Diffuse idiopathic skeletal hyperostosis in ancient clergymen
Identifieur interne : 000788 ( Ncbi/Merge ); précédent : 000787; suivant : 000789Diffuse idiopathic skeletal hyperostosis in ancient clergymen
Auteurs : J. J. Verlaan [Pays-Bas] ; F. C. Oner [Pays-Bas] ; G. J. R. Maat [Pays-Bas]Source :
- European Spine Journal [ 0940-6719 ] ; 2007.
English descriptors
- KwdEn :
- Adult, Aged, Anthropology, Physical (methods), Archaeology (methods), Bone and Bones (pathology), Clergy, Female, History, 15th Century, History, 16th Century, History, 17th Century, History, 18th Century, History, Medieval, Humans, Hyperostosis, Diffuse Idiopathic Skeletal (diagnosis), Hyperostosis, Diffuse Idiopathic Skeletal (etiology), Hyperostosis, Diffuse Idiopathic Skeletal (pathology), Male, Middle Aged, Paleopathology (methods).
- MESH :
- diagnosis : Hyperostosis, Diffuse Idiopathic Skeletal.
- etiology : Hyperostosis, Diffuse Idiopathic Skeletal.
- methods : Anthropology, Physical, Archaeology, Paleopathology.
- pathology : Bone and Bones, Hyperostosis, Diffuse Idiopathic Skeletal.
- Adult, Aged, Clergy, Female, History, 15th Century, History, 16th Century, History, 17th Century, History, 18th Century, History, Medieval, Humans, Male, Middle Aged.
Abstract
Diffuse idiopathic skeletal hyperostosis (DISH) is a common but often unrecognized systemic disorder observed mainly in the elderly. DISH is diagnosed when the anterior longitudinal ligament of the spine is ossified on at least four contiguous spinal levels or when multiple peripheral enthesopathies are present. The etiology of DISH is unknown but previous studies have shown a strong association with obesity and insulin-independent diabetes mellitus. DISH can lead to back pain, dysphagia, myelopathy, musculoskeletal impairment and grossly unstable spine fractures after minor trauma. In archeological studies a high prevalence of DISH has been demonstrated in ancient clergymen. The present study describes the pathological changes of human remains excavated from the abbey court (Pandhof) in the city of Maastricht, The Netherlands. Human remains of 51 individuals buried between 275 and 1795
Url:
DOI: 10.1007/s00586-007-0342-x
PubMed: 17390155
PubMed Central: 2200769
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000068
- to stream Pmc, to step Curation: 000068
- to stream Pmc, to step Checkpoint: 000230
- to stream PubMed, to step Corpus: 000507
- to stream PubMed, to step Curation: 000507
- to stream PubMed, to step Checkpoint: 000507
Links to Exploration step
PMC:2200769Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Diffuse idiopathic skeletal hyperostosis in ancient clergymen</title>
<author><name sortKey="Verlaan, J J" sort="Verlaan, J J" uniqKey="Verlaan J" first="J. J." last="Verlaan">J. J. Verlaan</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Orthopaedics, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Orthopaedics, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht</wicri:regionArea>
<wicri:noRegion>3584 CX Utrecht</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Oner, F C" sort="Oner, F C" uniqKey="Oner F" first="F. C." last="Oner">F. C. Oner</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Orthopaedics, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Orthopaedics, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht</wicri:regionArea>
<wicri:noRegion>3584 CX Utrecht</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Maat, G J R" sort="Maat, G J R" uniqKey="Maat G" first="G. J. R." last="Maat">G. J. R. Maat</name>
<affiliation wicri:level="3"><nlm:aff id="Aff2">Barge’s Anthropologica, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Barge’s Anthropologica, Leiden University Medical Center, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">17390155</idno>
<idno type="pmc">2200769</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2200769</idno>
<idno type="RBID">PMC:2200769</idno>
<idno type="doi">10.1007/s00586-007-0342-x</idno>
<date when="2007">2007</date>
<idno type="wicri:Area/Pmc/Corpus">000068</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000068</idno>
<idno type="wicri:Area/Pmc/Curation">000068</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000068</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000230</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000230</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">000507</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000507</idno>
<idno type="wicri:Area/PubMed/Curation">000507</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000507</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000507</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000507</idno>
<idno type="wicri:Area/Ncbi/Merge">000788</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Diffuse idiopathic skeletal hyperostosis in ancient clergymen</title>
<author><name sortKey="Verlaan, J J" sort="Verlaan, J J" uniqKey="Verlaan J" first="J. J." last="Verlaan">J. J. Verlaan</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Orthopaedics, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Orthopaedics, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht</wicri:regionArea>
<wicri:noRegion>3584 CX Utrecht</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Oner, F C" sort="Oner, F C" uniqKey="Oner F" first="F. C." last="Oner">F. C. Oner</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Orthopaedics, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Orthopaedics, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht</wicri:regionArea>
<wicri:noRegion>3584 CX Utrecht</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Maat, G J R" sort="Maat, G J R" uniqKey="Maat G" first="G. J. R." last="Maat">G. J. R. Maat</name>
<affiliation wicri:level="3"><nlm:aff id="Aff2">Barge’s Anthropologica, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Barge’s Anthropologica, Leiden University Medical Center, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">European Spine Journal</title>
<idno type="ISSN">0940-6719</idno>
<idno type="eISSN">1432-0932</idno>
<imprint><date when="2007">2007</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Anthropology, Physical (methods)</term>
<term>Archaeology (methods)</term>
<term>Bone and Bones (pathology)</term>
<term>Clergy</term>
<term>Female</term>
<term>History, 15th Century</term>
<term>History, 16th Century</term>
<term>History, 17th Century</term>
<term>History, 18th Century</term>
<term>History, Medieval</term>
<term>Humans</term>
<term>Hyperostosis, Diffuse Idiopathic Skeletal (diagnosis)</term>
<term>Hyperostosis, Diffuse Idiopathic Skeletal (etiology)</term>
<term>Hyperostosis, Diffuse Idiopathic Skeletal (pathology)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Paleopathology (methods)</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Hyperostosis, Diffuse Idiopathic Skeletal</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Hyperostosis, Diffuse Idiopathic Skeletal</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Anthropology, Physical</term>
<term>Archaeology</term>
<term>Paleopathology</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Bone and Bones</term>
<term>Hyperostosis, Diffuse Idiopathic Skeletal</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Clergy</term>
<term>Female</term>
<term>History, 15th Century</term>
<term>History, 16th Century</term>
<term>History, 17th Century</term>
<term>History, 18th Century</term>
<term>History, Medieval</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Diffuse idiopathic skeletal hyperostosis (DISH) is a common but often unrecognized systemic disorder observed mainly in the elderly. DISH is diagnosed when the anterior longitudinal ligament of the spine is ossified on at least four contiguous spinal levels or when multiple peripheral enthesopathies are present. The etiology of DISH is unknown but previous studies have shown a strong association with obesity and insulin-independent diabetes mellitus. DISH can lead to back pain, dysphagia, myelopathy, musculoskeletal impairment and grossly unstable spine fractures after minor trauma. In archeological studies a high prevalence of DISH has been demonstrated in ancient clergymen. The present study describes the pathological changes of human remains excavated from the abbey court (Pandhof) in the city of Maastricht, The Netherlands. Human remains of 51 individuals buried between 275 and 1795 <sc>ce</sc>
were excavated and examined. The remains were investigated according to a standardized physical anthropological report and individuals demonstrating ossification of spinal ligaments and/or multiple peripheral enthesopathies were included in the study group. The authors reviewed all available material and after reaching consensus, each abnormality found was given a diagnosis and subsequently recorded. After examination, 28 individuals were considered to be adult males; 11 adult females; three adults of indeterminate sex and nine individuals were of sub adult age. The mean age at death for adults was 36.8 years. Seventeen adult individuals (40.4% of all adults), displayed ossifications of at least four contiguous spinal levels and/or multiple enthesopathies of the appendicular skeleton and were therefore, assigned the diagnosis DISH. The mean age of these individuals was 49.5 ± 13.0 years. In at least three of these individuals, DISH had led to extensive ossification and subsequent ankylosis of axial and peripheral skeletal structures. In this population of (presumably) clergymen and high-ranking citizens, DISH was observed in unusual high numbers at a relatively young age. Some of the examined cases suggest that DISH may be a seriously incapacitating disorder when the more advanced stages of the disease have been reached. It is hypothesized that “a monastic way of life” can predispose to DISH. Present demographic trends in obesity and diabetes mellitus as potential co-factors for the development of DISH warrant further study to investigate its future prevalence.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Belanger, Ta" uniqKey="Belanger T">TA Belanger</name>
</author>
<author><name sortKey="Rowe, De" uniqKey="Rowe D">DE Rowe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Resnick, D" uniqKey="Resnick D">D Resnick</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Maat, Gjr" uniqKey="Maat G">GJR Maat</name>
</author>
<author><name sortKey="Mastwijk, Rw" uniqKey="Mastwijk R">RW Mastwijk</name>
</author>
<author><name sortKey="Velde, Ea" uniqKey="Velde E">EA Velde</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Resnick, D" uniqKey="Resnick D">D Resnick</name>
</author>
<author><name sortKey="Niwayama, G" uniqKey="Niwayama G">G Niwayama</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Julkunen, H" uniqKey="Julkunen H">H Julkunen</name>
</author>
<author><name sortKey="Knekt, P" uniqKey="Knekt P">P Knekt</name>
</author>
<author><name sortKey="Aromaa, A" uniqKey="Aromaa A">A Aromaa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kim, Sk" uniqKey="Kim S">SK Kim</name>
</author>
<author><name sortKey="Choi, Br" uniqKey="Choi B">BR Choi</name>
</author>
<author><name sortKey="Kim, Cg" uniqKey="Kim C">CG Kim</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Weinfeld, Rm" uniqKey="Weinfeld R">RM Weinfeld</name>
</author>
<author><name sortKey="Olson, Pn" uniqKey="Olson P">PN Olson</name>
</author>
<author><name sortKey="Maki, Dd" uniqKey="Maki D">DD Maki</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Denko, Cw" uniqKey="Denko C">CW Denko</name>
</author>
<author><name sortKey="Malemud, Cj" uniqKey="Malemud C">CJ Malemud</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kiss, C" uniqKey="Kiss C">C Kiss</name>
</author>
<author><name sortKey="Szilagyi, M" uniqKey="Szilagyi M">M Szilagyi</name>
</author>
<author><name sortKey="Paksy, A" uniqKey="Paksy A">A Paksy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sarzi Puttini, P" uniqKey="Sarzi Puttini P">P Sarzi-Puttini</name>
</author>
<author><name sortKey="Atzeni, F" uniqKey="Atzeni F">F Atzeni</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kiss, C" uniqKey="Kiss C">C Kiss</name>
</author>
<author><name sortKey="O Eill, Tw" uniqKey="O Eill T">TW O’Neill</name>
</author>
<author><name sortKey="Mituszova, M" uniqKey="Mituszova M">M Mituszova</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Canci, A" uniqKey="Canci A">A Canci</name>
</author>
<author><name sortKey="Marchi, D" uniqKey="Marchi D">D Marchi</name>
</author>
<author><name sortKey="Caramella, D" uniqKey="Caramella D">D Caramella</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chhem, Rk" uniqKey="Chhem R">RK Chhem</name>
</author>
<author><name sortKey="Schmit, P" uniqKey="Schmit P">P Schmit</name>
</author>
<author><name sortKey="Faure, C" uniqKey="Faure C">C Faure</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Crubezy, E" uniqKey="Crubezy E">E Crubezy</name>
</author>
<author><name sortKey="Trinkaus Shanidar, E" uniqKey="Trinkaus Shanidar E">E. Trinkaus Shanidar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Russell, As" uniqKey="Russell A">AS Russell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rothschild, Bm" uniqKey="Rothschild B">BM Rothschild</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Beyeler, C" uniqKey="Beyeler C">C Beyeler</name>
</author>
<author><name sortKey="Schlapbach, P" uniqKey="Schlapbach P">P Schlapbach</name>
</author>
<author><name sortKey="Gerber, Nj" uniqKey="Gerber N">NJ Gerber</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ebo, Dg" uniqKey="Ebo D">DG Ebo</name>
</author>
<author><name sortKey="Uytterhaegen, Pj" uniqKey="Uytterhaegen P">PJ Uytterhaegen</name>
</author>
<author><name sortKey="Lagae, Pl" uniqKey="Lagae P">PL Lagae</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Naik, B" uniqKey="Naik B">B Naik</name>
</author>
<author><name sortKey="Lobato, Eb" uniqKey="Lobato E">EB Lobato</name>
</author>
<author><name sortKey="Sulek, Ca" uniqKey="Sulek C">CA Sulek</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hendrix, Rw" uniqKey="Hendrix R">RW Hendrix</name>
</author>
<author><name sortKey="Melany, M" uniqKey="Melany M">M Melany</name>
</author>
<author><name sortKey="Miller, F" uniqKey="Miller F">F Miller</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Houk, Rw" uniqKey="Houk R">RW Houk</name>
</author>
<author><name sortKey="Hendrix, Rw" uniqKey="Hendrix R">RW Hendrix</name>
</author>
<author><name sortKey="Lee, C" uniqKey="Lee C">C Lee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fahrer, H" uniqKey="Fahrer H">H Fahrer</name>
</author>
<author><name sortKey="Barandum, R" uniqKey="Barandum R">R Barandum</name>
</author>
<author><name sortKey="Gerber, Nj" uniqKey="Gerber N">NJ Gerber</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schlapbach, P" uniqKey="Schlapbach P">P Schlapbach</name>
</author>
<author><name sortKey="Beyeler, C" uniqKey="Beyeler C">C Beyeler</name>
</author>
<author><name sortKey="Gerber, Nj" uniqKey="Gerber N">NJ Gerber</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Maat, Gjr" uniqKey="Maat G">GJR Maat</name>
</author>
<author><name sortKey="Panhuysen, Rgam" uniqKey="Panhuysen R">RGAM Panhuysen</name>
</author>
<author><name sortKey="Mastwijk, Rw" uniqKey="Mastwijk R">RW Mastwijk</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ciocci, A" uniqKey="Ciocci A">A Ciocci</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Forestier, J R Qj" uniqKey="Forestier J">J R-QJ Forestier</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Resnick, D" uniqKey="Resnick D">D Resnick</name>
</author>
<author><name sortKey="Shapiro, Rf" uniqKey="Shapiro R">RF Shapiro</name>
</author>
<author><name sortKey="Wiesner, Kb" uniqKey="Wiesner K">KB Wiesner</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tsukahara, S" uniqKey="Tsukahara S">S Tsukahara</name>
</author>
<author><name sortKey="Miyazawa, N" uniqKey="Miyazawa N">N Miyazawa</name>
</author>
<author><name sortKey="Akagawa, H" uniqKey="Akagawa H">H Akagawa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Inamasu, J" uniqKey="Inamasu J">J Inamasu</name>
</author>
<author><name sortKey="Guiot, Bh" uniqKey="Guiot B">BH Guiot</name>
</author>
<author><name sortKey="Sachs, Dc" uniqKey="Sachs D">DC Sachs</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rogers, J" uniqKey="Rogers J">J Rogers</name>
</author>
<author><name sortKey="Waldron, T" uniqKey="Waldron T">T Waldron</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Waldron, T" uniqKey="Waldron T">T Waldron</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Bray, Ga" uniqKey="Bray G">GA Bray</name>
</author>
<author><name sortKey="Bellanger, T" uniqKey="Bellanger T">T Bellanger</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Daniels" uniqKey="Daniels">Daniels</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<double pmid="17390155"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Diffuse idiopathic skeletal hyperostosis in ancient clergymen</title>
<author><name sortKey="Verlaan, J J" sort="Verlaan, J J" uniqKey="Verlaan J" first="J. J." last="Verlaan">J. J. Verlaan</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Orthopaedics, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Orthopaedics, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht</wicri:regionArea>
<wicri:noRegion>3584 CX Utrecht</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Oner, F C" sort="Oner, F C" uniqKey="Oner F" first="F. C." last="Oner">F. C. Oner</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Orthopaedics, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Orthopaedics, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht</wicri:regionArea>
<wicri:noRegion>3584 CX Utrecht</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Maat, G J R" sort="Maat, G J R" uniqKey="Maat G" first="G. J. R." last="Maat">G. J. R. Maat</name>
<affiliation wicri:level="3"><nlm:aff id="Aff2">Barge’s Anthropologica, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Barge’s Anthropologica, Leiden University Medical Center, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">17390155</idno>
<idno type="pmc">2200769</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2200769</idno>
<idno type="RBID">PMC:2200769</idno>
<idno type="doi">10.1007/s00586-007-0342-x</idno>
<date when="2007">2007</date>
<idno type="wicri:Area/Pmc/Corpus">000068</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000068</idno>
<idno type="wicri:Area/Pmc/Curation">000068</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000068</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000230</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000230</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Diffuse idiopathic skeletal hyperostosis in ancient clergymen</title>
<author><name sortKey="Verlaan, J J" sort="Verlaan, J J" uniqKey="Verlaan J" first="J. J." last="Verlaan">J. J. Verlaan</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Orthopaedics, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Orthopaedics, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht</wicri:regionArea>
<wicri:noRegion>3584 CX Utrecht</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Oner, F C" sort="Oner, F C" uniqKey="Oner F" first="F. C." last="Oner">F. C. Oner</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Orthopaedics, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Orthopaedics, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht</wicri:regionArea>
<wicri:noRegion>3584 CX Utrecht</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Maat, G J R" sort="Maat, G J R" uniqKey="Maat G" first="G. J. R." last="Maat">G. J. R. Maat</name>
<affiliation wicri:level="3"><nlm:aff id="Aff2">Barge’s Anthropologica, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Barge’s Anthropologica, Leiden University Medical Center, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">European Spine Journal</title>
<idno type="ISSN">0940-6719</idno>
<idno type="eISSN">1432-0932</idno>
<imprint><date when="2007">2007</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Diffuse idiopathic skeletal hyperostosis (DISH) is a common but often unrecognized systemic disorder observed mainly in the elderly. DISH is diagnosed when the anterior longitudinal ligament of the spine is ossified on at least four contiguous spinal levels or when multiple peripheral enthesopathies are present. The etiology of DISH is unknown but previous studies have shown a strong association with obesity and insulin-independent diabetes mellitus. DISH can lead to back pain, dysphagia, myelopathy, musculoskeletal impairment and grossly unstable spine fractures after minor trauma. In archeological studies a high prevalence of DISH has been demonstrated in ancient clergymen. The present study describes the pathological changes of human remains excavated from the abbey court (Pandhof) in the city of Maastricht, The Netherlands. Human remains of 51 individuals buried between 275 and 1795 <sc>ce</sc>
were excavated and examined. The remains were investigated according to a standardized physical anthropological report and individuals demonstrating ossification of spinal ligaments and/or multiple peripheral enthesopathies were included in the study group. The authors reviewed all available material and after reaching consensus, each abnormality found was given a diagnosis and subsequently recorded. After examination, 28 individuals were considered to be adult males; 11 adult females; three adults of indeterminate sex and nine individuals were of sub adult age. The mean age at death for adults was 36.8 years. Seventeen adult individuals (40.4% of all adults), displayed ossifications of at least four contiguous spinal levels and/or multiple enthesopathies of the appendicular skeleton and were therefore, assigned the diagnosis DISH. The mean age of these individuals was 49.5 ± 13.0 years. In at least three of these individuals, DISH had led to extensive ossification and subsequent ankylosis of axial and peripheral skeletal structures. In this population of (presumably) clergymen and high-ranking citizens, DISH was observed in unusual high numbers at a relatively young age. Some of the examined cases suggest that DISH may be a seriously incapacitating disorder when the more advanced stages of the disease have been reached. It is hypothesized that “a monastic way of life” can predispose to DISH. Present demographic trends in obesity and diabetes mellitus as potential co-factors for the development of DISH warrant further study to investigate its future prevalence.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Belanger, Ta" uniqKey="Belanger T">TA Belanger</name>
</author>
<author><name sortKey="Rowe, De" uniqKey="Rowe D">DE Rowe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Resnick, D" uniqKey="Resnick D">D Resnick</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Maat, Gjr" uniqKey="Maat G">GJR Maat</name>
</author>
<author><name sortKey="Mastwijk, Rw" uniqKey="Mastwijk R">RW Mastwijk</name>
</author>
<author><name sortKey="Velde, Ea" uniqKey="Velde E">EA Velde</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Resnick, D" uniqKey="Resnick D">D Resnick</name>
</author>
<author><name sortKey="Niwayama, G" uniqKey="Niwayama G">G Niwayama</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Julkunen, H" uniqKey="Julkunen H">H Julkunen</name>
</author>
<author><name sortKey="Knekt, P" uniqKey="Knekt P">P Knekt</name>
</author>
<author><name sortKey="Aromaa, A" uniqKey="Aromaa A">A Aromaa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kim, Sk" uniqKey="Kim S">SK Kim</name>
</author>
<author><name sortKey="Choi, Br" uniqKey="Choi B">BR Choi</name>
</author>
<author><name sortKey="Kim, Cg" uniqKey="Kim C">CG Kim</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Weinfeld, Rm" uniqKey="Weinfeld R">RM Weinfeld</name>
</author>
<author><name sortKey="Olson, Pn" uniqKey="Olson P">PN Olson</name>
</author>
<author><name sortKey="Maki, Dd" uniqKey="Maki D">DD Maki</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Denko, Cw" uniqKey="Denko C">CW Denko</name>
</author>
<author><name sortKey="Malemud, Cj" uniqKey="Malemud C">CJ Malemud</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kiss, C" uniqKey="Kiss C">C Kiss</name>
</author>
<author><name sortKey="Szilagyi, M" uniqKey="Szilagyi M">M Szilagyi</name>
</author>
<author><name sortKey="Paksy, A" uniqKey="Paksy A">A Paksy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sarzi Puttini, P" uniqKey="Sarzi Puttini P">P Sarzi-Puttini</name>
</author>
<author><name sortKey="Atzeni, F" uniqKey="Atzeni F">F Atzeni</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kiss, C" uniqKey="Kiss C">C Kiss</name>
</author>
<author><name sortKey="O Eill, Tw" uniqKey="O Eill T">TW O’Neill</name>
</author>
<author><name sortKey="Mituszova, M" uniqKey="Mituszova M">M Mituszova</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Canci, A" uniqKey="Canci A">A Canci</name>
</author>
<author><name sortKey="Marchi, D" uniqKey="Marchi D">D Marchi</name>
</author>
<author><name sortKey="Caramella, D" uniqKey="Caramella D">D Caramella</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chhem, Rk" uniqKey="Chhem R">RK Chhem</name>
</author>
<author><name sortKey="Schmit, P" uniqKey="Schmit P">P Schmit</name>
</author>
<author><name sortKey="Faure, C" uniqKey="Faure C">C Faure</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Crubezy, E" uniqKey="Crubezy E">E Crubezy</name>
</author>
<author><name sortKey="Trinkaus Shanidar, E" uniqKey="Trinkaus Shanidar E">E. Trinkaus Shanidar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Russell, As" uniqKey="Russell A">AS Russell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rothschild, Bm" uniqKey="Rothschild B">BM Rothschild</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Beyeler, C" uniqKey="Beyeler C">C Beyeler</name>
</author>
<author><name sortKey="Schlapbach, P" uniqKey="Schlapbach P">P Schlapbach</name>
</author>
<author><name sortKey="Gerber, Nj" uniqKey="Gerber N">NJ Gerber</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ebo, Dg" uniqKey="Ebo D">DG Ebo</name>
</author>
<author><name sortKey="Uytterhaegen, Pj" uniqKey="Uytterhaegen P">PJ Uytterhaegen</name>
</author>
<author><name sortKey="Lagae, Pl" uniqKey="Lagae P">PL Lagae</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Naik, B" uniqKey="Naik B">B Naik</name>
</author>
<author><name sortKey="Lobato, Eb" uniqKey="Lobato E">EB Lobato</name>
</author>
<author><name sortKey="Sulek, Ca" uniqKey="Sulek C">CA Sulek</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hendrix, Rw" uniqKey="Hendrix R">RW Hendrix</name>
</author>
<author><name sortKey="Melany, M" uniqKey="Melany M">M Melany</name>
</author>
<author><name sortKey="Miller, F" uniqKey="Miller F">F Miller</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Houk, Rw" uniqKey="Houk R">RW Houk</name>
</author>
<author><name sortKey="Hendrix, Rw" uniqKey="Hendrix R">RW Hendrix</name>
</author>
<author><name sortKey="Lee, C" uniqKey="Lee C">C Lee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fahrer, H" uniqKey="Fahrer H">H Fahrer</name>
</author>
<author><name sortKey="Barandum, R" uniqKey="Barandum R">R Barandum</name>
</author>
<author><name sortKey="Gerber, Nj" uniqKey="Gerber N">NJ Gerber</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schlapbach, P" uniqKey="Schlapbach P">P Schlapbach</name>
</author>
<author><name sortKey="Beyeler, C" uniqKey="Beyeler C">C Beyeler</name>
</author>
<author><name sortKey="Gerber, Nj" uniqKey="Gerber N">NJ Gerber</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Maat, Gjr" uniqKey="Maat G">GJR Maat</name>
</author>
<author><name sortKey="Panhuysen, Rgam" uniqKey="Panhuysen R">RGAM Panhuysen</name>
</author>
<author><name sortKey="Mastwijk, Rw" uniqKey="Mastwijk R">RW Mastwijk</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ciocci, A" uniqKey="Ciocci A">A Ciocci</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Forestier, J R Qj" uniqKey="Forestier J">J R-QJ Forestier</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Resnick, D" uniqKey="Resnick D">D Resnick</name>
</author>
<author><name sortKey="Shapiro, Rf" uniqKey="Shapiro R">RF Shapiro</name>
</author>
<author><name sortKey="Wiesner, Kb" uniqKey="Wiesner K">KB Wiesner</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tsukahara, S" uniqKey="Tsukahara S">S Tsukahara</name>
</author>
<author><name sortKey="Miyazawa, N" uniqKey="Miyazawa N">N Miyazawa</name>
</author>
<author><name sortKey="Akagawa, H" uniqKey="Akagawa H">H Akagawa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Inamasu, J" uniqKey="Inamasu J">J Inamasu</name>
</author>
<author><name sortKey="Guiot, Bh" uniqKey="Guiot B">BH Guiot</name>
</author>
<author><name sortKey="Sachs, Dc" uniqKey="Sachs D">DC Sachs</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rogers, J" uniqKey="Rogers J">J Rogers</name>
</author>
<author><name sortKey="Waldron, T" uniqKey="Waldron T">T Waldron</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Waldron, T" uniqKey="Waldron T">T Waldron</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Bray, Ga" uniqKey="Bray G">GA Bray</name>
</author>
<author><name sortKey="Bellanger, T" uniqKey="Bellanger T">T Bellanger</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Daniels" uniqKey="Daniels">Daniels</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
</pmc>
<pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Diffuse idiopathic skeletal hyperostosis in ancient clergymen.</title>
<author><name sortKey="Verlaan, J J" sort="Verlaan, J J" uniqKey="Verlaan J" first="J J" last="Verlaan">J J Verlaan</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Orthopaedics, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands. jj.verlaan@wxs.nl</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Orthopaedics, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht</wicri:regionArea>
<wicri:noRegion>3584 CX Utrecht</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Oner, F C" sort="Oner, F C" uniqKey="Oner F" first="F C" last="Oner">F C Oner</name>
</author>
<author><name sortKey="Maat, G J R" sort="Maat, G J R" uniqKey="Maat G" first="G J R" last="Maat">G J R. Maat</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2007">2007</date>
<idno type="RBID">pubmed:17390155</idno>
<idno type="pmid">17390155</idno>
<idno type="doi">10.1007/s00586-007-0342-x</idno>
<idno type="wicri:Area/PubMed/Corpus">000507</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000507</idno>
<idno type="wicri:Area/PubMed/Curation">000507</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000507</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000507</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000507</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Diffuse idiopathic skeletal hyperostosis in ancient clergymen.</title>
<author><name sortKey="Verlaan, J J" sort="Verlaan, J J" uniqKey="Verlaan J" first="J J" last="Verlaan">J J Verlaan</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Orthopaedics, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands. jj.verlaan@wxs.nl</nlm:affiliation>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Orthopaedics, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht</wicri:regionArea>
<wicri:noRegion>3584 CX Utrecht</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Oner, F C" sort="Oner, F C" uniqKey="Oner F" first="F C" last="Oner">F C Oner</name>
</author>
<author><name sortKey="Maat, G J R" sort="Maat, G J R" uniqKey="Maat G" first="G J R" last="Maat">G J R. Maat</name>
</author>
</analytic>
<series><title level="j">European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society</title>
<idno type="ISSN">0940-6719</idno>
<imprint><date when="2007" type="published">2007</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Anthropology, Physical (methods)</term>
<term>Archaeology (methods)</term>
<term>Bone and Bones (pathology)</term>
<term>Clergy</term>
<term>Female</term>
<term>History, 15th Century</term>
<term>History, 16th Century</term>
<term>History, 17th Century</term>
<term>History, 18th Century</term>
<term>History, Medieval</term>
<term>Humans</term>
<term>Hyperostosis, Diffuse Idiopathic Skeletal (diagnosis)</term>
<term>Hyperostosis, Diffuse Idiopathic Skeletal (etiology)</term>
<term>Hyperostosis, Diffuse Idiopathic Skeletal (pathology)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Paleopathology (methods)</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Hyperostosis, Diffuse Idiopathic Skeletal</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Hyperostosis, Diffuse Idiopathic Skeletal</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Anthropology, Physical</term>
<term>Archaeology</term>
<term>Paleopathology</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Bone and Bones</term>
<term>Hyperostosis, Diffuse Idiopathic Skeletal</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Clergy</term>
<term>Female</term>
<term>History, 15th Century</term>
<term>History, 16th Century</term>
<term>History, 17th Century</term>
<term>History, 18th Century</term>
<term>History, Medieval</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Diffuse idiopathic skeletal hyperostosis (DISH) is a common but often unrecognized systemic disorder observed mainly in the elderly. DISH is diagnosed when the anterior longitudinal ligament of the spine is ossified on at least four contiguous spinal levels or when multiple peripheral enthesopathies are present. The etiology of DISH is unknown but previous studies have shown a strong association with obesity and insulin-independent diabetes mellitus. DISH can lead to back pain, dysphagia, myelopathy, musculoskeletal impairment and grossly unstable spine fractures after minor trauma. In archeological studies a high prevalence of DISH has been demonstrated in ancient clergymen. The present study describes the pathological changes of human remains excavated from the abbey court (Pandhof) in the city of Maastricht, The Netherlands. Human remains of 51 individuals buried between 275 and 1795 CE: were excavated and examined. The remains were investigated according to a standardized physical anthropological report and individuals demonstrating ossification of spinal ligaments and/or multiple peripheral enthesopathies were included in the study group. The authors reviewed all available material and after reaching consensus, each abnormality found was given a diagnosis and subsequently recorded. After examination, 28 individuals were considered to be adult males; 11 adult females; three adults of indeterminate sex and nine individuals were of sub adult age. The mean age at death for adults was 36.8 years. Seventeen adult individuals (40.4% of all adults), displayed ossifications of at least four contiguous spinal levels and/or multiple enthesopathies of the appendicular skeleton and were therefore, assigned the diagnosis DISH. The mean age of these individuals was 49.5 +/- 13.0 years. In at least three of these individuals, DISH had led to extensive ossification and subsequent ankylosis of axial and peripheral skeletal structures. In this population of (presumably) clergymen and high-ranking citizens, DISH was observed in unusual high numbers at a relatively young age. Some of the examined cases suggest that DISH may be a seriously incapacitating disorder when the more advanced stages of the disease have been reached. It is hypothesized that "a monastic way of life" can predispose to DISH. Present demographic trends in obesity and diabetes mellitus as potential co-factors for the development of DISH warrant further study to investigate its future prevalence.</div>
</front>
</TEI>
</pubmed>
</double>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Archeologie/explor/PaleopathV1/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000788 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 000788 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Archeologie |area= PaleopathV1 |flux= Ncbi |étape= Merge |type= RBID |clé= PMC:2200769 |texte= Diffuse idiopathic skeletal hyperostosis in ancient clergymen }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:17390155" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \ | NlmPubMed2Wicri -a PaleopathV1
This area was generated with Dilib version V0.6.27. |