Clinical and neuropsychological correlates in two brothers with pantothenate kinase-associated neurodegeneration.
Identifieur interne : 003283 ( PubMed/Curation ); précédent : 003282; suivant : 003284Clinical and neuropsychological correlates in two brothers with pantothenate kinase-associated neurodegeneration.
Auteurs : Cecilia Marelli [Italie] ; Sylvie Piacentini ; Barbara Garavaglia ; Floriano Girotti ; Alberto AlbaneseSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2005.
English descriptors
- KwdEn :
- Adult, Attention (physiology), Cognition Disorders (physiopathology), Dystonia (genetics), Dystonia (pathology), Dystonia (physiopathology), Humans, Magnetic Resonance Imaging (methods), Male, Mental Status Schedule, Mutation, Missense (genetics), Neuropsychological Tests (statistics & numerical data), Phosphotransferases (Alcohol Group Acceptor) (genetics), Problem Solving (physiology), Siblings.
- MESH :
- chemical , genetics : Phosphotransferases (Alcohol Group Acceptor).
- genetics : Dystonia, Mutation, Missense.
- methods : Magnetic Resonance Imaging.
- pathology : Dystonia.
- physiology : Attention, Problem Solving.
- physiopathology : Cognition Disorders, Dystonia.
- statistics & numerical data : Neuropsychological Tests.
- Adult, Humans, Male, Mental Status Schedule, Siblings.
Abstract
Adult-onset focal dystonia was the presenting sign of pantothenate kinase-associated neurodegeneration (PKAN) in a patient with a novel homozygous missense mutation (C856T). His brother shared the same mutation and showed similar, albeit minor, motor signs, but a different behavioral profile. Both brothers had an atypical form of PKAN. The neuropsychological assessment showed that, despite a normal Mini-Mental State Examination, both patients presented a deficit of executive functions and of attention. The profile of cognitive impairment in these cases was typically that of a subcortical dementia. Both patients fulfilled Diagnostic and Statistical Manual for Mental Disorders criteria for obsessive-compulsive disorder; however, paranoia was associated with depression and aggressive behavior in Patient 1, whereas Patient 2 had hyperactivity, disinhibition, and euphoria. Our findings suggest that these two brothers had a different pattern of involvement of motor and nonmotor basal ganglia-thalamocortical circuits.
DOI: 10.1002/mds.20282
PubMed: 15390030
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pubmed:15390030Le document en format XML
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<author><name sortKey="Garavaglia, Barbara" sort="Garavaglia, Barbara" uniqKey="Garavaglia B" first="Barbara" last="Garavaglia">Barbara Garavaglia</name>
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<author><name sortKey="Girotti, Floriano" sort="Girotti, Floriano" uniqKey="Girotti F" first="Floriano" last="Girotti">Floriano Girotti</name>
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<front><div type="abstract" xml:lang="en">Adult-onset focal dystonia was the presenting sign of pantothenate kinase-associated neurodegeneration (PKAN) in a patient with a novel homozygous missense mutation (C856T). His brother shared the same mutation and showed similar, albeit minor, motor signs, but a different behavioral profile. Both brothers had an atypical form of PKAN. The neuropsychological assessment showed that, despite a normal Mini-Mental State Examination, both patients presented a deficit of executive functions and of attention. The profile of cognitive impairment in these cases was typically that of a subcortical dementia. Both patients fulfilled Diagnostic and Statistical Manual for Mental Disorders criteria for obsessive-compulsive disorder; however, paranoia was associated with depression and aggressive behavior in Patient 1, whereas Patient 2 had hyperactivity, disinhibition, and euphoria. Our findings suggest that these two brothers had a different pattern of involvement of motor and nonmotor basal ganglia-thalamocortical circuits.</div>
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<Abstract><AbstractText>Adult-onset focal dystonia was the presenting sign of pantothenate kinase-associated neurodegeneration (PKAN) in a patient with a novel homozygous missense mutation (C856T). His brother shared the same mutation and showed similar, albeit minor, motor signs, but a different behavioral profile. Both brothers had an atypical form of PKAN. The neuropsychological assessment showed that, despite a normal Mini-Mental State Examination, both patients presented a deficit of executive functions and of attention. The profile of cognitive impairment in these cases was typically that of a subcortical dementia. Both patients fulfilled Diagnostic and Statistical Manual for Mental Disorders criteria for obsessive-compulsive disorder; however, paranoia was associated with depression and aggressive behavior in Patient 1, whereas Patient 2 had hyperactivity, disinhibition, and euphoria. Our findings suggest that these two brothers had a different pattern of involvement of motor and nonmotor basal ganglia-thalamocortical circuits.</AbstractText>
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