Apomorphine enantiomers protect cultured pheochromocytoma (PC12) cells from oxidative stress induced by H2O2 and 6-hydroxydopamine.
Identifieur interne : 004476 ( PubMed/Curation ); précédent : 004475; suivant : 004477Apomorphine enantiomers protect cultured pheochromocytoma (PC12) cells from oxidative stress induced by H2O2 and 6-hydroxydopamine.
Auteurs : M. Gassen [Israël] ; A. Gross ; M B YoudimSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 1998.
English descriptors
- KwdEn :
- Animals, Apomorphine (pharmacology), Cell Survival (drug effects), Dopamine Agonists (pharmacology), Dose-Response Relationship, Drug, Humans, Hydrogen Peroxide (toxicity), Lipid Peroxidation (drug effects), Neuroprotective Agents (pharmacology), Neurotoxins (toxicity), Oxidants (toxicity), Oxidative Stress, Oxidopamine (toxicity), PC12 Cells (drug effects), Rats, Reactive Oxygen Species (metabolism), Stereoisomerism, Structure-Activity Relationship, Tumor Cells, Cultured.
- MESH :
- chemical , metabolism : Reactive Oxygen Species.
- chemical , pharmacology : Apomorphine, Dopamine Agonists, Neuroprotective Agents.
- drug effects : Cell Survival, Lipid Peroxidation, PC12 Cells.
- chemical , toxicity : Hydrogen Peroxide, Neurotoxins, Oxidants, Oxidopamine.
- Animals, Dose-Response Relationship, Drug, Humans, Oxidative Stress, Rats, Stereoisomerism, Structure-Activity Relationship, Tumor Cells, Cultured.
Abstract
A significant body of evidence has been provided to support the hypothesis that oxidant stress may be responsible for the degeneration of dopaminergic neurons in the substantia nigra pars compacta in Parkinson's disease. Apomorphine, a dopamine D1/D2-receptor agonist in the clinical therapy of Parkinson's disease, has been found to be a potent antioxidant and to prevent free radical reaction in rat brain mitochondrial fraction. In this article we show that 1-10 microM of apomorphine protects rat pheochromocytoma (PC12) cells from the toxic effects of H2O2 (0.6 mM) and the neurotoxin 6-hydroxydopamine (150 microM). These effects were not exhibited by ascorbic acid, desferal, lisuride, or bromocriptine. Although pergolide exhibited some protection of PC12 cells against H2O2 toxicity, it was not as potent as apomorphine. In light of the present findings and the clinical reports that parkinsonian patients on long-term apomorphine stabilize clinically and can be weaned off L-dopa, one may assume that apomorphine can exert a neuroprotective activity via its potent antioxidant properties.
DOI: 10.1002/mds.870130208
PubMed: 9539336
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Gross</name></author><author><name sortKey="Youdim, M B" sort="Youdim, M B" uniqKey="Youdim M" first="M B" last="Youdim">M B Youdim</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1998">1998</date><idno type="RBID">pubmed:9539336</idno><idno type="pmid">9539336</idno><idno type="doi">10.1002/mds.870130208</idno><idno type="wicri:Area/PubMed/Corpus">004476</idno><idno type="wicri:Area/PubMed/Curation">004476</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Apomorphine enantiomers protect cultured pheochromocytoma (PC12) cells from oxidative stress induced by H2O2 and 6-hydroxydopamine.</title><author><name sortKey="Gassen, M" sort="Gassen, M" uniqKey="Gassen M" first="M" last="Gassen">M. Gassen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacology, Bruce Rappaport Family Research Institute, Faculty of Medicine, Technion, Haifa, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Department of Pharmacology, Bruce Rappaport Family Research Institute, Faculty of Medicine, Technion, Haifa</wicri:regionArea></affiliation></author><author><name sortKey="Gross, A" sort="Gross, A" uniqKey="Gross A" first="A" last="Gross">A. Gross</name></author><author><name sortKey="Youdim, M B" sort="Youdim, M B" uniqKey="Youdim M" first="M B" last="Youdim">M B Youdim</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="1998" type="published">1998</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Apomorphine (pharmacology)</term><term>Cell Survival (drug effects)</term><term>Dopamine Agonists (pharmacology)</term><term>Dose-Response Relationship, Drug</term><term>Humans</term><term>Hydrogen Peroxide (toxicity)</term><term>Lipid Peroxidation (drug effects)</term><term>Neuroprotective Agents (pharmacology)</term><term>Neurotoxins (toxicity)</term><term>Oxidants (toxicity)</term><term>Oxidative Stress</term><term>Oxidopamine (toxicity)</term><term>PC12 Cells (drug effects)</term><term>Rats</term><term>Reactive Oxygen Species (metabolism)</term><term>Stereoisomerism</term><term>Structure-Activity Relationship</term><term>Tumor Cells, Cultured</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Reactive Oxygen Species</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Apomorphine</term><term>Dopamine Agonists</term><term>Neuroprotective Agents</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Survival</term><term>Lipid Peroxidation</term><term>PC12 Cells</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Hydrogen Peroxide</term><term>Neurotoxins</term><term>Oxidants</term><term>Oxidopamine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Dose-Response Relationship, Drug</term><term>Humans</term><term>Oxidative Stress</term><term>Rats</term><term>Stereoisomerism</term><term>Structure-Activity Relationship</term><term>Tumor Cells, Cultured</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A significant body of evidence has been provided to support the hypothesis that oxidant stress may be responsible for the degeneration of dopaminergic neurons in the substantia nigra pars compacta in Parkinson's disease. Apomorphine, a dopamine D1/D2-receptor agonist in the clinical therapy of Parkinson's disease, has been found to be a potent antioxidant and to prevent free radical reaction in rat brain mitochondrial fraction. In this article we show that 1-10 microM of apomorphine protects rat pheochromocytoma (PC12) cells from the toxic effects of H2O2 (0.6 mM) and the neurotoxin 6-hydroxydopamine (150 microM). These effects were not exhibited by ascorbic acid, desferal, lisuride, or bromocriptine. Although pergolide exhibited some protection of PC12 cells against H2O2 toxicity, it was not as potent as apomorphine. In light of the present findings and the clinical reports that parkinsonian patients on long-term apomorphine stabilize clinically and can be weaned off L-dopa, one may assume that apomorphine can exert a neuroprotective activity via its potent antioxidant properties.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">9539336</PMID><DateCreated><Year>1998</Year><Month>06</Month><Day>15</Day></DateCreated><DateCompleted><Year>1998</Year><Month>06</Month><Day>15</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN><JournalIssue CitedMedium="Print"><Volume>13</Volume><Issue>2</Issue><PubDate><Year>1998</Year><Month>Mar</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Apomorphine enantiomers protect cultured pheochromocytoma (PC12) cells from oxidative stress induced by H2O2 and 6-hydroxydopamine.</ArticleTitle><Pagination><MedlinePgn>242-8</MedlinePgn></Pagination><Abstract><AbstractText>A significant body of evidence has been provided to support the hypothesis that oxidant stress may be responsible for the degeneration of dopaminergic neurons in the substantia nigra pars compacta in Parkinson's disease. Apomorphine, a dopamine D1/D2-receptor agonist in the clinical therapy of Parkinson's disease, has been found to be a potent antioxidant and to prevent free radical reaction in rat brain mitochondrial fraction. In this article we show that 1-10 microM of apomorphine protects rat pheochromocytoma (PC12) cells from the toxic effects of H2O2 (0.6 mM) and the neurotoxin 6-hydroxydopamine (150 microM). These effects were not exhibited by ascorbic acid, desferal, lisuride, or bromocriptine. Although pergolide exhibited some protection of PC12 cells against H2O2 toxicity, it was not as potent as apomorphine. In light of the present findings and the clinical reports that parkinsonian patients on long-term apomorphine stabilize clinically and can be weaned off L-dopa, one may assume that apomorphine can exert a neuroprotective activity via its potent antioxidant properties.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gassen</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Pharmacology, Bruce Rappaport Family Research Institute, Faculty of Medicine, Technion, Haifa, Israel.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gross</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Youdim</LastName><ForeName>M B</ForeName><Initials>MB</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. 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UI="D013237">Stereoisomerism</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013329">Structure-Activity Relationship</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D014407">Tumor Cells, Cultured</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1998</Year><Month>4</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1998</Year><Month>4</Month><Day>16</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1998</Year><Month>4</Month><Day>16</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">9539336</ArticleId><ArticleId IdType="doi">10.1002/mds.870130208</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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