PandemieGrippaleV1, Hal, Curation, bibRecord, 000105

Clinical presentation, microbiological features and correlates of disease severity of 2009 pandemic influenza A (H1N1) infection

Identifieur interne : 000105 ( Hal/Curation ); précédent : 000104; suivant : 000106

Clinical presentation, microbiological features and correlates of disease severity of 2009 pandemic influenza A (H1N1) infection

Auteurs : S. Giambenedetto [Italie] ; L. Zileri Dal Verme [Italie] ; M. Sali [Italie] ; S. Farina [Italie] ; V. Cristo [Italie] ; S. Manzara [Italie] ; A. Luca [Italie] ; G. Pignataro [Italie] ; M. Prosperi [Italie] ; A. Franco [Italie] ; N. Gentiloni Silveri [Italie] ; G. Delogu [Italie] ; R. Cauda [Italie] ; M. Fabbiani [Italie] ; G. Fadda [Italie]

Source :

European Journal of Clinical Microbiology and Infectious Diseases [ 0934-9723 ] ; 2010-11-23.

RBID : Hal:hal-00643845

Descripteurs français

mix :
- Life Sciences.

Abstract

The purpose of this study was to describe epidemiological, clinical and microbiological characteristics of confirmed novel influenza A (H1N1) infection, investigating factors associated with disease severity. We retrospectively selected patients seeking care for respiratory symptoms in two periods (May-August and September-November 2009) with different epidemiological characteristics. Only patients with confirmed pandemic influenza A (H1N1) were enrolled in this study. A total of 104 patients with H1N1 infection were evaluated, mostly referring classic influenza symptoms; in addition, diarrhea and vomiting were often referred. Clinical signs, symptoms and respiratory complications were different in the two periods. Of all patients, 18 (17%) had pneumonia. Patients older than 50 years showed a lower probability of pneumonia diagnosis when compared to children aged 0-13 ( = 0.049); a longer duration of symptoms before medical care was associated with a higher probability of pneumonia ( = 0.026). Phylogenetic analysis showed a low variability both in hemagglutinin and neuraminidase genes. In addition, no neuraminidase mutation associated with antiviral resistance was detected. A detailed description of respiratory diseases associated with H1N1 infection was provided and factors associated with its severity were investigated, thus contributing to the insight into epidemiological, clinical and microbiological knowledge of the disease.

Url:

https://hal.archives-ouvertes.fr/hal-00643845

DOI: 10.1007/s10096-010-1116-7

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Le document en format XML

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<author><name sortKey="Farina, S" sort="Farina, S" uniqKey="Farina S" first="S." last="Farina">S. Farina</name>
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<author><name sortKey="Cristo, V" sort="Cristo, V" uniqKey="Cristo V" first="V." last="Cristo">V. Cristo</name>
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<author><name sortKey="Luca, A" sort="Luca, A" uniqKey="Luca A" first="A." last="Luca">A. Luca</name>
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</tutelle>
</tutelles>
</hal:affiliation>
<country>Italie</country>
</affiliation>
</author>
<author><name sortKey="Pignataro, G" sort="Pignataro, G" uniqKey="Pignataro G" first="G." last="Pignataro">G. Pignataro</name>
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          <desc>            <address>              <addrLine>Largo F. Vito1;00168;Rome</addrLine>
              <country key="IT"></country>
            </address>
          </desc>
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          <orgName type="acronym">Unicatt</orgName>
          <desc>            <address>              <addrLine>campus di Roma</addrLine>
              <country key="IT"></country>
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            <ref type="url">https://roma.unicatt.it/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Italie</country>
</affiliation>
</author>
<author><name sortKey="Prosperi, M" sort="Prosperi, M" uniqKey="Prosperi M" first="M." last="Prosperi">M. Prosperi</name>
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          <desc>            <address>              <addrLine>Largo F. Vito1;00168;Rome</addrLine>
              <country key="IT"></country>
            </address>
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          <orgName type="acronym">Unicatt</orgName>
          <desc>            <address>              <addrLine>campus di Roma</addrLine>
              <country key="IT"></country>
            </address>
            <ref type="url">https://roma.unicatt.it/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Italie</country>
</affiliation>
</author>
<author><name sortKey="Franco, A" sort="Franco, A" uniqKey="Franco A" first="A." last="Franco">A. Franco</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-174882" status="INCOMING">          <orgName>Institute of Microbiology</orgName>
          <desc>            <address>              <addrLine>Largo F. Vito1;00168;Rome</addrLine>
              <country key="IT"></country>
            </address>
          </desc>
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          </listRelation>
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          <orgName type="acronym">Unicatt</orgName>
          <desc>            <address>              <addrLine>campus di Roma</addrLine>
              <country key="IT"></country>
            </address>
            <ref type="url">https://roma.unicatt.it/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Italie</country>
</affiliation>
</author>
<author><name sortKey="Gentiloni Silveri, N" sort="Gentiloni Silveri, N" uniqKey="Gentiloni Silveri N" first="N." last="Gentiloni Silveri">N. Gentiloni Silveri</name>
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          <desc>            <address>              <addrLine>Largo F. Vito1;00168;Rome</addrLine>
              <country key="IT"></country>
            </address>
          </desc>
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          <orgName type="acronym">Unicatt</orgName>
          <desc>            <address>              <addrLine>campus di Roma</addrLine>
              <country key="IT"></country>
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        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Italie</country>
</affiliation>
</author>
<author><name sortKey="Delogu, G" sort="Delogu, G" uniqKey="Delogu G" first="G." last="Delogu">G. Delogu</name>
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          <desc>            <address>              <addrLine>Largo F. Vito1;00168;Rome</addrLine>
              <country key="IT"></country>
            </address>
          </desc>
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          <orgName type="acronym">Unicatt</orgName>
          <desc>            <address>              <addrLine>campus di Roma</addrLine>
              <country key="IT"></country>
            </address>
            <ref type="url">https://roma.unicatt.it/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Italie</country>
</affiliation>
</author>
<author><name sortKey="Cauda, R" sort="Cauda, R" uniqKey="Cauda R" first="R." last="Cauda">R. Cauda</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-174880" status="INCOMING">          <orgName>Institute of Clinical Infectious Diseases</orgName>
          <desc>            <address>              <addrLine>Largo F. Vito1;00168;Rome</addrLine>
              <country key="IT"></country>
            </address>
          </desc>
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          <orgName type="acronym">Unicatt</orgName>
          <desc>            <address>              <addrLine>campus di Roma</addrLine>
              <country key="IT"></country>
            </address>
            <ref type="url">https://roma.unicatt.it/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>Italie</country>
</affiliation>
</author>
<author><name sortKey="Fabbiani, M" sort="Fabbiani, M" uniqKey="Fabbiani M" first="M." last="Fabbiani">M. Fabbiani</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-174880" status="INCOMING">          <orgName>Institute of Clinical Infectious Diseases</orgName>
          <desc>            <address>              <addrLine>Largo F. Vito1;00168;Rome</addrLine>
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            </address>
          </desc>
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</tutelle>
</tutelles>
</hal:affiliation>
<country>Italie</country>
</affiliation>
</author>
<author><name sortKey="Fadda, G" sort="Fadda, G" uniqKey="Fadda G" first="G." last="Fadda">G. Fadda</name>
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          <desc>            <address>              <addrLine>Largo F. Vito1;00168;Rome</addrLine>
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</hal:affiliation>
<country>Italie</country>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1007/s10096-010-1116-7</idno>
<series><title level="j">European Journal of Clinical Microbiology and Infectious Diseases</title>
<idno type="ISSN">0934-9723</idno>
<imprint><date type="datePub">2010-11-23</date>
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<front><div type="abstract" xml:lang="en">              <p>The purpose of this study was to describe epidemiological, clinical and microbiological characteristics of confirmed novel influenza A (H1N1) infection, investigating factors associated with disease severity. We retrospectively selected patients seeking care for respiratory symptoms in two periods (May-August and September-November 2009) with different epidemiological characteristics. Only patients with confirmed pandemic influenza A (H1N1) were enrolled in this study. A total of 104 patients with H1N1 infection were evaluated, mostly referring classic influenza symptoms; in addition, diarrhea and vomiting were often referred. Clinical signs, symptoms and respiratory complications were different in the two periods. Of all patients, 18 (17%) had pneumonia. Patients older than 50 years showed a lower probability of pneumonia diagnosis when compared to children aged 0-13 ( = 0.049); a longer duration of symptoms before medical care was associated with a higher probability of pneumonia ( = 0.026). Phylogenetic analysis showed a low variability both in hemagglutinin and neuraminidase genes. In addition, no neuraminidase mutation associated with antiviral resistance was detected. A detailed description of respiratory diseases associated with H1N1 infection was provided and factors associated with its severity were investigated, thus contributing to the insight into epidemiological, clinical and microbiological knowledge of the disease.</p>
            </div>
</front>
</TEI>
<hal api="V3">          <titleStmt>            <title xml:lang="en">Clinical presentation, microbiological features and correlates of disease severity of 2009 pandemic influenza A (H1N1) infection</title>
            <author role="aut">              <persName>                <forename type="first">S.</forename>
                <surname>Giambenedetto</surname>
              </persName>
              <idno type="halauthorid">661569</idno>
              <affiliation ref="#struct-174880"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">L.</forename>
                <surname>Zileri Dal Verme</surname>
              </persName>
              <idno type="halauthorid">661570</idno>
              <affiliation ref="#struct-174881"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">M.</forename>
                <surname>Sali</surname>
              </persName>
              <idno type="halauthorid">661571</idno>
              <affiliation ref="#struct-174882"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">S.</forename>
                <surname>Farina</surname>
              </persName>
              <idno type="halauthorid">661572</idno>
              <affiliation ref="#struct-174880"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">V.</forename>
                <surname>Cristo</surname>
              </persName>
              <idno type="halauthorid">661573</idno>
              <affiliation ref="#struct-174880"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">S.</forename>
                <surname>Manzara</surname>
              </persName>
              <idno type="halauthorid">661574</idno>
              <affiliation ref="#struct-174882"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">A.</forename>
                <surname>Luca</surname>
              </persName>
              <idno type="halauthorid">447591</idno>
              <affiliation ref="#struct-174880"></affiliation>
              <affiliation ref="#struct-174883"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">G.</forename>
                <surname>Pignataro</surname>
              </persName>
              <idno type="halauthorid">661575</idno>
              <affiliation ref="#struct-174881"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">M.</forename>
                <surname>Prosperi</surname>
              </persName>
              <idno type="halauthorid">661576</idno>
              <affiliation ref="#struct-174880"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">A.</forename>
                <surname>Franco</surname>
              </persName>
              <idno type="halauthorid">180887</idno>
              <affiliation ref="#struct-174882"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">N.</forename>
                <surname>Gentiloni Silveri</surname>
              </persName>
              <idno type="halauthorid">661577</idno>
              <affiliation ref="#struct-174881"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">G.</forename>
                <surname>Delogu</surname>
              </persName>
              <idno type="halauthorid">661578</idno>
              <affiliation ref="#struct-174882"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">R.</forename>
                <surname>Cauda</surname>
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              <idno type="halauthorid">661579</idno>
              <affiliation ref="#struct-174880"></affiliation>
            </author>
            <author role="crp">              <persName>                <forename type="first">M.</forename>
                <surname>Fabbiani</surname>
              </persName>
              <email type="md5">1b0f2001493e4e9dcb4238965be0cd51</email>
              <email type="domain">alice.it</email>
              <idno type="halauthorid">661580</idno>
              <affiliation ref="#struct-174880"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">G.</forename>
                <surname>Fadda</surname>
              </persName>
              <idno type="halauthorid">142748</idno>
              <affiliation ref="#struct-174882"></affiliation>
            </author>
            <editor role="depositor">              <persName>                <forename>Hal</forename>
                <surname>Peer</surname>
              </persName>
              <email type="md5">86d0524708364ec39d879b6988476a91</email>
              <email type="domain">inria.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>            <edition n="v1" type="current">              <date type="whenSubmitted">2011-11-23 02:51:04</date>
              <date type="whenWritten">2010-08-04</date>
              <date type="whenModified">2018-11-13 15:30:03</date>
              <date type="whenReleased">2011-11-23 02:51:04</date>
              <date type="whenProduced">2010-11-23</date>
              <date type="whenEndEmbargoed">2011-11-23</date>
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            </edition>
            <respStmt>              <resp>contributor</resp>
              <name key="148147">                <persName>                  <forename>Hal</forename>
                  <surname>Peer</surname>
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                <email type="domain">inria.fr</email>
              </name>
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          </editionStmt>
          <publicationStmt>            <distributor>CCSD</distributor>
            <idno type="halId">hal-00643845</idno>
            <idno type="halUri">https://hal.archives-ouvertes.fr/hal-00643845</idno>
            <idno type="halBibtex">giambenedetto:hal-00643845</idno>
            <idno type="halRefHtml">European Journal of Clinical Microbiology and Infectious Diseases, Springer Verlag, 2010, 30 (4), pp.541-549. ⟨10.1007/s10096-010-1116-7⟩</idno>
            <idno type="halRef">European Journal of Clinical Microbiology and Infectious Diseases, Springer Verlag, 2010, 30 (4), pp.541-549. ⟨10.1007/s10096-010-1116-7⟩</idno>
          </publicationStmt>
          <seriesStmt>            <idno type="stamp" n="PEER">PEER Publishing and the Ecology of European Research</idno>
          </seriesStmt>
          <notesStmt>            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>            <biblStruct>              <analytic>                <title xml:lang="en">Clinical presentation, microbiological features and correlates of disease severity of 2009 pandemic influenza A (H1N1) infection</title>
                <author role="aut">                  <persName>                    <forename type="first">S.</forename>
                    <surname>Giambenedetto</surname>
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                  <idno type="halauthorid">661569</idno>
                  <affiliation ref="#struct-174880"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">L.</forename>
                    <surname>Zileri Dal Verme</surname>
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                  <idno type="halauthorid">661570</idno>
                  <affiliation ref="#struct-174881"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">M.</forename>
                    <surname>Sali</surname>
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                  <idno type="halauthorid">661571</idno>
                  <affiliation ref="#struct-174882"></affiliation>
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                <author role="aut">                  <persName>                    <forename type="first">S.</forename>
                    <surname>Farina</surname>
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                  <idno type="halauthorid">661572</idno>
                  <affiliation ref="#struct-174880"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">V.</forename>
                    <surname>Cristo</surname>
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                  <affiliation ref="#struct-174880"></affiliation>
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                <author role="aut">                  <persName>                    <forename type="first">S.</forename>
                    <surname>Manzara</surname>
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                <author role="aut">                  <persName>                    <forename type="first">A.</forename>
                    <surname>Luca</surname>
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                <author role="aut">                  <persName>                    <forename type="first">G.</forename>
                    <surname>Pignataro</surname>
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                  <idno type="halauthorid">661575</idno>
                  <affiliation ref="#struct-174881"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">M.</forename>
                    <surname>Prosperi</surname>
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                  <idno type="halauthorid">661576</idno>
                  <affiliation ref="#struct-174880"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">A.</forename>
                    <surname>Franco</surname>
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                  <idno type="halauthorid">180887</idno>
                  <affiliation ref="#struct-174882"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">N.</forename>
                    <surname>Gentiloni Silveri</surname>
                  </persName>
                  <idno type="halauthorid">661577</idno>
                  <affiliation ref="#struct-174881"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">G.</forename>
                    <surname>Delogu</surname>
                  </persName>
                  <idno type="halauthorid">661578</idno>
                  <affiliation ref="#struct-174882"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">R.</forename>
                    <surname>Cauda</surname>
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                  <idno type="halauthorid">661579</idno>
                  <affiliation ref="#struct-174880"></affiliation>
                </author>
                <author role="crp">                  <persName>                    <forename type="first">M.</forename>
                    <surname>Fabbiani</surname>
                  </persName>
                  <email type="md5">1b0f2001493e4e9dcb4238965be0cd51</email>
                  <email type="domain">alice.it</email>
                  <idno type="halauthorid">661580</idno>
                  <affiliation ref="#struct-174880"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">G.</forename>
                    <surname>Fadda</surname>
                  </persName>
                  <idno type="halauthorid">142748</idno>
                  <affiliation ref="#struct-174882"></affiliation>
                </author>
              </analytic>
              <monogr>                <idno type="halJournalId" status="VALID">13022</idno>
                <idno type="issn">0934-9723</idno>
                <idno type="eissn">1435-4373</idno>
                <title level="j">European Journal of Clinical Microbiology and Infectious Diseases</title>
                <imprint>                  <publisher>Springer Verlag</publisher>
                  <biblScope unit="volume">30</biblScope>
                  <biblScope unit="issue">4</biblScope>
                  <biblScope unit="pp">541-549</biblScope>
                  <date type="datePub">2010-11-23</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1007/s10096-010-1116-7</idno>
            </biblStruct>
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          <profileDesc>            <langUsage>              <language ident="en">English</language>
            </langUsage>
            <textClass>              <keywords scheme="author">                <term xml:lang="fr">Life Sciences</term>
              </keywords>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">              <p>The purpose of this study was to describe epidemiological, clinical and microbiological characteristics of confirmed novel influenza A (H1N1) infection, investigating factors associated with disease severity. We retrospectively selected patients seeking care for respiratory symptoms in two periods (May-August and September-November 2009) with different epidemiological characteristics. Only patients with confirmed pandemic influenza A (H1N1) were enrolled in this study. A total of 104 patients with H1N1 infection were evaluated, mostly referring classic influenza symptoms; in addition, diarrhea and vomiting were often referred. Clinical signs, symptoms and respiratory complications were different in the two periods. Of all patients, 18 (17%) had pneumonia. Patients older than 50 years showed a lower probability of pneumonia diagnosis when compared to children aged 0-13 ( = 0.049); a longer duration of symptoms before medical care was associated with a higher probability of pneumonia ( = 0.026). Phylogenetic analysis showed a low variability both in hemagglutinin and neuraminidase genes. In addition, no neuraminidase mutation associated with antiviral resistance was detected. A detailed description of respiratory diseases associated with H1N1 infection was provided and factors associated with its severity were investigated, thus contributing to the insight into epidemiological, clinical and microbiological knowledge of the disease.</p>
            </abstract>
          </profileDesc>
        </hal>
</record>

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Clinical presentation, microbiological features and correlates of disease severity of 2009 pandemic influenza A (H1N1) infection

Clinical presentation, microbiological features and correlates of disease severity of 2009 pandemic influenza A (H1N1) infection

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