Rare Case of an Ancient Craniofacial Osteosarcoma with Probable Surgical Intervention.
Identifieur interne : 001020 ( Ncbi/Curation ); précédent : 001019; suivant : 001021Rare Case of an Ancient Craniofacial Osteosarcoma with Probable Surgical Intervention.
Auteurs : Erika Molnár [Hongrie] ; Michael Schultz [Allemagne] ; Tyede H. Schmidt-Schultz [Allemagne] ; Ant Nia Marcsik [Hongrie] ; Krisztina Buczk [Hongrie] ; Péter Zádori [Hongrie] ; Gergely Bir [Hongrie] ; Zsolt Bernert [Hongrie] ; Daniel Baumhoer [Suisse] ; Tamás Hajdu [Hongrie]Source :
- Pathology oncology research : POR [ 1532-2807 ] ; 2016.
Abstract
Osteosarcoma is the most common primary malignant bone tumor both today and in antiquity. Nevertheless, it is a comparatively rare tumor. This paper describes a case of a highly aggressive craniofacial lesion from the 11th-12th centuries AD, most likely representing osteosarcoma. During the paleopathological study, macroscopic, endoscopic, radiological, scanning-electron and light microscopic investigations were performed. The skull of the approximately 40-50 year-old female revealed several pathological findings. The most impressive macroscopic feature was an extensively spiculated periosteal reaction ("sunburst" pattern) in combination with a massive bone destruction most likely derived from a highly aggressive tumor originating in the ethmoidal area of the medial wall of the orbit. The central parts of the lesion showed excessive new and most probably neoplastic bone formation indicating an underlying high-grade osteosarcoma. The light microscopic examination revealed three different levels of bony structures representing different qualities of bone tissues. Besides the mass lesion, signs of a healed multiple incomplete trephination of the left parietal bone was observed. This case represents a unique example in which the concomitance of a tumor and an incomplete trephination could be observed from the skeletal remains of an ancient individual. The case opens new considerations as to whether surgical interventions, such as incomplete trephination, might have been used already in the Middle Ages as a therapeutic approach.
DOI: 10.1007/s12253-016-0153-7
PubMed: 27866322
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Kreuzbergring 36, D-37075, Göttingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Anatomy, University Medical School Göttingen, Kreuzbergring 36, D-37075, Göttingen</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Göttingen</settlement></placeName></affiliation></author><author><name sortKey="Schmidt Schultz, Tyede H" sort="Schmidt Schultz, Tyede H" uniqKey="Schmidt Schultz T" first="Tyede H" last="Schmidt-Schultz">Tyede H. Schmidt-Schultz</name><affiliation wicri:level="3"><nlm:affiliation>Department of Anatomy, University Medical School Göttingen, Kreuzbergring 36, D-37075, Göttingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Anatomy, University Medical School Göttingen, Kreuzbergring 36, D-37075, Göttingen</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Göttingen</settlement></placeName></affiliation></author><author><name sortKey="Marcsik, Ant Nia" sort="Marcsik, Ant Nia" uniqKey="Marcsik A" first="Ant Nia" last="Marcsik">Ant Nia Marcsik</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biological Anthropology, University of Szeged, Közép fasor 52, Szeged, H-6726, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Biological Anthropology, University of Szeged, Közép fasor 52, Szeged, H-6726</wicri:regionArea><wicri:noRegion>H-6726</wicri:noRegion></affiliation></author><author><name sortKey="Buczk, Krisztina" sort="Buczk, Krisztina" uniqKey="Buczk K" first="Krisztina" last="Buczk">Krisztina Buczk</name><affiliation wicri:level="1"><nlm:affiliation>Department of Botany, Hungarian Natural History Museum, Könyves Kálmán körút 40, Budapest, H-1097, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Botany, Hungarian Natural History Museum, Könyves Kálmán körút 40, Budapest, H-1097</wicri:regionArea><wicri:noRegion>H-1097</wicri:noRegion></affiliation></author><author><name sortKey="Zadori, Peter" sort="Zadori, Peter" uniqKey="Zadori P" first="Péter" last="Zádori">Péter Zádori</name><affiliation wicri:level="1"><nlm:affiliation>Health Center, Kaposvár University, Guba Sándor utca 40, Kaposvár, H-7400, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Health Center, Kaposvár University, Guba Sándor utca 40, Kaposvár, H-7400</wicri:regionArea><wicri:noRegion>H-7400</wicri:noRegion></affiliation></author><author><name sortKey="Bir, Gergely" sort="Bir, Gergely" uniqKey="Bir G" first="Gergely" last="Bir">Gergely Bir</name><affiliation wicri:level="1"><nlm:affiliation>Health Center, Kaposvár University, Guba Sándor utca 40, Kaposvár, H-7400, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Health Center, Kaposvár University, Guba Sándor utca 40, Kaposvár, H-7400</wicri:regionArea><wicri:noRegion>H-7400</wicri:noRegion></affiliation></author><author><name sortKey="Bernert, Zsolt" sort="Bernert, Zsolt" uniqKey="Bernert Z" first="Zsolt" last="Bernert">Zsolt Bernert</name><affiliation wicri:level="1"><nlm:affiliation>Department of Anthropology, Hungarian Natural History Museum, Ludovika tér 2, Budapest, H-1083, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Anthropology, Hungarian Natural History Museum, Ludovika tér 2, Budapest, H-1083</wicri:regionArea><wicri:noRegion>H-1083</wicri:noRegion></affiliation></author><author><name sortKey="Baumhoer, Daniel" sort="Baumhoer, Daniel" uniqKey="Baumhoer D" first="Daniel" last="Baumhoer">Daniel Baumhoer</name><affiliation wicri:level="1"><nlm:affiliation>Bone Tumor Reference Center at the Institute of Pathology, University Hospital Basel, Schönbeinstrasse 40, D-, 4031, Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Bone Tumor Reference Center at the Institute of Pathology, University Hospital Basel, Schönbeinstrasse 40, D-, 4031, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Hajdu, Tamas" sort="Hajdu, Tamas" uniqKey="Hajdu T" first="Tamás" last="Hajdu">Tamás Hajdu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Anthropology, Hungarian Natural History Museum, Ludovika tér 2, Budapest, H-1083, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Anthropology, Hungarian Natural History Museum, Ludovika tér 2, Budapest, H-1083</wicri:regionArea><wicri:noRegion>H-1083</wicri:noRegion></affiliation></author></analytic><series><title level="j">Pathology oncology research : POR</title><idno type="eISSN">1532-2807</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Osteosarcoma is the most common primary malignant bone tumor both today and in antiquity. Nevertheless, it is a comparatively rare tumor. This paper describes a case of a highly aggressive craniofacial lesion from the 11th-12th centuries AD, most likely representing osteosarcoma. During the paleopathological study, macroscopic, endoscopic, radiological, scanning-electron and light microscopic investigations were performed. The skull of the approximately 40-50 year-old female revealed several pathological findings. The most impressive macroscopic feature was an extensively spiculated periosteal reaction ("sunburst" pattern) in combination with a massive bone destruction most likely derived from a highly aggressive tumor originating in the ethmoidal area of the medial wall of the orbit. The central parts of the lesion showed excessive new and most probably neoplastic bone formation indicating an underlying high-grade osteosarcoma. The light microscopic examination revealed three different levels of bony structures representing different qualities of bone tissues. Besides the mass lesion, signs of a healed multiple incomplete trephination of the left parietal bone was observed. This case represents a unique example in which the concomitance of a tumor and an incomplete trephination could be observed from the skeletal remains of an ancient individual. The case opens new considerations as to whether surgical interventions, such as incomplete trephination, might have been used already in the Middle Ages as a therapeutic approach.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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