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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Mucopolysaccharidosis type VI (Maroteaux-Lamy syndrome) in the pre-Columbian culture of Colombia</title><author><name sortKey="Pachajoa, Harry" sort="Pachajoa, Harry" uniqKey="Pachajoa H" first="Harry" last="Pachajoa">Harry Pachajoa</name><affiliation><nlm:aff id="aff1"> Centro de Investigaciones en Anomalías Congénitas y Enfermedades Raras. Universidad Icesi, Cali,<country>Colombia</country></nlm:aff></affiliation></author><author><name sortKey="Rodriguez, Carlos Armando" sort="Rodriguez, Carlos Armando" uniqKey="Rodriguez C" first="Carlos Armando" last="Rodriguez">Carlos Armando Rodriguez</name><affiliation><nlm:aff id="aff2"> Profesor Titular, Facultad de Salud, Universidad del Valle, Cali, Colombia</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25100895</idno><idno type="pmc">4123588</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123588</idno><idno type="RBID">PMC:4123588</idno><date when="????">????</date><idno type="wicri:Area/Pmc/Corpus">000331</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000331</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Mucopolysaccharidosis type VI (Maroteaux-Lamy syndrome) in the pre-Columbian culture of Colombia</title><author><name sortKey="Pachajoa, Harry" sort="Pachajoa, Harry" uniqKey="Pachajoa H" first="Harry" last="Pachajoa">Harry Pachajoa</name><affiliation><nlm:aff id="aff1"> Centro de Investigaciones en Anomalías Congénitas y Enfermedades Raras. Universidad Icesi, Cali,<country>Colombia</country></nlm:aff></affiliation></author><author><name sortKey="Rodriguez, Carlos Armando" sort="Rodriguez, Carlos Armando" uniqKey="Rodriguez C" first="Carlos Armando" last="Rodriguez">Carlos Armando Rodriguez</name><affiliation><nlm:aff id="aff2"> Profesor Titular, Facultad de Salud, Universidad del Valle, Cali, Colombia</nlm:aff></affiliation></author></analytic><series><title level="j">Colombia Médica : CM</title><idno type="ISSN">0120-8322</idno><idno type="eISSN">1657-9534</idno><imprint><date when="????">????</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Mucopolysaccharidosis type VI or Maroteaux Lamy syndrome is an autosomal recessive lysosomal storage disorder resulting from a deficiency of arylsulfatase B, the clinical features include short stature, hepatosplenomegaly, dysostosis multiplex, stiff joints, corneal clouding, cardiac abnormalities, and facial dysmorphism, with intelligence usually normal. We present evidence of the possible existence of Maroteaux Lamy syndrome in pre-Columbian pottery 2000 years ago, in the Colombo-Ecuadorian Pacific coast of the Tumaco-Tolita culture.
</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Maroteaux, P" uniqKey="Maroteaux P">P Maroteaux</name></author><author><name sortKey="Leveque, B" uniqKey="Leveque B">B Leveque</name></author><author><name sortKey="Marie, J" uniqKey="Marie J">J Marie</name></author><author><name sortKey="Lamy, M" uniqKey="Lamy M">M Lamy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Azevedo, Ac" uniqKey="Azevedo A">AC Azevedo</name></author><author><name sortKey="Schwartz, Iv" uniqKey="Schwartz I">IV Schwartz</name></author><author><name sortKey="Kalakun, L" uniqKey="Kalakun L">L Kalakun</name></author><author><name sortKey="Brustolin, S" uniqKey="Brustolin S">S Brustolin</name></author><author><name sortKey="Burin, Mg" uniqKey="Burin M">MG Burin</name></author><author><name sortKey="Beheregaray, Ap" uniqKey="Beheregaray A">AP Beheregaray</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pachajoa, H" uniqKey="Pachajoa H">H Pachajoa</name></author><author><name sortKey="Rodriguez, C" uniqKey="Rodriguez C">C Rodriguez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pachajoa, H" uniqKey="Pachajoa H">H Pachajoa</name></author><author><name sortKey="Rodriguez, Ca" uniqKey="Rodriguez C">CA Rodríguez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rodriguez, Ca" uniqKey="Rodriguez C">CA Rodríguez</name></author><author><name sortKey="Isaza, C" uniqKey="Isaza C">C Isaza</name></author><author><name sortKey="Pachajoa, H" uniqKey="Pachajoa H">H Pachajoa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nelson, J" uniqKey="Nelson J">J Nelson</name></author><author><name sortKey="Crowhurst, J" uniqKey="Crowhurst J">J Crowhurst</name></author><author><name sortKey="Carey, B" uniqKey="Carey B">B Carey</name></author><author><name sortKey="Greed, L" uniqKey="Greed L">L Greed</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rosselli, D" uniqKey="Rosselli D">D Rosselli</name></author><author><name sortKey="Rueda J D" uniqKey="Rueda J D">Rueda J-D</name></author><author><name sortKey="Solano, M" uniqKey="Solano M">M Solano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pachajoa, H" uniqKey="Pachajoa H">H Pachajoa</name></author><author><name sortKey="Ariza, Y" uniqKey="Ariza Y">Y Ariza</name></author><author><name sortKey="Villota, V" uniqKey="Villota V">V Villota</name></author><author><name sortKey="Mi O, Me" uniqKey="Mi O M">ME Miño</name></author><author><name sortKey="Acosta Arag N, Ma" uniqKey="Acosta Arag N M">MA Acosta-Aragón</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Colomb Med (Cali)</journal-id><journal-id journal-id-type="iso-abbrev">Colomb. Med</journal-id><journal-title-group><journal-title>Colombia Médica : CM</journal-title></journal-title-group><issn pub-type="ppub">0120-8322</issn><issn pub-type="epub">1657-9534</issn><publisher><publisher-name>Universidad del Valle</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25100895</article-id><article-id pub-id-type="pmc">4123588</article-id><article-categories><subj-group subj-group-type="heading"><subject>Windows To History</subject></subj-group></article-categories><title-group><article-title>Mucopolysaccharidosis type VI (Maroteaux-Lamy syndrome) in the pre-Columbian culture of Colombia</article-title><trans-title-group xml:lang="es"><trans-title>Mucopolisacaridosis tipo VI (Síndrome Maroteaux-Lamy) en la cultura precolombina de Colombia
</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Pachajoa</surname><given-names>Harry</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Rodriguez</surname><given-names>Carlos Armando</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib></contrib-group><aff id="aff1"><label>1</label> Centro de Investigaciones en Anomalías Congénitas y Enfermedades Raras. Universidad Icesi, Cali,<country>Colombia</country></aff><aff id="aff2"><label>2</label> Profesor Titular, Facultad de Salud, Universidad del Valle, Cali, Colombia</aff><author-notes><corresp id="c01">Harry Pachajoa, Centro de Investigaciones en Anomalías Congénitas y Enfermedades Raras. Universidad Icesi, Cali, Colombia
E mail: <email>hmpachajoa@icesi.edu.co</email></corresp><fn id="fn01" fn-type="conflict"><p><bold>Conflict of interest: </bold> The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the information reported. </p></fn></author-notes><pub-date date-type="pub" publication-format="electronic" iso-8601-date="2014-06-30"><day>30</day><month>6</month><year>2014</year></pub-date><pub-date date-type="collection" publication-format="electronic"><season>Apr-Jun</season><year>2014</year></pub-date><volume>45</volume><issue>2</issue><fpage>85</fpage><lpage>88</lpage><history><date date-type="received"><day>21</day><month>1</month><year>2013</year></date><date date-type="rev-recd"><day>28</day><month>5</month><year>2014</year></date><date date-type="accepted"><day>28</day><month>5</month><year>2014</year></date></history><permissions><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/3.0"><license-p>© 2014 Universidad del Valle. This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p></license></permissions><abstract><p>Mucopolysaccharidosis type VI or Maroteaux Lamy syndrome is an autosomal recessive lysosomal storage disorder resulting from a deficiency of arylsulfatase B, the clinical features include short stature, hepatosplenomegaly, dysostosis multiplex, stiff joints, corneal clouding, cardiac abnormalities, and facial dysmorphism, with intelligence usually normal. We present evidence of the possible existence of Maroteaux Lamy syndrome in pre-Columbian pottery 2000 years ago, in the Colombo-Ecuadorian Pacific coast of the Tumaco-Tolita culture.
</p></abstract><trans-abstract xml:lang="es"><p>La mucopolisacaridosis tipo VI o síndrome de Maroteaux Lamy es una enfermedad de depósito lisosomal autosómica recesiva que resulta de una deficiencia de la enzima arilsulfatasa B, las características clínicas incluyen talla baja, hepatoesplenomegalia, disostosis múltiple, rigidez en las articulaciones, opacidad corneal, anomalías cardíacas, y dismorfismo facial, con inteligencia generalmente normal. Presentamos evidencia de la posible existencia de síndrome de Maroteaux Lamy en la cerámica precolombina desde hace 2000 años, en la costa pacífica colombo-ecuatoriana pertenecientes a la cultura Tumaco-Tolita.
</p></trans-abstract><kwd-group><kwd>Mucopolysaccharidosis VI</kwd><kwd>mucopolysaccharidoses</kwd><kwd>history of medicine</kwd><kwd>paleopathology</kwd><kwd>inborn genetic diseases</kwd></kwd-group><counts><fig-count count="1"></fig-count><ref-count count="8"></ref-count><page-count count="4"></page-count></counts></article-meta></front><body><sec sec-type="intro"><title>Introduction</title><p>Mucopolysaccharidosis type VI or Maroteaux Lamy syndrome is an autosomal recessive lysosomal storage disorder resulting from a deficiency of arylsulfatase B. Maroteaux <italic>et al</italic>. first described this disorder as a novel dysostosis associated with increased urinary excretion of chondroitin sulfate in 1963 <xref rid="B01" ref-type="bibr">1</xref>.</p><p>Clinical features and severity are variable, but usually include short stature, hepatosplenomegaly, dysostosis multiplex, stiff joints, corneal clouding, cardiac abnormalities, and facial dysmorphism, with intelligence usually normal <xref rid="B02" ref-type="bibr">2</xref>.</p><p>We present a collection of pottery from the Tumaco-Tolita culture close to 2,000 years old with a possible representation of Maroteaux Lamy syndrome, which were evaluated by an archaeologist and a medical geneticist succeeded in identifying about 20 ceramic artifacts with representations of individuals with mucopolysaccharidosis type VI in about 10 museums and private collections in Ecuador and Colombia. The ceramic artifacts present phenotypical features like skeletal dysplasia, macrocephaly, mildly coarse facial features, broad mouth, prominent sternum, kyphosis, scoliosis (<xref ref-type="fig" rid="f01">Fig. 1</xref>) probably constituting evidence of this disease in the pre-Hispanic Latin-American and past world. The differential diagnosis includes Hurler syndrome and various types of skeletal dysplasia.</p><p>The Tumaco-Tolita culture inhabited the region of the Pacific Colombo-Ecuadorian coast during the years 300 BCE to 600 CE. This culture was characterized for realistically representing the different pathologies affecting their population. In their pottery work, they show evidence of genetic illnesses like Down syndrome, achondroplasia, sirenomelia, and other congenital malformations <xref rid="B03" ref-type="bibr">3</xref><sup>-</sup><xref rid="B05" ref-type="bibr">5</xref>. The representation of this syndrome in these populations could confirm the existence of this syndrome in these populations, and because of the high representation (20 ceramic pieces), it is suggested that it might have an increased prevalence, although it has not been possible to determine the population of these communities, and it is not possible to establish how many people had this disease, but the prevalence was almost certainly higher than currently reported for this syndrome (1 in 320,000 live newborns) <xref rid="B06" ref-type="bibr">6</xref>. </p><p>It is noteworthy that the figures represented are of young people or infants, clearly suggesting that the complications experienced by people with mucopolysaccharidosis type VI as cervical cord compression may have regulated the mortality of people with this disease, because at that time there was no orthopedic spine surgery. </p><p>These types of pre-Hispanic indigenous communities, and especially the Tumaco-Tolita, lived in isolation, probably engaging in consanguineous marriages, as done by current indigenous Colombian communities, increasing the occurrence of recessive diseases and the possible existence of a founder effect.</p><p>Currently, the presence of this syndrome has been documented in indigenous communities in Cauca <xref rid="B07" ref-type="bibr">7</xref> and the presence of one or two founder effects it have been suggesteted in this area in the Colombian southwest <xref rid="B08" ref-type="bibr">8</xref>. Because of the lack of genetic population studies in pre-Hispanic osseous remains of the Tumaco-Tolita, it is not possible to ensure that this population was related to the current residents of Cauca.</p><p><fig id="f01" fig-type="graphic" orientation="portrait" position="float"><label>Figure 1</label><caption><title><bold>A , B y C.</bold> Pottery sample from the Tumaco-Tolita culture representing a possible case of Maroteaux Lamy syndrome.
</title></caption><graphic xlink:href="1657-9534-cm-45-02-00085-gf01"></graphic></fig></p></sec></body><back><ref-list><title>References</title><ref id="B01"><label>1</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Maroteaux</surname><given-names>P</given-names></name><name><surname>Leveque</surname><given-names>B</given-names></name><name><surname>Marie</surname><given-names>J</given-names></name><name><surname>Lamy</surname><given-names>M</given-names></name></person-group><article-title xml:lang="fr">Une nouvelle dysostose avec elimination urinaire de chondroitine-sulfate B</article-title><source>Presse Med</source><year>1963</year><volume>71</volume><fpage>1849</fpage><lpage>1852</lpage><pub-id pub-id-type="pmid">14091597</pub-id></element-citation></ref><ref id="B02"><label>2</label><element-citation publication-type="journal"><person-group 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person-group-type="author"><name><surname>Nelson</surname><given-names>J</given-names></name><name><surname>Crowhurst</surname><given-names>J</given-names></name><name><surname>Carey</surname><given-names>B</given-names></name><name><surname>Greed</surname><given-names>L</given-names></name></person-group><article-title>Incidence of the mucopolysaccharidoses in western Australia</article-title><source>Am J Med Genet</source><year>2003</year><volume>123A</volume><fpage>310</fpage><lpage>313</lpage><pub-id pub-id-type="pmid">14608657</pub-id></element-citation></ref><ref id="B07"><label>7</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Rosselli</surname><given-names>D</given-names></name><name><surname>Rueda J-D</surname></name><name><surname>Solano</surname><given-names>M</given-names></name></person-group><article-title>Ethical and economic considerations of rare diseases in ethnic minorities: the case of mucopolysaccharidosis VI in Colombia</article-title><source>J Med Ethics</source><year>2012</year><volume>38</volume><issue>11</issue><fpage>699</fpage><lpage>700</lpage><pub-id pub-id-type="pmid">22550061</pub-id></element-citation></ref><ref id="B08"><label>8</label><element-citation publication-type="book"><person-group person-group-type="author"><name><surname>Pachajoa</surname><given-names>H</given-names></name><name><surname>Ariza</surname><given-names>Y</given-names></name><name><surname>Villota</surname><given-names>V</given-names></name><name><surname>Miño</surname><given-names>ME</given-names></name><name><surname>Acosta-Aragón</surname><given-names>MA</given-names></name></person-group><source xml:lang="es">Distribución geográfica de la mucopolisacridosis tipo VI en el centro del departamento del Cauca ¿es posible un efecto fundador?.</source><publisher-loc>Medellín</publisher-loc><publisher-name>Editorial</publisher-name><year>2013</year></element-citation></ref></ref-list></back></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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