Calcified Pulmonary Nodules Identified in a 350-Year-Old-Joseon Mummy: the First Report on Ancient Pulmonary Tuberculosis from Archaeologically Obtained Pre-modern Korean Samples
Identifieur interne : 000060 ( Pmc/Checkpoint ); précédent : 000059; suivant : 000061Calcified Pulmonary Nodules Identified in a 350-Year-Old-Joseon Mummy: the First Report on Ancient Pulmonary Tuberculosis from Archaeologically Obtained Pre-modern Korean Samples
Auteurs : Yi-Suk Kim [Corée du Sud] ; In Sun Lee [Corée du Sud] ; Chang Seok Oh [Corée du Sud] ; Myeung Ju Kim [Corée du Sud] ; Soon Chul Cha [Corée du Sud] ; Dong Hoon Shin [Corée du Sud]Source :
- Journal of Korean Medical Science [ 1011-8934 ] ; 2015.
Abstract
We found calcified pulmonary nodules in a middle-aged female mummy discovered from 350-yr-old Joseon tomb of Korea. In the CT scan, we found six radiopaque nodules in right lung, through the levels of thoracic vertebrae 1 to 6. We also found presumptive pleural adhesions in right thoracic cavity of CT images. We re-confirmed radiological findings by our post-factum dissection on the same mummy. By the differential diagnosis, we speculate that the radiopaque calcification nodules and associated pleural adhesion could have been caused by tuberculosis. This is the first-ever report on the pulmonary tuberculosis identified in archaeologically obtained, pre-modern Korean samples.
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DOI: 10.3346/jkms.2016.31.1.147
PubMed: 26770051
PubMed Central: 4712574
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Calcified Pulmonary Nodules Identified in a 350-Year-Old-Joseon Mummy: the First Report on Ancient Pulmonary Tuberculosis from Archaeologically Obtained Pre-modern Korean Samples</title><author><name sortKey="Kim, Yi Suk" sort="Kim, Yi Suk" uniqKey="Kim Y" first="Yi-Suk" last="Kim">Yi-Suk Kim</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Anatomy, Ewha Womans University School of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Anatomy, Ewha Womans University School of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Lee, In Sun" sort="Lee, In Sun" uniqKey="Lee I" first="In Sun" last="Lee">In Sun Lee</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Radiology, Seoul National University Bundang Hospital, Seongnam, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Radiology, Seoul National University Bundang Hospital, Seongnam</wicri:regionArea><wicri:noRegion>Seongnam</wicri:noRegion></affiliation></author><author><name sortKey="Oh, Chang Seok" sort="Oh, Chang Seok" uniqKey="Oh C" first="Chang Seok" last="Oh">Chang Seok Oh</name><affiliation wicri:level="3"><nlm:aff id="A3">Bioanthropology and Paleopathology Laboratory, Department of Anatomy/Institute of Forensic Science, Seoul National University College of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Bioanthropology and Paleopathology Laboratory, Department of Anatomy/Institute of Forensic Science, Seoul National University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Kim, Myeung Ju" sort="Kim, Myeung Ju" uniqKey="Kim M" first="Myeung Ju" last="Kim">Myeung Ju Kim</name><affiliation wicri:level="1"><nlm:aff id="A4">Department of Anatomy, Dankook University College of Medicine, Chonan, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Anatomy, Dankook University College of Medicine, Chonan</wicri:regionArea><wicri:noRegion>Chonan</wicri:noRegion></affiliation></author><author><name sortKey="Cha, Soon Chul" sort="Cha, Soon Chul" uniqKey="Cha S" first="Soon Chul" last="Cha">Soon Chul Cha</name><affiliation wicri:level="1"><nlm:aff id="A5">Dongguk Institute of Cultural Properties, Daegu, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Dongguk Institute of Cultural Properties, Daegu</wicri:regionArea><wicri:noRegion>Daegu</wicri:noRegion></affiliation></author><author><name sortKey="Shin, Dong Hoon" sort="Shin, Dong Hoon" uniqKey="Shin D" first="Dong Hoon" last="Shin">Dong Hoon Shin</name><affiliation wicri:level="3"><nlm:aff id="A3">Bioanthropology and Paleopathology Laboratory, Department of Anatomy/Institute of Forensic Science, Seoul National University College of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Bioanthropology and Paleopathology Laboratory, Department of Anatomy/Institute of Forensic Science, Seoul National University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26770051</idno><idno type="pmc">4712574</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712574</idno><idno type="RBID">PMC:4712574</idno><idno type="doi">10.3346/jkms.2016.31.1.147</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000041</idno><idno type="wicri:explorRef" wicri:stream="Pmc" 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Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Lee, In Sun" sort="Lee, In Sun" uniqKey="Lee I" first="In Sun" last="Lee">In Sun Lee</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Radiology, Seoul National University Bundang Hospital, Seongnam, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Radiology, Seoul National University Bundang Hospital, Seongnam</wicri:regionArea><wicri:noRegion>Seongnam</wicri:noRegion></affiliation></author><author><name sortKey="Oh, Chang Seok" sort="Oh, Chang Seok" uniqKey="Oh C" first="Chang Seok" last="Oh">Chang Seok Oh</name><affiliation wicri:level="3"><nlm:aff id="A3">Bioanthropology and Paleopathology Laboratory, Department of Anatomy/Institute of Forensic Science, Seoul National University College of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Bioanthropology and Paleopathology Laboratory, Department of Anatomy/Institute of Forensic Science, Seoul National University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Kim, Myeung Ju" sort="Kim, Myeung Ju" uniqKey="Kim M" first="Myeung Ju" last="Kim">Myeung Ju Kim</name><affiliation wicri:level="1"><nlm:aff id="A4">Department of Anatomy, Dankook University College of Medicine, Chonan, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Anatomy, Dankook University College of Medicine, Chonan</wicri:regionArea><wicri:noRegion>Chonan</wicri:noRegion></affiliation></author><author><name sortKey="Cha, Soon Chul" sort="Cha, Soon Chul" uniqKey="Cha S" first="Soon Chul" last="Cha">Soon Chul Cha</name><affiliation wicri:level="1"><nlm:aff id="A5">Dongguk Institute of Cultural Properties, Daegu, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Dongguk Institute of Cultural Properties, Daegu</wicri:regionArea><wicri:noRegion>Daegu</wicri:noRegion></affiliation></author><author><name sortKey="Shin, Dong Hoon" sort="Shin, Dong Hoon" uniqKey="Shin D" first="Dong Hoon" last="Shin">Dong Hoon Shin</name><affiliation wicri:level="3"><nlm:aff id="A3">Bioanthropology and Paleopathology Laboratory, Department of Anatomy/Institute of Forensic Science, Seoul National University College of Medicine, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Bioanthropology and Paleopathology Laboratory, Department of Anatomy/Institute of Forensic Science, Seoul National University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author></analytic><series><title level="j">Journal of Korean Medical 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In the CT scan, we found six radiopaque nodules in right lung, through the levels of thoracic vertebrae 1 to 6. We also found presumptive pleural adhesions in right thoracic cavity of CT images. We re-confirmed radiological findings by our post-factum dissection on the same mummy. By the differential diagnosis, we speculate that the radiopaque calcification nodules and associated pleural adhesion could have been caused by tuberculosis. This is the first-ever report on the pulmonary tuberculosis identified in archaeologically obtained, pre-modern Korean samples.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Masson, M" uniqKey="Masson M">M Masson</name></author><author><name sortKey="Molnar, E" uniqKey="Molnar E">E Molnár</name></author><author><name sortKey="Donoghue, Hd" uniqKey="Donoghue H">HD Donoghue</name></author><author><name sortKey="Besra, Gs" uniqKey="Besra G">GS Besra</name></author><author><name sortKey="Minnikin, De" uniqKey="Minnikin D">DE Minnikin</name></author><author><name sortKey="Wu, Hh" uniqKey="Wu H">HH Wu</name></author><author><name sortKey="Lee, Oy" uniqKey="Lee O">OY Lee</name></author><author><name sortKey="Bull, Id" uniqKey="Bull I">ID Bull</name></author><author><name sortKey="Palfi, G" uniqKey="Palfi G">G Pálfi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bos, Ki" uniqKey="Bos K">KI 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<front><journal-meta><journal-id journal-id-type="nlm-ta">J Korean Med Sci</journal-id><journal-id journal-id-type="iso-abbrev">J. Korean Med. Sci</journal-id><journal-id journal-id-type="publisher-id">JKMS</journal-id><journal-title-group><journal-title>Journal of Korean Medical Science</journal-title></journal-title-group><issn pub-type="ppub">1011-8934</issn><issn pub-type="epub">1598-6357</issn><publisher><publisher-name>The Korean Academy of Medical Sciences</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26770051</article-id><article-id pub-id-type="pmc">4712574</article-id><article-id pub-id-type="doi">10.3346/jkms.2016.31.1.147</article-id><article-categories><subj-group subj-group-type="heading"><subject>Case Report</subject><subj-group subj-group-type="subheading"><subject>Medical Imaging</subject></subj-group></subj-group></article-categories><title-group><article-title>Calcified Pulmonary Nodules Identified in a 350-Year-Old-Joseon Mummy: the First Report on Ancient Pulmonary Tuberculosis from Archaeologically Obtained Pre-modern Korean Samples</article-title></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">http://orcid.org/0000-0002-2865-3957</contrib-id><name><surname>Kim</surname><given-names>Yi-Suk</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">http://orcid.org/0000-0003-2532-0492</contrib-id><name><surname>Lee</surname><given-names>In Sun</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">http://orcid.org/0000-0001-6913-1832</contrib-id><name><surname>Oh</surname><given-names>Chang Seok</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">http://orcid.org/0000-0002-7455-5450</contrib-id><name><surname>Kim</surname><given-names>Myeung Ju</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">http://orcid.org/0000-0002-3066-0048</contrib-id><name><surname>Cha</surname><given-names>Soon Chul</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid" authenticated="true">http://orcid.org/0000-0001-8032-1266</contrib-id><name><surname>Shin</surname><given-names>Dong Hoon</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib></contrib-group><aff id="A1"><label>1</label>Department of Anatomy, Ewha Womans University School of Medicine, Seoul, Korea.</aff><aff id="A2"><label>2</label>Department of Radiology, Seoul National University Bundang Hospital, Seongnam, Korea.</aff><aff id="A3"><label>3</label>Bioanthropology and Paleopathology Laboratory, Department of Anatomy/Institute of Forensic Science, Seoul National University College of Medicine, Seoul, Korea.</aff><aff id="A4"><label>4</label>Department of Anatomy, Dankook University College of Medicine, Chonan, Korea.</aff><aff id="A5"><label>5</label>Dongguk Institute of Cultural Properties, Daegu, Korea.</aff><author-notes><corresp>Address for Correspondence: Dong Hoon Shin, MD. Bioanthropology and Paleopathology Laboratory, Department of Anatomy, and Institute of Forensic Science, Seoul National University College of Medicine, 103 Daehak-ro, Seoul 03080, Korea. Tel: +82.2-740-8203, Fax:+82.2-745-9528, <email>cuteminjae@gmail.com</email></corresp></author-notes><pub-date pub-type="ppub"><month>1</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>24</day><month>12</month><year>2015</year></pub-date><volume>31</volume><issue>1</issue><fpage>147</fpage><lpage>151</lpage><history><date date-type="received"><day>17</day><month>1</month><year>2015</year></date><date date-type="accepted"><day>01</day><month>4</month><year>2015</year></date></history><permissions><copyright-statement>© 2016 The Korean Academy of Medical Sciences.</copyright-statement><copyright-year>2016</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/">http://creativecommons.org/licenses/by-nc/4.0/</ext-link>) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><p>We found calcified pulmonary nodules in a middle-aged female mummy discovered from 350-yr-old Joseon tomb of Korea. In the CT scan, we found six radiopaque nodules in right lung, through the levels of thoracic vertebrae 1 to 6. We also found presumptive pleural adhesions in right thoracic cavity of CT images. We re-confirmed radiological findings by our post-factum dissection on the same mummy. By the differential diagnosis, we speculate that the radiopaque calcification nodules and associated pleural adhesion could have been caused by tuberculosis. This is the first-ever report on the pulmonary tuberculosis identified in archaeologically obtained, pre-modern Korean samples.</p></abstract><abstract abstract-type="graphical"><title>Graphical Abstract</title><p><graphic xlink:href="jkms-31-147-abf001.jpg" position="float" orientation="portrait"></graphic></p></abstract><kwd-group><kwd><italic>Mycobacterium tuberculosis</italic></kwd><kwd>Korean Mummy</kwd><kwd>Joseon Dynasty</kwd><kwd>Calcified Nodules</kwd><kwd>Lung</kwd></kwd-group><funding-group><award-group><funding-source country="KR"><institution-wrap><institution>National Research Foundation of Korea</institution><institution-id institution-id-type="CrossRef">http://dx.doi.org/10.13039/501100003725</institution-id></institution-wrap></funding-source><award-id>NRF-2013R1A1A2009688</award-id></award-group></funding-group></article-meta></front><floats-group><fig id="F1" orientation="portrait" position="float"><label>Fig. 1</label><caption><title>Female mummy examined in this study.</title></caption><graphic xlink:href="jkms-31-147-g001"></graphic></fig><fig id="F2" orientation="portrait" position="float"><label>Fig. 2</label><caption><title>Axial CT scans of Mungyeong mummy. Asterisks indicate calcified nodules in the right thoracic cavity. Each figure represent the level of (<bold>A</bold>) TV1, (<bold>B</bold>) TV4, (<bold>C</bold>) TV5, and (<bold>D</bold>) TV6. RL, Right Lung; Tr, Trachea; LL, Left Lung; Ht, Heart; PA, Pleural Adhesion. (<bold>E</bold>) Volume rendering image showing calcified pulmonary nodules from #1 to #6 in the right lung of mummy.</title></caption><graphic xlink:href="jkms-31-147-g002"></graphic></fig><fig id="F3" orientation="portrait" position="float"><label>Fig. 3</label><caption><title>Dissection of right thoracic cavity. (<bold>A</bold>) Pleural adhesion (indicated by asterisk). (<bold>B</bold>) Thoracic cavity after resection of anterior thoracic wall. (<bold>C</bold>) Right lung (removed). (<bold>D</bold>) and (<bold>E</bold>) Exposure of calcified nodules in right lung. (<bold>D</bold>) Two large calcified nodules (indicated by asterisk; sized over 1 cm in diameter) around pulmonary hilum. (<bold>E</bold>) Magnified image of calcified nodule (sectioned) in superior segment of right lower lobe.</title></caption><graphic xlink:href="jkms-31-147-g003"></graphic></fig><table-wrap id="T1" orientation="portrait" position="float"><label>Table 1</label><caption><title>Size information of calcified pulmonary nodules</title></caption><alternatives><graphic xlink:href="jkms-31-147-i001"></graphic><table frame="hsides" rules="rows"><thead><tr><th valign="top" align="left" rowspan="1" colspan="1">Nodule No.</th><th valign="top" align="center" rowspan="1" colspan="1">Width (mm)</th><th valign="top" align="center" rowspan="1" colspan="1">Height (mm)</th></tr></thead><tbody><tr><td valign="top" align="left" rowspan="1" colspan="1">1</td><td valign="top" align="right" rowspan="1" colspan="1">7.10</td><td valign="top" align="right" rowspan="1" colspan="1">8.85</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">2</td><td valign="top" align="right" rowspan="1" colspan="1">7.03</td><td valign="top" align="right" rowspan="1" colspan="1">6.23</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">3</td><td valign="top" align="right" rowspan="1" colspan="1">8.34</td><td valign="top" align="right" rowspan="1" colspan="1">5.49</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">4</td><td valign="top" align="right" rowspan="1" colspan="1">11.94</td><td valign="top" align="right" rowspan="1" colspan="1">17.38</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">5</td><td valign="top" align="right" rowspan="1" colspan="1">13.61</td><td valign="top" align="right" rowspan="1" colspan="1">10.53</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">6</td><td valign="top" align="right" rowspan="1" colspan="1">7.69</td><td valign="top" align="right" rowspan="1" colspan="1">6.23</td></tr></tbody></table></alternatives></table-wrap></floats-group></pmc><affiliations><list><country><li>Corée du Sud</li></country><settlement><li>Séoul</li></settlement></list><tree><country name="Corée du Sud"><noRegion><name sortKey="Kim, Yi Suk" sort="Kim, Yi Suk" uniqKey="Kim Y" first="Yi-Suk" last="Kim">Yi-Suk Kim</name></noRegion><name sortKey="Cha, Soon Chul" sort="Cha, Soon Chul" uniqKey="Cha S" first="Soon Chul" last="Cha">Soon Chul Cha</name><name sortKey="Kim, Myeung Ju" sort="Kim, Myeung Ju" uniqKey="Kim M" first="Myeung Ju" last="Kim">Myeung Ju Kim</name><name sortKey="Lee, In Sun" sort="Lee, In Sun" uniqKey="Lee I" first="In Sun" last="Lee">In Sun Lee</name><name sortKey="Oh, Chang Seok" sort="Oh, Chang Seok" uniqKey="Oh C" first="Chang Seok" last="Oh">Chang Seok Oh</name><name sortKey="Shin, Dong Hoon" sort="Shin, Dong Hoon" uniqKey="Shin D" first="Dong Hoon" last="Shin">Dong Hoon Shin</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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