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Olfactory loss may be a first sign of idiopathic Parkinson's disease.

Identifieur interne : 002810 ( PubMed/Curation ); précédent : 002809; suivant : 002811

Olfactory loss may be a first sign of idiopathic Parkinson's disease.

Auteurs : Antje Haehner [Allemagne] ; Thomas Hummel ; Cornelia Hummel ; Ulrike Sommer ; Susann Junghanns ; Heinz Reichmann

Source :

Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2007.

RBID : pubmed:17357143

English descriptors

KwdEn :
- Agnosia (etiology), Follow-Up Studies, Humans, Parkinson Disease (classification), Parkinson Disease (diagnosis), Parkinson Disease (radionuclide imaging), Reagent Kits, Diagnostic, Smell (physiology), Taste, Tomography, Emission-Computed, Single-Photon.
MESH :
- chemical : Reagent Kits, Diagnostic.
- classification : Parkinson Disease.
- diagnosis : Parkinson Disease.
- etiology : Agnosia.
- physiology : Smell.
- radionuclide imaging : Parkinson Disease.
- Follow-Up Studies, Humans, Taste, Tomography, Emission-Computed, Single-Photon.

Abstract

Recent studies support the idea of olfactory dysfunction as a very early sign of idiopathic Parkinson's disease (IPD). Aim of the present study was to clinically follow-up patients with idiopathic hyposmia to find out the percentage of patients developing IPD after 4 years time. At baseline, olfactory tests had been combined with transcranial sonography of the substantia nigra and (123)I-FP-CIT SPECT imaging. At the present neurological examination, 7% of the individuals with idiopathic hyposmia had developed clinical IPD. Altogether, 13% presented with abnormalities of the motor system. Our data suggest that a combination of olfactory testing and other tests may constitute a screening tool for the risk to develop IPD.

DOI: 10.1002/mds.21413
PubMed: 17357143

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pubmed:17357143

Le document en format XML

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<author><name sortKey="Haehner, Antje" sort="Haehner, Antje" uniqKey="Haehner A" first="Antje" last="Haehner">Antje Haehner</name>
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<author><name sortKey="Hummel, Cornelia" sort="Hummel, Cornelia" uniqKey="Hummel C" first="Cornelia" last="Hummel">Cornelia Hummel</name>
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<author><name sortKey="Junghanns, Susann" sort="Junghanns, Susann" uniqKey="Junghanns S" first="Susann" last="Junghanns">Susann Junghanns</name>
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<front><div type="abstract" xml:lang="en">Recent studies support the idea of olfactory dysfunction as a very early sign of idiopathic Parkinson's disease (IPD). Aim of the present study was to clinically follow-up patients with idiopathic hyposmia to find out the percentage of patients developing IPD after 4 years time. At baseline, olfactory tests had been combined with transcranial sonography of the substantia nigra and (123)I-FP-CIT SPECT imaging. At the present neurological examination, 7% of the individuals with idiopathic hyposmia had developed clinical IPD. Altogether, 13% presented with abnormalities of the motor system. Our data suggest that a combination of olfactory testing and other tests may constitute a screening tool for the risk to develop IPD.</div>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Olfactory loss may be a first sign of idiopathic Parkinson's disease.

Olfactory loss may be a first sign of idiopathic Parkinson's disease.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki