PET imaging of the pre-synaptic dopamine uptake sites in rapid-onset dystonia-parkinsonism (RDP).
Identifieur interne : 004275 ( PubMed/Curation ); précédent : 004274; suivant : 004276PET imaging of the pre-synaptic dopamine uptake sites in rapid-onset dystonia-parkinsonism (RDP).
Auteurs : A. Brashear [États-Unis] ; G K Mulholland ; Q H Zheng ; M R Farlow ; E R Siemers ; G D HutchinsSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 1999.
English descriptors
- KwdEn :
- Adult, Aged, Brain Mapping, Carbon Radioisotopes, Cocaine (analogs & derivatives), Cocaine (diagnostic use), Corpus Striatum (physiopathology), Corpus Striatum (radionuclide imaging), Diagnosis, Differential, Dopamine (metabolism), Dopamine Uptake Inhibitors (diagnostic use), Dystonia (genetics), Dystonia (physiopathology), Dystonia (radionuclide imaging), Female, Homovanillic Acid (cerebrospinal fluid), Humans, Male, Middle Aged, Parkinson Disease (genetics), Parkinson Disease (physiopathology), Parkinson Disease (radionuclide imaging), Parkinson Disease, Secondary (genetics), Parkinson Disease, Secondary (physiopathology), Parkinson Disease, Secondary (radionuclide imaging), Pilot Projects, Receptors, Dopamine (genetics), Receptors, Dopamine (physiology), Receptors, Presynaptic (genetics), Receptors, Presynaptic (physiology), Tomography, Emission-Computed.
- MESH :
- chemical , analogs & derivatives : Cocaine.
- chemical , cerebrospinal fluid : Homovanillic Acid.
- chemical , diagnostic use : Cocaine, Dopamine Uptake Inhibitors.
- chemical , genetics : Receptors, Dopamine, Receptors, Presynaptic.
- chemical , metabolism : Dopamine.
- chemical , physiology : Receptors, Dopamine, Receptors, Presynaptic.
- chemical : Carbon Radioisotopes.
- genetics : Dystonia, Parkinson Disease, Parkinson Disease, Secondary.
- physiopathology : Corpus Striatum, Dystonia, Parkinson Disease, Parkinson Disease, Secondary.
- radionuclide imaging : Corpus Striatum, Dystonia, Parkinson Disease, Parkinson Disease, Secondary.
- Adult, Aged, Brain Mapping, Diagnosis, Differential, Female, Humans, Male, Middle Aged, Pilot Projects, Tomography, Emission-Computed.
Abstract
Rapid-onset dystonia-parkinsonism (RDP) is a genetic movement disorder characterized by abrupt onset over hours to days of bradykinesia, postural instability, dysphagia, dysarthria, and severe dystonic spasms with decreased levels of the dopamine metabolite, homovanillic acid (HVA), in cerebrospinal fluid (CSF).
PubMed: 9918356
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">PET imaging of the pre-synaptic dopamine uptake sites in rapid-onset dystonia-parkinsonism (RDP).</title><author><name sortKey="Brashear, A" sort="Brashear, A" uniqKey="Brashear A" first="A" last="Brashear">A. Brashear</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Indiana University School of Medicine, Indianapolis 46202-5250, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Indiana University School of Medicine, Indianapolis 46202-5250</wicri:regionArea></affiliation></author><author><name sortKey="Mulholland, G K" sort="Mulholland, G K" uniqKey="Mulholland G" first="G K" last="Mulholland">G K Mulholland</name></author><author><name sortKey="Zheng, Q H" sort="Zheng, Q H" uniqKey="Zheng Q" first="Q H" last="Zheng">Q H Zheng</name></author><author><name sortKey="Farlow, M R" sort="Farlow, M R" uniqKey="Farlow M" first="M R" last="Farlow">M R Farlow</name></author><author><name sortKey="Siemers, E R" sort="Siemers, E R" uniqKey="Siemers E" first="E R" last="Siemers">E R Siemers</name></author><author><name sortKey="Hutchins, G D" sort="Hutchins, G D" uniqKey="Hutchins G" first="G D" last="Hutchins">G D Hutchins</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1999">1999</date><idno type="RBID">pubmed:9918356</idno><idno type="pmid">9918356</idno><idno type="wicri:Area/PubMed/Corpus">004275</idno><idno type="wicri:Area/PubMed/Curation">004275</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">PET imaging of the pre-synaptic dopamine uptake sites in rapid-onset dystonia-parkinsonism (RDP).</title><author><name sortKey="Brashear, A" sort="Brashear, A" uniqKey="Brashear A" first="A" last="Brashear">A. Brashear</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Indiana University School of Medicine, Indianapolis 46202-5250, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Indiana University School of Medicine, Indianapolis 46202-5250</wicri:regionArea></affiliation></author><author><name sortKey="Mulholland, G K" sort="Mulholland, G K" uniqKey="Mulholland G" first="G K" last="Mulholland">G K Mulholland</name></author><author><name sortKey="Zheng, Q H" sort="Zheng, Q H" uniqKey="Zheng Q" first="Q H" last="Zheng">Q H Zheng</name></author><author><name sortKey="Farlow, M R" sort="Farlow, M R" uniqKey="Farlow M" first="M R" last="Farlow">M R Farlow</name></author><author><name sortKey="Siemers, E R" sort="Siemers, E R" uniqKey="Siemers E" first="E R" last="Siemers">E R Siemers</name></author><author><name sortKey="Hutchins, G D" sort="Hutchins, G D" uniqKey="Hutchins G" first="G D" last="Hutchins">G D Hutchins</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="1999" type="published">1999</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Brain Mapping</term><term>Carbon Radioisotopes</term><term>Cocaine (analogs & derivatives)</term><term>Cocaine (diagnostic use)</term><term>Corpus Striatum (physiopathology)</term><term>Corpus Striatum (radionuclide imaging)</term><term>Diagnosis, Differential</term><term>Dopamine (metabolism)</term><term>Dopamine Uptake Inhibitors (diagnostic use)</term><term>Dystonia (genetics)</term><term>Dystonia (physiopathology)</term><term>Dystonia (radionuclide imaging)</term><term>Female</term><term>Homovanillic Acid (cerebrospinal fluid)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (genetics)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (radionuclide imaging)</term><term>Parkinson Disease, Secondary (genetics)</term><term>Parkinson Disease, Secondary (physiopathology)</term><term>Parkinson Disease, Secondary (radionuclide imaging)</term><term>Pilot Projects</term><term>Receptors, Dopamine (genetics)</term><term>Receptors, Dopamine (physiology)</term><term>Receptors, Presynaptic (genetics)</term><term>Receptors, Presynaptic (physiology)</term><term>Tomography, Emission-Computed</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Cocaine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="cerebrospinal fluid" xml:lang="en"><term>Homovanillic Acid</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Cocaine</term><term>Dopamine Uptake Inhibitors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Receptors, Dopamine</term><term>Receptors, Presynaptic</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dopamine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Receptors, Dopamine</term><term>Receptors, Presynaptic</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Carbon Radioisotopes</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Dystonia</term><term>Parkinson Disease</term><term>Parkinson Disease, Secondary</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Corpus Striatum</term><term>Dystonia</term><term>Parkinson Disease</term><term>Parkinson Disease, Secondary</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Corpus Striatum</term><term>Dystonia</term><term>Parkinson Disease</term><term>Parkinson Disease, Secondary</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Brain Mapping</term><term>Diagnosis, Differential</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Pilot Projects</term><term>Tomography, Emission-Computed</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Rapid-onset dystonia-parkinsonism (RDP) is a genetic movement disorder characterized by abrupt onset over hours to days of bradykinesia, postural instability, dysphagia, dysarthria, and severe dystonic spasms with decreased levels of the dopamine metabolite, homovanillic acid (HVA), in cerebrospinal fluid (CSF).</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">9918356</PMID><DateCreated><Year>1999</Year><Month>04</Month><Day>01</Day></DateCreated><DateCompleted><Year>1999</Year><Month>04</Month><Day>01</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN><JournalIssue CitedMedium="Print"><Volume>14</Volume><Issue>1</Issue><PubDate><Year>1999</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>PET imaging of the pre-synaptic dopamine uptake sites in rapid-onset dystonia-parkinsonism (RDP).</ArticleTitle><Pagination><MedlinePgn>132-7</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Rapid-onset dystonia-parkinsonism (RDP) is a genetic movement disorder characterized by abrupt onset over hours to days of bradykinesia, postural instability, dysphagia, dysarthria, and severe dystonic spasms with decreased levels of the dopamine metabolite, homovanillic acid (HVA), in cerebrospinal fluid (CSF).</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We imaged the dopamine re-uptake system with [O-methyl-11C]beta-CFT ([11C]beta-CFT) in three severely affected individuals with RDP and four patients with idiopathic Parkinson's disease (IPD). Results were compared with those of age-matched normal volunteers.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Positron emission tomography images from those patients with IPD demonstrated a dramatic reduction in the volume of distribution of [11C]beta-CFT whereas patients with RDP showed slightly elevated values.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The data suggest that patients with RDP do not have a decrease in the number of dopamine re-uptake sites. Our findings suggest that, unlike the situation in IPD, low CSF HVA concentrations seen in RDP patients are not the result of degeneration of striatal dopamine terminals or loss of dopamine re-uptake sites.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Brashear</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Neurology, Indiana University School of Medicine, Indianapolis 46202-5250, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mulholland</LastName><ForeName>G K</ForeName><Initials>GK</Initials></Author><Author ValidYN="Y"><LastName>Zheng</LastName><ForeName>Q H</ForeName><Initials>QH</Initials></Author><Author ValidYN="Y"><LastName>Farlow</LastName><ForeName>M R</ForeName><Initials>MR</Initials></Author><Author ValidYN="Y"><LastName>Siemers</LastName><ForeName>E R</ForeName><Initials>ER</Initials></Author><Author ValidYN="Y"><LastName>Hutchins</LastName><ForeName>G D</ForeName><Initials>GD</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>UNITED STATES</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D002250">Carbon Radioisotopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018765">Dopamine Uptake Inhibitors</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011954">Receptors, Dopamine</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D017661">Receptors, Presynaptic</NameOfSubstance></Chemical><Chemical><RegistryNumber>50370-56-4</RegistryNumber><NameOfSubstance UI="C021279">(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester</NameOfSubstance></Chemical><Chemical><RegistryNumber>I5Y540LHVR</RegistryNumber><NameOfSubstance UI="D003042">Cocaine</NameOfSubstance></Chemical><Chemical><RegistryNumber>VTD58H1Z2X</RegistryNumber><NameOfSubstance UI="D004298">Dopamine</NameOfSubstance></Chemical><Chemical><RegistryNumber>X77S6GMS36</RegistryNumber><NameOfSubstance UI="D006719">Homovanillic Acid</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000328">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001931">Brain Mapping</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D002250">Carbon Radioisotopes</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D003042">Cocaine</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000031">analogs & derivatives</QualifierName><QualifierName MajorTopicYN="N" UI="Q000176">diagnostic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D003342">Corpus Striatum</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000531">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D003937">Diagnosis, Differential</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004298">Dopamine</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D018765">Dopamine Uptake Inhibitors</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000176">diagnostic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004421">Dystonia</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000235">genetics</QualifierName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000531">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006719">Homovanillic Acid</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000134">cerebrospinal fluid</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000235">genetics</QualifierName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000531">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010302">Parkinson Disease, Secondary</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000235">genetics</QualifierName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000531">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010865">Pilot Projects</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011954">Receptors, Dopamine</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000235">genetics</QualifierName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D017661">Receptors, Presynaptic</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000235">genetics</QualifierName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D014055">Tomography, Emission-Computed</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1999</Year><Month>1</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1999</Year><Month>1</Month><Day>26</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1999</Year><Month>1</Month><Day>26</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">9918356</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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