Striatal gray matter loss in Huntington's disease is leftward biased.
Identifieur interne : 002787 ( PubMed/Curation ); précédent : 002786; suivant : 002788Striatal gray matter loss in Huntington's disease is leftward biased.
Auteurs : Mark Mühlau [Allemagne] ; Christian Gaser ; Afra M. Wohlschl Ger ; Adolf Weindl ; Michael St Dtler ; Michael Valet ; Claus Zimmer ; Jan Kassubek ; Alexander PeinemannSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2007.
English descriptors
- KwdEn :
- Adult, Aged, Brain (pathology), Cognition Disorders (diagnosis), Cognition Disorders (epidemiology), Corpus Striatum (pathology), Female, Functional Laterality (physiology), Humans, Huntington Disease (diagnosis), Huntington Disease (epidemiology), Huntington Disease (pathology), Male, Middle Aged, Nerve Degeneration (epidemiology), Nerve Degeneration (pathology), Neuropsychological Tests, Severity of Illness Index.
- MESH :
- diagnosis : Cognition Disorders, Huntington Disease.
- epidemiology : Cognition Disorders, Huntington Disease, Nerve Degeneration.
- pathology : Brain, Corpus Striatum, Huntington Disease, Nerve Degeneration.
- physiology : Functional Laterality.
- Adult, Aged, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Severity of Illness Index.
Abstract
In Huntington's disease (HD), the distribution of pathological changes throughout the brain is incompletely understood. Some studies have identified leftward-biased lateralization, whereas others did not. We performed magnetic resonance imaging and a voxel-based asymmetry analysis in 44 right-handed HD gene carriers (presymptomatic, n = 5; stage I, n = 28; stage II, n = 11) and 44 right-handed healthy controls. The group comparison revealed leftward-biased gray matter loss in the striatum. Further analyses showed no indication of asymmetry in presymptomatic HD patients but an increase in asymmetry in the course of the HD stages under examination. Our study demonstrates and discusses leftward-biased gray matter loss in HD.
DOI: 10.1002/mds.21137
PubMed: 17394246
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pubmed:17394246Le document en format XML
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Wohlschl Ger</name></author><author><name sortKey="Weindl, Adolf" sort="Weindl, Adolf" uniqKey="Weindl A" first="Adolf" last="Weindl">Adolf Weindl</name></author><author><name sortKey="St Dtler, Michael" sort="St Dtler, Michael" uniqKey="St Dtler M" first="Michael" last="St Dtler">Michael St Dtler</name></author><author><name sortKey="Valet, Michael" sort="Valet, Michael" uniqKey="Valet M" first="Michael" last="Valet">Michael Valet</name></author><author><name sortKey="Zimmer, Claus" sort="Zimmer, Claus" uniqKey="Zimmer C" first="Claus" last="Zimmer">Claus Zimmer</name></author><author><name sortKey="Kassubek, Jan" sort="Kassubek, Jan" uniqKey="Kassubek J" first="Jan" last="Kassubek">Jan Kassubek</name></author><author><name sortKey="Peinemann, Alexander" sort="Peinemann, Alexander" uniqKey="Peinemann A" first="Alexander" last="Peinemann">Alexander Peinemann</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="doi">10.1002/mds.21137</idno><idno type="RBID">pubmed:17394246</idno><idno type="pmid">17394246</idno><idno type="wicri:Area/PubMed/Corpus">002787</idno><idno type="wicri:Area/PubMed/Curation">002787</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Striatal gray matter loss in Huntington's disease is leftward biased.</title><author><name sortKey="Muhlau, Mark" sort="Muhlau, Mark" uniqKey="Muhlau M" first="Mark" last="Mühlau">Mark Mühlau</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Technische Universität München, Munich, Germany. m.muehlau@neuro.med.tum.de</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Technische Universität München, Munich</wicri:regionArea></affiliation></author><author><name sortKey="Gaser, Christian" sort="Gaser, Christian" uniqKey="Gaser C" first="Christian" last="Gaser">Christian Gaser</name></author><author><name sortKey="Wohlschl Ger, Afra M" sort="Wohlschl Ger, Afra M" uniqKey="Wohlschl Ger A" first="Afra M" last="Wohlschl Ger">Afra M. Wohlschl Ger</name></author><author><name sortKey="Weindl, Adolf" sort="Weindl, Adolf" uniqKey="Weindl A" first="Adolf" last="Weindl">Adolf Weindl</name></author><author><name sortKey="St Dtler, Michael" sort="St Dtler, Michael" uniqKey="St Dtler M" first="Michael" last="St Dtler">Michael St Dtler</name></author><author><name sortKey="Valet, Michael" sort="Valet, Michael" uniqKey="Valet M" first="Michael" last="Valet">Michael Valet</name></author><author><name sortKey="Zimmer, Claus" sort="Zimmer, Claus" uniqKey="Zimmer C" first="Claus" last="Zimmer">Claus Zimmer</name></author><author><name sortKey="Kassubek, Jan" sort="Kassubek, Jan" uniqKey="Kassubek J" first="Jan" last="Kassubek">Jan Kassubek</name></author><author><name sortKey="Peinemann, Alexander" sort="Peinemann, Alexander" uniqKey="Peinemann A" first="Alexander" last="Peinemann">Alexander Peinemann</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Brain (pathology)</term><term>Cognition Disorders (diagnosis)</term><term>Cognition Disorders (epidemiology)</term><term>Corpus Striatum (pathology)</term><term>Female</term><term>Functional Laterality (physiology)</term><term>Humans</term><term>Huntington Disease (diagnosis)</term><term>Huntington Disease (epidemiology)</term><term>Huntington Disease (pathology)</term><term>Male</term><term>Middle Aged</term><term>Nerve Degeneration (epidemiology)</term><term>Nerve Degeneration (pathology)</term><term>Neuropsychological Tests</term><term>Severity of Illness Index</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Cognition Disorders</term><term>Huntington Disease</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Cognition Disorders</term><term>Huntington Disease</term><term>Nerve Degeneration</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term><term>Corpus Striatum</term><term>Huntington Disease</term><term>Nerve Degeneration</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Functional Laterality</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Severity of Illness Index</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In Huntington's disease (HD), the distribution of pathological changes throughout the brain is incompletely understood. Some studies have identified leftward-biased lateralization, whereas others did not. We performed magnetic resonance imaging and a voxel-based asymmetry analysis in 44 right-handed HD gene carriers (presymptomatic, n = 5; stage I, n = 28; stage II, n = 11) and 44 right-handed healthy controls. The group comparison revealed leftward-biased gray matter loss in the striatum. Further analyses showed no indication of asymmetry in presymptomatic HD patients but an increase in asymmetry in the course of the HD stages under examination. Our study demonstrates and discusses leftward-biased gray matter loss in HD.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">17394246</PMID><DateCreated><Year>2007</Year><Month>07</Month><Day>30</Day></DateCreated><DateCompleted><Year>2007</Year><Month>09</Month><Day>07</Day></DateCompleted><Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN><JournalIssue CitedMedium="Print"><Volume>22</Volume><Issue>8</Issue><PubDate><Year>2007</Year><Month>Jun</Month><Day>15</Day></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Striatal gray matter loss in Huntington's disease is leftward biased.</ArticleTitle><Pagination><MedlinePgn>1169-73</MedlinePgn></Pagination><Abstract><AbstractText>In Huntington's disease (HD), the distribution of pathological changes throughout the brain is incompletely understood. Some studies have identified leftward-biased lateralization, whereas others did not. We performed magnetic resonance imaging and a voxel-based asymmetry analysis in 44 right-handed HD gene carriers (presymptomatic, n = 5; stage I, n = 28; stage II, n = 11) and 44 right-handed healthy controls. The group comparison revealed leftward-biased gray matter loss in the striatum. Further analyses showed no indication of asymmetry in presymptomatic HD patients but an increase in asymmetry in the course of the HD stages under examination. Our study demonstrates and discusses leftward-biased gray matter loss in HD.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Mühlau</LastName><ForeName>Mark</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Neurology, Technische Universität München, Munich, Germany. m.muehlau@neuro.med.tum.de</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gaser</LastName><ForeName>Christian</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Wohlschläger</LastName><ForeName>Afra M</ForeName><Initials>AM</Initials></Author><Author ValidYN="Y"><LastName>Weindl</LastName><ForeName>Adolf</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Städtler</LastName><ForeName>Michael</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Valet</LastName><ForeName>Michael</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Zimmer</LastName><ForeName>Claus</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Kassubek</LastName><ForeName>Jan</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Peinemann</LastName><ForeName>Alexander</ForeName><Initials>A</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000328">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001921">Brain</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000473">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D003072">Cognition Disorders</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000175">diagnosis</QualifierName><QualifierName MajorTopicYN="N" UI="Q000453">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D003342">Corpus Striatum</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000473">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007839">Functional Laterality</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006816">Huntington Disease</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000175">diagnosis</QualifierName><QualifierName MajorTopicYN="N" UI="Q000453">epidemiology</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000473">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009410">Nerve Degeneration</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000453">epidemiology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009483">Neuropsychological Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012720">Severity of Illness Index</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2007</Year><Month>3</Month><Day>31</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2007</Year><Month>9</Month><Day>8</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2007</Year><Month>3</Month><Day>31</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mds.21137</ArticleId><ArticleId IdType="pubmed">17394246</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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