The contribution of natural selection to present-day susceptibility to chronic inflammatory and autoimmune disease
Identifieur interne : 000319 ( Pmc/Curation ); précédent : 000318; suivant : 000320The contribution of natural selection to present-day susceptibility to chronic inflammatory and autoimmune disease
Auteurs : Jessica F. Brinkworth [Canada] ; Luis B. Barreiro [Canada]Source :
- Current opinion in immunology [ 0952-7915 ] ; 2014.
Abstract
Chronic inflammatory and autoimmune diseases have been the focus of many genome-wide association studies (GWAS) because they represent a significant cause of illness and morbidity, and many are heritable. Almost a decade of GWAS studies suggests that the pathological inflammation associated with these diseases is controlled by a limited number of networked immune system genes. Chronic inflammatory and autoimmune diseases are enigmatic from an evolutionary perspective because they exert a negative affect on reproductive fitness. The persistence of these conditions may be partially explained by the important roles the implicated immune genes play in pathogen defense and other functions thought to be under strong natural selection in humans. The evolutionary reasons for chronic inflammatory and autoimmune disease persistence and uneven distribution across populations are the focus of this review.
Url:
DOI: 10.1016/j.coi.2014.09.008
PubMed: 25458997
PubMed Central: 4344185
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000319
Links to Exploration step
PMC:4344185Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The contribution of natural selection to present-day susceptibility to chronic inflammatory and autoimmune disease</title><author><name sortKey="Brinkworth, Jessica F" sort="Brinkworth, Jessica F" uniqKey="Brinkworth J" first="Jessica F" last="Brinkworth">Jessica F. Brinkworth</name><affiliation wicri:level="1"><nlm:aff id="A1"> Sainte-Justine Hospital Research Centre, Montréal, Quebec H3T 1C5, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea> Sainte-Justine Hospital Research Centre, Montréal, Quebec H3T 1C5</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2"> Department of Pediatrics, Faculty of Medicine, University of Montreal, Montreal, Quebec H3T 1J4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea> Department of Pediatrics, Faculty of Medicine, University of Montreal, Montreal, Quebec H3T 1J4</wicri:regionArea></affiliation></author><author><name sortKey="Barreiro, Luis B" sort="Barreiro, Luis B" uniqKey="Barreiro L" first="Luis B" last="Barreiro">Luis B. Barreiro</name><affiliation wicri:level="1"><nlm:aff id="A1"> Sainte-Justine Hospital Research Centre, Montréal, Quebec H3T 1C5, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea> Sainte-Justine Hospital Research Centre, Montréal, Quebec H3T 1C5</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2"> Department of Pediatrics, Faculty of Medicine, University of Montreal, Montreal, Quebec H3T 1J4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea> Department of Pediatrics, Faculty of Medicine, University of Montreal, Montreal, Quebec H3T 1J4</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25458997</idno><idno type="pmc">4344185</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344185</idno><idno type="RBID">PMC:4344185</idno><idno type="doi">10.1016/j.coi.2014.09.008</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000319</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000319</idno><idno type="wicri:Area/Pmc/Curation">000319</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000319</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The contribution of natural selection to present-day susceptibility to chronic inflammatory and autoimmune disease</title><author><name sortKey="Brinkworth, Jessica F" sort="Brinkworth, Jessica F" uniqKey="Brinkworth J" first="Jessica F" last="Brinkworth">Jessica F. Brinkworth</name><affiliation wicri:level="1"><nlm:aff id="A1"> Sainte-Justine Hospital Research Centre, Montréal, Quebec H3T 1C5, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea> Sainte-Justine Hospital Research Centre, Montréal, Quebec H3T 1C5</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2"> Department of Pediatrics, Faculty of Medicine, University of Montreal, Montreal, Quebec H3T 1J4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea> Department of Pediatrics, Faculty of Medicine, University of Montreal, Montreal, Quebec H3T 1J4</wicri:regionArea></affiliation></author><author><name sortKey="Barreiro, Luis B" sort="Barreiro, Luis B" uniqKey="Barreiro L" first="Luis B" last="Barreiro">Luis B. Barreiro</name><affiliation wicri:level="1"><nlm:aff id="A1"> Sainte-Justine Hospital Research Centre, Montréal, Quebec H3T 1C5, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea> Sainte-Justine Hospital Research Centre, Montréal, Quebec H3T 1C5</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A2"> Department of Pediatrics, Faculty of Medicine, University of Montreal, Montreal, Quebec H3T 1J4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea> Department of Pediatrics, Faculty of Medicine, University of Montreal, Montreal, Quebec H3T 1J4</wicri:regionArea></affiliation></author></analytic><series><title level="j">Current opinion in immunology</title><idno type="ISSN">0952-7915</idno><idno type="eISSN">1879-0372</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Chronic inflammatory and autoimmune diseases have been the focus of many genome-wide association studies (GWAS) because they represent a significant cause of illness and morbidity, and many are heritable. Almost a decade of GWAS studies suggests that the pathological inflammation associated with these diseases is controlled by a limited number of networked immune system genes. Chronic inflammatory and autoimmune diseases are enigmatic from an evolutionary perspective because they exert a negative affect on reproductive fitness. The persistence of these conditions may be partially explained by the important roles the implicated immune genes play in pathogen defense and other functions thought to be under strong natural selection in humans. The evolutionary reasons for chronic inflammatory and autoimmune disease persistence and uneven distribution across populations are the focus of this review.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8900118</journal-id><journal-id journal-id-type="pubmed-jr-id">1461</journal-id><journal-id journal-id-type="nlm-ta">Curr Opin Immunol</journal-id><journal-id journal-id-type="iso-abbrev">Curr. Opin. Immunol.</journal-id><journal-title-group><journal-title>Current opinion in immunology</journal-title></journal-title-group><issn pub-type="ppub">0952-7915</issn><issn pub-type="epub">1879-0372</issn></journal-meta><article-meta><article-id pub-id-type="pmid">25458997</article-id><article-id pub-id-type="pmc">4344185</article-id><article-id pub-id-type="doi">10.1016/j.coi.2014.09.008</article-id><article-id pub-id-type="manuscript">NIHMS665763</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>The contribution of natural selection to present-day susceptibility to chronic inflammatory and autoimmune disease</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Brinkworth</surname><given-names>Jessica F</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Barreiro</surname><given-names>Luis B</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib></contrib-group><aff id="A1"><label>1</label> Sainte-Justine Hospital Research Centre, Montréal, Quebec H3T 1C5, Canada</aff><aff id="A2"><label>2</label> Department of Pediatrics, Faculty of Medicine, University of Montreal, Montreal, Quebec H3T 1J4, Canada</aff><author-notes><corresp id="CR1">Corresponding author: Barreiro, Luis B (<email>luis.barreiro@umontreal.ca</email>, <email>luis.barreiro@gmail.com</email>)</corresp></author-notes><pub-date pub-type="nihms-submitted"><day>21</day><month>2</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>22</day><month>10</month><year>2014</year></pub-date><pub-date pub-type="ppub"><month>12</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>12</month><year>2015</year></pub-date><volume>31</volume><fpage>66</fpage><lpage>78</lpage><pmc-comment>elocation-id from pubmed: 10.1016/j.coi.2014.09.008</pmc-comment>
<permissions><copyright-statement>© 2014 Elsevier Ltd. All rights reserved</copyright-statement><copyright-year>2014</copyright-year></permissions><abstract><p id="P1">Chronic inflammatory and autoimmune diseases have been the focus of many genome-wide association studies (GWAS) because they represent a significant cause of illness and morbidity, and many are heritable. Almost a decade of GWAS studies suggests that the pathological inflammation associated with these diseases is controlled by a limited number of networked immune system genes. Chronic inflammatory and autoimmune diseases are enigmatic from an evolutionary perspective because they exert a negative affect on reproductive fitness. The persistence of these conditions may be partially explained by the important roles the implicated immune genes play in pathogen defense and other functions thought to be under strong natural selection in humans. The evolutionary reasons for chronic inflammatory and autoimmune disease persistence and uneven distribution across populations are the focus of this review.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Archeologie/explor/PaleopathV1/Data/Pmc/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000319 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 000319 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Archeologie
|area= PaleopathV1
|flux= Pmc
|étape= Curation
|type= RBID
|clé= PMC:4344185
|texte= The contribution of natural selection to present-day susceptibility to chronic inflammatory and autoimmune disease
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i -Sk "pubmed:25458997" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \
| NlmPubMed2Wicri -a PaleopathV1
| This area was generated with Dilib version V0.6.27. |  |