Other pharmacological treatments for motor complications and dyskinesias.
Identifieur interne : 003082 ( PubMed/Curation ); précédent : 003081; suivant : 003083Other pharmacological treatments for motor complications and dyskinesias.
Auteurs : Cheryl Waters [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2005.
English descriptors
- KwdEn :
- Amantadine (pharmacology), Amantadine (therapeutic use), Antiparkinson Agents (adverse effects), Antiparkinson Agents (therapeutic use), Catechol O-Methyltransferase Inhibitors, Dopamine Agonists (therapeutic use), Dyskinesia, Drug-Induced (drug therapy), Dyskinesia, Drug-Induced (etiology), Gait (drug effects), Humans, Levodopa (adverse effects), Levodopa (therapeutic use), Monoamine Oxidase (metabolism), Monoamine Oxidase Inhibitors (pharmacology), Monoamine Oxidase Inhibitors (therapeutic use), Parkinson Disease (drug therapy), Periodicity, Purinergic P1 Receptor Antagonists, Purines (pharmacology), Purines (therapeutic use), Selegiline (pharmacology), Selegiline (therapeutic use).
- MESH :
- chemical , adverse effects : Antiparkinson Agents, Levodopa.
- chemical , metabolism : Monoamine Oxidase.
- chemical , pharmacology : Amantadine, Monoamine Oxidase Inhibitors, Purines, Selegiline.
- chemical , therapeutic use : Amantadine, Antiparkinson Agents, Dopamine Agonists, Levodopa, Monoamine Oxidase Inhibitors, Purines, Selegiline.
- chemical : Catechol O-Methyltransferase Inhibitors, Purinergic P1 Receptor Antagonists.
- drug effects : Gait.
- drug therapy : Dyskinesia, Drug-Induced, Parkinson Disease.
- etiology : Dyskinesia, Drug-Induced.
- Humans, Periodicity.
Abstract
Controlling motor complications becomes increasingly difficult with disease progression. The "wearing-off" phenomenon is the most-common motor fluctuation. Wearing-off can be treated by dietary manipulation, shortening the dosing interval, substituting sustained-release levodopa, adding amantadine, or monoamine oxidase type B inhibitors, and other options, including catechol-O-methyltransferase inhibitors and the approved dopamine agonists addressed in another chapter. The rotigotine constant-delivery system is being developed to treat wearing-off symptoms. Istradefylline (KW-6002), an adenosine A(2A) receptor antagonist, has been studied for wearing-off and the results will be discussed. The on-off fluctuations can be treated with liquid levodopa and the rescue therapy of injectable apomorphine. Patients may also suffer from dyskinesias. Dyskinesias can be treated with small doses of liquefied levodopa-carbidopa, amantadine, and clozapine, an atypical neuroleptic.
DOI: 10.1002/mds.20462
PubMed: 15822104
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pubmed:15822104Le document en format XML
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<author><name sortKey="Waters, Cheryl" sort="Waters, Cheryl" uniqKey="Waters C" first="Cheryl" last="Waters">Cheryl Waters</name>
<affiliation wicri:level="1"><nlm:affiliation>Division of Movement Disorders, Department of Neurology, Columbia University, 710 West 168th Street, New York, NY 10032, USA. cw345@columbia.edu</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Movement Disorders, Department of Neurology, Columbia University, 710 West 168th Street, New York, NY 10032</wicri:regionArea>
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<term>Amantadine (therapeutic use)</term>
<term>Antiparkinson Agents (adverse effects)</term>
<term>Antiparkinson Agents (therapeutic use)</term>
<term>Catechol O-Methyltransferase Inhibitors</term>
<term>Dopamine Agonists (therapeutic use)</term>
<term>Dyskinesia, Drug-Induced (drug therapy)</term>
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<term>Gait (drug effects)</term>
<term>Humans</term>
<term>Levodopa (adverse effects)</term>
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<term>Monoamine Oxidase (metabolism)</term>
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<term>Parkinson Disease (drug therapy)</term>
<term>Periodicity</term>
<term>Purinergic P1 Receptor Antagonists</term>
<term>Purines (pharmacology)</term>
<term>Purines (therapeutic use)</term>
<term>Selegiline (pharmacology)</term>
<term>Selegiline (therapeutic use)</term>
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<term>Levodopa</term>
<term>Monoamine Oxidase Inhibitors</term>
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<term>Purinergic P1 Receptor Antagonists</term>
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<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Dyskinesia, Drug-Induced</term>
<term>Parkinson Disease</term>
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<front><div type="abstract" xml:lang="en">Controlling motor complications becomes increasingly difficult with disease progression. The "wearing-off" phenomenon is the most-common motor fluctuation. Wearing-off can be treated by dietary manipulation, shortening the dosing interval, substituting sustained-release levodopa, adding amantadine, or monoamine oxidase type B inhibitors, and other options, including catechol-O-methyltransferase inhibitors and the approved dopamine agonists addressed in another chapter. The rotigotine constant-delivery system is being developed to treat wearing-off symptoms. Istradefylline (KW-6002), an adenosine A(2A) receptor antagonist, has been studied for wearing-off and the results will be discussed. The on-off fluctuations can be treated with liquid levodopa and the rescue therapy of injectable apomorphine. Patients may also suffer from dyskinesias. Dyskinesias can be treated with small doses of liquefied levodopa-carbidopa, amantadine, and clozapine, an atypical neuroleptic.</div>
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<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
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<Abstract><AbstractText>Controlling motor complications becomes increasingly difficult with disease progression. The "wearing-off" phenomenon is the most-common motor fluctuation. Wearing-off can be treated by dietary manipulation, shortening the dosing interval, substituting sustained-release levodopa, adding amantadine, or monoamine oxidase type B inhibitors, and other options, including catechol-O-methyltransferase inhibitors and the approved dopamine agonists addressed in another chapter. The rotigotine constant-delivery system is being developed to treat wearing-off symptoms. Istradefylline (KW-6002), an adenosine A(2A) receptor antagonist, has been studied for wearing-off and the results will be discussed. The on-off fluctuations can be treated with liquid levodopa and the rescue therapy of injectable apomorphine. Patients may also suffer from dyskinesias. Dyskinesias can be treated with small doses of liquefied levodopa-carbidopa, amantadine, and clozapine, an atypical neuroleptic.</AbstractText>
<CopyrightInformation>(c) 2005 Movement Disorder Society.</CopyrightInformation>
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