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Shigella sonnei genome sequencing and phylogenetic analysis indicate recent global dissemination from Europe

Identifieur interne : 000536 ( Hal/Corpus ); précédent : 000535; suivant : 000537

Shigella sonnei genome sequencing and phylogenetic analysis indicate recent global dissemination from Europe

Auteurs : Kathryn E. Holt ; Stephen Baker ; François-Xavier Weill ; Edward C. Holmes ; Andrew Kitchen ; Jun Yu ; Vartul Sangal ; Derek J. Brown ; John E. Coia ; Dong-Wook Kim ; Choi Seon Young ; Su Hee Kim ; Wanderley Dias Da Silveira ; Derek Pickard ; Jeremy J. Farrar ; Julian Parkhill ; Gordon Dougan ; Nicholas R. Thomson

Source :

RBID : Hal:pasteur-01117702

Abstract

Shigella are human-adapted Escherichia coli that have gained the ability to invade the human gut mucosa and cause dysentery(1,2), spreading efficiently via low-dose fecal-oral transmission(3,4). Historically, S. sonnei has been predominantly responsible for dysentery in developed countries but is now emerging as a problem in the developing world, seeming to replace the more diverse Shigella flexneri in areas undergoing economic development and improvements in water quality(4-6). Classical approaches have shown that S. sonnei is genetically conserved and clonal(7). We report here whole-genome sequencing of 132 globally distributed isolates. Our phylogenetic analysis shows that the current S. sonnei population descends from a common ancestor that existed less than 500 years ago and that diversified into several distinct lineages with unique characteristics. Our analysis suggests that the majority of this diversification occurred in Europe and was followed by more recent establishment of local pathogen populations on other continents, predominantly due to the pandemic spread of a single, rapidly evolving, multidrug-resistant lineage.


Url:
DOI: 10.1038/ng.2369

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Hal:pasteur-01117702

Le document en format XML

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<p>Shigella are human-adapted Escherichia coli that have gained the ability to invade the human gut mucosa and cause dysentery(1,2), spreading efficiently via low-dose fecal-oral transmission(3,4). Historically, S. sonnei has been predominantly responsible for dysentery in developed countries but is now emerging as a problem in the developing world, seeming to replace the more diverse Shigella flexneri in areas undergoing economic development and improvements in water quality(4-6). Classical approaches have shown that S. sonnei is genetically conserved and clonal(7). We report here whole-genome sequencing of 132 globally distributed isolates. Our phylogenetic analysis shows that the current S. sonnei population descends from a common ancestor that existed less than 500 years ago and that diversified into several distinct lineages with unique characteristics. Our analysis suggests that the majority of this diversification occurred in Europe and was followed by more recent establishment of local pathogen populations on other continents, predominantly due to the pandemic spread of a single, rapidly evolving, multidrug-resistant lineage.</p>
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<titleStmt>
<title xml:lang="en">Shigella sonnei genome sequencing and phylogenetic analysis indicate recent global dissemination from Europe</title>
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<persName>
<forename type="first">Kathryn E.</forename>
<surname>Holt</surname>
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<idno type="halauthorid">1129428</idno>
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</author>
<author role="aut">
<persName>
<forename type="first">Stephen</forename>
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<idno type="halauthorid">1129429</idno>
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<author role="aut">
<persName>
<forename type="first">François-Xavier</forename>
<surname>Weill</surname>
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</author>
<author role="aut">
<persName>
<forename type="first">Edward C</forename>
<surname>Holmes</surname>
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</author>
<author role="aut">
<persName>
<forename type="first">Andrew</forename>
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<forename type="first">Jun</forename>
<surname>Yu</surname>
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<persName>
<forename type="first">Vartul</forename>
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</author>
<author role="aut">
<persName>
<forename type="first">Derek J</forename>
<surname>Brown</surname>
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<persName>
<forename type="first">John E.</forename>
<surname>Coia</surname>
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</author>
<author role="aut">
<persName>
<forename type="first">Dong-Wook</forename>
<surname>Kim</surname>
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</author>
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<persName>
<forename type="first">Choi</forename>
<surname>Seon Young</surname>
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<forename type="first">Su</forename>
<surname>Hee Kim</surname>
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<forename type="first">Jeremy J.</forename>
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<author role="aut">
<persName>
<forename type="first">Julian</forename>
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<idno type="halauthorid">317238</idno>
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</author>
<author role="aut">
<persName>
<forename type="first">Gordon</forename>
<surname>Dougan</surname>
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<email type="domain">pasteur.fr</email>
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<funder>This work was supported by the Wellcome Trust (0689) and a Victorian Life Sciences Computation Initiative (VLSCI) grant (VR0082) on its Peak Computing Facility at the University of Melbourne (an initiative of the Victorian Government, Australia). K.E.H. was supported by a Fellowship from the National Health & Medical Research Council (NHMRC) of Australia (628930); S.B. is supported by an Oak Foundation Fellowship through Oxford University (OAKF9) and by the Li Ka Shing foundation (LG13); F.X.W. was partially funded by the Institut de Veille Sanitaire; J.Y. was supported by a UK Medical Research Council (MRC) grant (G0800173); and D.W.K. was partially supported by grant RTI05-01-01 from the Korean Ministry of Knowledge and Economy (MKE).</funder>
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<p>Shigella are human-adapted Escherichia coli that have gained the ability to invade the human gut mucosa and cause dysentery(1,2), spreading efficiently via low-dose fecal-oral transmission(3,4). Historically, S. sonnei has been predominantly responsible for dysentery in developed countries but is now emerging as a problem in the developing world, seeming to replace the more diverse Shigella flexneri in areas undergoing economic development and improvements in water quality(4-6). Classical approaches have shown that S. sonnei is genetically conserved and clonal(7). We report here whole-genome sequencing of 132 globally distributed isolates. Our phylogenetic analysis shows that the current S. sonnei population descends from a common ancestor that existed less than 500 years ago and that diversified into several distinct lineages with unique characteristics. Our analysis suggests that the majority of this diversification occurred in Europe and was followed by more recent establishment of local pathogen populations on other continents, predominantly due to the pandemic spread of a single, rapidly evolving, multidrug-resistant lineage.</p>
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