Exercise improves efficacy of levodopa in patients with Parkinson's disease.
Identifieur interne : 002916 ( PubMed/Curation ); précédent : 002915; suivant : 002917Exercise improves efficacy of levodopa in patients with Parkinson's disease.
Auteurs : Siegfried Muhlack [Allemagne] ; Jacub Welnic ; Dirk Woitalla ; Thomas MüllerSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2007.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Antiparkinson Agents, Levodopa.
- blood : Parkinsonian Disorders.
- therapy : Parkinsonian Disorders.
- Aged, Area Under Curve, Exercise, Humans, Male, Middle Aged, Severity of Illness Index, Time Factors.
Abstract
The objective was to investigate the impact of exercise on absorption and efficacy of levodopa (LD) in patients with Parkinson's disease (PD). A soluble, immediate release LD formulation was given followed by exercise near the aerobic limit on one day to PD patients, who underwent the same procedure only at rest on the second day. LD plasma behavior did not significantly differ between both conditions, but the motor response was significantly better 120 and 150 min after LD intake on the day with exercise than on the day with rest. Moderate exercise increases clinical efficacy of LD.
DOI: 10.1002/mds.21346
PubMed: 17226855
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pubmed:17226855Le document en format XML
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<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Neurology, St. Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, Bochum 44791</wicri:regionArea>
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<term>Male</term>
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<front><div type="abstract" xml:lang="en">The objective was to investigate the impact of exercise on absorption and efficacy of levodopa (LD) in patients with Parkinson's disease (PD). A soluble, immediate release LD formulation was given followed by exercise near the aerobic limit on one day to PD patients, who underwent the same procedure only at rest on the second day. LD plasma behavior did not significantly differ between both conditions, but the motor response was significantly better 120 and 150 min after LD intake on the day with exercise than on the day with rest. Moderate exercise increases clinical efficacy of LD.</div>
</front>
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<Abstract><AbstractText>The objective was to investigate the impact of exercise on absorption and efficacy of levodopa (LD) in patients with Parkinson's disease (PD). A soluble, immediate release LD formulation was given followed by exercise near the aerobic limit on one day to PD patients, who underwent the same procedure only at rest on the second day. LD plasma behavior did not significantly differ between both conditions, but the motor response was significantly better 120 and 150 min after LD intake on the day with exercise than on the day with rest. Moderate exercise increases clinical efficacy of LD.</AbstractText>
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