Olfactory loss may be a first sign of idiopathic Parkinson's disease.
Identifieur interne : 002810 ( PubMed/Curation ); précédent : 002809; suivant : 002811Olfactory loss may be a first sign of idiopathic Parkinson's disease.
Auteurs : Antje Haehner [Allemagne] ; Thomas Hummel ; Cornelia Hummel ; Ulrike Sommer ; Susann Junghanns ; Heinz ReichmannSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2007.
English descriptors
- KwdEn :
- MESH :
- chemical : Reagent Kits, Diagnostic.
- classification : Parkinson Disease.
- diagnosis : Parkinson Disease.
- etiology : Agnosia.
- physiology : Smell.
- radionuclide imaging : Parkinson Disease.
- Follow-Up Studies, Humans, Taste, Tomography, Emission-Computed, Single-Photon.
Abstract
Recent studies support the idea of olfactory dysfunction as a very early sign of idiopathic Parkinson's disease (IPD). Aim of the present study was to clinically follow-up patients with idiopathic hyposmia to find out the percentage of patients developing IPD after 4 years time. At baseline, olfactory tests had been combined with transcranial sonography of the substantia nigra and (123)I-FP-CIT SPECT imaging. At the present neurological examination, 7% of the individuals with idiopathic hyposmia had developed clinical IPD. Altogether, 13% presented with abnormalities of the motor system. Our data suggest that a combination of olfactory testing and other tests may constitute a screening tool for the risk to develop IPD.
DOI: 10.1002/mds.21413
PubMed: 17357143
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pubmed:17357143Le document en format XML
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<front><div type="abstract" xml:lang="en">Recent studies support the idea of olfactory dysfunction as a very early sign of idiopathic Parkinson's disease (IPD). Aim of the present study was to clinically follow-up patients with idiopathic hyposmia to find out the percentage of patients developing IPD after 4 years time. At baseline, olfactory tests had been combined with transcranial sonography of the substantia nigra and (123)I-FP-CIT SPECT imaging. At the present neurological examination, 7% of the individuals with idiopathic hyposmia had developed clinical IPD. Altogether, 13% presented with abnormalities of the motor system. Our data suggest that a combination of olfactory testing and other tests may constitute a screening tool for the risk to develop IPD.</div>
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<Abstract><AbstractText>Recent studies support the idea of olfactory dysfunction as a very early sign of idiopathic Parkinson's disease (IPD). Aim of the present study was to clinically follow-up patients with idiopathic hyposmia to find out the percentage of patients developing IPD after 4 years time. At baseline, olfactory tests had been combined with transcranial sonography of the substantia nigra and (123)I-FP-CIT SPECT imaging. At the present neurological examination, 7% of the individuals with idiopathic hyposmia had developed clinical IPD. Altogether, 13% presented with abnormalities of the motor system. Our data suggest that a combination of olfactory testing and other tests may constitute a screening tool for the risk to develop IPD.</AbstractText>
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