Characterization of pandemic influenza immune memory signature after vaccination or infection
Identifieur interne : 000097 ( Hal/Corpus ); précédent : 000096; suivant : 000098Characterization of pandemic influenza immune memory signature after vaccination or infection
Auteurs : Olivia Bonduelle ; Fabrice Carrat ; Charles-Edouard Luyt ; Catherine Leport ; Anne Mosnier ; Nora Benhabiles ; Anne Krivine ; Flore Rozenberg ; Nora Yahia ; Assia Samri ; Dominique Rousset ; Sylvie Van Der Werf ; Brigitte Autran ; Behazine CombadiereSource :
- Journal of Clinical Investigation [ 0021-9738 ] ; 2014-07-01.
Abstract
The magnitude, quality, and maintenance of immunological memory after infection or vaccination must be considered for future design of effective influenza vaccines. In 2009, the influenza pandemic produced disease that ranged from mild to severe, even fatal, illness in infected healthy adults and led to vaccination of a portion of the population with the adjuvanted, inactivated influenza A(H1N1)pdm09 vaccine. Here, we have proposed a multi-parameter quantitative and qualitative approach to comparing adaptive immune memory to influenza 1 year after mild or severe infection or vaccination. One year after antigen encounter, severely ill subjects maintained high levels of humoral and polyfunctional effector/memory CD4$^+$ T cells responses, while mildly ill and vaccinated subjects retained strong cellular immunity, as indicated by high levels of mucosal homing and degranulation markers on IFN-$\gamma^+$ antigen-specific T cells. A principal component analysis distinguished 3 distinct clusters of individuals. The first group comprised vaccinated and mildly ill subjects, while clusters 2 and 3 included mainly infected individuals. Each cluster had immune memory profiles that differed in magnitude and quality. These data provide evidence that there are substantial similarities between the antiinfluenza response that mildly ill and vaccinated individuals develop and that this immune memory signature is different from that seen in severely ill individuals.
Url:
DOI: 10.1172/JCI74565
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Hal:hal-01329320Le document en format XML
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<author><name sortKey="Combadiere, Behazine" sort="Combadiere, Behazine" uniqKey="Combadiere B" first="Behazine" last="Combadiere">Behazine Combadiere</name>
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<idno type="DOI">10.1172/JCI74565</idno>
<series><title level="j">Journal of Clinical Investigation</title>
<idno type="ISSN">0021-9738</idno>
<imprint><date type="datePub">2014-07-01</date>
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<front><div type="abstract" xml:lang="en"> <p>The magnitude, quality, and maintenance of immunological memory after infection or vaccination must be considered for future design of effective influenza vaccines. In 2009, the influenza pandemic produced disease that ranged from mild to severe, even fatal, illness in infected healthy adults and led to vaccination of a portion of the population with the adjuvanted, inactivated influenza A(H1N1)pdm09 vaccine. Here, we have proposed a multi-parameter quantitative and qualitative approach to comparing adaptive immune memory to influenza 1 year after mild or severe infection or vaccination. One year after antigen encounter, severely ill subjects maintained high levels of humoral and polyfunctional effector/memory CD4$^+$ T cells responses, while mildly ill and vaccinated subjects retained strong cellular immunity, as indicated by high levels of mucosal homing and degranulation markers on IFN-$\gamma^+$ antigen-specific T cells. A principal component analysis distinguished 3 distinct clusters of individuals. The first group comprised vaccinated and mildly ill subjects, while clusters 2 and 3 included mainly infected individuals. Each cluster had immune memory profiles that differed in magnitude and quality. These data provide evidence that there are substantial similarities between the antiinfluenza response that mildly ill and vaccinated individuals develop and that this immune memory signature is different from that seen in severely ill individuals.</p>
</div>
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<hal api="V3"> <titleStmt> <title xml:lang="en">Characterization of pandemic influenza immune memory signature after vaccination or infection</title>
<author role="aut"> <persName> <forename type="first">Olivia</forename>
<surname>Bonduelle</surname>
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<funder>This study was supported by a grant from the Programme de Recherche, A(H1N1) coordinated by the Institut de Microbiologie et Maladies Infectieuses (IMMI, France).</funder>
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<sourceDesc> <biblStruct> <analytic> <title xml:lang="en">Characterization of pandemic influenza immune memory signature after vaccination or infection</title>
<author role="aut"> <persName> <forename type="first">Olivia</forename>
<surname>Bonduelle</surname>
</persName>
<idno type="halauthorid">412019</idno>
<affiliation ref="#struct-246601"></affiliation>
<affiliation ref="#struct-459026"></affiliation>
</author>
<author role="aut"> <persName> <forename type="first">Fabrice</forename>
<surname>Carrat</surname>
</persName>
<email type="md5">d3fac14bbecb5ab5a5029e3cc79cb4ca</email>
<email type="domain">iplesp.upmc.fr</email>
<idno type="idhal" notation="string">fabrice-carrat</idno>
<idno type="idhal" notation="numeric">181388</idno>
<idno type="halauthorid">422828</idno>
<idno type="ORCID">https://orcid.org/0000-0002-8672-7918</idno>
<idno type="ResearcherId">http://www.researcherid.com/rid/P-6177-2017</idno>
<affiliation ref="#struct-267618"></affiliation>
<affiliation ref="#struct-166335"></affiliation>
<affiliation ref="#struct-459026"></affiliation>
</author>
<author role="aut"> <persName> <forename type="first">Charles-Edouard</forename>
<surname>Luyt</surname>
</persName>
<idno type="halauthorid">843821</idno>
<affiliation ref="#struct-214582"></affiliation>
<affiliation ref="#struct-459026"></affiliation>
</author>
<author role="aut"> <persName> <forename type="first">Catherine</forename>
<surname>Leport</surname>
</persName>
<idno type="halauthorid">80110</idno>
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<affiliation ref="#struct-247341"></affiliation>
<affiliation ref="#struct-459027"></affiliation>
</author>
<author role="aut"> <persName> <forename type="first">Anne</forename>
<surname>Mosnier</surname>
</persName>
<idno type="halauthorid">727095</idno>
<affiliation ref="#struct-192803"></affiliation>
<affiliation ref="#struct-459026"></affiliation>
</author>
<author role="aut"> <persName> <forename type="first">Nora</forename>
<surname>Benhabiles</surname>
</persName>
<idno type="halauthorid">1348841</idno>
<affiliation ref="#struct-459026"></affiliation>
<affiliation ref="#struct-528161"></affiliation>
</author>
<author role="aut"> <persName> <forename type="first">Anne</forename>
<surname>Krivine</surname>
</persName>
<idno type="halauthorid">1113641</idno>
<affiliation ref="#struct-459026"></affiliation>
<affiliation ref="#struct-459028"></affiliation>
</author>
<author role="aut"> <persName> <forename type="first">Flore</forename>
<surname>Rozenberg</surname>
</persName>
<idno type="halauthorid">323186</idno>
<affiliation ref="#struct-459026"></affiliation>
<affiliation ref="#struct-459028"></affiliation>
</author>
<author role="aut"> <persName> <forename type="first">Nora</forename>
<surname>Yahia</surname>
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<affiliation ref="#struct-246601"></affiliation>
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</author>
<author role="aut"> <persName> <forename type="first">Assia</forename>
<surname>Samri</surname>
</persName>
<idno type="halauthorid">120160</idno>
<affiliation ref="#struct-246601"></affiliation>
<affiliation ref="#struct-459026"></affiliation>
</author>
<author role="aut"> <persName> <forename type="first">Dominique</forename>
<surname>Rousset</surname>
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</author>
<author role="aut"> <persName> <forename type="first">Sylvie</forename>
<surname>Van Der Werf</surname>
</persName>
<idno type="halauthorid">202082</idno>
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<affiliation ref="#struct-417138"></affiliation>
</author>
<author role="aut"> <persName> <forename type="first">Brigitte</forename>
<surname>Autran</surname>
</persName>
<idno type="halauthorid">203206</idno>
<affiliation ref="#struct-45150"></affiliation>
<affiliation ref="#struct-246601"></affiliation>
<affiliation ref="#struct-459026"></affiliation>
</author>
<author role="aut"> <persName> <forename type="first">Behazine</forename>
<surname>Combadiere</surname>
</persName>
<idno type="halauthorid">1348843</idno>
<affiliation ref="#struct-246601"></affiliation>
<affiliation ref="#struct-459026"></affiliation>
</author>
</analytic>
<monogr> <idno type="halJournalId" status="VALID">1386</idno>
<idno type="issn">0021-9738</idno>
<title level="j">Journal of Clinical Investigation</title>
<imprint> <publisher>American Society for Clinical Investigation</publisher>
<biblScope unit="volume">124</biblScope>
<biblScope unit="issue">7</biblScope>
<biblScope unit="pp">3129-3136</biblScope>
<date type="datePub">2014-07-01</date>
</imprint>
</monogr>
<idno type="doi">10.1172/JCI74565</idno>
</biblStruct>
</sourceDesc>
<profileDesc> <langUsage> <language ident="en">English</language>
</langUsage>
<textClass> <classCode scheme="mesh">immunological memory after infection or vaccination </classCode>
<classCode scheme="mesh">influenza </classCode>
<classCode scheme="mesh">humoral and polyfunctional memory</classCode>
<classCode scheme="mesh">cellular immunity</classCode>
<classCode scheme="mesh">immune memory signature</classCode>
<classCode scheme="mesh">clustering</classCode>
<classCode scheme="halDomain" n="sdv.spee">Life Sciences [q-bio]/Santé publique et épidémiologie</classCode>
<classCode scheme="halDomain" n="sdv.imm">Life Sciences [q-bio]/Immunology</classCode>
<classCode scheme="halTypology" n="ART">Journal articles</classCode>
</textClass>
<abstract xml:lang="en"> <p>The magnitude, quality, and maintenance of immunological memory after infection or vaccination must be considered for future design of effective influenza vaccines. In 2009, the influenza pandemic produced disease that ranged from mild to severe, even fatal, illness in infected healthy adults and led to vaccination of a portion of the population with the adjuvanted, inactivated influenza A(H1N1)pdm09 vaccine. Here, we have proposed a multi-parameter quantitative and qualitative approach to comparing adaptive immune memory to influenza 1 year after mild or severe infection or vaccination. One year after antigen encounter, severely ill subjects maintained high levels of humoral and polyfunctional effector/memory CD4$^+$ T cells responses, while mildly ill and vaccinated subjects retained strong cellular immunity, as indicated by high levels of mucosal homing and degranulation markers on IFN-$\gamma^+$ antigen-specific T cells. A principal component analysis distinguished 3 distinct clusters of individuals. The first group comprised vaccinated and mildly ill subjects, while clusters 2 and 3 included mainly infected individuals. Each cluster had immune memory profiles that differed in magnitude and quality. These data provide evidence that there are substantial similarities between the antiinfluenza response that mildly ill and vaccinated individuals develop and that this immune memory signature is different from that seen in severely ill individuals.</p>
</abstract>
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