Skeletal Lesions in Human Tuberculosis May Sometimes Heal: An Aid to Palaeopathological Diagnoses
Identifieur interne : 000370 ( Pmc/Curation ); précédent : 000369; suivant : 000371Skeletal Lesions in Human Tuberculosis May Sometimes Heal: An Aid to Palaeopathological Diagnoses
Auteurs : Kara L. Holloway [Australie] ; Karl Link [Suisse] ; Frank Rühli [Suisse] ; Maciej Henneberg [Australie]Source :
- PLoS ONE [ 1932-6203 ] ; 2013.
Abstract
In three to five percent of active cases of tuberculosis, skeletal lesions develop. Typically, these occur on the vertebrae and are destructive in nature. In this paper, we examined cases of skeletal tuberculosis from a skeletal collection (Galler Collection) with focus on the manifestation of bony changes due to tuberculosis in various body regions in association with antibiotic introduction. This skeletal collection was created in 1925–1977 by a pathologist at the University Hospital in Zürich, Ernst Galler. It includes the remains of 2426 individuals with documented clinical histories as well as autopsies. It contained 29 cases of skeletal tuberculosis lesions. We observed natural healing of vertebral lesions through several processes including fusion of vertebrae, bone deposition and fusion of posterior elements. In these cases, we observed a higher frequency and proportion of bone deposition and fusion of posterior vertebral elements where pharmacological agents were used. There were also four cases of artificial healing through surgically induced posterior spinal fusion. With the introduction of pharmaceutical treatments, the number of individuals with multiple tuberculous foci decreased from 80% to 25% when compared to individuals who did not receive any drug therapy. Investigation of comorbidities showed that pneumonia, pleuritis and being underweight were consistently present, even with pharmaceutical treatment. Our results have applications in palaeopathological diagnoses where healing and consequent bone deposition may complicate differential diagnoses.
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DOI: 10.1371/journal.pone.0062798
PubMed: 23638146
PubMed Central: 3634763
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Holloway</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Biological Anthropology and Comparative Anatomy Research Unit, The University of Adelaide, South Australia, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Biological Anthropology and Comparative Anatomy Research Unit, The University of Adelaide, South Australia</wicri:regionArea></affiliation></author><author><name sortKey="Link, Karl" sort="Link, Karl" uniqKey="Link K" first="Karl" last="Link">Karl Link</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Centre for Evolutionary Medicine, Institute of Anatomy, University of Zürich, Zürich, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Centre for Evolutionary Medicine, Institute of Anatomy, University of Zürich, Zürich</wicri:regionArea></affiliation></author><author><name sortKey="Ruhli, Frank" sort="Ruhli, Frank" uniqKey="Ruhli F" first="Frank" last="Rühli">Frank Rühli</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Centre for Evolutionary Medicine, Institute of Anatomy, University of Zürich, Zürich, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Centre for Evolutionary Medicine, Institute of Anatomy, University of Zürich, Zürich</wicri:regionArea></affiliation></author><author><name sortKey="Henneberg, Maciej" sort="Henneberg, Maciej" uniqKey="Henneberg M" first="Maciej" last="Henneberg">Maciej Henneberg</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Biological Anthropology and Comparative Anatomy Research Unit, The University of Adelaide, South Australia, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Biological Anthropology and Comparative Anatomy Research Unit, The University of Adelaide, South Australia</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23638146</idno><idno type="pmc">3634763</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634763</idno><idno type="RBID">PMC:3634763</idno><idno type="doi">10.1371/journal.pone.0062798</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000370</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000370</idno><idno type="wicri:Area/Pmc/Curation">000370</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000370</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Skeletal Lesions in Human Tuberculosis May Sometimes Heal: An Aid to Palaeopathological Diagnoses</title><author><name sortKey="Holloway, Kara L" sort="Holloway, Kara L" uniqKey="Holloway K" first="Kara L." last="Holloway">Kara L. 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Typically, these occur on the vertebrae and are destructive in nature. In this paper, we examined cases of skeletal tuberculosis from a skeletal collection (Galler Collection) with focus on the manifestation of bony changes due to tuberculosis in various body regions in association with antibiotic introduction. This skeletal collection was created in 1925–1977 by a pathologist at the University Hospital in Zürich, Ernst Galler. It includes the remains of 2426 individuals with documented clinical histories as well as autopsies. It contained 29 cases of skeletal tuberculosis lesions. We observed natural healing of vertebral lesions through several processes including fusion of vertebrae, bone deposition and fusion of posterior elements. In these cases, we observed a higher frequency and proportion of bone deposition and fusion of posterior vertebral elements where pharmacological agents were used. There were also four cases of artificial healing through surgically induced posterior spinal fusion. With the introduction of pharmaceutical treatments, the number of individuals with multiple tuberculous foci decreased from 80% to 25% when compared to individuals who did not receive any drug therapy. Investigation of comorbidities showed that pneumonia, pleuritis and being underweight were consistently present, even with pharmaceutical treatment. 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Dye</name></author><author><name sortKey="Williams, Bg" uniqKey="Williams B">BG Williams</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Klaus, Hd" uniqKey="Klaus H">HD Klaus</name></author><author><name sortKey="Wilbur, Ak" uniqKey="Wilbur A">AK Wilbur</name></author><author><name sortKey="Temple, Dh" uniqKey="Temple D">DH Temple</name></author><author><name sortKey="Buikstra, Je" uniqKey="Buikstra J">JE Buikstra</name></author><author><name sortKey="Stone, Ac" uniqKey="Stone A">AC Stone</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Murphy, Em" uniqKey="Murphy E">EM Murphy</name></author><author><name sortKey="Chistov, Yk" uniqKey="Chistov Y">YK Chistov</name></author><author><name sortKey="Hopkins, R" uniqKey="Hopkins R">R Hopkins</name></author><author><name sortKey="Rutland, P" uniqKey="Rutland P">P Rutland</name></author><author><name sortKey="Taylor, Gm" uniqKey="Taylor G">GM 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Gulyas-Fekete</name></author><author><name sortKey="Marcsik, A" uniqKey="Marcsik A">A Marcsik</name></author><author><name sortKey="Molnar, E" uniqKey="Molnar E">E Molnár</name></author><author><name sortKey="Palfi, G" uniqKey="Palfi G">G Pálfi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Redman, Je" uniqKey="Redman J">JE Redman</name></author><author><name sortKey="Shaw, Mj" uniqKey="Shaw M">MJ Shaw</name></author><author><name sortKey="Mallet, Ai" uniqKey="Mallet A">AI Mallet</name></author><author><name sortKey="Santos, Al" uniqKey="Santos A">AL Santos</name></author><author><name sortKey="Roberts, Ca" uniqKey="Roberts C">CA Roberts</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Waddington, K" uniqKey="Waddington K">K Waddington</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS One</journal-id><journal-id journal-id-type="iso-abbrev">PLoS ONE</journal-id><journal-id journal-id-type="publisher-id">plos</journal-id><journal-id journal-id-type="pmc">plosone</journal-id><journal-title-group><journal-title>PLoS ONE</journal-title></journal-title-group><issn pub-type="epub">1932-6203</issn><publisher><publisher-name>Public Library of Science</publisher-name><publisher-loc>San Francisco, USA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23638146</article-id><article-id pub-id-type="pmc">3634763</article-id><article-id pub-id-type="publisher-id">PONE-D-13-09097</article-id><article-id pub-id-type="doi">10.1371/journal.pone.0062798</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Biology</subject><subj-group><subject>Anatomy and Physiology</subject><subj-group><subject>Musculoskeletal System</subject><subj-group><subject>Musculoskeletal Anatomy</subject></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Medicine</subject><subj-group><subject>Anatomy and Physiology</subject><subj-group><subject>Musculoskeletal System</subject><subj-group><subject>Musculoskeletal Anatomy</subject></subj-group></subj-group></subj-group><subj-group><subject>Diagnostic Medicine</subject><subj-group><subject>Pathology</subject><subj-group><subject>Anatomical Pathology</subject><subj-group><subject>Autopsy Pathology</subject></subj-group></subj-group><subj-group><subject>General Pathology</subject></subj-group></subj-group></subj-group><subj-group><subject>Infectious Diseases</subject><subj-group><subject>Bacterial Diseases</subject><subj-group><subject>Tuberculosis</subject></subj-group></subj-group><subj-group><subject>Tropical Diseases (Non-Neglected)</subject><subj-group><subject>Tuberculosis</subject></subj-group></subj-group></subj-group></subj-group></article-categories><title-group><article-title>Skeletal Lesions in Human Tuberculosis May Sometimes Heal: An Aid to Palaeopathological Diagnoses</article-title><alt-title alt-title-type="running-head">Healing of Skeletal Lesions in Tuberculosis</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Holloway</surname><given-names>Kara L.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib><contrib contrib-type="author"><name><surname>Link</surname><given-names>Karl</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Rühli</surname><given-names>Frank</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Henneberg</surname><given-names>Maciej</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib></contrib-group><aff id="aff1"><label>1</label><addr-line>Biological Anthropology and Comparative Anatomy Research Unit, The University of Adelaide, South Australia, Australia</addr-line></aff><aff id="aff2"><label>2</label><addr-line>Centre for Evolutionary Medicine, Institute of Anatomy, University of Zürich, Zürich, Switzerland</addr-line></aff><contrib-group><contrib contrib-type="editor"><name><surname>Neyrolles</surname><given-names>Olivier</given-names></name><role>Editor</role><xref ref-type="aff" rid="edit1"></xref></contrib></contrib-group><aff id="edit1"><addr-line>Institut de Pharmacologie et de Biologie Structurale, France</addr-line></aff><author-notes><corresp id="cor1">* E-mail: <email>kara.holloway@adelaide.edu.au</email></corresp><fn fn-type="conflict"><p><bold>Competing Interests: </bold>The authors have declared that no competing interests exist.</p></fn><fn fn-type="con"><p>Conceived and designed the experiments: KLH KL MH. Performed the experiments: KLH KL. Analyzed the data: KLH. Contributed reagents/materials/analysis tools: KL FR. Wrote the paper: KLH.</p></fn></author-notes><pub-date pub-type="collection"><year>2013</year></pub-date><pub-date pub-type="epub"><day>24</day><month>4</month><year>2013</year></pub-date><volume>8</volume><issue>4</issue><elocation-id>e62798</elocation-id><history><date date-type="received"><day>27</day><month>2</month><year>2013</year></date><date date-type="accepted"><day>24</day><month>3</month><year>2013</year></date></history><permissions><copyright-year>2013</copyright-year><copyright-holder>Holloway et al</copyright-holder><license><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p></license></permissions><abstract><sec><title></title><p>In three to five percent of active cases of tuberculosis, skeletal lesions develop. Typically, these occur on the vertebrae and are destructive in nature. In this paper, we examined cases of skeletal tuberculosis from a skeletal collection (Galler Collection) with focus on the manifestation of bony changes due to tuberculosis in various body regions in association with antibiotic introduction. This skeletal collection was created in 1925–1977 by a pathologist at the University Hospital in Zürich, Ernst Galler. It includes the remains of 2426 individuals with documented clinical histories as well as autopsies. It contained 29 cases of skeletal tuberculosis lesions. We observed natural healing of vertebral lesions through several processes including fusion of vertebrae, bone deposition and fusion of posterior elements. In these cases, we observed a higher frequency and proportion of bone deposition and fusion of posterior vertebral elements where pharmacological agents were used. There were also four cases of artificial healing through surgically induced posterior spinal fusion. With the introduction of pharmaceutical treatments, the number of individuals with multiple tuberculous foci decreased from 80% to 25% when compared to individuals who did not receive any drug therapy. Investigation of comorbidities showed that pneumonia, pleuritis and being underweight were consistently present, even with pharmaceutical treatment. Our results have applications in palaeopathological diagnoses where healing and consequent bone deposition may complicate differential diagnoses.</p></sec></abstract><funding-group><funding-statement>This work is supported by the Australian Postgraduate Award, Dorothy and Walter Duncan Trust Award, School of Medical Sciences Postgraduate Travel Award, Research Abroad Scholarship, Faculty of Health Sciences Postgraduate Travelling Fellowship, The University of Adelaide and the Mäxi Foundation Zürich. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.</funding-statement></funding-group><counts><page-count count="17"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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