Effects of deep brain stimulation and medication on strength, bradykinesia, and electromyographic patterns of the ankle joint in Parkinson's disease.
Identifieur interne : 002E95 ( PubMed/Curation ); précédent : 002E94; suivant : 002E96Effects of deep brain stimulation and medication on strength, bradykinesia, and electromyographic patterns of the ankle joint in Parkinson's disease.
Auteurs : David E. Vaillancourt [États-Unis] ; Janey Prodoehl ; Molly M. Sturman ; Roy A E. Bakay ; Leo Verhagen Metman ; Daniel M. CorcosSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2006.
English descriptors
- KwdEn :
- Ankle Joint (innervation), Antiparkinson Agents (administration & dosage), Antiparkinson Agents (adverse effects), Biomechanical Phenomena, Carbidopa (administration & dosage), Carbidopa (adverse effects), Combined Modality Therapy, Deep Brain Stimulation (methods), Electrodes, Implanted, Electromyography (drug effects), Humans, Hypokinesia (physiopathology), Hypokinesia (therapy), Isometric Contraction (drug effects), Isometric Contraction (physiology), Levodopa (administration & dosage), Levodopa (adverse effects), Muscle Weakness (physiopathology), Muscle Weakness (therapy), Muscle, Skeletal (innervation), Parkinson Disease (diagnosis), Parkinson Disease (physiopathology), Parkinson Disease (therapy), Reference Values, Signal Processing, Computer-Assisted, Statistics as Topic, Torque, Treatment Outcome, Tremor (physiopathology), Tremor (therapy).
- MESH :
- chemical , administration & dosage : Antiparkinson Agents, Carbidopa, Levodopa.
- chemical , adverse effects : Antiparkinson Agents, Carbidopa, Levodopa.
- diagnosis : Parkinson Disease.
- drug effects : Electromyography, Isometric Contraction.
- innervation : Ankle Joint, Muscle, Skeletal.
- methods : Deep Brain Stimulation.
- physiology : Isometric Contraction.
- physiopathology : Hypokinesia, Muscle Weakness, Parkinson Disease, Tremor.
- therapy : Hypokinesia, Muscle Weakness, Parkinson Disease, Tremor.
- Biomechanical Phenomena, Combined Modality Therapy, Electrodes, Implanted, Humans, Reference Values, Signal Processing, Computer-Assisted, Statistics as Topic, Torque, Treatment Outcome.
Abstract
We investigated the control of movement in 12 patients with Parkinson's disease (PD) after they received surgically implanted high-frequency stimulating electrodes in the subthalamic nucleus (STN). The experiment studied ankle strength, movement velocity, and the associated electromyographic patterns in PD patients, six of whom had tremor at the ankle. The patients were studied off treatment, ON STN deep brain stimulation (DBS), on medication, and on medication plus STN DBS. Twelve matched control subjects were also examined. Medication alone and STN DBS alone increased patients' ankle strength, ankle velocity, agonist muscle burst amplitude, and agonist burst duration, while reducing the number of agonist bursts during movement. These findings were similar for PD patients with and without tremor. The combination of medication plus STN DBS normalized maximal strength at the ankle joint, but ankle movement velocity and electromyographic patterns were not normalized. The findings are the first to demonstrate that STN DBS and medication increase strength and movement velocity at the ankle joint.
DOI: 10.1002/mds.20672
PubMed: 16124011
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Vaillancourt</name><affiliation wicri:level="1"><nlm:affiliation>Department of Movement Science, University of Illinois, Chicago, Illinois 60612, USA. court1@uic.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Movement Science, University of Illinois, Chicago, Illinois 60612</wicri:regionArea></affiliation></author><author><name sortKey="Prodoehl, Janey" sort="Prodoehl, Janey" uniqKey="Prodoehl J" first="Janey" last="Prodoehl">Janey Prodoehl</name></author><author><name sortKey="Sturman, Molly M" sort="Sturman, Molly M" uniqKey="Sturman M" first="Molly M" last="Sturman">Molly M. Sturman</name></author><author><name sortKey="Bakay, Roy A E" sort="Bakay, Roy A E" uniqKey="Bakay R" first="Roy A E" last="Bakay">Roy A E. 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Vaillancourt</name><affiliation wicri:level="1"><nlm:affiliation>Department of Movement Science, University of Illinois, Chicago, Illinois 60612, USA. court1@uic.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Movement Science, University of Illinois, Chicago, Illinois 60612</wicri:regionArea></affiliation></author><author><name sortKey="Prodoehl, Janey" sort="Prodoehl, Janey" uniqKey="Prodoehl J" first="Janey" last="Prodoehl">Janey Prodoehl</name></author><author><name sortKey="Sturman, Molly M" sort="Sturman, Molly M" uniqKey="Sturman M" first="Molly M" last="Sturman">Molly M. Sturman</name></author><author><name sortKey="Bakay, Roy A E" sort="Bakay, Roy A E" uniqKey="Bakay R" first="Roy A E" last="Bakay">Roy A E. Bakay</name></author><author><name sortKey="Metman, Leo Verhagen" sort="Metman, Leo Verhagen" uniqKey="Metman L" first="Leo Verhagen" last="Metman">Leo Verhagen Metman</name></author><author><name sortKey="Corcos, Daniel M" sort="Corcos, Daniel M" uniqKey="Corcos D" first="Daniel M" last="Corcos">Daniel M. Corcos</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Ankle Joint (innervation)</term><term>Antiparkinson Agents (administration & dosage)</term><term>Antiparkinson Agents (adverse effects)</term><term>Biomechanical Phenomena</term><term>Carbidopa (administration & dosage)</term><term>Carbidopa (adverse effects)</term><term>Combined Modality Therapy</term><term>Deep Brain Stimulation (methods)</term><term>Electrodes, Implanted</term><term>Electromyography (drug effects)</term><term>Humans</term><term>Hypokinesia (physiopathology)</term><term>Hypokinesia (therapy)</term><term>Isometric Contraction (drug effects)</term><term>Isometric Contraction (physiology)</term><term>Levodopa (administration & dosage)</term><term>Levodopa (adverse effects)</term><term>Muscle Weakness (physiopathology)</term><term>Muscle Weakness (therapy)</term><term>Muscle, Skeletal (innervation)</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (therapy)</term><term>Reference Values</term><term>Signal Processing, Computer-Assisted</term><term>Statistics as Topic</term><term>Torque</term><term>Treatment Outcome</term><term>Tremor (physiopathology)</term><term>Tremor (therapy)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antiparkinson Agents</term><term>Carbidopa</term><term>Levodopa</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antiparkinson Agents</term><term>Carbidopa</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Electromyography</term><term>Isometric Contraction</term></keywords><keywords scheme="MESH" qualifier="innervation" xml:lang="en"><term>Ankle Joint</term><term>Muscle, Skeletal</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Isometric Contraction</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Hypokinesia</term><term>Muscle Weakness</term><term>Parkinson Disease</term><term>Tremor</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Hypokinesia</term><term>Muscle Weakness</term><term>Parkinson Disease</term><term>Tremor</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Biomechanical Phenomena</term><term>Combined Modality Therapy</term><term>Electrodes, Implanted</term><term>Humans</term><term>Reference Values</term><term>Signal Processing, Computer-Assisted</term><term>Statistics as Topic</term><term>Torque</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We investigated the control of movement in 12 patients with Parkinson's disease (PD) after they received surgically implanted high-frequency stimulating electrodes in the subthalamic nucleus (STN). The experiment studied ankle strength, movement velocity, and the associated electromyographic patterns in PD patients, six of whom had tremor at the ankle. The patients were studied off treatment, ON STN deep brain stimulation (DBS), on medication, and on medication plus STN DBS. Twelve matched control subjects were also examined. Medication alone and STN DBS alone increased patients' ankle strength, ankle velocity, agonist muscle burst amplitude, and agonist burst duration, while reducing the number of agonist bursts during movement. These findings were similar for PD patients with and without tremor. The combination of medication plus STN DBS normalized maximal strength at the ankle joint, but ankle movement velocity and electromyographic patterns were not normalized. The findings are the first to demonstrate that STN DBS and medication increase strength and movement velocity at the ankle joint.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">16124011</PMID><DateCreated><Year>2006</Year><Month>01</Month><Day>19</Day></DateCreated><DateCompleted><Year>2006</Year><Month>07</Month><Day>03</Day></DateCompleted><DateRevised><Year>2014</Year><Month>09</Month><Day>20</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN><JournalIssue CitedMedium="Print"><Volume>21</Volume><Issue>1</Issue><PubDate><Year>2006</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Effects of deep brain stimulation and medication on strength, bradykinesia, and electromyographic patterns of the ankle joint in Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>50-8</MedlinePgn></Pagination><Abstract><AbstractText>We investigated the control of movement in 12 patients with Parkinson's disease (PD) after they received surgically implanted high-frequency stimulating electrodes in the subthalamic nucleus (STN). The experiment studied ankle strength, movement velocity, and the associated electromyographic patterns in PD patients, six of whom had tremor at the ankle. The patients were studied off treatment, ON STN deep brain stimulation (DBS), on medication, and on medication plus STN DBS. Twelve matched control subjects were also examined. Medication alone and STN DBS alone increased patients' ankle strength, ankle velocity, agonist muscle burst amplitude, and agonist burst duration, while reducing the number of agonist bursts during movement. These findings were similar for PD patients with and without tremor. The combination of medication plus STN DBS normalized maximal strength at the ankle joint, but ankle movement velocity and electromyographic patterns were not normalized. The findings are the first to demonstrate that STN DBS and medication increase strength and movement velocity at the ankle joint.</AbstractText><CopyrightInformation>Copyright (c) 2005 Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Vaillancourt</LastName><ForeName>David E</ForeName><Initials>DE</Initials><AffiliationInfo><Affiliation>Department of Movement Science, University of Illinois, Chicago, Illinois 60612, USA. court1@uic.edu</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Prodoehl</LastName><ForeName>Janey</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Sturman</LastName><ForeName>Molly M</ForeName><Initials>MM</Initials></Author><Author ValidYN="Y"><LastName>Bakay</LastName><ForeName>Roy A E</ForeName><Initials>RA</Initials></Author><Author ValidYN="Y"><LastName>Metman</LastName><ForeName>Leo Verhagen</ForeName><Initials>LV</Initials></Author><Author ValidYN="Y"><LastName>Corcos</LastName><ForeName>Daniel M</ForeName><Initials>DM</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>F32-NS-44727</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 NS052318</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 NS052318-02</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01-AR-33189</GrantID><Acronym>AR</Acronym><Agency>NIAMS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01-NS-28127</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01-NS-40902</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01-NS-52318</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000978">Antiparkinson Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>46627O600J</RegistryNumber><NameOfSubstance UI="D007980">Levodopa</NameOfSubstance></Chemical><Chemical><RegistryNumber>MNX7R8C5VO</RegistryNumber><NameOfSubstance 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UI="D007980">Levodopa</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000008">administration & dosage</QualifierName><QualifierName MajorTopicYN="N" UI="Q000009">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D018908">Muscle Weakness</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000628">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D018482">Muscle, Skeletal</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000294">innervation</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000175">diagnosis</QualifierName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000628">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName 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