Interleukin-1A (-889) genetic polymorphism increases the risk of multiple system atrophy.
Identifieur interne : 003621 ( PubMed/Curation ); précédent : 003620; suivant : 003622Interleukin-1A (-889) genetic polymorphism increases the risk of multiple system atrophy.
Auteurs : Onofre Combarros [Espagne] ; Jon Infante ; Javier Llorca ; José BercianoSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2003.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Interleukin-1.
- genetics : Multiple System Atrophy, Polymorphism, Genetic, Promoter Regions, Genetic.
- immunology : Multiple System Atrophy.
- Adult, Aged, Female, Genotype, Humans, Male, Middle Aged, Risk Factors.
Abstract
In a case-control study using a clinically well-defined group of 30 multiple system atrophy (MSA) patients and 110 control subjects, homozygosity for interleukin-1A (IL-1A) allele 2 (high secretor of proinflammatory cytokine) in the regulatory region (-889) of the IL-1A gene was associated with a fivefold increased risk for MSA.
DOI: 10.1002/mds.10540
PubMed: 14639688
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