Interspecies transmission, adaptation to humans and pathogenicity of animal influenza viruses
Identifieur interne : 000343 ( Hal/Corpus ); précédent : 000342; suivant : 000344Interspecies transmission, adaptation to humans and pathogenicity of animal influenza viruses
Auteurs : S. Munier ; D. Moisy ; Daniel Marc ; N. NaffakhSource :
- Pathologie Biologie [ 0369-8114 ] ; 2010-04.
Descripteurs français
- mix :
English descriptors
- mix :
Abstract
The emergence in 2009 of a novel A(H1N1)v influenza virus of swine origin and the regular occurrence since 2003 of human cases of infection with A(H5N1) avian influenza viruses underline the zoonotic and pandemic potential of type A influenza viruses. Influenza viruses from the wild aquatic birds reservoir usually do not replicate efficiently in humans. Domestic poultry and swine can act as intermediate hosts for the acquisition of determinants that increase the potential of transmission and adaptation to humans, through the accumulation of mutations or by genetic reassortment. The rapid evolution of influenza viruses following interspecies transmission probably results from the selection of genetic variations that favor optimal interactions between viral proteins and cellular factors, leading to an increased multiplication potential and a better escape to the host antiviral response. Whereas influenza viruses usually cause asymptomatic infections in wild aquatic birds, they may be highly pathogenic in other species. Molecular determinants of host-specificity and pathogenesis have been identified in most viral genes, notably in genes that encode viral surface glycoproteins, proteins involved in the viral genome replication, and proteins that counteract the host immune response. However, our knowledge of these numerous and interdependant determinants remains incomplete, and the molecular mechanisms involved are still to be understood.
Url:
DOI: 10.1016/j.patbio.2010.01.012
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Hal:hal-01594423Le document en format XML
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<front><div type="abstract" xml:lang="en"> <p>The emergence in 2009 of a novel A(H1N1)v influenza virus of swine origin and the regular occurrence since 2003 of human cases of infection with A(H5N1) avian influenza viruses underline the zoonotic and pandemic potential of type A influenza viruses. Influenza viruses from the wild aquatic birds reservoir usually do not replicate efficiently in humans. Domestic poultry and swine can act as intermediate hosts for the acquisition of determinants that increase the potential of transmission and adaptation to humans, through the accumulation of mutations or by genetic reassortment. The rapid evolution of influenza viruses following interspecies transmission probably results from the selection of genetic variations that favor optimal interactions between viral proteins and cellular factors, leading to an increased multiplication potential and a better escape to the host antiviral response. Whereas influenza viruses usually cause asymptomatic infections in wild aquatic birds, they may be highly pathogenic in other species. Molecular determinants of host-specificity and pathogenesis have been identified in most viral genes, notably in genes that encode viral surface glycoproteins, proteins involved in the viral genome replication, and proteins that counteract the host immune response. However, our knowledge of these numerous and interdependant determinants remains incomplete, and the molecular mechanisms involved are still to be understood.</p>
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<ref type="seeAlso" target="http://www.sciencedirect.com/science/article/pii/S0369811410000337">http://www.sciencedirect.com/science/article/pii/S0369811410000337</ref>
<ref type="seeAlso" target="https://archives-publications.inrae.fr/368379.pdf">https://archives-publications.inrae.fr/368379.pdf</ref>
</biblStruct>
</sourceDesc>
<profileDesc> <langUsage> <language ident="fr">French</language>
</langUsage>
<textClass> <keywords scheme="author"> <term xml:lang="en">Influenza viruses</term>
<term xml:lang="en">Interspecies transmission</term>
<term xml:lang="en">Host-specificity</term>
<term xml:lang="en">Pathogenesis</term>
<term xml:lang="en">Zoonosis</term>
<term xml:lang="en">Pandemic</term>
<term xml:lang="fr">transmission de la maladie</term>
<term xml:lang="fr">interaction entre espèces</term>
<term xml:lang="fr">virus influenza aviaire</term>
<term xml:lang="fr">zoonose</term>
<term xml:lang="fr">spectre d'hôte</term>
</keywords>
<classCode scheme="mesh">Adaptation, Physiological</classCode>
<classCode scheme="mesh">Animals</classCode>
<classCode scheme="mesh">Phylogeny</classCode>
<classCode scheme="mesh">Receptors, Virus</classCode>
<classCode scheme="mesh">Ribonucleoproteins</classCode>
<classCode scheme="mesh">Species Specificity</classCode>
<classCode scheme="mesh">Swine</classCode>
<classCode scheme="mesh">Swine Diseases</classCode>
<classCode scheme="mesh">Viral Proteins</classCode>
<classCode scheme="mesh">Viral Tropism</classCode>
<classCode scheme="mesh">Virulence</classCode>
<classCode scheme="mesh">Zoonoses</classCode>
<classCode scheme="mesh">Birds</classCode>
<classCode scheme="mesh">Disease Outbreaks</classCode>
<classCode scheme="mesh">Disease Reservoirs</classCode>
<classCode scheme="mesh">Humans</classCode>
<classCode scheme="mesh">Influenza in Birds</classCode>
<classCode scheme="mesh">Influenza, Human</classCode>
<classCode scheme="mesh">Orthomyxoviridae</classCode>
<classCode scheme="mesh">Orthomyxoviridae Infections</classCode>
<classCode scheme="halDomain" n="sdv.spee">Life Sciences [q-bio]/Santé publique et épidémiologie</classCode>
<classCode scheme="halDomain" n="sdv.ba.mvsa">Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health</classCode>
<classCode scheme="VOCINRA" n="virus influenza aviaire">virus influenza aviaire</classCode>
<classCode scheme="VOCINRA" n="spectre d'hôte">spectre d'hôte</classCode>
<classCode scheme="VOCINRA" n="transmission de la maladie">transmission de la maladie</classCode>
<classCode scheme="VOCINRA" n="zoonose">zoonose</classCode>
<classCode scheme="VOCINRA" n="interaction entre espèces">interaction entre espèces</classCode>
<classCode scheme="halTypology" n="ART">Journal articles</classCode>
</textClass>
<abstract xml:lang="en"> <p>The emergence in 2009 of a novel A(H1N1)v influenza virus of swine origin and the regular occurrence since 2003 of human cases of infection with A(H5N1) avian influenza viruses underline the zoonotic and pandemic potential of type A influenza viruses. Influenza viruses from the wild aquatic birds reservoir usually do not replicate efficiently in humans. Domestic poultry and swine can act as intermediate hosts for the acquisition of determinants that increase the potential of transmission and adaptation to humans, through the accumulation of mutations or by genetic reassortment. The rapid evolution of influenza viruses following interspecies transmission probably results from the selection of genetic variations that favor optimal interactions between viral proteins and cellular factors, leading to an increased multiplication potential and a better escape to the host antiviral response. Whereas influenza viruses usually cause asymptomatic infections in wild aquatic birds, they may be highly pathogenic in other species. Molecular determinants of host-specificity and pathogenesis have been identified in most viral genes, notably in genes that encode viral surface glycoproteins, proteins involved in the viral genome replication, and proteins that counteract the host immune response. However, our knowledge of these numerous and interdependant determinants remains incomplete, and the molecular mechanisms involved are still to be understood.</p>
</abstract>
</profileDesc>
</hal>
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