Impaired heteronymous somatosensory motor cortical inhibition in dystonia.
Identifieur interne : 003626 ( PubMed/Curation ); précédent : 003625; suivant : 003627Impaired heteronymous somatosensory motor cortical inhibition in dystonia.
Auteurs : Laura Bertolasi [Italie] ; Silvia Romito ; Michele Tinazzi ; Niccol Rizzuto ; Alberto PrioriSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2003.
English descriptors
- KwdEn :
- Adult, Dystonia Musculorum Deformans (diagnosis), Dystonia Musculorum Deformans (physiopathology), Electric Stimulation (instrumentation), Evoked Potentials, Motor (physiology), Evoked Potentials, Somatosensory (physiology), Female, Functional Laterality (physiology), Humans, Male, Median Nerve (physiology), Middle Aged, Motor Cortex (physiopathology), Muscle, Skeletal (innervation), Muscle, Skeletal (physiopathology), Neural Inhibition (physiology), Skull.
- MESH :
- diagnosis : Dystonia Musculorum Deformans.
- innervation : Muscle, Skeletal.
- instrumentation : Electric Stimulation.
- physiology : Evoked Potentials, Motor, Evoked Potentials, Somatosensory, Functional Laterality, Median Nerve, Neural Inhibition.
- physiopathology : Dystonia Musculorum Deformans, Motor Cortex, Muscle, Skeletal.
- Adult, Female, Humans, Male, Middle Aged, Skull.
Abstract
A typical pathophysiological abnormality in dystonia is cocontraction of antagonist muscles, with impaired reciprocal inhibitory mechanisms in the spinal cord. Recent experimental data have shown that inhibitory interactions between antagonist muscles have also a parallel control at the level of the sensorimotor cortex. The aim of this work was to study heteronymous effects of a median nerve stimulus on the corticospinal projections to forearm muscles in dystonia. We used the technique of antagonist cortical inhibition, which assesses the conditioning effect of median nerve afferent input on motor evoked potentials (MEPs) elicited by transcranial magnetic stimulation (TMS) in ipsilateral forearm extensor muscles at rest. Nine healthy subjects and 10 patients with torsion dystonia participated in the study. MEPs and somatosensory evoked potentials were normal in patients. In healthy subjects, median nerve stimulation at 15- to 18-msec intervals inhibited the test MEPs in forearm extensors. In dystonic patients, median nerve stimulation delivered at the same conditioning-test intervals elicited significantly less inhibition of the test MEP. On the whole, these data suggest an impaired sensory-motor integration in dystonia and, more specifically, the decreased antagonistic cortical inhibition could suggest that functional interactions between antagonist muscles are primarily impaired at the cortical level.
DOI: 10.1002/mds.10514
PubMed: 14639683
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Impaired heteronymous somatosensory motor cortical inhibition in dystonia.</title><author><name sortKey="Bertolasi, Laura" sort="Bertolasi, Laura" uniqKey="Bertolasi L" first="Laura" last="Bertolasi">Laura Bertolasi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurological Sciences and Vision, Section of Neurology, University of Verona, Verona, Italy. laurabertolasi@netscape.net</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences and Vision, Section of Neurology, University of Verona, Verona</wicri:regionArea></affiliation></author><author><name sortKey="Romito, Silvia" sort="Romito, Silvia" uniqKey="Romito S" first="Silvia" last="Romito">Silvia Romito</name></author><author><name sortKey="Tinazzi, Michele" sort="Tinazzi, Michele" uniqKey="Tinazzi M" first="Michele" last="Tinazzi">Michele Tinazzi</name></author><author><name sortKey="Rizzuto, Niccol" sort="Rizzuto, Niccol" uniqKey="Rizzuto N" first="Niccol" last="Rizzuto">Niccol Rizzuto</name></author><author><name sortKey="Priori, Alberto" sort="Priori, Alberto" uniqKey="Priori A" first="Alberto" last="Priori">Alberto Priori</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2003">2003</date><idno type="RBID">pubmed:14639683</idno><idno type="pmid">14639683</idno><idno type="doi">10.1002/mds.10514</idno><idno type="wicri:Area/PubMed/Corpus">003626</idno><idno type="wicri:Area/PubMed/Curation">003626</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Impaired heteronymous somatosensory motor cortical inhibition in dystonia.</title><author><name sortKey="Bertolasi, Laura" sort="Bertolasi, Laura" uniqKey="Bertolasi L" first="Laura" last="Bertolasi">Laura Bertolasi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurological Sciences and Vision, Section of Neurology, University of Verona, Verona, Italy. laurabertolasi@netscape.net</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences and Vision, Section of Neurology, University of Verona, Verona</wicri:regionArea></affiliation></author><author><name sortKey="Romito, Silvia" sort="Romito, Silvia" uniqKey="Romito S" first="Silvia" last="Romito">Silvia Romito</name></author><author><name sortKey="Tinazzi, Michele" sort="Tinazzi, Michele" uniqKey="Tinazzi M" first="Michele" last="Tinazzi">Michele Tinazzi</name></author><author><name sortKey="Rizzuto, Niccol" sort="Rizzuto, Niccol" uniqKey="Rizzuto N" first="Niccol" last="Rizzuto">Niccol Rizzuto</name></author><author><name sortKey="Priori, Alberto" sort="Priori, Alberto" uniqKey="Priori A" first="Alberto" last="Priori">Alberto Priori</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2003" type="published">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Dystonia Musculorum Deformans (diagnosis)</term><term>Dystonia Musculorum Deformans (physiopathology)</term><term>Electric Stimulation (instrumentation)</term><term>Evoked Potentials, Motor (physiology)</term><term>Evoked Potentials, Somatosensory (physiology)</term><term>Female</term><term>Functional Laterality (physiology)</term><term>Humans</term><term>Male</term><term>Median Nerve (physiology)</term><term>Middle Aged</term><term>Motor Cortex (physiopathology)</term><term>Muscle, Skeletal (innervation)</term><term>Muscle, Skeletal (physiopathology)</term><term>Neural Inhibition (physiology)</term><term>Skull</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Dystonia Musculorum Deformans</term></keywords><keywords scheme="MESH" qualifier="innervation" xml:lang="en"><term>Muscle, Skeletal</term></keywords><keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Electric Stimulation</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Evoked Potentials, Motor</term><term>Evoked Potentials, Somatosensory</term><term>Functional Laterality</term><term>Median Nerve</term><term>Neural Inhibition</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Dystonia Musculorum Deformans</term><term>Motor Cortex</term><term>Muscle, Skeletal</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Skull</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A typical pathophysiological abnormality in dystonia is cocontraction of antagonist muscles, with impaired reciprocal inhibitory mechanisms in the spinal cord. Recent experimental data have shown that inhibitory interactions between antagonist muscles have also a parallel control at the level of the sensorimotor cortex. The aim of this work was to study heteronymous effects of a median nerve stimulus on the corticospinal projections to forearm muscles in dystonia. We used the technique of antagonist cortical inhibition, which assesses the conditioning effect of median nerve afferent input on motor evoked potentials (MEPs) elicited by transcranial magnetic stimulation (TMS) in ipsilateral forearm extensor muscles at rest. Nine healthy subjects and 10 patients with torsion dystonia participated in the study. MEPs and somatosensory evoked potentials were normal in patients. In healthy subjects, median nerve stimulation at 15- to 18-msec intervals inhibited the test MEPs in forearm extensors. In dystonic patients, median nerve stimulation delivered at the same conditioning-test intervals elicited significantly less inhibition of the test MEP. On the whole, these data suggest an impaired sensory-motor integration in dystonia and, more specifically, the decreased antagonistic cortical inhibition could suggest that functional interactions between antagonist muscles are primarily impaired at the cortical level.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">14639683</PMID><DateCreated><Year>2003</Year><Month>11</Month><Day>25</Day></DateCreated><DateCompleted><Year>2004</Year><Month>03</Month><Day>25</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN><JournalIssue CitedMedium="Print"><Volume>18</Volume><Issue>11</Issue><PubDate><Year>2003</Year><Month>Nov</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Impaired heteronymous somatosensory motor cortical inhibition in dystonia.</ArticleTitle><Pagination><MedlinePgn>1367-73</MedlinePgn></Pagination><Abstract><AbstractText>A typical pathophysiological abnormality in dystonia is cocontraction of antagonist muscles, with impaired reciprocal inhibitory mechanisms in the spinal cord. Recent experimental data have shown that inhibitory interactions between antagonist muscles have also a parallel control at the level of the sensorimotor cortex. The aim of this work was to study heteronymous effects of a median nerve stimulus on the corticospinal projections to forearm muscles in dystonia. We used the technique of antagonist cortical inhibition, which assesses the conditioning effect of median nerve afferent input on motor evoked potentials (MEPs) elicited by transcranial magnetic stimulation (TMS) in ipsilateral forearm extensor muscles at rest. Nine healthy subjects and 10 patients with torsion dystonia participated in the study. MEPs and somatosensory evoked potentials were normal in patients. In healthy subjects, median nerve stimulation at 15- to 18-msec intervals inhibited the test MEPs in forearm extensors. In dystonic patients, median nerve stimulation delivered at the same conditioning-test intervals elicited significantly less inhibition of the test MEP. On the whole, these data suggest an impaired sensory-motor integration in dystonia and, more specifically, the decreased antagonistic cortical inhibition could suggest that functional interactions between antagonist muscles are primarily impaired at the cortical level.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Bertolasi</LastName><ForeName>Laura</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Neurological Sciences and Vision, Section of Neurology, University of Verona, Verona, Italy. laurabertolasi@netscape.net</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Romito</LastName><ForeName>Silvia</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Tinazzi</LastName><ForeName>Michele</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Rizzuto</LastName><ForeName>Niccoló</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Priori</LastName><ForeName>Alberto</ForeName><Initials>A</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000328">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004422">Dystonia Musculorum Deformans</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000175">diagnosis</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004558">Electric Stimulation</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000295">instrumentation</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D019054">Evoked Potentials, Motor</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005073">Evoked Potentials, Somatosensory</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007839">Functional Laterality</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008475">Median Nerve</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009044">Motor Cortex</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D018482">Muscle, Skeletal</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000294">innervation</QualifierName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009433">Neural Inhibition</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012886">Skull</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2003</Year><Month>11</Month><Day>26</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2004</Year><Month>3</Month><Day>26</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2003</Year><Month>11</Month><Day>26</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">14639683</ArticleId><ArticleId IdType="doi">10.1002/mds.10514</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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