName> <forename type="first">Jonathan S.</forename> <surname>Nguyen-Van-Tam</surname> </persName> <idno type="halauthorid">1294333</idno> </author> </analytic> <monogr> <idno type="halJournalId" status="VALID">113394</idno> <idno type="issn">2213-2600</idno> <idno type="eissn">2213-2619</idno> <title level="j">Lancet Respiratory medicine</title> <imprint> <publisher>Elsevier</publisher> <biblScope unit="volume">2</biblScope> <biblScope unit="issue">5</biblScope> <biblScope unit="pp">395-404</biblScope> <date type="datePub">2014</date> <date type="dateEpub">2014-03-19</date> </imprint> </monogr> <idno type="doi">10.1016/S2213-2600(14)70041-4</idno> <ref type="seeAlso" target="http://www.sciencedirect.com/science/article/pii/S2213260014700414">http://www.sciencedirect.com/science/article/pii/S2213260014700414</ref> </biblStruct> </sourceDesc> <profileDesc> <langUsage> <language ident="en">English</language> </langUsage> <textClass> <classCode scheme="halDomain" n="sdv.sp.pharma">Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology</classCode> <classCode scheme="halDomain" n="sdv.mhep.mi">Life Sciences [q-bio]/Human health and pathology/Infectious diseases</classCode> <classCode scheme="halDomain" n="sdv.mhep.me">Life Sciences [q-bio]/Human health and pathology/Emerging diseases</classCode> <classCode scheme="halTypology" n="ART">Journal articles</classCode> </textClass> <abstract xml:lang="en"> <p>Background: Neuraminidase inhibitors were widely used during the 2009–10 influenza A H1N1 pandemic, but evidence for their effectiveness in reducing mortality is uncertain. We did a meta-analysis of individual participant data to investigate the association between use of neuraminidase inhibitors and mortality in patients admitted to hospital with pandemic influenza A H1N1pdm09 virus infection.Methods: We assembled data for patients (all ages) admitted to hospital worldwide with laboratory confirmed or clinically diagnosed pandemic influenza A H1N1pdm09 virus infection. We identified potential data contributors from an earlier systematic review of reported studies addressing the same research question. In our systematic review, eligible studies were done between March 1, 2009 (Mexico), or April 1, 2009 (rest of the world), until the WHO declaration of the end of the pandemic (Aug 10, 2010); however, we continued to receive data up to March 14, 2011, from ongoing studies. We did a meta-analysis of individual participant data to assess the association between neuraminidase inhibitor treatment and mortality (primary outcome), adjusting for both treatment propensity and potential confounders, using generalised linear mixed modelling. We assessed the association with time to treatment using time-dependent Cox regression shared frailty modelling.Findings: We included data for 29 234 patients from 78 studies of patients admitted to hospital between Jan 2, 2009, and March 14, 2011. Compared with no treatment, neuraminidase inhibitor treatment (irrespective of timing) was associated with a reduction in mortality risk (adjusted odds ratio [OR] 0·81; 95% CI 0·70–0·93; p=0·0024). Compared with later treatment, early treatment (within 2 days of symptom onset) was associated with a reduction in mortality risk (adjusted OR 0·48; 95% CI 0·41–0·56; p<0·0001). Early treatment versus no treatment was also associated with a reduction in mortality (adjusted OR 0·50; 95% CI 0·37–0·67; p<0·0001). These associations with reduced mortality risk were less pronounced and not significant in children. There was an increase in the mortality hazard rate with each day's delay in initiation of treatment up to day 5 as compared with treatment initiated within 2 days of symptom onset (adjusted hazard ratio [HR 1·23] [95% CI 1·18–1·28]; p<0·0001 for the increasing HR with each day's delay).Interpretation: We advocate early instigation of neuraminidase inhibitor treatment in adults admitted to hospital with suspected or proven influenza infection. Funding F Hoffmann-La Roche.</p> </abstract> </profileDesc> </hal></record>Pour manipuler ce document sous Unix (Dilib)
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