MovDisordV3, PubMed, Curation, bibRecord, 003948

Excessive daytime sleepiness in de novo and treated Parkinson's disease.

Identifieur interne : 003948 ( PubMed/Curation ); précédent : 003947; suivant : 003949

Excessive daytime sleepiness in de novo and treated Parkinson's disease.

Auteurs : Giovanni Fabbrini [Italie] ; Piero Barbanti ; Cinzia Aurilia ; Nicola Vanacore ; Caterina Pauletti ; Giuseppe Meco

Source :

Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2002.

RBID : pubmed:12360553

English descriptors

KwdEn :
- Disorders of Excessive Somnolence (complications), Dopamine Agonists (therapeutic use), Female, Humans, Levodopa (therapeutic use), Male, Middle Aged, Parkinson Disease (complications), Parkinson Disease (drug therapy).
MESH :
- chemical , therapeutic use : Dopamine Agonists, Levodopa.
- complications : Disorders of Excessive Somnolence, Parkinson Disease.
- drug therapy : Parkinson Disease.
- Female, Humans, Male, Middle Aged.

Abstract

Excessive daytime sleepiness (EDS) in Parkinson's disease (PD) is due to either treatment-related factors or the disease itself. The study of this disturbing phenomenon in de novo parkinsonian patients may contribute to a better understanding of its pathophysiology. We conducted a case control study in which we compared 25 PD patients who had never been treated before with dopaminergic drugs (de novo PD), 50 PD patients being treated with dopaminergic drugs (treated PD), and 25 healthy control subjects, all of whom were matched for age and gender. EDS was measured by means of the Epworth Sleepiness Scale (ESS) and quality of sleep by means of the Pittsburgh Sleep Quality Index (PSQI). ESS and PSQI scores were not statistically different between de novo PD patients and controls, whereas they were significantly higher in treated PD. Differences in ESS score variability were best explained by the treatment effect, whereas there was no clear correlation between PSQI and any of the clinical variables considered.

DOI: 10.1002/mds.10193
PubMed: 12360553

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pubmed:12360553

Le document en format XML

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<author><name sortKey="Fabbrini, Giovanni" sort="Fabbrini, Giovanni" uniqKey="Fabbrini G" first="Giovanni" last="Fabbrini">Giovanni Fabbrini</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurological Sciences, University La Sapienza, Rome, Italy. giovanni.fabbrini@uniroma.it</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Neurological Sciences, University La Sapienza, Rome</wicri:regionArea>
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<author><name sortKey="Barbanti, Piero" sort="Barbanti, Piero" uniqKey="Barbanti P" first="Piero" last="Barbanti">Piero Barbanti</name>
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<author><name sortKey="Aurilia, Cinzia" sort="Aurilia, Cinzia" uniqKey="Aurilia C" first="Cinzia" last="Aurilia">Cinzia Aurilia</name>
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<author><name sortKey="Vanacore, Nicola" sort="Vanacore, Nicola" uniqKey="Vanacore N" first="Nicola" last="Vanacore">Nicola Vanacore</name>
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<author><name sortKey="Pauletti, Caterina" sort="Pauletti, Caterina" uniqKey="Pauletti C" first="Caterina" last="Pauletti">Caterina Pauletti</name>
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<term>Levodopa (therapeutic use)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (complications)</term>
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<front><div type="abstract" xml:lang="en">Excessive daytime sleepiness (EDS) in Parkinson's disease (PD) is due to either treatment-related factors or the disease itself. The study of this disturbing phenomenon in de novo parkinsonian patients may contribute to a better understanding of its pathophysiology. We conducted a case control study in which we compared 25 PD patients who had never been treated before with dopaminergic drugs (de novo PD), 50 PD patients being treated with dopaminergic drugs (treated PD), and 25 healthy control subjects, all of whom were matched for age and gender. EDS was measured by means of the Epworth Sleepiness Scale (ESS) and quality of sleep by means of the Pittsburgh Sleep Quality Index (PSQI). ESS and PSQI scores were not statistically different between de novo PD patients and controls, whereas they were significantly higher in treated PD. Differences in ESS score variability were best explained by the treatment effect, whereas there was no clear correlation between PSQI and any of the clinical variables considered.</div>
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<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
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<ArticleTitle>Excessive daytime sleepiness in de novo and treated Parkinson's disease.</ArticleTitle>
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<Abstract><AbstractText>Excessive daytime sleepiness (EDS) in Parkinson's disease (PD) is due to either treatment-related factors or the disease itself. The study of this disturbing phenomenon in de novo parkinsonian patients may contribute to a better understanding of its pathophysiology. We conducted a case control study in which we compared 25 PD patients who had never been treated before with dopaminergic drugs (de novo PD), 50 PD patients being treated with dopaminergic drugs (treated PD), and 25 healthy control subjects, all of whom were matched for age and gender. EDS was measured by means of the Epworth Sleepiness Scale (ESS) and quality of sleep by means of the Pittsburgh Sleep Quality Index (PSQI). ESS and PSQI scores were not statistically different between de novo PD patients and controls, whereas they were significantly higher in treated PD. Differences in ESS score variability were best explained by the treatment effect, whereas there was no clear correlation between PSQI and any of the clinical variables considered.</AbstractText>
<CopyrightInformation>Copyright 2002 Movement Disorder Society</CopyrightInformation>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Excessive daytime sleepiness in de novo and treated Parkinson's disease.

Excessive daytime sleepiness in de novo and treated Parkinson's disease.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki