Identification of HPV Types and Mycobacterium Tuberculosis Complex in Historical Long-Term Preserved Formalin Fixed Tissues in Different Human Organs
Identifieur interne : 001032 ( Ncbi/Merge ); précédent : 001031; suivant : 001033Identification of HPV Types and Mycobacterium Tuberculosis Complex in Historical Long-Term Preserved Formalin Fixed Tissues in Different Human Organs
Auteurs : Maja Hühns ; Andreas Erbersdobler ; Annette Obliers ; Paula RöpenackSource :
- PLoS ONE [ 1932-6203 ] ; 2017.
Abstract
University anatomical-pathological collections represent huge sources of human tissues and preparations from a variety of different diseases. With the help of modern genetic and histological methods, preserved fixed tissues from pathological collections can be used to re-evaluate former diagnoses. We analysed 25 specimens from our pathological collection with ages ranging from 78 to 112 years. The tissues originated from the oral cavity, lip, tongue, lung, bone, kidney, spleen, thymus, larynx, lymph node, penis and uterine cervix with an original diagnosis of epithelial cancers or tuberculosis. Amplifiable DNA was extracted and in epithelial cancers, potential HPV infection was investigated. Specimens with an original diagnosis of tuberculosis were examined for mycobacterial infection. The tissues were also examined using modern histological methods. Our data showed that in 24/25 specimens the histological structure was preserved and in 10/11 specimens the diagnosis of squamous cell carcinoma could be confirmed. Additionally, HPV type 16 was detected in 8 specimens. The histological pattern of tuberculosis was found in 11/14 specimens and the
Url:
DOI: 10.1371/journal.pone.0170353
PubMed: 28114406
PubMed Central: 5256871
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Identification of HPV Types and Mycobacterium Tuberculosis Complex in Historical Long-Term Preserved Formalin Fixed Tissues in Different Human Organs</title>
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<front><div type="abstract" xml:lang="en"><p>University anatomical-pathological collections represent huge sources of human tissues and preparations from a variety of different diseases. With the help of modern genetic and histological methods, preserved fixed tissues from pathological collections can be used to re-evaluate former diagnoses. We analysed 25 specimens from our pathological collection with ages ranging from 78 to 112 years. The tissues originated from the oral cavity, lip, tongue, lung, bone, kidney, spleen, thymus, larynx, lymph node, penis and uterine cervix with an original diagnosis of epithelial cancers or tuberculosis. Amplifiable DNA was extracted and in epithelial cancers, potential HPV infection was investigated. Specimens with an original diagnosis of tuberculosis were examined for mycobacterial infection. The tissues were also examined using modern histological methods. Our data showed that in 24/25 specimens the histological structure was preserved and in 10/11 specimens the diagnosis of squamous cell carcinoma could be confirmed. Additionally, HPV type 16 was detected in 8 specimens. The histological pattern of tuberculosis was found in 11/14 specimens and the <italic>Mycobacterium tuberculosis</italic>
complex was ascertained in four specimens. Our study showed that pathogens such as HPV or <italic>Mycobacterium tuberculosis</italic>
can be detected in historical pathological preparations, and that these collections are suitable for further epidemiological research.</p>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS One</journal-id>
<journal-id journal-id-type="iso-abbrev">PLoS ONE</journal-id>
<journal-id journal-id-type="publisher-id">plos</journal-id>
<journal-id journal-id-type="pmc">plosone</journal-id>
<journal-title-group><journal-title>PLoS ONE</journal-title>
</journal-title-group>
<issn pub-type="epub">1932-6203</issn>
<publisher><publisher-name>Public Library of Science</publisher-name>
<publisher-loc>San Francisco, CA USA</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">28114406</article-id>
<article-id pub-id-type="pmc">5256871</article-id>
<article-id pub-id-type="doi">10.1371/journal.pone.0170353</article-id>
<article-id pub-id-type="publisher-id">PONE-D-16-38431</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject>
<subj-group><subject>Organisms</subject>
<subj-group><subject>Bacteria</subject>
<subj-group><subject>Actinobacteria</subject>
<subj-group><subject>Mycobacterium Tuberculosis</subject>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject>
<subj-group><subject>Anatomy</subject>
<subj-group><subject>Histology</subject>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject>
<subj-group><subject>Anatomy</subject>
<subj-group><subject>Histology</subject>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject>
<subj-group><subject>Molecular Biology</subject>
<subj-group><subject>Molecular Biology Techniques</subject>
<subj-group><subject>Artificial Gene Amplification and Extension</subject>
<subj-group><subject>Polymerase Chain Reaction</subject>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Research and Analysis Methods</subject>
<subj-group><subject>Molecular Biology Techniques</subject>
<subj-group><subject>Artificial Gene Amplification and Extension</subject>
<subj-group><subject>Polymerase Chain Reaction</subject>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject>
<subj-group><subject>Urology</subject>
<subj-group><subject>Genitourinary Infections</subject>
<subj-group><subject>Human Papillomavirus Infection</subject>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject>
<subj-group><subject>Infectious Diseases</subject>
<subj-group><subject>Sexually Transmitted Diseases</subject>
<subj-group><subject>Human Papillomavirus Infection</subject>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject>
<subj-group><subject>Infectious Diseases</subject>
<subj-group><subject>Viral Diseases</subject>
<subj-group><subject>Human Papillomavirus Infection</subject>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject>
<subj-group><subject>Infectious Diseases</subject>
<subj-group><subject>Bacterial Diseases</subject>
<subj-group><subject>Tuberculosis</subject>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject>
<subj-group><subject>Tropical Diseases</subject>
<subj-group><subject>Tuberculosis</subject>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject>
<subj-group><subject>Diagnostic Medicine</subject>
<subj-group><subject>Cancer Detection and Diagnosis</subject>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject>
<subj-group><subject>Oncology</subject>
<subj-group><subject>Cancer Detection and Diagnosis</subject>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject>
<subj-group><subject>Oncology</subject>
<subj-group><subject>Cancers and Neoplasms</subject>
<subj-group><subject>Carcinomas</subject>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject>
<subj-group><subject>Infectious Diseases</subject>
<subj-group><subject>Bacterial Diseases</subject>
<subj-group><subject>Tuberculosis</subject>
<subj-group><subject>Miliary Tuberculosis</subject>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject>
<subj-group><subject>Tropical Diseases</subject>
<subj-group><subject>Tuberculosis</subject>
<subj-group><subject>Miliary Tuberculosis</subject>
</subj-group>
</subj-group>
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</subj-group>
</article-categories>
<title-group><article-title>Identification of HPV Types and Mycobacterium Tuberculosis Complex in Historical Long-Term Preserved Formalin Fixed Tissues in Different Human Organs</article-title>
<alt-title alt-title-type="running-head">Detection of HPV and Mycobacteria in Long-Term Formalin Fixed Tissues</alt-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Hühns</surname>
<given-names>Maja</given-names>
</name>
<xref ref-type="corresp" rid="cor001">*</xref>
<xref ref-type="aff" rid="aff001"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Erbersdobler</surname>
<given-names>Andreas</given-names>
</name>
<xref ref-type="aff" rid="aff001"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Obliers</surname>
<given-names>Annette</given-names>
</name>
<xref ref-type="aff" rid="aff001"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Röpenack</surname>
<given-names>Paula</given-names>
</name>
<xref ref-type="aff" rid="aff001"></xref>
</contrib>
</contrib-group>
<aff id="aff001"><addr-line>Institute of Pathology, University Medicine of Rostock, Rostock, Germany</addr-line>
</aff>
<contrib-group><contrib contrib-type="editor"><name><surname>Spigelman</surname>
<given-names>Mark</given-names>
</name>
<role>Editor</role>
<xref ref-type="aff" rid="edit1"></xref>
</contrib>
</contrib-group>
<aff id="edit1"><addr-line>Hebrew University, ISRAEL</addr-line>
</aff>
<author-notes><fn fn-type="COI-statement" id="coi001"><p><bold>Competing Interests: </bold>
The authors have declared that no competing interests exist.</p>
</fn>
<fn fn-type="con"><p><list list-type="simple"><list-item><p><bold>Conceptualization:</bold>
MH AE AO PR.</p>
</list-item>
<list-item><p><bold>Formal analysis:</bold>
MH PR.</p>
</list-item>
<list-item><p><bold>Investigation:</bold>
MH PR.</p>
</list-item>
<list-item><p><bold>Methodology:</bold>
MH AE PR.</p>
</list-item>
<list-item><p><bold>Project administration:</bold>
MH AE PR.</p>
</list-item>
<list-item><p><bold>Validation:</bold>
MH PR.</p>
</list-item>
<list-item><p><bold>Visualization:</bold>
MH PR.</p>
</list-item>
<list-item><p><bold>Writing – original draft:</bold>
MH AE PR.</p>
</list-item>
<list-item><p><bold>Writing – review & editing:</bold>
MH AE PR.</p>
</list-item>
</list>
</p>
</fn>
<corresp id="cor001">* E-mail: <email>maja.huehns@med.uni-rostock.de</email>
</corresp>
</author-notes>
<pub-date pub-type="epub"><day>23</day>
<month>1</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="collection"><year>2017</year>
</pub-date>
<volume>12</volume>
<issue>1</issue>
<elocation-id>e0170353</elocation-id>
<history><date date-type="received"><day>26</day>
<month>9</month>
<year>2016</year>
</date>
<date date-type="accepted"><day>3</day>
<month>1</month>
<year>2017</year>
</date>
</history>
<permissions><copyright-statement>© 2017 Hühns et al</copyright-statement>
<copyright-year>2017</copyright-year>
<copyright-holder>Hühns et al</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License</ext-link>
, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p>
</license>
</permissions>
<self-uri content-type="pdf" xlink:href="pone.0170353.pdf"></self-uri>
<abstract><p>University anatomical-pathological collections represent huge sources of human tissues and preparations from a variety of different diseases. With the help of modern genetic and histological methods, preserved fixed tissues from pathological collections can be used to re-evaluate former diagnoses. We analysed 25 specimens from our pathological collection with ages ranging from 78 to 112 years. The tissues originated from the oral cavity, lip, tongue, lung, bone, kidney, spleen, thymus, larynx, lymph node, penis and uterine cervix with an original diagnosis of epithelial cancers or tuberculosis. Amplifiable DNA was extracted and in epithelial cancers, potential HPV infection was investigated. Specimens with an original diagnosis of tuberculosis were examined for mycobacterial infection. The tissues were also examined using modern histological methods. Our data showed that in 24/25 specimens the histological structure was preserved and in 10/11 specimens the diagnosis of squamous cell carcinoma could be confirmed. Additionally, HPV type 16 was detected in 8 specimens. The histological pattern of tuberculosis was found in 11/14 specimens and the <italic>Mycobacterium tuberculosis</italic>
complex was ascertained in four specimens. Our study showed that pathogens such as HPV or <italic>Mycobacterium tuberculosis</italic>
can be detected in historical pathological preparations, and that these collections are suitable for further epidemiological research.</p>
</abstract>
<funding-group><funding-statement>The authors received no specific funding for this work.</funding-statement>
</funding-group>
<counts><fig-count count="3"></fig-count>
<table-count count="5"></table-count>
<page-count count="14"></page-count>
</counts>
<custom-meta-group><custom-meta id="data-availability"><meta-name>Data Availability</meta-name>
<meta-value>All relevant data are within the paper.</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
<notes><title>Data Availability</title>
<p>All relevant data are within the paper.</p>
</notes>
</front>
</pmc>
<affiliations><list></list>
<tree><noCountry><name sortKey="Erbersdobler, Andreas" sort="Erbersdobler, Andreas" uniqKey="Erbersdobler A" first="Andreas" last="Erbersdobler">Andreas Erbersdobler</name>
<name sortKey="Huhns, Maja" sort="Huhns, Maja" uniqKey="Huhns M" first="Maja" last="Hühns">Maja Hühns</name>
<name sortKey="Obliers, Annette" sort="Obliers, Annette" uniqKey="Obliers A" first="Annette" last="Obliers">Annette Obliers</name>
<name sortKey="Ropenack, Paula" sort="Ropenack, Paula" uniqKey="Ropenack P" first="Paula" last="Röpenack">Paula Röpenack</name>
</noCountry>
</tree>
</affiliations>
</record>
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