Cribra orbitalia as a potential indicator of childhood stress: Evidence from paleopathology, stable C, N, and O isotopes, and trace element concentrations in children from a 17(th)-18(th) century cemetery in Jēkabpils, Latvia.
Identifieur interne : 000010 ( PubMed/Curation ); précédent : 000009; suivant : 000011Cribra orbitalia as a potential indicator of childhood stress: Evidence from paleopathology, stable C, N, and O isotopes, and trace element concentrations in children from a 17(th)-18(th) century cemetery in Jēkabpils, Latvia.
Auteurs : Gunita Zari A [Lettonie] ; Sabrina B. Sholts [États-Unis] ; Alina Tichinin [États-Unis] ; Vita Rudovica [Lettonie] ; Arturs V Ksna [Lettonie] ; Austra Eng Zere [Lettonie] ; Vitolds Muižnieks [Lettonie] ; Eric J. Bartelink [États-Unis] ; Sebastian K T S. W Rml Nder [États-Unis]Source :
- Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) [ 1878-3252 ] ; 2016.
Abstract
Cribra orbitalia (CO), or porotic hyperostosis (PH) of the orbital roof, is one of the most common pathological conditions found in archaeological subadult skeletal remains. Reaching frequencies higher than 50% in many prehistoric samples, CO has been generally attributed to a variety of factors including malnutrition (e.g., megaloblastic anemia) and parasitism. In this study, we tested the relationship between CO, trace element concentrations, and stable isotope values (δ(13)C, δ(15)N, δ(18)O) in subadult skeletons from a 17(th) to 18(th) century cemetery in the historic town of Jēkabpils, Latvia. A total of 28 subadults were examined, seven of which (25%) showed evidence of CO. Bioarchaeological evidence indicated high mortality for children in this cemetery: half of the burials were subadults under the age of 14, while a third were under the age of four. Life expectancy at birth was estimated to have been only 21.6 years. Trace element concentrations measured by Inductively Coupled Plasma - Mass Spectrometry (ICP-MS) showed no relationship between presence or absence of CO and levels of manganese, zinc, strontium, barium, copper, cadmium, or lead in the bones (p>0.05). However, a significant correlation (p<0.05) was found between the presence of CO and decreased levels of iron. The correlations between CO and decreased levels of copper and lead approached significance (p=0.056 for both elements). Individuals with CO furthermore displayed significantly lower δ(15)N isotope values, suggesting greater consumption of lower trophic level food resources than those unaffected by CO; δ(13)C and δ(18)O values, in contrast, showed no significant differences. These results suggest that the prevalence of CO may be related to dietary deficiencies. In this case, low iron levels may also signify a diet low in other key vitamins (e.g., B9 and B12), which are known to cause megaloblastic anemia.
DOI: 10.1016/j.jtemb.2016.05.008
PubMed: 27289401
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Sholts</name><affiliation wicri:level="1"><nlm:affiliation>Department of Anthropology, National Museum of Natural History, Smithsonian Institution, Washington DC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Anthropology, National Museum of Natural History, Smithsonian Institution, Washington DC</wicri:regionArea></affiliation></author><author><name sortKey="Tichinin, Alina" sort="Tichinin, Alina" uniqKey="Tichinin A" first="Alina" last="Tichinin">Alina Tichinin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Anthropology, California State University, Chico, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Anthropology, California State University, Chico, CA</wicri:regionArea></affiliation></author><author><name sortKey="Rudovica, Vita" sort="Rudovica, Vita" uniqKey="Rudovica V" first="Vita" last="Rudovica">Vita Rudovica</name><affiliation wicri:level="1"><nlm:affiliation>Department of Analytical Chemistry, University of Latvia, Riga, Latvia.</nlm:affiliation><country xml:lang="fr">Lettonie</country><wicri:regionArea>Department of Analytical Chemistry, University of Latvia, Riga</wicri:regionArea></affiliation></author><author><name sortKey="V Ksna, Arturs" sort="V Ksna, Arturs" uniqKey="V Ksna A" first="Arturs" last="V Ksna">Arturs V Ksna</name><affiliation wicri:level="1"><nlm:affiliation>Department of Analytical Chemistry, University of Latvia, Riga, Latvia.</nlm:affiliation><country xml:lang="fr">Lettonie</country><wicri:regionArea>Department of Analytical Chemistry, University of Latvia, Riga</wicri:regionArea></affiliation></author><author><name sortKey="Eng Zere, Austra" sort="Eng Zere, Austra" uniqKey="Eng Zere A" first="Austra" last="Eng Zere">Austra Eng Zere</name><affiliation wicri:level="1"><nlm:affiliation>Latvian National Museum of History, Riga, Latvia.</nlm:affiliation><country xml:lang="fr">Lettonie</country><wicri:regionArea>Latvian National Museum of History, Riga</wicri:regionArea></affiliation></author><author><name sortKey="Muiznieks, Vitolds" sort="Muiznieks, Vitolds" uniqKey="Muiznieks V" first="Vitolds" last="Muižnieks">Vitolds Muižnieks</name><affiliation wicri:level="1"><nlm:affiliation>Latvian National Museum of History, Riga, Latvia.</nlm:affiliation><country xml:lang="fr">Lettonie</country><wicri:regionArea>Latvian National Museum of History, Riga</wicri:regionArea></affiliation></author><author><name sortKey="Bartelink, Eric J" sort="Bartelink, Eric J" uniqKey="Bartelink E" first="Eric J" last="Bartelink">Eric J. 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Electronic address: seb@dbb.su.se.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Biophysics, Stockholm University, Sweden; Cotsen Institute of Archaeology, UCLA/Getty Conservation Programme, UCLA, Los Angeles, CA</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27289401</idno><idno type="pmid">27289401</idno><idno type="doi">10.1016/j.jtemb.2016.05.008</idno><idno type="wicri:Area/PubMed/Corpus">000010</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000010</idno><idno type="wicri:Area/PubMed/Curation">000010</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000010</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Cribra orbitalia as a potential indicator of childhood stress: Evidence from paleopathology, stable C, N, and O isotopes, and trace element concentrations in children from a 17(th)-18(th) century cemetery in Jēkabpils, Latvia.</title><author><name sortKey="Zari A, Gunita" sort="Zari A, Gunita" uniqKey="Zari A G" first="Gunita" last="Zari A">Gunita Zari A</name><affiliation wicri:level="1"><nlm:affiliation>Institute of the Latvian History at the University of Latvia, Riga, Latvia.</nlm:affiliation><country xml:lang="fr">Lettonie</country><wicri:regionArea>Institute of the Latvian History at the University of Latvia, Riga</wicri:regionArea></affiliation></author><author><name sortKey="Sholts, Sabrina B" sort="Sholts, Sabrina B" uniqKey="Sholts S" first="Sabrina B" last="Sholts">Sabrina B. Sholts</name><affiliation wicri:level="1"><nlm:affiliation>Department of Anthropology, National Museum of Natural History, Smithsonian Institution, Washington DC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Anthropology, National Museum of Natural History, Smithsonian Institution, Washington DC</wicri:regionArea></affiliation></author><author><name sortKey="Tichinin, Alina" sort="Tichinin, Alina" uniqKey="Tichinin A" first="Alina" last="Tichinin">Alina Tichinin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Anthropology, California State University, Chico, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Anthropology, California State University, Chico, CA</wicri:regionArea></affiliation></author><author><name sortKey="Rudovica, Vita" sort="Rudovica, Vita" uniqKey="Rudovica V" first="Vita" last="Rudovica">Vita Rudovica</name><affiliation wicri:level="1"><nlm:affiliation>Department of Analytical Chemistry, University of Latvia, Riga, Latvia.</nlm:affiliation><country xml:lang="fr">Lettonie</country><wicri:regionArea>Department of Analytical Chemistry, University of Latvia, Riga</wicri:regionArea></affiliation></author><author><name sortKey="V Ksna, Arturs" sort="V Ksna, Arturs" uniqKey="V Ksna A" first="Arturs" last="V Ksna">Arturs V Ksna</name><affiliation wicri:level="1"><nlm:affiliation>Department of Analytical Chemistry, University of Latvia, Riga, Latvia.</nlm:affiliation><country xml:lang="fr">Lettonie</country><wicri:regionArea>Department of Analytical Chemistry, University of Latvia, Riga</wicri:regionArea></affiliation></author><author><name sortKey="Eng Zere, Austra" sort="Eng Zere, Austra" uniqKey="Eng Zere A" first="Austra" last="Eng Zere">Austra Eng Zere</name><affiliation wicri:level="1"><nlm:affiliation>Latvian National Museum of History, Riga, Latvia.</nlm:affiliation><country xml:lang="fr">Lettonie</country><wicri:regionArea>Latvian National Museum of History, Riga</wicri:regionArea></affiliation></author><author><name sortKey="Muiznieks, Vitolds" sort="Muiznieks, Vitolds" uniqKey="Muiznieks V" first="Vitolds" last="Muižnieks">Vitolds Muižnieks</name><affiliation wicri:level="1"><nlm:affiliation>Latvian National Museum of History, Riga, Latvia.</nlm:affiliation><country xml:lang="fr">Lettonie</country><wicri:regionArea>Latvian National Museum of History, Riga</wicri:regionArea></affiliation></author><author><name sortKey="Bartelink, Eric J" sort="Bartelink, Eric J" uniqKey="Bartelink E" first="Eric J" last="Bartelink">Eric J. Bartelink</name><affiliation wicri:level="1"><nlm:affiliation>Department of Anthropology, California State University, Chico, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Anthropology, California State University, Chico, CA</wicri:regionArea></affiliation></author><author><name sortKey="W Rml Nder, Sebastian K T S" sort="W Rml Nder, Sebastian K T S" uniqKey="W Rml Nder S" first="Sebastian K T S" last="W Rml Nder">Sebastian K T S. W Rml Nder</name><affiliation wicri:level="1"><nlm:affiliation>Division of Biophysics, Stockholm University, Sweden; Cotsen Institute of Archaeology, UCLA/Getty Conservation Programme, UCLA, Los Angeles, CA, United States. Electronic address: seb@dbb.su.se.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Biophysics, Stockholm University, Sweden; Cotsen Institute of Archaeology, UCLA/Getty Conservation Programme, UCLA, Los Angeles, CA</wicri:regionArea></affiliation></author></analytic><series><title level="j">Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)</title><idno type="eISSN">1878-3252</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Cribra orbitalia (CO), or porotic hyperostosis (PH) of the orbital roof, is one of the most common pathological conditions found in archaeological subadult skeletal remains. Reaching frequencies higher than 50% in many prehistoric samples, CO has been generally attributed to a variety of factors including malnutrition (e.g., megaloblastic anemia) and parasitism. In this study, we tested the relationship between CO, trace element concentrations, and stable isotope values (δ(13)C, δ(15)N, δ(18)O) in subadult skeletons from a 17(th) to 18(th) century cemetery in the historic town of Jēkabpils, Latvia. A total of 28 subadults were examined, seven of which (25%) showed evidence of CO. Bioarchaeological evidence indicated high mortality for children in this cemetery: half of the burials were subadults under the age of 14, while a third were under the age of four. Life expectancy at birth was estimated to have been only 21.6 years. Trace element concentrations measured by Inductively Coupled Plasma - Mass Spectrometry (ICP-MS) showed no relationship between presence or absence of CO and levels of manganese, zinc, strontium, barium, copper, cadmium, or lead in the bones (p>0.05). However, a significant correlation (p<0.05) was found between the presence of CO and decreased levels of iron. The correlations between CO and decreased levels of copper and lead approached significance (p=0.056 for both elements). Individuals with CO furthermore displayed significantly lower δ(15)N isotope values, suggesting greater consumption of lower trophic level food resources than those unaffected by CO; δ(13)C and δ(18)O values, in contrast, showed no significant differences. These results suggest that the prevalence of CO may be related to dietary deficiencies. In this case, low iron levels may also signify a diet low in other key vitamins (e.g., B9 and B12), which are known to cause megaloblastic anemia.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">27289401</PMID><DateCreated><Year>2016</Year><Month>06</Month><Day>12</Day></DateCreated><DateRevised><Year>2016</Year><Month>12</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1878-3252</ISSN><JournalIssue CitedMedium="Internet"><Volume>38</Volume><PubDate><Year>2016</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)</Title><ISOAbbreviation>J Trace Elem Med Biol</ISOAbbreviation></Journal><ArticleTitle>Cribra orbitalia as a potential indicator of childhood stress: Evidence from paleopathology, stable C, N, and O isotopes, and trace element concentrations in children from a 17(th)-18(th) century cemetery in Jēkabpils, Latvia.</ArticleTitle><Pagination><MedlinePgn>131-137</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0946-672X(16)30078-5</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jtemb.2016.05.008</ELocationID><Abstract><AbstractText NlmCategory="UNASSIGNED">Cribra orbitalia (CO), or porotic hyperostosis (PH) of the orbital roof, is one of the most common pathological conditions found in archaeological subadult skeletal remains. Reaching frequencies higher than 50% in many prehistoric samples, CO has been generally attributed to a variety of factors including malnutrition (e.g., megaloblastic anemia) and parasitism. In this study, we tested the relationship between CO, trace element concentrations, and stable isotope values (δ(13)C, δ(15)N, δ(18)O) in subadult skeletons from a 17(th) to 18(th) century cemetery in the historic town of Jēkabpils, Latvia. A total of 28 subadults were examined, seven of which (25%) showed evidence of CO. Bioarchaeological evidence indicated high mortality for children in this cemetery: half of the burials were subadults under the age of 14, while a third were under the age of four. Life expectancy at birth was estimated to have been only 21.6 years. Trace element concentrations measured by Inductively Coupled Plasma - Mass Spectrometry (ICP-MS) showed no relationship between presence or absence of CO and levels of manganese, zinc, strontium, barium, copper, cadmium, or lead in the bones (p>0.05). However, a significant correlation (p<0.05) was found between the presence of CO and decreased levels of iron. The correlations between CO and decreased levels of copper and lead approached significance (p=0.056 for both elements). Individuals with CO furthermore displayed significantly lower δ(15)N isotope values, suggesting greater consumption of lower trophic level food resources than those unaffected by CO; δ(13)C and δ(18)O values, in contrast, showed no significant differences. These results suggest that the prevalence of CO may be related to dietary deficiencies. In this case, low iron levels may also signify a diet low in other key vitamins (e.g., B9 and B12), which are known to cause megaloblastic anemia.</AbstractText><CopyrightInformation>Copyright © 2016 Elsevier GmbH. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zariņa</LastName><ForeName>Gunita</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Institute of the Latvian History at the University of Latvia, Riga, Latvia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sholts</LastName><ForeName>Sabrina B</ForeName><Initials>SB</Initials><AffiliationInfo><Affiliation>Department of Anthropology, National Museum of Natural History, Smithsonian Institution, Washington DC, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tichinin</LastName><ForeName>Alina</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Anthropology, California State University, Chico, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rudovica</LastName><ForeName>Vita</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Department of Analytical Chemistry, University of Latvia, Riga, Latvia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vīksna</LastName><ForeName>Arturs</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Analytical Chemistry, University of Latvia, Riga, Latvia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Engīzere</LastName><ForeName>Austra</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Latvian National Museum of History, Riga, Latvia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Muižnieks</LastName><ForeName>Vitolds</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Latvian National Museum of History, Riga, Latvia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bartelink</LastName><ForeName>Eric J</ForeName><Initials>EJ</Initials><AffiliationInfo><Affiliation>Department of Anthropology, California State University, Chico, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wärmländer</LastName><ForeName>Sebastian K T S</ForeName><Initials>SK</Initials><AffiliationInfo><Affiliation>Division of Biophysics, Stockholm University, Sweden; Cotsen Institute of Archaeology, UCLA/Getty Conservation Programme, UCLA, Los Angeles, CA, United States. Electronic address: seb@dbb.su.se.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>05</Month><Day>24</Day></ArticleDate></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>J Trace Elem Med Biol</MedlineTA><NlmUniqueID>9508274</NlmUniqueID><ISSNLinking>0946-672X</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Bioarchaeology</Keyword><Keyword MajorTopicYN="N">Cribra orbitalia</Keyword><Keyword MajorTopicYN="N">Epidemiology</Keyword><Keyword MajorTopicYN="N">Nutrition</Keyword><Keyword MajorTopicYN="N">Physical anthropology</Keyword><Keyword MajorTopicYN="N">Trace elements</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>02</Month><Day>29</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2016</Year><Month>05</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>05</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>6</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>6</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>6</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27289401</ArticleId><ArticleId IdType="pii">S0946-672X(16)30078-5</ArticleId><ArticleId IdType="doi">10.1016/j.jtemb.2016.05.008</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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