Lipid biomarkers provide evolutionary signposts for the oldest known cases of tuberculosis.
Identifieur interne : 000139 ( Main/Merge ); précédent : 000138; suivant : 000140Lipid biomarkers provide evolutionary signposts for the oldest known cases of tuberculosis.
Auteurs : Oona Y-C Lee [Royaume-Uni] ; Houdini H T. Wu [Royaume-Uni] ; Gurdyal S. Besra [Royaume-Uni] ; Bruce M. Rothschild (médecin) [États-Unis] ; Mark Spigelman [Israël] ; Israel Hershkovitz [Israël] ; Gila Kahila Bar-Gal [Israël] ; Helen D. Donoghue [Royaume-Uni] ; David E. Minnikin [Royaume-Uni]Source :
- Tuberculosis (Edinburgh, Scotland) [ 1873-281X ] ; 2015.
English descriptors
- KwdEn :
- MESH :
- chemical , analysis : Biomarkers, Lipids, Mycolic Acids.
- chemical , genetics : Lipids.
- genetics : Tuberculosis, Osteoarticular.
- history : Tuberculosis, Osteoarticular.
- methods : Paleopathology.
- Animals, Biological Evolution, Cattle, Child, Preschool, Female, History, Ancient, Humans.
Abstract
Studies on the evolution of tuberculosis, and the influence of this disease on human and animal development and interaction, require the accumulation of indisputable biomarker evidence. Ideally, the determination of full genomes would provide all the necessary information, but for very old specimens DNA preservation may be compromised and only limited DNA amplification may be a possibility. Mycobacterium tuberculosis is characterised by the presence of unusual cell envelope lipids, with specific biomarker potential. Lipid biomarker recognition has been decisive in pinpointing the oldest known cases of human and animal tuberculosis; the former are a woman and child from a pre-pottery settlement at Atlit-Yam, Israel (∼9,000 ka) and the latter is an extinct Bison antiquus from Natural Trap Cave, Wyoming (∼17,000 ka). Including some new data, it is demonstrated how analysis of a combination of mycolic, mycocerosic and mycolipenic acid and phthiocerol biomarkers provide incontrovertible evidence for tuberculosis in these landmark specimens.
DOI: 10.1016/j.tube.2015.02.013
PubMed: 25797611
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000094
- to stream PubMed, to step Curation: 000094
- to stream PubMed, to step Checkpoint: 000094
- to stream Ncbi, to step Merge: 000E41
- to stream Ncbi, to step Curation: 000E41
- to stream Ncbi, to step Checkpoint: 000E41
Links to Exploration step
pubmed:25797611Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Lipid biomarkers provide evolutionary signposts for the oldest known cases of tuberculosis.</title>
<author><name sortKey="Lee, Oona Y C" sort="Lee, Oona Y C" uniqKey="Lee O" first="Oona Y-C" last="Lee">Oona Y-C Lee</name>
<affiliation wicri:level="4"><nlm:affiliation>Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, UK. Electronic address: leeoy@bham.ac.uk.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham</wicri:regionArea>
<placeName><settlement type="city">Birmingham</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Midlands de l'Ouest</region>
</placeName>
<orgName type="university">Université de Birmingham</orgName>
</affiliation>
</author>
<author><name sortKey="Wu, Houdini H T" sort="Wu, Houdini H T" uniqKey="Wu H" first="Houdini H T" last="Wu">Houdini H T. Wu</name>
<affiliation wicri:level="4"><nlm:affiliation>Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, UK. Electronic address: h.wu.2@bham.ac.uk.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham</wicri:regionArea>
<placeName><settlement type="city">Birmingham</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Midlands de l'Ouest</region>
</placeName>
<orgName type="university">Université de Birmingham</orgName>
</affiliation>
</author>
<author><name sortKey="Besra, Gurdyal S" sort="Besra, Gurdyal S" uniqKey="Besra G" first="Gurdyal S" last="Besra">Gurdyal S. Besra</name>
<affiliation wicri:level="4"><nlm:affiliation>Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, UK. Electronic address: g.besra@bham.ac.uk.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham</wicri:regionArea>
<placeName><settlement type="city">Birmingham</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Midlands de l'Ouest</region>
</placeName>
<orgName type="university">Université de Birmingham</orgName>
</affiliation>
</author>
<author><name sortKey="Rothschild, Bruce M" sort="Rothschild, Bruce M" uniqKey="Rothschild B" first="Bruce M" last="Rothschild">Bruce M. Rothschild (médecin)</name>
<affiliation wicri:level="4"><nlm:affiliation>Biodiversity Institute and Departments of Anthropology and Geology, University of Kansas, Lawrence, KS 66045, USA. Electronic address: bmr@ku.edu.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Biodiversity Institute and Departments of Anthropology and Geology, University of Kansas, Lawrence, KS 66045</wicri:regionArea>
<placeName><region type="state">Kansas</region>
<settlement type="city">Lawrence (Kansas)</settlement>
</placeName>
<orgName type="university">Université du Kansas</orgName>
<placeName><settlement type="city">Lawrence (Kansas)</settlement>
<region type="state">Kansas</region>
</placeName>
<orgName type="university" n="3">Université du Kansas</orgName>
</affiliation>
</author>
<author><name sortKey="Spigelman, Mark" sort="Spigelman, Mark" uniqKey="Spigelman M" first="Mark" last="Spigelman">Mark Spigelman</name>
<affiliation wicri:level="1"><nlm:affiliation>Kuvin Center for the Study of Infectious and Tropical Diseases and Ancient DNA, Hadassah Medical School, Hebrew University, Jerusalem, Israel. Electronic address: spigelman@btinternet.com.</nlm:affiliation>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>Kuvin Center for the Study of Infectious and Tropical Diseases and Ancient DNA, Hadassah Medical School, Hebrew University, Jerusalem</wicri:regionArea>
<wicri:noRegion>Jerusalem</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hershkovitz, Israel" sort="Hershkovitz, Israel" uniqKey="Hershkovitz I" first="Israel" last="Hershkovitz">Israel Hershkovitz</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. Electronic address: anatom2@post.tau.ac.il.</nlm:affiliation>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv</wicri:regionArea>
<wicri:noRegion>Tel-Aviv</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bar Gal, Gila Kahila" sort="Bar Gal, Gila Kahila" uniqKey="Bar Gal G" first="Gila Kahila" last="Bar-Gal">Gila Kahila Bar-Gal</name>
<affiliation wicri:level="1"><nlm:affiliation>Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot, Israel. Electronic address: gila.kahila@mail.huji.ac.il.</nlm:affiliation>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot</wicri:regionArea>
<wicri:noRegion>Rehovot</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Donoghue, Helen D" sort="Donoghue, Helen D" uniqKey="Donoghue H" first="Helen D" last="Donoghue">Helen D. Donoghue</name>
<affiliation wicri:level="4"><nlm:affiliation>Centres for Clinical Microbiology and the History of Medicine, University College London, UK. Electronic address: h.donoghue@ucl.ac.uk.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centres for Clinical Microbiology and the History of Medicine, University College London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author><name sortKey="Minnikin, David E" sort="Minnikin, David E" uniqKey="Minnikin D" first="David E" last="Minnikin">David E. Minnikin</name>
<affiliation wicri:level="4"><nlm:affiliation>Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, UK. Electronic address: d.e.minnikin@bham.ac.uk.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham</wicri:regionArea>
<placeName><settlement type="city">Birmingham</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Midlands de l'Ouest</region>
</placeName>
<orgName type="university">Université de Birmingham</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2015">2015</date>
<idno type="RBID">pubmed:25797611</idno>
<idno type="pmid">25797611</idno>
<idno type="doi">10.1016/j.tube.2015.02.013</idno>
<idno type="wicri:Area/PubMed/Corpus">000094</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000094</idno>
<idno type="wicri:Area/PubMed/Curation">000094</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000094</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000094</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000094</idno>
<idno type="wicri:Area/Ncbi/Merge">000E41</idno>
<idno type="wicri:Area/Ncbi/Curation">000E41</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000E41</idno>
<idno type="wicri:Area/Main/Merge">000139</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Lipid biomarkers provide evolutionary signposts for the oldest known cases of tuberculosis.</title>
<author><name sortKey="Lee, Oona Y C" sort="Lee, Oona Y C" uniqKey="Lee O" first="Oona Y-C" last="Lee">Oona Y-C Lee</name>
<affiliation wicri:level="4"><nlm:affiliation>Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, UK. Electronic address: leeoy@bham.ac.uk.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham</wicri:regionArea>
<placeName><settlement type="city">Birmingham</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Midlands de l'Ouest</region>
</placeName>
<orgName type="university">Université de Birmingham</orgName>
</affiliation>
</author>
<author><name sortKey="Wu, Houdini H T" sort="Wu, Houdini H T" uniqKey="Wu H" first="Houdini H T" last="Wu">Houdini H T. Wu</name>
<affiliation wicri:level="4"><nlm:affiliation>Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, UK. Electronic address: h.wu.2@bham.ac.uk.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham</wicri:regionArea>
<placeName><settlement type="city">Birmingham</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Midlands de l'Ouest</region>
</placeName>
<orgName type="university">Université de Birmingham</orgName>
</affiliation>
</author>
<author><name sortKey="Besra, Gurdyal S" sort="Besra, Gurdyal S" uniqKey="Besra G" first="Gurdyal S" last="Besra">Gurdyal S. Besra</name>
<affiliation wicri:level="4"><nlm:affiliation>Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, UK. Electronic address: g.besra@bham.ac.uk.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham</wicri:regionArea>
<placeName><settlement type="city">Birmingham</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Midlands de l'Ouest</region>
</placeName>
<orgName type="university">Université de Birmingham</orgName>
</affiliation>
</author>
<author><name sortKey="Rothschild, Bruce M" sort="Rothschild, Bruce M" uniqKey="Rothschild B" first="Bruce M" last="Rothschild">Bruce M. Rothschild (médecin)</name>
<affiliation wicri:level="4"><nlm:affiliation>Biodiversity Institute and Departments of Anthropology and Geology, University of Kansas, Lawrence, KS 66045, USA. Electronic address: bmr@ku.edu.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Biodiversity Institute and Departments of Anthropology and Geology, University of Kansas, Lawrence, KS 66045</wicri:regionArea>
<placeName><region type="state">Kansas</region>
<settlement type="city">Lawrence (Kansas)</settlement>
</placeName>
<orgName type="university">Université du Kansas</orgName>
<placeName><settlement type="city">Lawrence (Kansas)</settlement>
<region type="state">Kansas</region>
</placeName>
<orgName type="university" n="3">Université du Kansas</orgName>
</affiliation>
</author>
<author><name sortKey="Spigelman, Mark" sort="Spigelman, Mark" uniqKey="Spigelman M" first="Mark" last="Spigelman">Mark Spigelman</name>
<affiliation wicri:level="1"><nlm:affiliation>Kuvin Center for the Study of Infectious and Tropical Diseases and Ancient DNA, Hadassah Medical School, Hebrew University, Jerusalem, Israel. Electronic address: spigelman@btinternet.com.</nlm:affiliation>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>Kuvin Center for the Study of Infectious and Tropical Diseases and Ancient DNA, Hadassah Medical School, Hebrew University, Jerusalem</wicri:regionArea>
<wicri:noRegion>Jerusalem</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hershkovitz, Israel" sort="Hershkovitz, Israel" uniqKey="Hershkovitz I" first="Israel" last="Hershkovitz">Israel Hershkovitz</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. Electronic address: anatom2@post.tau.ac.il.</nlm:affiliation>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv</wicri:regionArea>
<wicri:noRegion>Tel-Aviv</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bar Gal, Gila Kahila" sort="Bar Gal, Gila Kahila" uniqKey="Bar Gal G" first="Gila Kahila" last="Bar-Gal">Gila Kahila Bar-Gal</name>
<affiliation wicri:level="1"><nlm:affiliation>Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot, Israel. Electronic address: gila.kahila@mail.huji.ac.il.</nlm:affiliation>
<country xml:lang="fr">Israël</country>
<wicri:regionArea>Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot</wicri:regionArea>
<wicri:noRegion>Rehovot</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Donoghue, Helen D" sort="Donoghue, Helen D" uniqKey="Donoghue H" first="Helen D" last="Donoghue">Helen D. Donoghue</name>
<affiliation wicri:level="4"><nlm:affiliation>Centres for Clinical Microbiology and the History of Medicine, University College London, UK. Electronic address: h.donoghue@ucl.ac.uk.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centres for Clinical Microbiology and the History of Medicine, University College London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author><name sortKey="Minnikin, David E" sort="Minnikin, David E" uniqKey="Minnikin D" first="David E" last="Minnikin">David E. Minnikin</name>
<affiliation wicri:level="4"><nlm:affiliation>Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, UK. Electronic address: d.e.minnikin@bham.ac.uk.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham</wicri:regionArea>
<placeName><settlement type="city">Birmingham</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Midlands de l'Ouest</region>
</placeName>
<orgName type="university">Université de Birmingham</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j">Tuberculosis (Edinburgh, Scotland)</title>
<idno type="eISSN">1873-281X</idno>
<imprint><date when="2015" type="published">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Biological Evolution</term>
<term>Biomarkers (analysis)</term>
<term>Cattle</term>
<term>Child, Preschool</term>
<term>Female</term>
<term>History, Ancient</term>
<term>Humans</term>
<term>Lipids (analysis)</term>
<term>Lipids (genetics)</term>
<term>Mycolic Acids (analysis)</term>
<term>Paleopathology (methods)</term>
<term>Tuberculosis, Osteoarticular (genetics)</term>
<term>Tuberculosis, Osteoarticular (history)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Biomarkers</term>
<term>Lipids</term>
<term>Mycolic Acids</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Lipids</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Tuberculosis, Osteoarticular</term>
</keywords>
<keywords scheme="MESH" qualifier="history" xml:lang="en"><term>Tuberculosis, Osteoarticular</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Paleopathology</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Biological Evolution</term>
<term>Cattle</term>
<term>Child, Preschool</term>
<term>Female</term>
<term>History, Ancient</term>
<term>Humans</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Studies on the evolution of tuberculosis, and the influence of this disease on human and animal development and interaction, require the accumulation of indisputable biomarker evidence. Ideally, the determination of full genomes would provide all the necessary information, but for very old specimens DNA preservation may be compromised and only limited DNA amplification may be a possibility. Mycobacterium tuberculosis is characterised by the presence of unusual cell envelope lipids, with specific biomarker potential. Lipid biomarker recognition has been decisive in pinpointing the oldest known cases of human and animal tuberculosis; the former are a woman and child from a pre-pottery settlement at Atlit-Yam, Israel (∼9,000 ka) and the latter is an extinct Bison antiquus from Natural Trap Cave, Wyoming (∼17,000 ka). Including some new data, it is demonstrated how analysis of a combination of mycolic, mycocerosic and mycolipenic acid and phthiocerol biomarkers provide incontrovertible evidence for tuberculosis in these landmark specimens.</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Archeologie/explor/PaleopathV1/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000139 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 000139 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Archeologie |area= PaleopathV1 |flux= Main |étape= Merge |type= RBID |clé= pubmed:25797611 |texte= Lipid biomarkers provide evolutionary signposts for the oldest known cases of tuberculosis. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Merge/RBID.i -Sk "pubmed:25797611" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Merge/biblio.hfd \ | NlmPubMed2Wicri -a PaleopathV1
![]() | This area was generated with Dilib version V0.6.27. | ![]() |