Efficient strategy for constructing duck enteritis virus-based live attenuated vaccine against homologous and heterologous H5N1 avian influenza virus and duck enteritis virus infection
Identifieur interne : 000184 ( Hal/Corpus ); précédent : 000183; suivant : 000185Efficient strategy for constructing duck enteritis virus-based live attenuated vaccine against homologous and heterologous H5N1 avian influenza virus and duck enteritis virus infection
Auteurs : Zhong Zou ; Yong Hu ; Zhigang Liu ; Wei Zhong ; Hangzhou Cao ; Huanchun Chen ; Meilin JinSource :
- Veterinary Research [ 0928-4249 ] ; 2015-12.
Abstract
Duck is susceptible to many pathogens, such as duck hepatitis virus, duck enteritis virus (DEV), duck tembusu virus, H5N1 highly pathogenic avian influenza virus (HPAIV) in particular. With the significant role of duck in the evolution of H5N1 HPAIV, control and eradication of H5N1 HPAIV in duck through vaccine immunization is considered an effective method in minimizing the threat of a pandemic outbreak. Consequently, a practical strategy to construct a vaccine against these pathogens should be determined. In this study, the DEV was examined as a candidate vaccine vector to deliver the hemagglutinin (HA) gene of H5N1, and its potential as a polyvalent vaccine was evaluated. A modified mini-F vector was inserted into the gB and UL26 gene junction of the attenuated DEV vaccine strain C-KCE genome to generate an infectious bacterial artificial chromosome (BAC) of C-KCE (vBAC-C-KCE). The HA gene of A/duck/Hubei/xn/2007 (H5N1) was inserted into the C-KCE genome via the mating-assisted genetically integrated cloning (MAGIC) to generate the recombinant vector pBAC-C-KCE-HA. A bivalent vaccine C-KCE-HA was developed by eliminating the BAC backbone. Ducks immunized with C-KCE-HA induced both the cross-reactive antibodies and T cell response against H5. Moreover, C-KCE-HA-immunized ducks provided rapid and long-lasting protection against homologous and heterologous HPAIV H5N1 and DEV clinical signs, death, and primary viral replication. In conclusion, our BAC-C-KCE is a promising platform for developing a polyvalent live attenuated vaccine.
Url:
DOI: 10.1186/s13567-015-0174-3
Links to Exploration step
Hal:hal-01303102Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Efficient strategy for constructing duck enteritis virus-based live attenuated vaccine against homologous and heterologous H5N1 avian influenza virus and duck enteritis virus infection</title><author><name sortKey="Zou, Zhong" sort="Zou, Zhong" uniqKey="Zou Z" first="Zhong" last="Zou">Zhong Zou</name></author><author><name sortKey="Hu, Yong" sort="Hu, Yong" uniqKey="Hu Y" first="Yong" last="Hu">Yong Hu</name></author><author><name sortKey="Liu, Zhigang" sort="Liu, Zhigang" uniqKey="Liu Z" first="Zhigang" last="Liu">Zhigang Liu</name></author><author><name sortKey="Zhong, Wei" sort="Zhong, Wei" uniqKey="Zhong W" first="Wei" last="Zhong">Wei Zhong</name></author><author><name sortKey="Cao, Hangzhou" sort="Cao, Hangzhou" uniqKey="Cao H" first="Hangzhou" last="Cao">Hangzhou Cao</name></author><author><name sortKey="Chen, Huanchun" sort="Chen, Huanchun" uniqKey="Chen H" first="Huanchun" last="Chen">Huanchun Chen</name></author><author><name sortKey="Jin, Meilin" sort="Jin, Meilin" uniqKey="Jin M" first="Meilin" last="Jin">Meilin Jin</name></author></titleStmt><publicationStmt><idno type="wicri:source">HAL</idno><idno type="RBID">Hal:hal-01303102</idno><idno type="halId">hal-01303102</idno><idno type="halUri">https://hal.archives-ouvertes.fr/hal-01303102</idno><idno type="url">https://hal.archives-ouvertes.fr/hal-01303102</idno><idno type="doi">10.1186/s13567-015-0174-3</idno><date when="2015-12">2015-12</date><idno type="wicri:Area/Hal/Corpus">000184</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Efficient strategy for constructing duck enteritis virus-based live attenuated vaccine against homologous and heterologous H5N1 avian influenza virus and duck enteritis virus infection</title><author><name sortKey="Zou, Zhong" sort="Zou, Zhong" uniqKey="Zou Z" first="Zhong" last="Zou">Zhong Zou</name></author><author><name sortKey="Hu, Yong" sort="Hu, Yong" uniqKey="Hu Y" first="Yong" last="Hu">Yong Hu</name></author><author><name sortKey="Liu, Zhigang" sort="Liu, Zhigang" uniqKey="Liu Z" first="Zhigang" last="Liu">Zhigang Liu</name></author><author><name sortKey="Zhong, Wei" sort="Zhong, Wei" uniqKey="Zhong W" first="Wei" last="Zhong">Wei Zhong</name></author><author><name sortKey="Cao, Hangzhou" sort="Cao, Hangzhou" uniqKey="Cao H" first="Hangzhou" last="Cao">Hangzhou Cao</name></author><author><name sortKey="Chen, Huanchun" sort="Chen, Huanchun" uniqKey="Chen H" first="Huanchun" last="Chen">Huanchun Chen</name></author><author><name sortKey="Jin, Meilin" sort="Jin, Meilin" uniqKey="Jin M" first="Meilin" last="Jin">Meilin Jin</name></author></analytic><idno type="DOI">10.1186/s13567-015-0174-3</idno><series><title level="j">Veterinary Research</title><idno type="ISSN">0928-4249</idno><imprint><date type="datePub">2015-12</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"> <p>Duck is susceptible to many pathogens, such as duck hepatitis virus, duck enteritis virus (DEV), duck tembusu virus, H5N1 highly pathogenic avian influenza virus (HPAIV) in particular. With the significant role of duck in the evolution of H5N1 HPAIV, control and eradication of H5N1 HPAIV in duck through vaccine immunization is considered an effective method in minimizing the threat of a pandemic outbreak. Consequently, a practical strategy to construct a vaccine against these pathogens should be determined. In this study, the DEV was examined as a candidate vaccine vector to deliver the hemagglutinin (HA) gene of H5N1, and its potential as a polyvalent vaccine was evaluated. A modified mini-F vector was inserted into the gB and UL26 gene junction of the attenuated DEV vaccine strain C-KCE genome to generate an infectious bacterial artificial chromosome (BAC) of C-KCE (vBAC-C-KCE). The HA gene of A/duck/Hubei/xn/2007 (H5N1) was inserted into the C-KCE genome via the mating-assisted genetically integrated cloning (MAGIC) to generate the recombinant vector pBAC-C-KCE-HA. A bivalent vaccine C-KCE-HA was developed by eliminating the BAC backbone. Ducks immunized with C-KCE-HA induced both the cross-reactive antibodies and T cell response against H5. Moreover, C-KCE-HA-immunized ducks provided rapid and long-lasting protection against homologous and heterologous HPAIV H5N1 and DEV clinical signs, death, and primary viral replication. In conclusion, our BAC-C-KCE is a promising platform for developing a polyvalent live attenuated vaccine.</p> </div></front></TEI><hal api="V3"> <titleStmt> <title xml:lang="en">Efficient strategy for constructing duck enteritis virus-based live attenuated vaccine against homologous and heterologous H5N1 avian influenza virus and duck enteritis virus infection</title> <author role="aut"> <persName> <forename type="first">Zhong</forename> <surname>Zou</surname> </persName> <email type="md5">91633e02ae5148ecc7db9064395b6c4e</email> <email type="domain">126.com</email> <idno type="halauthorid">1326057</idno> </author> <author role="aut"> <persName> <forename type="first">Yong</forename> <surname>Hu</surname> </persName> <email type="md5">05f445f56f53a48e8811fb9c9ed1180a</email> <email type="domain">qq.com</email> <idno type="halauthorid">1326058</idno> </author> <author role="aut"> <persName> <forename type="first">Zhigang</forename> <surname>Liu</surname> </persName> <email type="md5">c9d3b3b24ae004327b9e4d3ec0600099</email> <email type="domain">qq.com</email> <idno type="halauthorid">1326059</idno> </author> <author role="aut"> <persName> <forename type="first">Wei</forename> <surname>Zhong</surname> </persName> <email type="md5">956d247d18a122995b67754f5da81a72</email> <email type="domain">qq.com</email> <idno type="halauthorid">1326060</idno> </author> <author role="aut"> <persName> <forename type="first">Hangzhou</forename> <surname>Cao</surname> </persName> <email type="md5">5b96a4b70ac609c7f18dbe5618316566</email> <email type="domain">qq.com</email> <idno type="halauthorid">1326061</idno> </author> <author role="aut"> <persName> <forename type="first">Huanchun</forename> <surname>Chen</surname> </persName> <email type="md5">14994a36424280437653a10645730a87</email> <email type="domain">mail.hzau.edu.cn</email> <idno type="halauthorid">1326062</idno> </author> <author role="crp"> <persName> <forename type="first">Meilin</forename> <surname>Jin</surname> </persName> <email type="md5">62eee960aca1ca3c8a6d0c084ffb2aeb</email> <email type="domain">126.com</email> <idno type="halauthorid">1326063</idno> </author> <editor role="depositor"> <persName> <forename>BMC</forename> <surname>BMC</surname> </persName> <email type="md5">750df22138c3a8cb85044e5ee79ee867</email> <email type="domain">biomedcentral.com</email> </editor> </titleStmt> <editionStmt> <edition n="v1" type="current"> <date type="whenSubmitted">2016-04-15 20:04:07</date> <date type="whenModified">2016-07-23 01:06:08</date> <date type="whenReleased">2016-07-21 14:03:53</date> <date type="whenProduced">2015-12</date> <date type="whenEndEmbargoed">2016-04-15</date> <ref type="file" target="https://hal.archives-ouvertes.fr/hal-01303102/document"> <date notBefore="2016-04-15"></date> </ref> <ref type="file" subtype="publisherPaid" n="1" target="https://hal.archives-ouvertes.fr/hal-01303102/file/13567_2015_Article_174.pdf"> <date notBefore="2016-04-15"></date> </ref> <ref type="annex" subtype="undefined" n="0" target="https://hal.archives-ouvertes.fr/hal-01303102/file/13567_2015_174_MOESM1_ESM.pdf"> <date notBefore="2016-04-15"></date> </ref> <ref type="annex" subtype="undefined" n="0" target="https://hal.archives-ouvertes.fr/hal-01303102/file/13567_2015_174_MOESM2_ESM.pdf"> <date notBefore="2016-04-15"></date> </ref> <ref type="annex" subtype="undefined" n="0" target="https://hal.archives-ouvertes.fr/hal-01303102/file/13567_2015_174_MOESM3_ESM.pdf"> <date notBefore="2016-04-15"></date> </ref> <ref type="annex" subtype="undefined" n="0" target="https://hal.archives-ouvertes.fr/hal-01303102/file/13567_2015_174_MOESM4_ESM.docx"> <date notBefore="2016-04-15"></date> </ref> <ref type="externalLink" target="https://veterinaryresearch.biomedcentral.com/track/pdf/10.1186/s13567-015-0174-3"></ref> </edition> <respStmt> <resp>contributor</resp> <name key="326461"> <persName> <forename>BMC</forename> <surname>BMC</surname> </persName> <email type="md5">750df22138c3a8cb85044e5ee79ee867</email> <email type="domain">biomedcentral.com</email> </name> </respStmt> </editionStmt> <publicationStmt> <distributor>CCSD</distributor> <idno type="halId">hal-01303102</idno> <idno type="halUri">https://hal.archives-ouvertes.fr/hal-01303102</idno> <idno type="halBibtex">zou:hal-01303102</idno> <idno type="halRefHtml">Veterinary Research, BioMed Central, 2015, 46 (1), pp.42. ⟨10.1186/s13567-015-0174-3⟩</idno> <idno type="halRef">Veterinary Research, BioMed Central, 2015, 46 (1), pp.42. ⟨10.1186/s13567-015-0174-3⟩</idno> </publicationStmt> <seriesStmt> <idno type="stamp" n="ARINRA-VETR" corresp="ARINRA">Veterinary research</idno> <idno type="stamp" n="ARINRA">Archives des revues INRA</idno> </seriesStmt> <notesStmt> <note type="audience" n="2">International</note> <note type="popular" n="0">No</note> <note type="peer" n="1">Yes</note> </notesStmt> <sourceDesc> <biblStruct> <analytic> <title xml:lang="en">Efficient strategy for constructing duck enteritis virus-based live attenuated vaccine against homologous and heterologous H5N1 avian influenza virus and duck enteritis virus infection</title> <author role="aut"> <persName> <forename type="first">Zhong</forename> <surname>Zou</surname> </persName> <email type="md5">91633e02ae5148ecc7db9064395b6c4e</email> <email type="domain">126.com</email> <idno type="halauthorid">1326057</idno> </author> <author role="aut"> <persName> <forename type="first">Yong</forename> <surname>Hu</surname> </persName> <email type="md5">05f445f56f53a48e8811fb9c9ed1180a</email> <email type="domain">qq.com</email> <idno type="halauthorid">1326058</idno> </author> <author role="aut"> <persName> <forename type="first">Zhigang</forename> <surname>Liu</surname> </persName> <email type="md5">c9d3b3b24ae004327b9e4d3ec0600099</email> <email type="domain">qq.com</email> <idno type="halauthorid">1326059</idno> </author> <author role="aut"> <persName> <forename type="first">Wei</forename> <surname>Zhong</surname> </persName> <email type="md5">956d247d18a122995b67754f5da81a72</email> <email type="domain">qq.com</email> <idno type="halauthorid">1326060</idno> </author> <author role="aut"> <persName> <forename type="first">Hangzhou</forename> <surname>Cao</surname> </persName> <email type="md5">5b96a4b70ac609c7f18dbe5618316566</email> <email type="domain">qq.com</email> <idno type="halauthorid">1326061</idno> </author> <author role="aut"> <persName> <forename type="first">Huanchun</forename> <surname>Chen</surname> </persName> <email type="md5">14994a36424280437653a10645730a87</email> <email type="domain">mail.hzau.edu.cn</email> <idno type="halauthorid">1326062</idno> </author> <author role="crp"> <persName> <forename type="first">Meilin</forename> <surname>Jin</surname> </persName> <email type="md5">62eee960aca1ca3c8a6d0c084ffb2aeb</email> <email type="domain">126.com</email> <idno type="halauthorid">1326063</idno> </author> </analytic> <monogr> <idno type="halJournalId" status="VALID">19840</idno> <idno type="issn">0928-4249</idno> <idno type="eissn">1297-9716</idno> <title level="j">Veterinary Research</title> <imprint> <publisher>BioMed Central</publisher> <biblScope unit="volume">46</biblScope> <biblScope unit="issue">1</biblScope> <biblScope unit="pp">42</biblScope> <date type="datePub">2015-12</date> <date type="dateEpub">2015</date> </imprint> </monogr> <idno type="doi">10.1186/s13567-015-0174-3</idno> </biblStruct> </sourceDesc> <profileDesc> <langUsage> <language ident="en">English</language> </langUsage> <textClass> <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode> <classCode scheme="halTypology" n="ART">Journal articles</classCode> </textClass> <abstract xml:lang="en"> <p>Duck is susceptible to many pathogens, such as duck hepatitis virus, duck enteritis virus (DEV), duck tembusu virus, H5N1 highly pathogenic avian influenza virus (HPAIV) in particular. With the significant role of duck in the evolution of H5N1 HPAIV, control and eradication of H5N1 HPAIV in duck through vaccine immunization is considered an effective method in minimizing the threat of a pandemic outbreak. Consequently, a practical strategy to construct a vaccine against these pathogens should be determined. In this study, the DEV was examined as a candidate vaccine vector to deliver the hemagglutinin (HA) gene of H5N1, and its potential as a polyvalent vaccine was evaluated. A modified mini-F vector was inserted into the gB and UL26 gene junction of the attenuated DEV vaccine strain C-KCE genome to generate an infectious bacterial artificial chromosome (BAC) of C-KCE (vBAC-C-KCE). The HA gene of A/duck/Hubei/xn/2007 (H5N1) was inserted into the C-KCE genome via the mating-assisted genetically integrated cloning (MAGIC) to generate the recombinant vector pBAC-C-KCE-HA. A bivalent vaccine C-KCE-HA was developed by eliminating the BAC backbone. Ducks immunized with C-KCE-HA induced both the cross-reactive antibodies and T cell response against H5. Moreover, C-KCE-HA-immunized ducks provided rapid and long-lasting protection against homologous and heterologous HPAIV H5N1 and DEV clinical signs, death, and primary viral replication. In conclusion, our BAC-C-KCE is a promising platform for developing a polyvalent live attenuated vaccine.</p> </abstract> </profileDesc> </hal></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/PandemieGrippaleV1/Data/Hal/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000184 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Hal/Corpus/biblio.hfd -nk 000184 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= PandemieGrippaleV1
|flux= Hal
|étape= Corpus
|type= RBID
|clé= Hal:hal-01303102
|texte= Efficient strategy for constructing duck enteritis virus-based live attenuated vaccine against homologous and heterologous H5N1 avian influenza virus and duck enteritis virus infection
}}
| This area was generated with Dilib version V0.6.34. |  |