Hemiballism and chorea in a patient with parkinsonism due to a multisystem degeneration.
Identifieur interne : 004D55 ( PubMed/Curation ); précédent : 004D54; suivant : 004D56Hemiballism and chorea in a patient with parkinsonism due to a multisystem degeneration.
Auteurs : M J Steiger [Royaume-Uni] ; M. Pires ; F. Scaravilli ; N P Quinn ; C D MarsdenSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 1992.
English descriptors
- KwdEn :
- Aged, Antiparkinson Agents (adverse effects), Antiparkinson Agents (therapeutic use), Atrophy, Brain (pathology), Carbidopa (adverse effects), Carbidopa (therapeutic use), Central Nervous System Diseases (complications), Central Nervous System Diseases (pathology), Chorea (chemically induced), Chorea (etiology), Chorea (pathology), Diagnosis, Differential, Drug Combinations, Female, Humans, Levodopa (adverse effects), Levodopa (therapeutic use), Movement Disorders (etiology), Movement Disorders (pathology), Nerve Degeneration (physiology), Parkinson Disease (drug therapy), Parkinson Disease (etiology), Parkinson Disease (pathology), Spinal Cord (pathology).
- MESH :
- chemical , adverse effects : Antiparkinson Agents, Carbidopa, Levodopa.
- chemical , therapeutic use : Antiparkinson Agents, Carbidopa, Levodopa.
- chemically induced : Chorea.
- complications : Central Nervous System Diseases.
- drug therapy : Parkinson Disease.
- etiology : Chorea, Movement Disorders, Parkinson Disease.
- pathology : Brain, Central Nervous System Diseases, Chorea, Movement Disorders, Parkinson Disease, Spinal Cord.
- physiology : Nerve Degeneration.
- Aged, Atrophy, Diagnosis, Differential, Drug Combinations, Female, Humans.
Abstract
Dyskinesias associated with dopaminergic treatment in idiopathic Parkinson's disease (PD) can be indistinguishable from those arising spontaneously in other conditions involving degeneration of, or damage to, the basal ganglia. However, those due to levodopa treatment of PD disappear on cessation of therapy. We report a patient with a clinical diagnosis of PD who, on levodopa treatment, developed hemiballism and chorea that were originally thought to be drug induced. However, the dyskinesias persisted despite stopping levodopa. Postmortem analysis showed a multisystem degeneration.
DOI: 10.1002/mds.870070115
PubMed: 1557069
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pubmed:1557069Le document en format XML
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<author><name sortKey="Steiger, M J" sort="Steiger, M J" uniqKey="Steiger M" first="M J" last="Steiger">M J Steiger</name>
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<author><name sortKey="Pires, M" sort="Pires, M" uniqKey="Pires M" first="M" last="Pires">M. Pires</name>
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<author><name sortKey="Scaravilli, F" sort="Scaravilli, F" uniqKey="Scaravilli F" first="F" last="Scaravilli">F. Scaravilli</name>
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<author><name sortKey="Quinn, N P" sort="Quinn, N P" uniqKey="Quinn N" first="N P" last="Quinn">N P Quinn</name>
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<author><name sortKey="Marsden, C D" sort="Marsden, C D" uniqKey="Marsden C" first="C D" last="Marsden">C D Marsden</name>
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<author><name sortKey="Steiger, M J" sort="Steiger, M J" uniqKey="Steiger M" first="M J" last="Steiger">M J Steiger</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Antiparkinson Agents (adverse effects)</term>
<term>Antiparkinson Agents (therapeutic use)</term>
<term>Atrophy</term>
<term>Brain (pathology)</term>
<term>Carbidopa (adverse effects)</term>
<term>Carbidopa (therapeutic use)</term>
<term>Central Nervous System Diseases (complications)</term>
<term>Central Nervous System Diseases (pathology)</term>
<term>Chorea (chemically induced)</term>
<term>Chorea (etiology)</term>
<term>Chorea (pathology)</term>
<term>Diagnosis, Differential</term>
<term>Drug Combinations</term>
<term>Female</term>
<term>Humans</term>
<term>Levodopa (adverse effects)</term>
<term>Levodopa (therapeutic use)</term>
<term>Movement Disorders (etiology)</term>
<term>Movement Disorders (pathology)</term>
<term>Nerve Degeneration (physiology)</term>
<term>Parkinson Disease (drug therapy)</term>
<term>Parkinson Disease (etiology)</term>
<term>Parkinson Disease (pathology)</term>
<term>Spinal Cord (pathology)</term>
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<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antiparkinson Agents</term>
<term>Carbidopa</term>
<term>Levodopa</term>
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<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term>
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<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Chorea</term>
<term>Movement Disorders</term>
<term>Parkinson Disease</term>
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<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term>
<term>Central Nervous System Diseases</term>
<term>Chorea</term>
<term>Movement Disorders</term>
<term>Parkinson Disease</term>
<term>Spinal Cord</term>
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<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Nerve Degeneration</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Atrophy</term>
<term>Diagnosis, Differential</term>
<term>Drug Combinations</term>
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<front><div type="abstract" xml:lang="en">Dyskinesias associated with dopaminergic treatment in idiopathic Parkinson's disease (PD) can be indistinguishable from those arising spontaneously in other conditions involving degeneration of, or damage to, the basal ganglia. However, those due to levodopa treatment of PD disappear on cessation of therapy. We report a patient with a clinical diagnosis of PD who, on levodopa treatment, developed hemiballism and chorea that were originally thought to be drug induced. However, the dyskinesias persisted despite stopping levodopa. Postmortem analysis showed a multisystem degeneration.</div>
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<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
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<Abstract><AbstractText>Dyskinesias associated with dopaminergic treatment in idiopathic Parkinson's disease (PD) can be indistinguishable from those arising spontaneously in other conditions involving degeneration of, or damage to, the basal ganglia. However, those due to levodopa treatment of PD disappear on cessation of therapy. We report a patient with a clinical diagnosis of PD who, on levodopa treatment, developed hemiballism and chorea that were originally thought to be drug induced. However, the dyskinesias persisted despite stopping levodopa. Postmortem analysis showed a multisystem degeneration.</AbstractText>
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