Modeling Clinical States and Metabolic Rhythms in Bioarcheology
Identifieur interne : 000136 ( Main/Merge ); précédent : 000135; suivant : 000137Modeling Clinical States and Metabolic Rhythms in Bioarcheology
Auteurs : Clifford Qualls [États-Unis] ; Raffaella Bianucci [Norvège, Italie] ; Michael N. Spilde [États-Unis] ; Genevieve Phillips [États-Unis] ; Cecilia Wu [États-Unis] ; Otto Appenzeller [États-Unis]Source :
- BioMed Research International [ 2314-6133 ] ; 2015.
Descripteurs français
- Wicri :
- geographic : Pays-Bas.
English descriptors
- KwdEn :
- MESH :
- geographic : Netherlands.
- innervation : Hair Follicle.
- metabolism : Autonomic Pathways, Hair Follicle.
- ultrastructure : Autonomic Pathways, Hair Follicle.
- Female, History, Ancient, Humans, Male, Models, Biological, Paleopathology.
Abstract
Bioarcheology is cross disciplinary research encompassing the study of human remains. However, life's activities have, up till now, eluded bioarcheological investigation. We hypothesized that growth lines in hair might archive the biologic rhythms, growth rate, and metabolism during life. Computational modeling predicted the physical appearance, derived from hair growth rate, biologic rhythms, and mental state for human remains from the Roman period. The width of repeat growth intervals (RI's) on the hair, shown by confocal microscopy, allowed computation of time series of periodicities of the RI's to model growth rates of the hairs. Our results are based on four hairs from controls yielding 212 data points and the RI's of six cropped hairs from Zweeloo woman's scalp yielding 504 data points. Hair growth was, ten times faster than normal consistent with hypertrichosis. Cantú syndrome consists of hypertrichosis, dyschondrosteosis, short stature, and cardiomegaly. Sympathetic activation and enhanced metabolic state suggesting arousal was also present. Two-photon microscopy visualized preserved portions of autonomic nerve fibers surrounding the hair bulb. Scanning electron microscopy found evidence that a knife was used to cut the hair three to five days before death. Thus computational modeling enabled the elucidation of life's activities 2000 years after death in this individual with Cantu syndrome. This may have implications for archeology and forensic sciences.
Url:
DOI: 10.1155/2015/818724
PubMed: 26346040
PubMed Central: 4544883
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Sciences Center, University of New Mexico, Albuquerque, NM, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Health Sciences Center, University of New Mexico, Albuquerque, NM</wicri:regionArea><placeName><region type="state">Nouveau-Mexique</region></placeName></affiliation></author><author><name sortKey="Bianucci, Raffaella" sort="Bianucci, Raffaella" uniqKey="Bianucci R" first="Raffaella" last="Bianucci">Raffaella Bianucci</name><affiliation wicri:level="1"><nlm:aff id="I2">Department of Biosciences, Centre for Ecological and Evolutionary Synthesis (CEES), University of Oslo, Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Biosciences, Centre for Ecological and Evolutionary Synthesis (CEES), University of Oslo, Oslo</wicri:regionArea><wicri:noRegion>Oslo</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="I3">Department of Public Health and Pediatric Sciences, University of Turin, Turin, 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Spilde</name><affiliation wicri:level="2"><nlm:aff id="I4">Department of Earth and Planetary Sciences, Institute of Meteoritics, University of New Mexico, Albuquerque, NM, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Earth and Planetary Sciences, Institute of Meteoritics, University of New Mexico, Albuquerque, NM</wicri:regionArea><placeName><region type="state">Nouveau-Mexique</region></placeName></affiliation></author><author><name sortKey="Phillips, Genevieve" sort="Phillips, Genevieve" uniqKey="Phillips G" first="Genevieve" last="Phillips">Genevieve Phillips</name><affiliation wicri:level="2"><nlm:aff id="I5">Cancer Research and Treatment, Center Fluorescence Microscopy Facility, University of New Mexico, Albuquerque, NM, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Research and Treatment, Center Fluorescence Microscopy Facility, University of New Mexico, Albuquerque, NM</wicri:regionArea><placeName><region type="state">Nouveau-Mexique</region></placeName></affiliation></author><author><name sortKey="Wu, Cecilia" sort="Wu, Cecilia" uniqKey="Wu C" first="Cecilia" last="Wu">Cecilia Wu</name><affiliation wicri:level="2"><nlm:aff id="I6">Department of Pathology, University of New Mexico, Albuquerque, NM, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of New Mexico, Albuquerque, NM</wicri:regionArea><placeName><region type="state">Nouveau-Mexique</region></placeName></affiliation></author><author><name sortKey="Appenzeller, Otto" sort="Appenzeller, Otto" uniqKey="Appenzeller O" first="Otto" last="Appenzeller">Otto Appenzeller</name><affiliation wicri:level="2"><nlm:aff id="I7">New Mexico Health Enhancement and Marathon Clinics Research Foundation, Albuquerque, NM, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>New Mexico Health Enhancement and Marathon Clinics Research Foundation, Albuquerque, NM</wicri:regionArea><placeName><region type="state">Nouveau-Mexique</region></placeName></affiliation></author></analytic><series><title level="j">BioMed Research International</title><idno type="ISSN">2314-6133</idno><idno type="eISSN">2314-6141</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Autonomic Pathways (metabolism)</term><term>Autonomic Pathways (ultrastructure)</term><term>Female</term><term>Hair Follicle (innervation)</term><term>Hair Follicle (metabolism)</term><term>Hair Follicle (ultrastructure)</term><term>History, Ancient</term><term>Humans</term><term>Male</term><term>Models, Biological</term><term>Netherlands</term><term>Paleopathology</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Netherlands</term></keywords><keywords scheme="MESH" qualifier="innervation" xml:lang="en"><term>Hair Follicle</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Autonomic Pathways</term><term>Hair Follicle</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Autonomic Pathways</term><term>Hair Follicle</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Female</term><term>History, Ancient</term><term>Humans</term><term>Male</term><term>Models, Biological</term><term>Paleopathology</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Pays-Bas</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Bioarcheology is cross disciplinary research encompassing the study of human remains. However, life's activities have, up till now, eluded bioarcheological investigation. We hypothesized that growth lines in hair might archive the biologic rhythms, growth rate, and metabolism during life. Computational modeling predicted the physical appearance, derived from hair growth rate, biologic rhythms, and mental state for human remains from the Roman period. The width of repeat growth intervals (RI's) on the hair, shown by confocal microscopy, allowed computation of time series of periodicities of the RI's to model growth rates of the hairs. Our results are based on four hairs from controls yielding 212 data points and the RI's of six cropped hairs from Zweeloo woman's scalp yielding 504 data points. Hair growth was, ten times faster than normal consistent with hypertrichosis. Cantú syndrome consists of hypertrichosis, dyschondrosteosis, short stature, and cardiomegaly. Sympathetic activation and enhanced metabolic state suggesting arousal was also present. Two-photon microscopy visualized preserved portions of autonomic nerve fibers surrounding the hair bulb. Scanning electron microscopy found evidence that a knife was used to cut the hair three to five days before death. Thus computational modeling enabled the elucidation of life's activities 2000 years after death in this individual with Cantu syndrome. This may have implications for archeology and forensic sciences.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Bianucci, R" uniqKey="Bianucci R">R. Bianucci</name></author><author><name sortKey="Brothwell, D" uniqKey="Brothwell D">D. Brothwell</name></author><author><name sortKey="Van Der Sanden, W" uniqKey="Van Der Sanden W">W. van der Sanden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Palmetun Ekb Ck, M" uniqKey="Palmetun Ekb Ck M">M. Palmetun Ekbäck</name></author><author><name sortKey="Lindberg, M" uniqKey="Lindberg M">M. Lindberg</name></author><author><name sortKey="Benzein, E" uniqKey="Benzein E">E. Benzein</name></author><author><name sortKey="Arestedt, K" uniqKey="Arestedt K">K. Arestedt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lazalde, B" uniqKey="Lazalde B">B. Lazalde</name></author><author><name sortKey="Sanchez Urbina, R" uniqKey="Sanchez Urbina R">R. Sánchez-Urbina</name></author><author><name sortKey="Nu O Arana, I" uniqKey="Nu O Arana I">I. Nuňo-Arana</name></author><author><name sortKey="Bitar, W E" uniqKey="Bitar W">W. E. Bitar</name></author><author><name sortKey="De Lourdes Ramirez Due As, M" uniqKey="De Lourdes Ramirez Due As M">M. de Lourdes Ramírez-Dueñas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sharp, Z D" uniqKey="Sharp Z">Z. D. Sharp</name></author><author><name sortKey="Atudorei, V" uniqKey="Atudorei V">V. Atudorei</name></author><author><name sortKey="Panarello, H O" uniqKey="Panarello H">H. O. Panarello</name></author><author><name sortKey="Fernandez, J" uniqKey="Fernandez J">J. Fernández</name></author><author><name sortKey="Douthitt, C" uniqKey="Douthitt C">C. Douthitt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pincus, S M" uniqKey="Pincus S">S. M. Pincus</name></author><author><name sortKey="Goldberger, A L" uniqKey="Goldberger A">A. L. Goldberger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eckardt, H" uniqKey="Eckardt H">H. Eckardt</name></author><author><name sortKey="Crummy, N" uniqKey="Crummy N">N. Crummy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Richman, J S" uniqKey="Richman J">J. S. Richman</name></author><author><name sortKey="Moorman, J R" uniqKey="Moorman J">J. R. Moorman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Paus, R" uniqKey="Paus R">R. Paus</name></author><author><name sortKey="Cotsarelis, G" uniqKey="Cotsarelis G">G. Cotsarelis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bromage, T G" uniqKey="Bromage T">T. G. Bromage</name></author><author><name sortKey="Hogg, R T" uniqKey="Hogg R">R. T. Hogg</name></author><author><name sortKey="Lacruz, R S" uniqKey="Lacruz R">R. S. Lacruz</name></author><author><name sortKey="Hou, C" uniqKey="Hou C">C. Hou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cygankiewicz, I" uniqKey="Cygankiewicz I">I. Cygankiewicz</name></author><author><name sortKey="Zareba, W" uniqKey="Zareba W">W. Zareba</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rodushkin, I" uniqKey="Rodushkin I">I. Rodushkin</name></author><author><name sortKey="Axelsson, M D" uniqKey="Axelsson M">M. D. Axelsson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Appenzeller, O" uniqKey="Appenzeller O">O. Appenzeller</name></author><author><name sortKey="Qualls, C" uniqKey="Qualls C">C. Qualls</name></author><author><name sortKey="Barbic, F" uniqKey="Barbic F">F. Barbic</name></author><author><name sortKey="Furlan, R" uniqKey="Furlan R">R. Furlan</name></author><author><name sortKey="Porta, A" uniqKey="Porta A">A. Porta</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Richman, J S" uniqKey="Richman J">J. S. Richman</name></author><author><name sortKey="Moorman, J R" uniqKey="Moorman J">J. R. Moorman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Duque, T" uniqKey="Duque T">T. Duque</name></author><author><name sortKey="Hassan Samee, M A" uniqKey="Hassan Samee M">M. A. Hassan Samee</name></author><author><name sortKey="Kazemian, M" uniqKey="Kazemian M">M. Kazemian</name></author><author><name sortKey="Pham, H N" uniqKey="Pham H">H. N. Pham</name></author><author><name sortKey="Brodsky, M H" uniqKey="Brodsky M">M. H. Brodsky</name></author><author><name sortKey="Sinha, S" uniqKey="Sinha S">S. Sinha</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wallot, S" uniqKey="Wallot S">S. Wallot</name></author><author><name sortKey="Fusaroli, R" uniqKey="Fusaroli R">R. Fusaroli</name></author><author><name sortKey="Tylen, K" uniqKey="Tylen K">K. Tylén</name></author><author><name sortKey="Jegind, E M" uniqKey="Jegind E">E.-M. Jegindø</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ekb Ck, M" uniqKey="Ekb Ck M">M. Ekbäck</name></author><author><name sortKey="Wijma, K" uniqKey="Wijma K">K. Wijma</name></author><author><name sortKey="Benzein, E" uniqKey="Benzein E">E. Benzein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reitsema, L J" uniqKey="Reitsema L">L. J. Reitsema</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roksandic, M" uniqKey="Roksandic M">M. Roksandic</name></author><author><name sortKey="Armstrong, S D" uniqKey="Armstrong S">S. D. Armstrong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Malliani, A" uniqKey="Malliani A">A. Malliani</name></author><author><name sortKey="Pagani, M" uniqKey="Pagani M">M. Pagani</name></author><author><name sortKey="Lombardi, F" uniqKey="Lombardi F">F. Lombardi</name></author><author><name sortKey="Cerutti, S" uniqKey="Cerutti S">S. Cerutti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Spilde, M" uniqKey="Spilde M">M. Spilde</name></author><author><name sortKey="Lanzirotti, A" uniqKey="Lanzirotti A">A. Lanzirotti</name></author><author><name sortKey="Qualls, C" uniqKey="Qualls C">C. Qualls</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grubb, T C" uniqKey="Grubb T">T. C. Grubb</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Scudellari, M" uniqKey="Scudellari M">M. Scudellari</name></author></analytic></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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