Effects of dopaminergic cell degeneration on electrophysiological characteristics and GAD65/GAD67 expression in the substantia nigra: different action on GABA cell subpopulations.
Identifieur interne : 003839 ( PubMed/Curation ); précédent : 003838; suivant : 003840Effects of dopaminergic cell degeneration on electrophysiological characteristics and GAD65/GAD67 expression in the substantia nigra: different action on GABA cell subpopulations.
Auteurs : Manuel Rodríguez Díaz [Espagne] ; Pedro Barroso-Chinea ; Abraham Acevedo ; Tomás González-HernándezSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2003.
English descriptors
- KwdEn :
- Action Potentials, Animals, Dopamine (metabolism), Electrophysiology, Glutamate Decarboxylase (genetics), Glutamate Decarboxylase (metabolism), Immunohistochemistry, In Situ Hybridization, Isoenzymes (genetics), Isoenzymes (metabolism), Male, Nerve Degeneration (physiopathology), Neurons (metabolism), Neurons (physiology), Oxidopamine, RNA, Messenger (metabolism), Rats, Rats, Sprague-Dawley, Substantia Nigra (metabolism), Substantia Nigra (pathology), Substantia Nigra (physiopathology), gamma-Aminobutyric Acid (metabolism).
- MESH :
- chemical , genetics : Glutamate Decarboxylase, Isoenzymes.
- chemical , metabolism : Dopamine, Glutamate Decarboxylase, Isoenzymes, RNA, Messenger, gamma-Aminobutyric Acid.
- metabolism : Neurons, Substantia Nigra.
- pathology : Substantia Nigra.
- physiology : Neurons.
- physiopathology : Nerve Degeneration, Substantia Nigra.
- Action Potentials, Animals, Electrophysiology, Immunohistochemistry, In Situ Hybridization, Male, Oxidopamine, Rats, Rats, Sprague-Dawley.
Abstract
The motor disturbances occurring in Parkinson's disease have been partially attributed to a hyperactivity of gamma-aminobutyric acid (GABA)-ergic nigral cells largely in the substantia nigra pars reticulata (SNr) secondary to the degeneration of dopaminergic nigrostriatal neurons. However, some aspects of this response remain unclear. In this work, different electrophysiological and neurochemical parameters were studied in GABAergic cells of the SN after unilateral nigrostriatal dopaminergic lesion using 6-hydroxydopamine injection in rats. Our data showed that 1) the SN under normal conditions contains different subsets of GABAergic cells according to their firing pattern and glutamic acid decarboxylase mRNA levels, and 2) the response of these GABAergic cell subgroups was different after the ipsi- and contralateral dopaminergic cell degeneration. These findings indicate a complex regulation of nigral GABAergic activity after nigrostriatal dopaminergic degeneration that probably involves local mechanisms, the nigro-striato-nigral loop, as well as interhemispheric mechanisms whose anatomical basis remains unstudied.
DOI: 10.1002/mds.10345
PubMed: 12621628
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :003839
Links to Exploration step
pubmed:12621628Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effects of dopaminergic cell degeneration on electrophysiological characteristics and GAD65/GAD67 expression in the substantia nigra: different action on GABA cell subpopulations.</title><author><name sortKey="Diaz, Manuel Rodriguez" sort="Diaz, Manuel Rodriguez" uniqKey="Diaz M" first="Manuel Rodríguez" last="Díaz">Manuel Rodríguez Díaz</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Neurobiology and Experimental Neurology, Department of Physiology, Faculty of Medicine, University of La Laguna, La Laguna, Tenerife, Canary Islands, Spain. mrdiaz@ull.es</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Laboratory of Neurobiology and Experimental Neurology, Department of Physiology, Faculty of Medicine, University of La Laguna, La Laguna, Tenerife, Canary Islands</wicri:regionArea></affiliation></author><author><name sortKey="Barroso Chinea, Pedro" sort="Barroso Chinea, Pedro" uniqKey="Barroso Chinea P" first="Pedro" last="Barroso-Chinea">Pedro Barroso-Chinea</name></author><author><name sortKey="Acevedo, Abraham" sort="Acevedo, Abraham" uniqKey="Acevedo A" first="Abraham" last="Acevedo">Abraham Acevedo</name></author><author><name sortKey="Gonzalez Hernandez, Tomas" sort="Gonzalez Hernandez, Tomas" uniqKey="Gonzalez Hernandez T" first="Tomás" last="González-Hernández">Tomás González-Hernández</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2003">2003</date><idno type="RBID">pubmed:12621628</idno><idno type="pmid">12621628</idno><idno type="doi">10.1002/mds.10345</idno><idno type="wicri:Area/PubMed/Corpus">003839</idno><idno type="wicri:Area/PubMed/Curation">003839</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Effects of dopaminergic cell degeneration on electrophysiological characteristics and GAD65/GAD67 expression in the substantia nigra: different action on GABA cell subpopulations.</title><author><name sortKey="Diaz, Manuel Rodriguez" sort="Diaz, Manuel Rodriguez" uniqKey="Diaz M" first="Manuel Rodríguez" last="Díaz">Manuel Rodríguez Díaz</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Neurobiology and Experimental Neurology, Department of Physiology, Faculty of Medicine, University of La Laguna, La Laguna, Tenerife, Canary Islands, Spain. mrdiaz@ull.es</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Laboratory of Neurobiology and Experimental Neurology, Department of Physiology, Faculty of Medicine, University of La Laguna, La Laguna, Tenerife, Canary Islands</wicri:regionArea></affiliation></author><author><name sortKey="Barroso Chinea, Pedro" sort="Barroso Chinea, Pedro" uniqKey="Barroso Chinea P" first="Pedro" last="Barroso-Chinea">Pedro Barroso-Chinea</name></author><author><name sortKey="Acevedo, Abraham" sort="Acevedo, Abraham" uniqKey="Acevedo A" first="Abraham" last="Acevedo">Abraham Acevedo</name></author><author><name sortKey="Gonzalez Hernandez, Tomas" sort="Gonzalez Hernandez, Tomas" uniqKey="Gonzalez Hernandez T" first="Tomás" last="González-Hernández">Tomás González-Hernández</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2003" type="published">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Action Potentials</term><term>Animals</term><term>Dopamine (metabolism)</term><term>Electrophysiology</term><term>Glutamate Decarboxylase (genetics)</term><term>Glutamate Decarboxylase (metabolism)</term><term>Immunohistochemistry</term><term>In Situ Hybridization</term><term>Isoenzymes (genetics)</term><term>Isoenzymes (metabolism)</term><term>Male</term><term>Nerve Degeneration (physiopathology)</term><term>Neurons (metabolism)</term><term>Neurons (physiology)</term><term>Oxidopamine</term><term>RNA, Messenger (metabolism)</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Substantia Nigra (metabolism)</term><term>Substantia Nigra (pathology)</term><term>Substantia Nigra (physiopathology)</term><term>gamma-Aminobutyric Acid (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Glutamate Decarboxylase</term><term>Isoenzymes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dopamine</term><term>Glutamate Decarboxylase</term><term>Isoenzymes</term><term>RNA, Messenger</term><term>gamma-Aminobutyric Acid</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Neurons</term><term>Substantia Nigra</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Substantia Nigra</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Neurons</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Nerve Degeneration</term><term>Substantia Nigra</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Action Potentials</term><term>Animals</term><term>Electrophysiology</term><term>Immunohistochemistry</term><term>In Situ Hybridization</term><term>Male</term><term>Oxidopamine</term><term>Rats</term><term>Rats, Sprague-Dawley</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The motor disturbances occurring in Parkinson's disease have been partially attributed to a hyperactivity of gamma-aminobutyric acid (GABA)-ergic nigral cells largely in the substantia nigra pars reticulata (SNr) secondary to the degeneration of dopaminergic nigrostriatal neurons. However, some aspects of this response remain unclear. In this work, different electrophysiological and neurochemical parameters were studied in GABAergic cells of the SN after unilateral nigrostriatal dopaminergic lesion using 6-hydroxydopamine injection in rats. Our data showed that 1) the SN under normal conditions contains different subsets of GABAergic cells according to their firing pattern and glutamic acid decarboxylase mRNA levels, and 2) the response of these GABAergic cell subgroups was different after the ipsi- and contralateral dopaminergic cell degeneration. These findings indicate a complex regulation of nigral GABAergic activity after nigrostriatal dopaminergic degeneration that probably involves local mechanisms, the nigro-striato-nigral loop, as well as interhemispheric mechanisms whose anatomical basis remains unstudied.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">12621628</PMID><DateCreated><Year>2003</Year><Month>03</Month><Day>06</Day></DateCreated><DateCompleted><Year>2003</Year><Month>06</Month><Day>17</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN><JournalIssue CitedMedium="Print"><Volume>18</Volume><Issue>3</Issue><PubDate><Year>2003</Year><Month>Mar</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Effects of dopaminergic cell degeneration on electrophysiological characteristics and GAD65/GAD67 expression in the substantia nigra: different action on GABA cell subpopulations.</ArticleTitle><Pagination><MedlinePgn>254-66</MedlinePgn></Pagination><Abstract><AbstractText>The motor disturbances occurring in Parkinson's disease have been partially attributed to a hyperactivity of gamma-aminobutyric acid (GABA)-ergic nigral cells largely in the substantia nigra pars reticulata (SNr) secondary to the degeneration of dopaminergic nigrostriatal neurons. However, some aspects of this response remain unclear. In this work, different electrophysiological and neurochemical parameters were studied in GABAergic cells of the SN after unilateral nigrostriatal dopaminergic lesion using 6-hydroxydopamine injection in rats. Our data showed that 1) the SN under normal conditions contains different subsets of GABAergic cells according to their firing pattern and glutamic acid decarboxylase mRNA levels, and 2) the response of these GABAergic cell subgroups was different after the ipsi- and contralateral dopaminergic cell degeneration. These findings indicate a complex regulation of nigral GABAergic activity after nigrostriatal dopaminergic degeneration that probably involves local mechanisms, the nigro-striato-nigral loop, as well as interhemispheric mechanisms whose anatomical basis remains unstudied.</AbstractText><CopyrightInformation>Copyright 2002 Movement Disorder Society</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Díaz</LastName><ForeName>Manuel Rodríguez</ForeName><Initials>MR</Initials><AffiliationInfo><Affiliation>Laboratory of Neurobiology and Experimental Neurology, Department of Physiology, Faculty of Medicine, University of La Laguna, La Laguna, Tenerife, Canary Islands, Spain. mrdiaz@ull.es</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Barroso-Chinea</LastName><ForeName>Pedro</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Acevedo</LastName><ForeName>Abraham</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>González-Hernández</LastName><ForeName>Tomás</ForeName><Initials>T</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007527">Isoenzymes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012333">RNA, Messenger</NameOfSubstance></Chemical><Chemical><RegistryNumber>56-12-2</RegistryNumber><NameOfSubstance UI="D005680">gamma-Aminobutyric Acid</NameOfSubstance></Chemical><Chemical><RegistryNumber>8HW4YBZ748</RegistryNumber><NameOfSubstance UI="D016627">Oxidopamine</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 4.1.1.15</RegistryNumber><NameOfSubstance UI="D005968">Glutamate Decarboxylase</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 4.1.1.15</RegistryNumber><NameOfSubstance UI="C402565">glutamate decarboxylase 1</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 4.1.1.15</RegistryNumber><NameOfSubstance UI="C401141">glutamate decarboxylase 2</NameOfSubstance></Chemical><Chemical><RegistryNumber>VTD58H1Z2X</RegistryNumber><NameOfSubstance UI="D004298">Dopamine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000200">Action Potentials</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000818">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004298">Dopamine</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004594">Electrophysiology</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005968">Glutamate Decarboxylase</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000235">genetics</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007150">Immunohistochemistry</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D017403">In Situ Hybridization</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007527">Isoenzymes</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000235">genetics</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009410">Nerve Degeneration</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009474">Neurons</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D016627">Oxidopamine</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012333">RNA, Messenger</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000378">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D051381">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D017207">Rats, Sprague-Dawley</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013378">Substantia Nigra</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000378">metabolism</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000473">pathology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005680">gamma-Aminobutyric Acid</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000378">metabolism</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2003</Year><Month>3</Month><Day>7</Day><Hour>4</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2003</Year><Month>6</Month><Day>18</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2003</Year><Month>3</Month><Day>7</Day><Hour>4</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">12621628</ArticleId><ArticleId IdType="doi">10.1002/mds.10345</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/PubMed/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003839 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd -nk 003839 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= PubMed
|étape= Curation
|type= RBID
|clé= pubmed:12621628
|texte= Effects of dopaminergic cell degeneration on electrophysiological characteristics and GAD65/GAD67 expression in the substantia nigra: different action on GABA cell subpopulations.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Curation/RBID.i -Sk "pubmed:12621628" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd \
| NlmPubMed2Wicri -a MovDisordV3
| This area was generated with Dilib version V0.6.23. |  |