Neuronal inclusions of Parkinson's disease.
Identifieur interne : 004E28 ( PubMed/Curation ); précédent : 004E27; suivant : 004E29Neuronal inclusions of Parkinson's disease.
Auteurs : W R Gibb [Royaume-Uni] ; T. Scott ; A J LeesSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 1991.
English descriptors
- KwdEn :
- Antibodies, Monoclonal (diagnostic use), Autonomic Nervous System (pathology), Brain (pathology), Cerebral Cortex (pathology), Ganglia, Sympathetic (pathology), Humans, Immunoenzyme Techniques, Inclusion Bodies (ultrastructure), Intermediate Filament Proteins (analysis), Limbic System (pathology), Locus Coeruleus (pathology), Microscopy, Electron, Nerve Degeneration (physiology), Neurofilament Proteins, Neurons (ultrastructure), Vagus Nerve (pathology).
- MESH :
- chemical , analysis : Intermediate Filament Proteins.
- chemical , diagnostic use : Antibodies, Monoclonal.
- pathology : Autonomic Nervous System, Brain, Cerebral Cortex, Ganglia, Sympathetic, Limbic System, Locus Coeruleus, Vagus Nerve.
- physiology : Nerve Degeneration.
- ultrastructure : Inclusion Bodies, Neurons.
- Humans, Immunoenzyme Techniques, Microscopy, Electron, Neurofilament Proteins.
Abstract
Two distinct neuronal inclusions occur in Parkinson's disease. The Lewy body is the diagnostic hallmark and is recognized by its eosinophilic body and unstained halo. It can be found in specific regions of the nervous system, where its frequency, size, shape, and structure differ. Large neurons of the dorsal vagal nucleus and sympathetic ganglia often contain particularly large quantities of Lewy-body-like matter. It consists of filament in the outer part and electron dense material in the core, the outer part staining with silver and with antibodies to neurofilament and tubulin. The pale body is restricted to the substantia nigra and locus ceruleus. It does not react with conventional stains, silver, or neurofilament antibodies, and has a homogeneous structure with a granular and vesicular surface texture. It contains sparse granular matter, vacuoles, and filaments, surrounded by melanin. The Lewy body and pale body may be juxtaposed or contiguous in some cells, but their distinct appearances and structures indicate that they are separate inclusions.
DOI: 10.1002/mds.870060103
PubMed: 1848677
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Scott</name></author><author><name sortKey="Lees, A J" sort="Lees, A J" uniqKey="Lees A" first="A J" last="Lees">A J Lees</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1991">1991</date><idno type="RBID">pubmed:1848677</idno><idno type="pmid">1848677</idno><idno type="doi">10.1002/mds.870060103</idno><idno type="wicri:Area/PubMed/Corpus">004E28</idno><idno type="wicri:Area/PubMed/Curation">004E28</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Neuronal inclusions of Parkinson's disease.</title><author><name sortKey="Gibb, W R" sort="Gibb, W R" uniqKey="Gibb W" first="W R" last="Gibb">W R Gibb</name><affiliation wicri:level="2"><nlm:affiliation>University Department of Neurology, King's College School of Medicine and Dentistry, London, England.</nlm:affiliation><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>University Department of Neurology, King's College School of Medicine and Dentistry, London</wicri:cityArea></affiliation></author><author><name sortKey="Scott, T" sort="Scott, T" uniqKey="Scott T" first="T" last="Scott">T. Scott</name></author><author><name sortKey="Lees, A J" sort="Lees, A J" uniqKey="Lees A" first="A J" last="Lees">A J Lees</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="1991" type="published">1991</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antibodies, Monoclonal (diagnostic use)</term><term>Autonomic Nervous System (pathology)</term><term>Brain (pathology)</term><term>Cerebral Cortex (pathology)</term><term>Ganglia, Sympathetic (pathology)</term><term>Humans</term><term>Immunoenzyme Techniques</term><term>Inclusion Bodies (ultrastructure)</term><term>Intermediate Filament Proteins (analysis)</term><term>Limbic System (pathology)</term><term>Locus Coeruleus (pathology)</term><term>Microscopy, Electron</term><term>Nerve Degeneration (physiology)</term><term>Neurofilament Proteins</term><term>Neurons (ultrastructure)</term><term>Vagus Nerve (pathology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Intermediate Filament Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Antibodies, Monoclonal</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Autonomic Nervous System</term><term>Brain</term><term>Cerebral Cortex</term><term>Ganglia, Sympathetic</term><term>Limbic System</term><term>Locus Coeruleus</term><term>Vagus Nerve</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Nerve Degeneration</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Inclusion Bodies</term><term>Neurons</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Immunoenzyme Techniques</term><term>Microscopy, Electron</term><term>Neurofilament Proteins</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Two distinct neuronal inclusions occur in Parkinson's disease. The Lewy body is the diagnostic hallmark and is recognized by its eosinophilic body and unstained halo. It can be found in specific regions of the nervous system, where its frequency, size, shape, and structure differ. Large neurons of the dorsal vagal nucleus and sympathetic ganglia often contain particularly large quantities of Lewy-body-like matter. It consists of filament in the outer part and electron dense material in the core, the outer part staining with silver and with antibodies to neurofilament and tubulin. The pale body is restricted to the substantia nigra and locus ceruleus. It does not react with conventional stains, silver, or neurofilament antibodies, and has a homogeneous structure with a granular and vesicular surface texture. It contains sparse granular matter, vacuoles, and filaments, surrounded by melanin. The Lewy body and pale body may be juxtaposed or contiguous in some cells, but their distinct appearances and structures indicate that they are separate inclusions.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">1848677</PMID><DateCreated><Year>1991</Year><Month>04</Month><Day>19</Day></DateCreated><DateCompleted><Year>1991</Year><Month>04</Month><Day>19</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN><JournalIssue CitedMedium="Print"><Volume>6</Volume><Issue>1</Issue><PubDate><Year>1991</Year></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Neuronal inclusions of Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>2-11</MedlinePgn></Pagination><Abstract><AbstractText>Two distinct neuronal inclusions occur in Parkinson's disease. The Lewy body is the diagnostic hallmark and is recognized by its eosinophilic body and unstained halo. It can be found in specific regions of the nervous system, where its frequency, size, shape, and structure differ. Large neurons of the dorsal vagal nucleus and sympathetic ganglia often contain particularly large quantities of Lewy-body-like matter. It consists of filament in the outer part and electron dense material in the core, the outer part staining with silver and with antibodies to neurofilament and tubulin. The pale body is restricted to the substantia nigra and locus ceruleus. It does not react with conventional stains, silver, or neurofilament antibodies, and has a homogeneous structure with a granular and vesicular surface texture. It contains sparse granular matter, vacuoles, and filaments, surrounded by melanin. The Lewy body and pale body may be juxtaposed or contiguous in some cells, but their distinct appearances and structures indicate that they are separate inclusions.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gibb</LastName><ForeName>W R</ForeName><Initials>WR</Initials><AffiliationInfo><Affiliation>University Department of Neurology, King's College School of Medicine and Dentistry, London, England.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Scott</LastName><ForeName>T</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Lees</LastName><ForeName>A J</ForeName><Initials>AJ</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>UNITED STATES</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000911">Antibodies, Monoclonal</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007381">Intermediate Filament Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016900">Neurofilament Proteins</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000911">Antibodies, Monoclonal</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000176">diagnostic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001341">Autonomic Nervous System</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000473">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001921">Brain</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000473">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D002540">Cerebral Cortex</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005728">Ganglia, Sympathetic</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007124">Immunoenzyme Techniques</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D002479">Inclusion Bodies</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000648">ultrastructure</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007381">Intermediate Filament Proteins</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000032">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008032">Limbic System</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008125">Locus Coeruleus</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008854">Microscopy, Electron</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009410">Nerve Degeneration</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D016900">Neurofilament Proteins</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009474">Neurons</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000648">ultrastructure</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D014630">Vagus Nerve</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1991</Year><Month>1</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1991</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1991</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">1848677</ArticleId><ArticleId IdType="doi">10.1002/mds.870060103</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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