A singular mutation in the hemagglutinin of the 1918 pandemic virus.
Identifieur interne : 000285 ( France/Analysis ); précédent : 000284; suivant : 000286A singular mutation in the hemagglutinin of the 1918 pandemic virus.
Auteurs : Yves-Henri Sanejouand [France]Source :
- Archives of biochemistry and biophysics [ 1096-0384 ] ; 2017.
Descripteurs français
- KwdFr :
- MESH :
- génétique : Glycoprotéine hémagglutinine du virus influenza, Sous-type H1N1 du virus de la grippe A.
- virologie : Grippe humaine.
- épidémiologie : Grippe humaine.
- Humains, Modèles moléculaires, Mutation ponctuelle, Pandémies, Substitution d'acide aminé.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Hemagglutinin Glycoproteins, Influenza Virus.
- epidemiology : Influenza, Human.
- genetics : Influenza A Virus, H1N1 Subtype.
- virology : Influenza, Human.
- Amino Acid Substitution, Humans, Models, Molecular, Pandemics, Point Mutation.
Abstract
The influenza pandemic of 1918-1919 killed at least 50 million people. The reasons why this pandemic was so deadly remain largely unknown [9]. However, It has been shown that the 1918 viral hemagglutinin allows to reproduce the hallmarks of the illness observed during the original pandemic [11]. Thanks to the wealth of hemagglutinin sequences accumulated over the last decades, amino-acid substitutions that are found in the 1918-1919 sequences but rare otherwise can be identified with high confidence. Noteworthy, Gly 188, which is located within a key motif of the receptor binding site, has never been observed again in sequences of human viruses of subtype H1. Monitoring this singular mutation in viral sequences may help prevent another dramatic pandemic.
Url:
DOI: 10.1016/j.abb.2017.05.013
PubMed: 28577911
Affiliations:
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pubmed:28577911Le document en format XML
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<front><div type="abstract" xml:lang="en">The influenza pandemic of 1918-1919 killed at least 50 million people. The reasons why this pandemic was so deadly remain largely unknown [9]. However, It has been shown that the 1918 viral hemagglutinin allows to reproduce the hallmarks of the illness observed during the original pandemic [11]. Thanks to the wealth of hemagglutinin sequences accumulated over the last decades, amino-acid substitutions that are found in the 1918-1919 sequences but rare otherwise can be identified with high confidence. Noteworthy, Gly 188, which is located within a key motif of the receptor binding site, has never been observed again in sequences of human viruses of subtype H1. Monitoring this singular mutation in viral sequences may help prevent another dramatic pandemic.</div>
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