Reversal of behavioural abnormalities by fetal allografts in a novel rat model of striatonigral degeneration.
Identifieur interne : 004786 ( PubMed/Curation ); précédent : 004785; suivant : 004787Reversal of behavioural abnormalities by fetal allografts in a novel rat model of striatonigral degeneration.
Auteurs : G K Wenning [Royaume-Uni] ; R. Granata ; P M Laboyrie ; N P Quinn ; P. Jenner ; C D MarsdenSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 1996.
English descriptors
- KwdEn :
- Amphetamines (pharmacology), Animals, Apomorphine (pharmacology), Behavior, Animal (drug effects), Corpus Striatum (drug effects), Corpus Striatum (physiopathology), Fetal Tissue Transplantation, Graft Survival, Immunohistochemistry, Male, Mesencephalon (embryology), Mesencephalon (surgery), Nerve Degeneration, Oxidopamine (pharmacology), Quinolinic Acid (pharmacology), Rats, Rats, Wistar, Substantia Nigra (drug effects), Substantia Nigra (physiopathology), Transplantation, Homologous.
- MESH :
- chemical , pharmacology : Amphetamines, Apomorphine, Oxidopamine, Quinolinic Acid.
- drug effects : Behavior, Animal, Corpus Striatum, Substantia Nigra.
- embryology : Mesencephalon.
- physiopathology : Corpus Striatum, Substantia Nigra.
- surgery : Mesencephalon.
- Animals, Fetal Tissue Transplantation, Graft Survival, Immunohistochemistry, Male, Nerve Degeneration, Rats, Rats, Wistar, Transplantation, Homologous.
Abstract
We have developed a rodent model of striatonigral degeneration, one of the core pathologies underlying the disease multiple system atrophy (MSA). 6-Hydroxydopamine (6-OHDA) was administered into the left medial forebrain bundle of male Wistar rats, followed 3-4 weeks later by intrastriatal injection of quinolinic acid into the ipsilateral striatum. The 6-OHDA lesion resulted in ipsilateral rotation to (+)-amphetamine and contralateral rotation to apomorphine. Following the subsequent striatal lesion, amphetamine-induced ipsilateral rotation persisted, but apomorphine-induced contralateral rotation was reduced or abolished. Subsequently, the lesioned striatum was implanted with fetal CNS allografts consisting of cell suspensions derived from striatal primordium alone or combined with cografts of ventral mesencephalon. Cografted rats showed a reduction or reversal of amphetamine-induced rotation. This was not observed in animals receiving striatal grafts alone. Apomorphine-induced contralateral rotation was restored after striatal grafts alone, but only partially in animals receiving sham or cografts. Tyrosine hydroxylase (TH) and dopamine- and cyclic adenosine 3':5'-monophosphate-regulated phosphoprotein (DARPP 32) immunocytochemistry showed mesencephalic and striatal graft survival in most animals. However, dopaminergic outgrowth was restricted to the graft deposit. The latter was surrounded by a markedly gliotic glial fibrillary acidic protein-positive capsule continuous with corpus callosum. Dopaminergic reinnervation of denervated and lesioned adult striatum itself was absent, suggesting that rotational recovery was due to diffuse dopamine release. The study shows that combined unilateral lesioning of rodent medial forebrain bundle and striatum results in a characteristic drug-induced rotational response that can be partly restored by mesencephalic/striatal cografts.
DOI: 10.1002/mds.870110507
PubMed: 8866493
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Reversal of behavioural abnormalities by fetal allografts in a novel rat model of striatonigral degeneration.</title><author><name sortKey="Wenning, G K" sort="Wenning, G K" uniqKey="Wenning G" first="G K" last="Wenning">G K Wenning</name><affiliation wicri:level="1"><nlm:affiliation>Neurodegenerative Diseases Research Centre, King's College, London, England, U.K.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Neurodegenerative Diseases Research Centre, King's College, London, England</wicri:regionArea></affiliation></author><author><name sortKey="Granata, R" sort="Granata, R" uniqKey="Granata R" first="R" last="Granata">R. Granata</name></author><author><name sortKey="Laboyrie, P M" sort="Laboyrie, P M" uniqKey="Laboyrie P" first="P M" last="Laboyrie">P M Laboyrie</name></author><author><name sortKey="Quinn, N P" sort="Quinn, N P" uniqKey="Quinn N" first="N P" last="Quinn">N P Quinn</name></author><author><name sortKey="Jenner, P" sort="Jenner, P" uniqKey="Jenner P" first="P" last="Jenner">P. Jenner</name></author><author><name sortKey="Marsden, C D" sort="Marsden, C D" uniqKey="Marsden C" first="C D" last="Marsden">C D Marsden</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1996">1996</date><idno type="RBID">pubmed:8866493</idno><idno type="pmid">8866493</idno><idno type="doi">10.1002/mds.870110507</idno><idno type="wicri:Area/PubMed/Corpus">004786</idno><idno type="wicri:Area/PubMed/Curation">004786</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Reversal of behavioural abnormalities by fetal allografts in a novel rat model of striatonigral degeneration.</title><author><name sortKey="Wenning, G K" sort="Wenning, G K" uniqKey="Wenning G" first="G K" last="Wenning">G K Wenning</name><affiliation wicri:level="1"><nlm:affiliation>Neurodegenerative Diseases Research Centre, King's College, London, England, U.K.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Neurodegenerative Diseases Research Centre, King's College, London, England</wicri:regionArea></affiliation></author><author><name sortKey="Granata, R" sort="Granata, R" uniqKey="Granata R" first="R" last="Granata">R. Granata</name></author><author><name sortKey="Laboyrie, P M" sort="Laboyrie, P M" uniqKey="Laboyrie P" first="P M" last="Laboyrie">P M Laboyrie</name></author><author><name sortKey="Quinn, N P" sort="Quinn, N P" uniqKey="Quinn N" first="N P" last="Quinn">N P Quinn</name></author><author><name sortKey="Jenner, P" sort="Jenner, P" uniqKey="Jenner P" first="P" last="Jenner">P. Jenner</name></author><author><name sortKey="Marsden, C D" sort="Marsden, C D" uniqKey="Marsden C" first="C D" last="Marsden">C D Marsden</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="1996" type="published">1996</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amphetamines (pharmacology)</term><term>Animals</term><term>Apomorphine (pharmacology)</term><term>Behavior, Animal (drug effects)</term><term>Corpus Striatum (drug effects)</term><term>Corpus Striatum (physiopathology)</term><term>Fetal Tissue Transplantation</term><term>Graft Survival</term><term>Immunohistochemistry</term><term>Male</term><term>Mesencephalon (embryology)</term><term>Mesencephalon (surgery)</term><term>Nerve Degeneration</term><term>Oxidopamine (pharmacology)</term><term>Quinolinic Acid (pharmacology)</term><term>Rats</term><term>Rats, Wistar</term><term>Substantia Nigra (drug effects)</term><term>Substantia Nigra (physiopathology)</term><term>Transplantation, Homologous</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Amphetamines</term><term>Apomorphine</term><term>Oxidopamine</term><term>Quinolinic Acid</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Behavior, Animal</term><term>Corpus Striatum</term><term>Substantia Nigra</term></keywords><keywords scheme="MESH" qualifier="embryology" xml:lang="en"><term>Mesencephalon</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Corpus Striatum</term><term>Substantia Nigra</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Mesencephalon</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Fetal Tissue Transplantation</term><term>Graft Survival</term><term>Immunohistochemistry</term><term>Male</term><term>Nerve Degeneration</term><term>Rats</term><term>Rats, Wistar</term><term>Transplantation, Homologous</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We have developed a rodent model of striatonigral degeneration, one of the core pathologies underlying the disease multiple system atrophy (MSA). 6-Hydroxydopamine (6-OHDA) was administered into the left medial forebrain bundle of male Wistar rats, followed 3-4 weeks later by intrastriatal injection of quinolinic acid into the ipsilateral striatum. The 6-OHDA lesion resulted in ipsilateral rotation to (+)-amphetamine and contralateral rotation to apomorphine. Following the subsequent striatal lesion, amphetamine-induced ipsilateral rotation persisted, but apomorphine-induced contralateral rotation was reduced or abolished. Subsequently, the lesioned striatum was implanted with fetal CNS allografts consisting of cell suspensions derived from striatal primordium alone or combined with cografts of ventral mesencephalon. Cografted rats showed a reduction or reversal of amphetamine-induced rotation. This was not observed in animals receiving striatal grafts alone. Apomorphine-induced contralateral rotation was restored after striatal grafts alone, but only partially in animals receiving sham or cografts. Tyrosine hydroxylase (TH) and dopamine- and cyclic adenosine 3':5'-monophosphate-regulated phosphoprotein (DARPP 32) immunocytochemistry showed mesencephalic and striatal graft survival in most animals. However, dopaminergic outgrowth was restricted to the graft deposit. The latter was surrounded by a markedly gliotic glial fibrillary acidic protein-positive capsule continuous with corpus callosum. Dopaminergic reinnervation of denervated and lesioned adult striatum itself was absent, suggesting that rotational recovery was due to diffuse dopamine release. The study shows that combined unilateral lesioning of rodent medial forebrain bundle and striatum results in a characteristic drug-induced rotational response that can be partly restored by mesencephalic/striatal cografts.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">8866493</PMID><DateCreated><Year>1997</Year><Month>01</Month><Day>10</Day></DateCreated><DateCompleted><Year>1997</Year><Month>01</Month><Day>10</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN><JournalIssue CitedMedium="Print"><Volume>11</Volume><Issue>5</Issue><PubDate><Year>1996</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Reversal of behavioural abnormalities by fetal allografts in a novel rat model of striatonigral degeneration.</ArticleTitle><Pagination><MedlinePgn>522-32</MedlinePgn></Pagination><Abstract><AbstractText>We have developed a rodent model of striatonigral degeneration, one of the core pathologies underlying the disease multiple system atrophy (MSA). 6-Hydroxydopamine (6-OHDA) was administered into the left medial forebrain bundle of male Wistar rats, followed 3-4 weeks later by intrastriatal injection of quinolinic acid into the ipsilateral striatum. The 6-OHDA lesion resulted in ipsilateral rotation to (+)-amphetamine and contralateral rotation to apomorphine. Following the subsequent striatal lesion, amphetamine-induced ipsilateral rotation persisted, but apomorphine-induced contralateral rotation was reduced or abolished. Subsequently, the lesioned striatum was implanted with fetal CNS allografts consisting of cell suspensions derived from striatal primordium alone or combined with cografts of ventral mesencephalon. Cografted rats showed a reduction or reversal of amphetamine-induced rotation. This was not observed in animals receiving striatal grafts alone. Apomorphine-induced contralateral rotation was restored after striatal grafts alone, but only partially in animals receiving sham or cografts. Tyrosine hydroxylase (TH) and dopamine- and cyclic adenosine 3':5'-monophosphate-regulated phosphoprotein (DARPP 32) immunocytochemistry showed mesencephalic and striatal graft survival in most animals. However, dopaminergic outgrowth was restricted to the graft deposit. The latter was surrounded by a markedly gliotic glial fibrillary acidic protein-positive capsule continuous with corpus callosum. Dopaminergic reinnervation of denervated and lesioned adult striatum itself was absent, suggesting that rotational recovery was due to diffuse dopamine release. The study shows that combined unilateral lesioning of rodent medial forebrain bundle and striatum results in a characteristic drug-induced rotational response that can be partly restored by mesencephalic/striatal cografts.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wenning</LastName><ForeName>G K</ForeName><Initials>GK</Initials><AffiliationInfo><Affiliation>Neurodegenerative Diseases Research Centre, King's College, London, England, U.K.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Granata</LastName><ForeName>R</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Laboyrie</LastName><ForeName>P M</ForeName><Initials>PM</Initials></Author><Author ValidYN="Y"><LastName>Quinn</LastName><ForeName>N P</ForeName><Initials>NP</Initials></Author><Author ValidYN="Y"><LastName>Jenner</LastName><ForeName>P</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Marsden</LastName><ForeName>C D</ForeName><Initials>CD</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>UNITED STATES</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000662">Amphetamines</NameOfSubstance></Chemical><Chemical><RegistryNumber>8HW4YBZ748</RegistryNumber><NameOfSubstance UI="D016627">Oxidopamine</NameOfSubstance></Chemical><Chemical><RegistryNumber>F6F0HK1URN</RegistryNumber><NameOfSubstance UI="D017378">Quinolinic Acid</NameOfSubstance></Chemical><Chemical><RegistryNumber>N21FAR7B4S</RegistryNumber><NameOfSubstance 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