Severe resting clonus caused by thyrotoxicosis in a 16-year-old girl with hereditary spastic paraparesis: a case report.
Identifieur interne : 003431 ( PubMed/Curation ); précédent : 003430; suivant : 003432Severe resting clonus caused by thyrotoxicosis in a 16-year-old girl with hereditary spastic paraparesis: a case report.
Auteurs : Terence D. Sanger [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2004.
English descriptors
- KwdEn :
- MESH :
- chemical , blood : Thyrotropin.
- blood : Thyrotoxicosis.
- complications : Paraparesis, Spastic, Thyrotoxicosis.
- diagnosis : Seizures.
- etiology : Seizures.
- genetics : Paraparesis, Spastic.
- Adolescent, Female, Humans, Rest, Severity of Illness Index.
Abstract
A 16-year-old girl with a history of hereditary spastic paraparesis developed the subacute onset of severe clonus and new upper-extremity spasticity due to thyrotoxicosis. This case demonstrates the ability of hyperthyroid states to worsen symptoms of spasticity in a child with an underlying spastic disorder. It also demonstrates the importance of investigating for common systemic diseases as a cause of movement disorders even in children with underlying known genetic disorders.
DOI: 10.1002/mds.20015
PubMed: 15197716
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Sanger</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology and Neurological Sciences, Stanford University Medical Center, Stanford, California 94305-5235, USA. sanger@stanford.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology and Neurological Sciences, Stanford University Medical Center, Stanford, California 94305-5235</wicri:regionArea></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Female</term><term>Humans</term><term>Paraparesis, Spastic (complications)</term><term>Paraparesis, Spastic (genetics)</term><term>Rest</term><term>Seizures (diagnosis)</term><term>Seizures (etiology)</term><term>Severity of Illness Index</term><term>Thyrotoxicosis (blood)</term><term>Thyrotoxicosis (complications)</term><term>Thyrotropin (blood)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Thyrotropin</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Thyrotoxicosis</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Paraparesis, Spastic</term><term>Thyrotoxicosis</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Seizures</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Seizures</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Paraparesis, Spastic</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Female</term><term>Humans</term><term>Rest</term><term>Severity of Illness Index</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A 16-year-old girl with a history of hereditary spastic paraparesis developed the subacute onset of severe clonus and new upper-extremity spasticity due to thyrotoxicosis. 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