A paleoneurohistological study of 3,000-year-old mummified brain tissue from the mediterranean bronze age.
Identifieur interne : 000304 ( PubMed/Curation ); précédent : 000303; suivant : 000305A paleoneurohistological study of 3,000-year-old mummified brain tissue from the mediterranean bronze age.
Auteurs : Gemma Prats-Mu Oz [Espagne] ; Assumpci Malgosa ; Nuria Armentano ; Ignasi Galtés ; Jordi Esteban ; Josep A. Bombi ; Montserrat Tortosa ; Eva Fernández ; Xavier Jordana ; Albert Isidro ; Josep M. Fullola ; M Ngels Petit ; Victor M. Guerrero ; Manuel Calvo ; Pedro L. FernándezSource :
- Pathobiology : journal of immunopathology, molecular and cellular biology [ 1423-0291 ] ; 2012.
Descripteurs français
- Wicri :
- geographic : Espagne.
English descriptors
- KwdEn :
- Adult, Brain (pathology), Burial (history), Child, Child, Preschool, Female, Histocytochemistry, History, Ancient, Humans, Imaging, Three-Dimensional, Male, Microscopy, Electron, Scanning, Microscopy, Electron, Transmission, Middle Aged, Mummies (history), Mummies (pathology), Neurology (methods), Neurons (pathology), Paleopathology (methods), Spain, Specimen Handling, Staining and Labeling.
- MESH :
- geographic : Spain.
- history : Burial, Mummies.
- methods : Neurology, Paleopathology.
- pathology : Brain, Mummies, Neurons.
- Adult, Child, Child, Preschool, Female, Histocytochemistry, History, Ancient, Humans, Imaging, Three-Dimensional, Male, Microscopy, Electron, Scanning, Microscopy, Electron, Transmission, Middle Aged, Specimen Handling, Staining and Labeling.
Abstract
Mummified nervous tissue is very rarely found in ancient remains and usually corresponds to corpses which were frozen or preserved in bogs, conditions which limit tissue autolysis and bacterial degradation. Here, we show the unusual finding of spontaneously mummified brain tissue from several individuals from the little known megalithic talaiotic culture of the island of Minorca, dating approximately 3,000 years before present and corresponding to the late Mediterranean Bronze Age.
DOI: 10.1159/000334353
PubMed: 22722563
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Bombi</name></author><author><name sortKey="Tortosa, Montserrat" sort="Tortosa, Montserrat" uniqKey="Tortosa M" first="Montserrat" last="Tortosa">Montserrat Tortosa</name></author><author><name sortKey="Fernandez, Eva" sort="Fernandez, Eva" uniqKey="Fernandez E" first="Eva" last="Fernández">Eva Fernández</name></author><author><name sortKey="Jordana, Xavier" sort="Jordana, Xavier" uniqKey="Jordana X" first="Xavier" last="Jordana">Xavier Jordana</name></author><author><name sortKey="Isidro, Albert" sort="Isidro, Albert" uniqKey="Isidro A" first="Albert" last="Isidro">Albert Isidro</name></author><author><name sortKey="Fullola, Josep M" sort="Fullola, Josep M" uniqKey="Fullola J" first="Josep M" last="Fullola">Josep M. Fullola</name></author><author><name sortKey="Petit, M Ngels" sort="Petit, M Ngels" uniqKey="Petit M" first="M Ngels" last="Petit">M Ngels Petit</name></author><author><name sortKey="Guerrero, Victor M" sort="Guerrero, Victor M" uniqKey="Guerrero V" first="Victor M" last="Guerrero">Victor M. Guerrero</name></author><author><name sortKey="Calvo, Manuel" sort="Calvo, Manuel" uniqKey="Calvo M" first="Manuel" last="Calvo">Manuel Calvo</name></author><author><name sortKey="Fernandez, Pedro L" sort="Fernandez, Pedro L" uniqKey="Fernandez P" first="Pedro L" last="Fernández">Pedro L. Fernández</name></author></analytic><series><title level="j">Pathobiology : journal of immunopathology, molecular and cellular biology</title><idno type="eISSN">1423-0291</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Brain (pathology)</term><term>Burial (history)</term><term>Child</term><term>Child, Preschool</term><term>Female</term><term>Histocytochemistry</term><term>History, Ancient</term><term>Humans</term><term>Imaging, Three-Dimensional</term><term>Male</term><term>Microscopy, Electron, Scanning</term><term>Microscopy, Electron, Transmission</term><term>Middle Aged</term><term>Mummies (history)</term><term>Mummies (pathology)</term><term>Neurology (methods)</term><term>Neurons (pathology)</term><term>Paleopathology (methods)</term><term>Spain</term><term>Specimen Handling</term><term>Staining and Labeling</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Spain</term></keywords><keywords scheme="MESH" qualifier="history" xml:lang="en"><term>Burial</term><term>Mummies</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Neurology</term><term>Paleopathology</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term><term>Mummies</term><term>Neurons</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Child</term><term>Child, Preschool</term><term>Female</term><term>Histocytochemistry</term><term>History, Ancient</term><term>Humans</term><term>Imaging, Three-Dimensional</term><term>Male</term><term>Microscopy, Electron, Scanning</term><term>Microscopy, Electron, Transmission</term><term>Middle Aged</term><term>Specimen Handling</term><term>Staining and Labeling</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Espagne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Mummified nervous tissue is very rarely found in ancient remains and usually corresponds to corpses which were frozen or preserved in bogs, conditions which limit tissue autolysis and bacterial degradation. Here, we show the unusual finding of spontaneously mummified brain tissue from several individuals from the little known megalithic talaiotic culture of the island of Minorca, dating approximately 3,000 years before present and corresponding to the late Mediterranean Bronze Age.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">22722563</PMID><DateCreated><Year>2012</Year><Month>06</Month><Day>22</Day></DateCreated><DateCompleted><Year>2012</Year><Month>10</Month><Day>23</Day></DateCompleted><DateRevised><Year>2012</Year><Month>06</Month><Day>22</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1423-0291</ISSN><JournalIssue CitedMedium="Internet"><Volume>79</Volume><Issue>5</Issue><PubDate><Year>2012</Year></PubDate></JournalIssue><Title>Pathobiology : journal of immunopathology, molecular and cellular biology</Title><ISOAbbreviation>Pathobiology</ISOAbbreviation></Journal><ArticleTitle>A paleoneurohistological study of 3,000-year-old mummified brain tissue from the mediterranean bronze age.</ArticleTitle><Pagination><MedlinePgn>239-46</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1159/000334353</ELocationID><Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">Mummified nervous tissue is very rarely found in ancient remains and usually corresponds to corpses which were frozen or preserved in bogs, conditions which limit tissue autolysis and bacterial degradation. Here, we show the unusual finding of spontaneously mummified brain tissue from several individuals from the little known megalithic talaiotic culture of the island of Minorca, dating approximately 3,000 years before present and corresponding to the late Mediterranean Bronze Age.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">These individuals were part of an intact burial site containing 66 subjects. Intracraneal samples were carefully rehydrated with Sandison's solution. We used classical histochemical as well as 2D and 3D (scanning) electron-microscopic techniques.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">We provide evidence of the nervous nature of the samples as well as a detailed description of the morphological features of these ancient tissues. The intracranial material consisted of well-preserved eosinophilic reticular tissue and, although mostly absent, some exceptional pigment-containing neurons were identified.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">We present a detailed morphological analysis which can provide valuable information and guidelines for the interpretation of this scarce type of mummified samples and provide explanations for this surprising preservation.</AbstractText><CopyrightInformation>Copyright © 2012 S. Karger AG, Basel.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Prats-Muñoz</LastName><ForeName>Gemma</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Prehistory, Ancient History and Archaeology, Hospital Clínic and Institut d'Investigacions August Pi i Sunyer, University of Barcelona, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Malgosa</LastName><ForeName>Assumpció</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Armentano</LastName><ForeName>Nuria</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Galtés</LastName><ForeName>Ignasi</ForeName><Initials>I</Initials></Author><Author ValidYN="Y"><LastName>Esteban</LastName><ForeName>Jordi</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Bombi</LastName><ForeName>Josep A</ForeName><Initials>JA</Initials></Author><Author ValidYN="Y"><LastName>Tortosa</LastName><ForeName>Montserrat</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Fernández</LastName><ForeName>Eva</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Jordana</LastName><ForeName>Xavier</ForeName><Initials>X</Initials></Author><Author ValidYN="Y"><LastName>Isidro</LastName><ForeName>Albert</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Fullola</LastName><ForeName>Josep M</ForeName><Initials>JM</Initials></Author><Author ValidYN="Y"><LastName>Petit</LastName><ForeName>M Àngels</ForeName><Initials>MÀ</Initials></Author><Author ValidYN="Y"><LastName>Guerrero</LastName><ForeName>Victor M</ForeName><Initials>VM</Initials></Author><Author ValidYN="Y"><LastName>Calvo</LastName><ForeName>Manuel</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Fernández</LastName><ForeName>Pedro L</ForeName><Initials>PL</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016456">Historical Article</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2012</Year><Month>06</Month><Day>21</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Pathobiology</MedlineTA><NlmUniqueID>9007504</NlmUniqueID><ISSNLinking>1015-2008</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001921" MajorTopicYN="N">Brain</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002048" MajorTopicYN="N">Burial</DescriptorName><QualifierName UI="Q000266" MajorTopicYN="N">history</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006651" MajorTopicYN="N">Histocytochemistry</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D049690" MajorTopicYN="N">History, Ancient</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D021621" MajorTopicYN="N">Imaging, Three-Dimensional</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008855" MajorTopicYN="N">Microscopy, Electron, Scanning</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D046529" MajorTopicYN="N">Microscopy, Electron, Transmission</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009106" MajorTopicYN="N">Mummies</DescriptorName><QualifierName UI="Q000266" MajorTopicYN="N">history</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009462" MajorTopicYN="N">Neurology</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009474" MajorTopicYN="N">Neurons</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010164" MajorTopicYN="N">Paleopathology</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013030" MajorTopicYN="N" Type="Geographic">Spain</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013048" MajorTopicYN="N">Specimen Handling</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013194" MajorTopicYN="N">Staining and Labeling</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>6</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>6</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2012</Year><Month>10</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">22722563</ArticleId><ArticleId 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