The contribution of natural selection to present-day susceptibility to chronic inflammatory and autoimmune disease
Identifieur interne : 000319 ( Pmc/Curation ); précédent : 000318; suivant : 000320The contribution of natural selection to present-day susceptibility to chronic inflammatory and autoimmune disease
Auteurs : Jessica F. Brinkworth [Canada] ; Luis B. Barreiro [Canada]Source :
- Current opinion in immunology [ 0952-7915 ] ; 2014.
Abstract
Chronic inflammatory and autoimmune diseases have been the focus of many genome-wide association studies (GWAS) because they represent a significant cause of illness and morbidity, and many are heritable. Almost a decade of GWAS studies suggests that the pathological inflammation associated with these diseases is controlled by a limited number of networked immune system genes. Chronic inflammatory and autoimmune diseases are enigmatic from an evolutionary perspective because they exert a negative affect on reproductive fitness. The persistence of these conditions may be partially explained by the important roles the implicated immune genes play in pathogen defense and other functions thought to be under strong natural selection in humans. The evolutionary reasons for chronic inflammatory and autoimmune disease persistence and uneven distribution across populations are the focus of this review.
Url:
DOI: 10.1016/j.coi.2014.09.008
PubMed: 25458997
PubMed Central: 4344185
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<front><div type="abstract" xml:lang="en"><p id="P1">Chronic inflammatory and autoimmune diseases have been the focus of many genome-wide association studies (GWAS) because they represent a significant cause of illness and morbidity, and many are heritable. Almost a decade of GWAS studies suggests that the pathological inflammation associated with these diseases is controlled by a limited number of networked immune system genes. Chronic inflammatory and autoimmune diseases are enigmatic from an evolutionary perspective because they exert a negative affect on reproductive fitness. The persistence of these conditions may be partially explained by the important roles the implicated immune genes play in pathogen defense and other functions thought to be under strong natural selection in humans. The evolutionary reasons for chronic inflammatory and autoimmune disease persistence and uneven distribution across populations are the focus of this review.</p>
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<aff id="A1"><label>1</label>
Sainte-Justine Hospital Research Centre, Montréal, Quebec H3T 1C5, Canada</aff>
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Department of Pediatrics, Faculty of Medicine, University of Montreal, Montreal, Quebec H3T 1J4, Canada</aff>
<author-notes><corresp id="CR1">Corresponding author: Barreiro, Luis B (<email>luis.barreiro@umontreal.ca</email>
, <email>luis.barreiro@gmail.com</email>
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<volume>31</volume>
<fpage>66</fpage>
<lpage>78</lpage>
<pmc-comment>elocation-id from pubmed: 10.1016/j.coi.2014.09.008</pmc-comment>
<permissions><copyright-statement>© 2014 Elsevier Ltd. All rights reserved</copyright-statement>
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<abstract><p id="P1">Chronic inflammatory and autoimmune diseases have been the focus of many genome-wide association studies (GWAS) because they represent a significant cause of illness and morbidity, and many are heritable. Almost a decade of GWAS studies suggests that the pathological inflammation associated with these diseases is controlled by a limited number of networked immune system genes. Chronic inflammatory and autoimmune diseases are enigmatic from an evolutionary perspective because they exert a negative affect on reproductive fitness. The persistence of these conditions may be partially explained by the important roles the implicated immune genes play in pathogen defense and other functions thought to be under strong natural selection in humans. The evolutionary reasons for chronic inflammatory and autoimmune disease persistence and uneven distribution across populations are the focus of this review.</p>
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