Comorbidity of the nonmotor symptoms of Parkinson's disease.
Identifieur interne : 003D41 ( PubMed/Curation ); précédent : 003D40; suivant : 003D42Comorbidity of the nonmotor symptoms of Parkinson's disease.
Auteurs : L M Shulman [États-Unis] ; R L Taback ; J. Bean ; W J WeinerSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2001.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Anxiety (epidemiology), Anxiety (etiology), Comorbidity, Depression (epidemiology), Depression (etiology), Fatigue (epidemiology), Fatigue (etiology), Female, Humans, Male, Middle Aged, Paresthesia (epidemiology), Paresthesia (etiology), Parkinson Disease (complications), Parkinson Disease (epidemiology), Population Surveillance, Psychological Tests, Severity of Illness Index, Sleep Disorders (epidemiology), Sleep Disorders (etiology).
- MESH :
- complications : Parkinson Disease.
- epidemiology : Anxiety, Depression, Fatigue, Paresthesia, Parkinson Disease, Sleep Disorders.
- etiology : Anxiety, Depression, Fatigue, Paresthesia, Sleep Disorders.
- Aged, Aged, 80 and over, Comorbidity, Female, Humans, Male, Middle Aged, Population Surveillance, Psychological Tests, Severity of Illness Index.
Abstract
Many patients with Parkinson's disease (PD) have clinically significant anxiety, depression, fatigue, sleep disturbance, or sensory symptoms. The comorbidity of these nonmotor symptoms and their relationship to PD severity has not been extensively evaluated. Ninety- nine nondemented PD patients were evaluated with the following battery of tests: Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI), Fatigue Severity Scale (FSS), Pittsburgh Sleep Quality Index (PSQI), a sensory symptom questionnaire, Unified Parkinson's Disease Rating Scale (UPDRS), Hoehn & Yahr (H/Y) Stage, and the Schwab & England ADL scale (S/E). The comorbidity of the nonmotor symptoms and their relationship to PD severity was analyzed. Thirty-six percent of the study population had depression (BDI > or =10), 33% had anxiety (BAI > or =10), 40% had fatigue (FSS > 4), 47% had sleep disturbance (PSQI > 5), and 63% reported sensory symptoms. Only 12% of the sample had no nonmotor symptoms. Fifty-nine percent of the patients had two or more nonmotor symptoms, and nearly 25% had four or more. Increased comorbidity was associated with greater PD severity (P < 001). This study reveals that the nonmotor symptoms of PD frequently occur together in the same patients. Increased comorbidity of the five nonmotor symptoms was associated with greater PD severity. These results suggest that recognition of these diverse nonmotor symptoms may be enhanced by looking for others when one nonmotor symptom has been identified.
PubMed: 11391746
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Comorbidity of the nonmotor symptoms of Parkinson's disease.</title><author><name sortKey="Shulman, L M" sort="Shulman, L M" uniqKey="Shulman L" first="L M" last="Shulman">L M Shulman</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University of Maryland School of Medicine, 22 S. Greene St., Baltimore, MD 21201, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Maryland School of Medicine, 22 S. Greene St., Baltimore, MD 21201</wicri:regionArea></affiliation></author><author><name sortKey="Taback, R L" sort="Taback, R L" uniqKey="Taback R" first="R L" last="Taback">R L Taback</name></author><author><name sortKey="Bean, J" sort="Bean, J" uniqKey="Bean J" first="J" last="Bean">J. Bean</name></author><author><name sortKey="Weiner, W J" sort="Weiner, W J" uniqKey="Weiner W" first="W J" last="Weiner">W J Weiner</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2001">2001</date><idno type="RBID">pubmed:11391746</idno><idno type="pmid">11391746</idno><idno type="wicri:Area/PubMed/Corpus">003D41</idno><idno type="wicri:Area/PubMed/Curation">003D41</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Comorbidity of the nonmotor symptoms of Parkinson's disease.</title><author><name sortKey="Shulman, L M" sort="Shulman, L M" uniqKey="Shulman L" first="L M" last="Shulman">L M Shulman</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University of Maryland School of Medicine, 22 S. Greene St., Baltimore, MD 21201, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Maryland School of Medicine, 22 S. Greene St., Baltimore, MD 21201</wicri:regionArea></affiliation></author><author><name sortKey="Taback, R L" sort="Taback, R L" uniqKey="Taback R" first="R L" last="Taback">R L Taback</name></author><author><name sortKey="Bean, J" sort="Bean, J" uniqKey="Bean J" first="J" last="Bean">J. Bean</name></author><author><name sortKey="Weiner, W J" sort="Weiner, W J" uniqKey="Weiner W" first="W J" last="Weiner">W J Weiner</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2001" type="published">2001</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Anxiety (epidemiology)</term><term>Anxiety (etiology)</term><term>Comorbidity</term><term>Depression (epidemiology)</term><term>Depression (etiology)</term><term>Fatigue (epidemiology)</term><term>Fatigue (etiology)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Paresthesia (epidemiology)</term><term>Paresthesia (etiology)</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (epidemiology)</term><term>Population Surveillance</term><term>Psychological Tests</term><term>Severity of Illness Index</term><term>Sleep Disorders (epidemiology)</term><term>Sleep Disorders (etiology)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Anxiety</term><term>Depression</term><term>Fatigue</term><term>Paresthesia</term><term>Parkinson Disease</term><term>Sleep Disorders</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Anxiety</term><term>Depression</term><term>Fatigue</term><term>Paresthesia</term><term>Sleep Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Comorbidity</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Population Surveillance</term><term>Psychological Tests</term><term>Severity of Illness Index</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Many patients with Parkinson's disease (PD) have clinically significant anxiety, depression, fatigue, sleep disturbance, or sensory symptoms. The comorbidity of these nonmotor symptoms and their relationship to PD severity has not been extensively evaluated. Ninety- nine nondemented PD patients were evaluated with the following battery of tests: Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI), Fatigue Severity Scale (FSS), Pittsburgh Sleep Quality Index (PSQI), a sensory symptom questionnaire, Unified Parkinson's Disease Rating Scale (UPDRS), Hoehn & Yahr (H/Y) Stage, and the Schwab & England ADL scale (S/E). The comorbidity of the nonmotor symptoms and their relationship to PD severity was analyzed. Thirty-six percent of the study population had depression (BDI > or =10), 33% had anxiety (BAI > or =10), 40% had fatigue (FSS > 4), 47% had sleep disturbance (PSQI > 5), and 63% reported sensory symptoms. Only 12% of the sample had no nonmotor symptoms. Fifty-nine percent of the patients had two or more nonmotor symptoms, and nearly 25% had four or more. Increased comorbidity was associated with greater PD severity (P < 001). This study reveals that the nonmotor symptoms of PD frequently occur together in the same patients. Increased comorbidity of the five nonmotor symptoms was associated with greater PD severity. These results suggest that recognition of these diverse nonmotor symptoms may be enhanced by looking for others when one nonmotor symptom has been identified.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">11391746</PMID><DateCreated><Year>2001</Year><Month>06</Month><Day>06</Day></DateCreated><DateCompleted><Year>2001</Year><Month>08</Month><Day>16</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN><JournalIssue CitedMedium="Print"><Volume>16</Volume><Issue>3</Issue><PubDate><Year>2001</Year><Month>May</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Comorbidity of the nonmotor symptoms of Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>507-10</MedlinePgn></Pagination><Abstract><AbstractText>Many patients with Parkinson's disease (PD) have clinically significant anxiety, depression, fatigue, sleep disturbance, or sensory symptoms. The comorbidity of these nonmotor symptoms and their relationship to PD severity has not been extensively evaluated. Ninety- nine nondemented PD patients were evaluated with the following battery of tests: Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI), Fatigue Severity Scale (FSS), Pittsburgh Sleep Quality Index (PSQI), a sensory symptom questionnaire, Unified Parkinson's Disease Rating Scale (UPDRS), Hoehn & Yahr (H/Y) Stage, and the Schwab & England ADL scale (S/E). The comorbidity of the nonmotor symptoms and their relationship to PD severity was analyzed. Thirty-six percent of the study population had depression (BDI > or =10), 33% had anxiety (BAI > or =10), 40% had fatigue (FSS > 4), 47% had sleep disturbance (PSQI > 5), and 63% reported sensory symptoms. Only 12% of the sample had no nonmotor symptoms. Fifty-nine percent of the patients had two or more nonmotor symptoms, and nearly 25% had four or more. Increased comorbidity was associated with greater PD severity (P < 001). This study reveals that the nonmotor symptoms of PD frequently occur together in the same patients. Increased comorbidity of the five nonmotor symptoms was associated with greater PD severity. These results suggest that recognition of these diverse nonmotor symptoms may be enhanced by looking for others when one nonmotor symptom has been identified.</AbstractText><CopyrightInformation>Copyright 2001 Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Shulman</LastName><ForeName>L M</ForeName><Initials>LM</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of Maryland School of Medicine, 22 S. Greene St., Baltimore, MD 21201, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Taback</LastName><ForeName>R L</ForeName><Initials>RL</Initials></Author><Author ValidYN="Y"><LastName>Bean</LastName><ForeName>J</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Weiner</LastName><ForeName>W J</ForeName><Initials>WJ</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000369">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001007">Anxiety</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000453">epidemiology</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000209">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D015897">Comorbidity</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D003863">Depression</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000453">epidemiology</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000209">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005221">Fatigue</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000453">epidemiology</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000209">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010292">Paresthesia</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000453">epidemiology</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000209">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000150">complications</QualifierName><QualifierName MajorTopicYN="N" UI="Q000453">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011159">Population Surveillance</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011581">Psychological Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012720">Severity of Illness Index</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012893">Sleep Disorders</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000453">epidemiology</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000209">etiology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2001</Year><Month>6</Month><Day>8</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2001</Year><Month>8</Month><Day>17</Day><Hour>10</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2001</Year><Month>6</Month><Day>8</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">11391746</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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