Incidence of H1N1 2009 virus infection through the analysis of paired plasma specimens among blood donors, France.
Identifieur interne : 000317 ( Hal/Corpus ); précédent : 000316; suivant : 000318Incidence of H1N1 2009 virus infection through the analysis of paired plasma specimens among blood donors, France.
Auteurs : Angie Bone ; Jean-Paul Guthmann ; Azzedine Assal ; Dominique Rousset ; Armelle Degeorges ; Pascal Morel ; Martine Valette ; Vincent Enouf ; Eric Jacquot ; Bertrand Pelletier ; Yann Le Strat ; Josiane Pillonel ; Laure Fonteneau ; Sylvie Van Der Werf ; Bruno Lina ; Pierre Tiberghien ; Daniel Lévy-BruhlSource :
- PLoS ONE [ 1932-6203 ] ; 2012.
Abstract
BACKGROUND: Knowledge of the age-specific prevalence of seroprotection and incidence of seroconversion infection is necessary to complement clinical surveillance data and statistical models. It provides the basis for estimating the future impact of influenza A (H1N1pdm09) and implementing appropriate prevention and response strategies. METHODS: Using a cross-sectional design, two-stage stratified sampling and paired plasma samples, we estimated the age-specific prevalence of a protective level of H1N1pdm09 antibodies in the French adult population before and after the 2009/10 pandemic, and the proportion of those susceptible that seroconverted due to infection, from a single sample of 1,936 blood donors aged 20-70 years in mainland France in June 2010. Samples with a haemagglutination inhibition (HI) titre ≥1∶40 were considered seropositive, and seroconversion due to infection was defined as a 4-fold increase in titre in the absence of H1N1pdm09 vaccination or pre-pandemic seropositivity. RESULTS: Out of the 1,936 donors, 1,708 were included in the analysis. Seroprevalence before the pandemic was 6.7% (95% CI 5.0, 8.9) with no significant differences by age-group (p = 0.3). Seroprevalence afterwards was 23.0% (95% CI 17.7, 29.3) with 20-29 year olds having a higher level than older groups (p<0.001). Seroconversion due to infection was 12.2% (95% CI 6.9, 20.5). Younger age-group, vaccination against H1N1 and being seropositive before the pandemic were strongly associated with post-pandemic seropositivity. CONCLUSIONS: Before the 2009/2010 winter influenza season, only 6.7% of the French mainland population aged 20-70 had a level of antibodies usually considered protective. During the first pandemic wave, 12.2% of the population seroconverted due to infection and the seroprevalence after the wave rose to 23%, either due to prepandemic seropositivity, infection or vaccination. This relatively low latter figure contributed to an extension of target groups for influenza vaccination for the 2010/2011 season.
Url:
DOI: 10.1371/journal.pone.0033056
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Hal:inserm-00722692Le document en format XML
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<author><name sortKey="Le Strat, Yann" sort="Le Strat, Yann" uniqKey="Le Strat Y" first="Yann" last="Le Strat">Yann Le Strat</name>
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<author><name sortKey="Pillonel, Josiane" sort="Pillonel, Josiane" uniqKey="Pillonel J" first="Josiane" last="Pillonel">Josiane Pillonel</name>
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<author><name sortKey="Fonteneau, Laure" sort="Fonteneau, Laure" uniqKey="Fonteneau L" first="Laure" last="Fonteneau">Laure Fonteneau</name>
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<author><name sortKey="Van Der Werf, Sylvie" sort="Van Der Werf, Sylvie" uniqKey="Van Der Werf S" first="Sylvie" last="Van Der Werf">Sylvie Van Der Werf</name>
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<orgName>Centre National de la Recherche Scientifique</orgName>
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<author><name sortKey="Lina, Bruno" sort="Lina, Bruno" uniqKey="Lina B" first="Bruno" last="Lina">Bruno Lina</name>
<affiliation><hal:affiliation type="laboratory" xml:id="struct-92345" status="VALID"> <orgName>Centre National de Référence Virus Influenza (Région Sud)</orgName>
<desc> <address> <addrLine>Lyon</addrLine>
<country key="FR"></country>
</address>
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<author><name sortKey="Tiberghien, Pierre" sort="Tiberghien, Pierre" uniqKey="Tiberghien P" first="Pierre" last="Tiberghien">Pierre Tiberghien</name>
<affiliation><hal:affiliation type="institution" xml:id="struct-199980" status="VALID"> <orgName>Etablissement Français du Sang [La Plaine Saint-Denis]</orgName>
<orgName type="acronym">EFS</orgName>
<desc> <address> <addrLine>20 Avenue du Stade de France93218 La Plaine Saint Denis</addrLine>
<country key="FR"></country>
</address>
<ref type="url">https://www.dondusang.net</ref>
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</author>
<author><name sortKey="Levy Bruhl, Daniel" sort="Levy Bruhl, Daniel" uniqKey="Levy Bruhl D" first="Daniel" last="Lévy-Bruhl">Daniel Lévy-Bruhl</name>
<affiliation><hal:affiliation type="institution" xml:id="struct-300053" status="VALID"> <orgName>Institut de Veille Sanitaire </orgName>
<orgName type="acronym">INVS</orgName>
<desc> <address> <addrLine>12 rue du Val d'Osne, 94415 Saint Maurice Cedex, France</addrLine>
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</address>
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<idno type="DOI">10.1371/journal.pone.0033056</idno>
<series><title level="j">PLoS ONE</title>
<idno type="ISSN">1932-6203</idno>
<imprint><date type="datePub">2012</date>
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<front><div type="abstract" xml:lang="en"> <p>BACKGROUND: Knowledge of the age-specific prevalence of seroprotection and incidence of seroconversion infection is necessary to complement clinical surveillance data and statistical models. It provides the basis for estimating the future impact of influenza A (H1N1pdm09) and implementing appropriate prevention and response strategies. METHODS: Using a cross-sectional design, two-stage stratified sampling and paired plasma samples, we estimated the age-specific prevalence of a protective level of H1N1pdm09 antibodies in the French adult population before and after the 2009/10 pandemic, and the proportion of those susceptible that seroconverted due to infection, from a single sample of 1,936 blood donors aged 20-70 years in mainland France in June 2010. Samples with a haemagglutination inhibition (HI) titre ≥1∶40 were considered seropositive, and seroconversion due to infection was defined as a 4-fold increase in titre in the absence of H1N1pdm09 vaccination or pre-pandemic seropositivity. RESULTS: Out of the 1,936 donors, 1,708 were included in the analysis. Seroprevalence before the pandemic was 6.7% (95% CI 5.0, 8.9) with no significant differences by age-group (p = 0.3). Seroprevalence afterwards was 23.0% (95% CI 17.7, 29.3) with 20-29 year olds having a higher level than older groups (p<0.001). Seroconversion due to infection was 12.2% (95% CI 6.9, 20.5). Younger age-group, vaccination against H1N1 and being seropositive before the pandemic were strongly associated with post-pandemic seropositivity. CONCLUSIONS: Before the 2009/2010 winter influenza season, only 6.7% of the French mainland population aged 20-70 had a level of antibodies usually considered protective. During the first pandemic wave, 12.2% of the population seroconverted due to infection and the seroprevalence after the wave rose to 23%, either due to prepandemic seropositivity, infection or vaccination. This relatively low latter figure contributed to an extension of target groups for influenza vaccination for the 2010/2011 season.</p>
</div>
</front>
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<hal api="V3"> <titleStmt> <title xml:lang="en">Incidence of H1N1 2009 virus infection through the analysis of paired plasma specimens among blood donors, France.</title>
<author role="crp"> <persName> <forename type="first">Angie</forename>
<surname>Bone</surname>
</persName>
<email type="md5">743f28e9cf9dc12842e972c377cb532b</email>
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<author role="aut"> <persName> <forename type="first">Jean-Paul</forename>
<surname>Guthmann</surname>
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<idno type="halauthorid">751163</idno>
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</author>
<author role="aut"> <persName> <forename type="first">Azzedine</forename>
<surname>Assal</surname>
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</author>
<author role="aut"> <persName> <forename type="first">Dominique</forename>
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<author role="aut"> <persName> <forename type="first">Armelle</forename>
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</author>
<author role="aut"> <persName> <forename type="first">Pascal</forename>
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<affiliation ref="#struct-199980"></affiliation>
</author>
<author role="aut"> <persName> <forename type="first">Martine</forename>
<surname>Valette</surname>
</persName>
<idno type="halauthorid">751164</idno>
<affiliation ref="#struct-92345"></affiliation>
</author>
<author role="aut"> <persName> <forename type="first">Vincent</forename>
<surname>Enouf</surname>
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<idno type="halauthorid">400918</idno>
<affiliation ref="#struct-109174"></affiliation>
</author>
<author role="aut"> <persName> <forename type="first">Eric</forename>
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<author role="aut"> <persName> <forename type="first">Bertrand</forename>
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</author>
<author role="aut"> <persName> <forename type="first">Yann</forename>
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<author role="aut"> <persName> <forename type="first">Josiane</forename>
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<author role="aut"> <persName> <forename type="first">Laure</forename>
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</author>
<author role="aut"> <persName> <forename type="first">Sylvie</forename>
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<idno type="halauthorid">202082</idno>
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<author role="aut"> <persName> <forename type="first">Bruno</forename>
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</author>
<author role="aut"> <persName> <forename type="first">Pierre</forename>
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<idno type="halauthorid">308895</idno>
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</author>
<author role="aut"> <persName> <forename type="first">Daniel</forename>
<surname>Lévy-Bruhl</surname>
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<idno type="halauthorid">739946</idno>
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<editor role="depositor"> <persName> <forename>Philippe</forename>
<surname>Saas</surname>
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<author role="aut"> <persName> <forename type="first">Armelle</forename>
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<author role="aut"> <persName> <forename type="first">Martine</forename>
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<author role="aut"> <persName> <forename type="first">Vincent</forename>
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<author role="aut"> <persName> <forename type="first">Eric</forename>
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<author role="aut"> <persName> <forename type="first">Bertrand</forename>
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<author role="aut"> <persName> <forename type="first">Yann</forename>
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<author role="aut"> <persName> <forename type="first">Josiane</forename>
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<author role="aut"> <persName> <forename type="first">Laure</forename>
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<author role="aut"> <persName> <forename type="first">Sylvie</forename>
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<author role="aut"> <persName> <forename type="first">Bruno</forename>
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<author role="aut"> <persName> <forename type="first">Pierre</forename>
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<author role="aut"> <persName> <forename type="first">Daniel</forename>
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<idno type="doi">10.1371/journal.pone.0033056</idno>
<idno type="pubmed">22457734</idno>
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<profileDesc> <langUsage> <language ident="en">English</language>
</langUsage>
<textClass> <classCode scheme="mesh">Adult</classCode>
<classCode scheme="mesh">Aged</classCode>
<classCode scheme="mesh">Male</classCode>
<classCode scheme="mesh">Middle Aged</classCode>
<classCode scheme="mesh">Seroepidemiologic Studies</classCode>
<classCode scheme="mesh">Blood Donors</classCode>
<classCode scheme="mesh">Cross-Sectional Studies</classCode>
<classCode scheme="mesh">Female</classCode>
<classCode scheme="mesh">France</classCode>
<classCode scheme="mesh">Humans</classCode>
<classCode scheme="mesh">Incidence</classCode>
<classCode scheme="mesh">Influenza A Virus, H1N1 Subtype</classCode>
<classCode scheme="mesh">Influenza, Human</classCode>
<classCode scheme="halDomain" n="sdv.imm">Life Sciences [q-bio]/Immunology</classCode>
<classCode scheme="halTypology" n="ART">Journal articles</classCode>
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<abstract xml:lang="en"> <p>BACKGROUND: Knowledge of the age-specific prevalence of seroprotection and incidence of seroconversion infection is necessary to complement clinical surveillance data and statistical models. It provides the basis for estimating the future impact of influenza A (H1N1pdm09) and implementing appropriate prevention and response strategies. METHODS: Using a cross-sectional design, two-stage stratified sampling and paired plasma samples, we estimated the age-specific prevalence of a protective level of H1N1pdm09 antibodies in the French adult population before and after the 2009/10 pandemic, and the proportion of those susceptible that seroconverted due to infection, from a single sample of 1,936 blood donors aged 20-70 years in mainland France in June 2010. Samples with a haemagglutination inhibition (HI) titre ≥1∶40 were considered seropositive, and seroconversion due to infection was defined as a 4-fold increase in titre in the absence of H1N1pdm09 vaccination or pre-pandemic seropositivity. RESULTS: Out of the 1,936 donors, 1,708 were included in the analysis. Seroprevalence before the pandemic was 6.7% (95% CI 5.0, 8.9) with no significant differences by age-group (p = 0.3). Seroprevalence afterwards was 23.0% (95% CI 17.7, 29.3) with 20-29 year olds having a higher level than older groups (p<0.001). Seroconversion due to infection was 12.2% (95% CI 6.9, 20.5). Younger age-group, vaccination against H1N1 and being seropositive before the pandemic were strongly associated with post-pandemic seropositivity. CONCLUSIONS: Before the 2009/2010 winter influenza season, only 6.7% of the French mainland population aged 20-70 had a level of antibodies usually considered protective. During the first pandemic wave, 12.2% of the population seroconverted due to infection and the seroprevalence after the wave rose to 23%, either due to prepandemic seropositivity, infection or vaccination. This relatively low latter figure contributed to an extension of target groups for influenza vaccination for the 2010/2011 season.</p>
</abstract>
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